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Clinical and Translational Science Institute

Keywords
Last Name

William B. Applegate, MD, MPH, MACP

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine - Gerontology
Address
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    K07AG000126     (APPLEGATE, WILLIAM B)Jan 1, 1981 - Dec 31, 1985
    NIH/NIA
    GERIATRIC MEDICINE ACADEMIC AWARD
    Role: Principal Investigator

    U01HL037849     (SATTERFIELD, SUZANNE)Sep 30, 1986 - Jun 30, 1995
    NIH/NHLBI
    TRIALS OF HYPERTENSION PREVENTION (TOHP) PHASE II
    Role: Co-Principal Investigator

    T32AG000182     (APPLEGATE, WILLIAM B)Sep 1, 1989 - Apr 30, 2001
    NIH/NIA
    TRAINING GRANT: GERONTOLOGY AND GERIATRIC MEDICINE
    Role: Principal Investigator

    U01HL044298     (APPLEGATE, WILLIAM B)Jul 1, 1990 - Jun 30, 1992
    NIH/NHLBI
    HMG COA REDUCTASE INHIBITORS IN THE ELDERLY
    Role: Principal Investigator

    P60AG010484     (PAHOR, MARCO)Sep 30, 1991 - Sep 30, 2002
    NIH/NIA
    CLAUDE D PEPPER OLDER AMERICANS INDEPENDENCE CENTERS
    Role: Co-Principal Investigator

    R01AG009771     (APPLEGATE, WILLIAM B)Sep 15, 1992 - Mar 31, 1996
    NIH/NIA
    DIETARY INTERVENTIONS IN THE ELDERLY TRIAL
    Role: Principal Investigator

    M01RR007122     (APPLEGATE, WILLIAM B)Sep 30, 1992 - Aug 28, 2011
    NIH/NCRR
    General Clinical Research Center
    Role: Principal Investigator

    N01WH032118     (JOHNSON, KAREN C)Apr 13, 1993 - Sep 14, 2005
    NIH/WHI
    VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVE
    Role: Co-Principal Investigator

    N01HC045137     (APPLEGATE, WILLIAM B)Sep 28, 1994 - Sep 30, 2000
    NIH/NHLBI
    PHYSICAL ACTIVITY FOR HIGH-RISK SEDENTARY ADULTS
    Role: Principal Investigator

    S07RR018164     (APPLEGATE, WILLIAM B)Sep 1, 2002 - Aug 31, 2005
    NIH/NCRR
    Human Research Subjects Protections Program Outreach
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Stott DJ, Applegate WB. Perspectives on Hypertension Treatment in Older Persons. J Am Geriatr Soc. 2018 Jul; 66(6):1060-1061. PMID: 30133691.
      View in: PubMed
    2. Stott DJ, Applegate WB. Perspectives on hypertension treatment in older persons. Age Ageing. 2018 May 21. PMID: 29788159.
      View in: PubMed
    3. Colenda CC, Blazer DG, Reifler BV, Applegate WB. Battles Worth Fighting. J Am Geriatr Soc. 2018 Mar; 66(3):431-432. PMID: 29377060.
      View in: PubMed
    4. Lundebjerg NE, Trucil DE, Applegate WB. Reply to: Language Matters, So Geriatricians Should Talk of Declining Health and Death. J Am Geriatr Soc. 2017 Dec; 65(12):2743-2744. PMID: 29091268.
      View in: PubMed
    5. Applegate WB, Ouslander JG. Inaugural JAGS "Mini-Focus" Issue: Cardiovascular Disease. J Am Geriatr Soc. 2017 Nov; 65(11):2348. PMID: 29124730.
      View in: PubMed
    6. Cushman WC, Johnson KC, Applegate WB, Cutler JA. Pharmacologic Treatment of Hypertension in Adults Aged 60 Years or Older. Ann Intern Med. 2017 08 15; 167(4):290-291. PMID: 28806805.
      View in: PubMed
    7. Lundebjerg NE, Trucil DE, Hammond EC, Applegate WB. When It Comes to Older Adults, Language Matters: Journal of the American Geriatrics Society Adopts Modified American Medical Association Style. J Am Geriatr Soc. 2017 Jul; 65(7):1386-1388. PMID: 28568284.
      View in: PubMed
    8. Applegate WB, Ouslander JG. Journal of the American Geriatrics Society: Evolving Strategies and Processes. J Am Geriatr Soc. 2017 Jun; 65(6):1132-1133. PMID: 28631429.
      View in: PubMed
    9. Applegate WB. Across the Pond. J Am Geriatr Soc. 2017 May; 65(5):901-902. PMID: 28346657.
      View in: PubMed
    10. Applegate WB, Ip E. The Evolving Taxonomy of Health in Older Persons. JAMA. 2016 12 20; 316(23):2487-2488. PMID: 27997661.
      View in: PubMed
    11. Papademetriou V, Lovato L, Tsioufis C, Cushman W, Applegate WB, Mottle A, Punthakee Z, Nylen E, Doumas M. Effects of High Density Lipoprotein Raising Therapies on Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus, with or without Renal Impairment: The Action to Control Cardiovascular Risk in Diabetes Study. Am J Nephrol. 2017; 45(2):136-145. PMID: 27992863.
      View in: PubMed
    12. Odden MC, Wu C, Shlipak MG, Psaty BM, Katz R, Applegate WB, Harris T, Newman AB, Peralta CA. Blood Pressure Trajectory, Gait Speed, and Outcomes: The Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2016 12; 71(12):e1. PMID: 27838648.
      View in: PubMed
    13. Yoshikawa TT, Ouslander JG, Applegate WB. Influence of Studies Published by the Journal of the American Geriatrics Society: Top 20 Articles from 2000-2015. J Am Geriatr Soc. 2016 09; 64(9):1763-8. PMID: 27553684.
      View in: PubMed
    14. Applegate WB. JAGS Evolves: Creating a Proactive Forum. J Am Geriatr Soc. 2016 09; 64(9):1769. PMID: 27549398.
      View in: PubMed
    15. Applegate WB, Ouslander JG. Journal of the American Geriatrics Society in Transition: 15 Years of Innovation and Excellence Paves the Way for a Bright Future. J Am Geriatr Soc. 2016 07; 64(7):1399. PMID: 27401845.
      View in: PubMed
    16. Williamson JD, Supiano MA, Applegate WB, Berlowitz DR, Campbell RC, Chertow GM, Fine LJ, Haley WE, Hawfield AT, Ix JH, Kitzman DW, Kostis JB, Krousel-Wood MA, Launer LJ, Oparil S, Rodriguez CJ, Roumie CL, Shorr RI, Sink KM, Wadley VG, Whelton PK, Whittle J, Woolard NF, Wright JT, Pajewski NM. Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged =75 Years: A Randomized Clinical Trial. JAMA. 2016 Jun 28; 315(24):2673-82. PMID: 27195814; PMCID: PMC4988796 [Available on 12/28/16].
    17. Odden MC, Wu C, Shlipak MG, Psaty BM, Katz R, Applegate WB, Harris T, Newman AB, Peralta CA. Blood Pressure Trajectory, Gait Speed, and Outcomes: The Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2016 12; 71(12):1688-1694. PMID: 27142696.
      View in: PubMed
    18. Marsh AP, Applegate WB, Guralnik JM, Jack Rejeski W, Church TS, Fielding RA, Gill TM, King AC, Kritchevsky SB, Manini TM, McDermott MM, Newman AB, Stowe CL, Walkup MP, Pahor M, Miller ME. Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial. J Am Geriatr Soc. 2016 05; 64(5):933-43. PMID: 27225353.
      View in: PubMed
    19. Papademetriou V, Zaheer M, Doumas M, Lovato L, Applegate WB, Tsioufis C, Mottle A, Punthakee Z, Cushman WC. Cardiovascular Outcomes in Action to Control Cardiovascular Risk in Diabetes: Impact of Blood Pressure Level and Presence of Kidney Disease. Am J Nephrol. 2016; 43(4):271-80. PMID: 27161620.
      View in: PubMed
    20. Pajewski NM, Williamson JD, Applegate WB, Berlowitz DR, Bolin LP, Chertow GM, Krousel-Wood MA, Lopez-Barrera N, Powell JR, Roumie CL, Still C, Sink KM, Tang R, Wright CB, Supiano MA. Characterizing Frailty Status in the Systolic Blood Pressure Intervention Trial. J Gerontol A Biol Sci Med Sci. 2016 May; 71(5):649-55. PMID: 26755682; PMCID: PMC5007741 [Available on 05/01/17].
    21. Neiberg RH, Rejeski JJ, Applegate WB, Clark JM, Knowler WC, Bray GA, Espeland MA, Cheskin LJ. Self-Reported Gastrointestinal Symptoms in Type 2 Diabetes Improve With an Intensive Lifestyle Intervention: Results From the Action for Health in Diabetes (Look AHEAD) Clinical Trial. Clin Diabetes. 2015 Oct; 33(4):181-8. PMID: 26487792; PMCID: PMC4608270 [Available on 10/01/16].
    22. Applegate WB, Sink KM, Williamson JD. Managing high blood pressure in older persons with decline in function. Am J Kidney Dis. 2015 Nov; 66(5):745-7. PMID: 26188432.
      View in: PubMed
    23. Kalogeropoulos AP, Georgiopoulou VV, Murphy RA, Newman AB, Bauer DC, Harris TB, Yang Z, Applegate WB, Kritchevsky SB. Dietary sodium content, mortality, and risk for cardiovascular events in older adults: the Health, Aging, and Body Composition (Health ABC) Study. JAMA Intern Med. 2015 Mar; 175(3):410-9. PMID: 25599120.
      View in: PubMed
    24. Ober KP, Applegate WB. The electronic health record. Are we the tools of our tools? Pharos Alpha Omega Alpha Honor Med Soc. 2015; 78(1):8-14. PMID: 25796660.
      View in: PubMed
    25. Papademetriou V, Lovato L, Doumas M, Nylen E, Mottl A, Cohen RM, Applegate WB, Puntakee Z, Yale JF, Cushman WC. Chronic kidney disease and intensive glycemic control increase cardiovascular risk in patients with type 2 diabetes. Kidney Int. 2015 Mar; 87(3):649-59. PMID: 25229335.
      View in: PubMed
    26. Gencer B, Butler J, Bauer DC, Auer R, Kalogeropoulos A, Marques-Vidal P, Applegate WB, Satterfield S, Harris T, Newman A, Vittinghoff E, Rodondi N. Association of electrocardiogram abnormalities and incident heart failure events. Am Heart J. 2014 Jun; 167(6):869-75.e3. PMID: 24890537.
      View in: PubMed
    27. McDermott MM, Applegate WB, Bonds DE, Buford TW, Church T, Espeland MA, Gill TM, Guralnik JM, Haskell W, Lovato LC, Pahor M, Pepine CJ, Reid KF, Newman A. Ankle brachial index values, leg symptoms, and functional performance among community-dwelling older men and women in the lifestyle interventions and independence for elders study. J Am Heart Assoc. 2013 Nov 12; 2(6):e000257. PMID: 24222666; PMCID: PMC3886743.
    28. Miller ME, Williamson JD, Gerstein HC, Byington RP, Cushman WC, Ginsberg HN, Ambrosius WT, Lovato L, Applegate WB. Effects of randomization to intensive glucose control on adverse events, cardiovascular disease, and mortality in older versus younger adults in the ACCORD Trial. Diabetes Care. 2014; 37(3):634-43. PMID: 24170759; PMCID: PMC3931381.
    29. Mandyam MC, Soliman EZ, Alonso A, Dewland TA, Heckbert SR, Vittinghoff E, Cummings SR, Ellinor PT, Chaitman BR, Stocke K, Applegate WB, Arking DE, Butler J, Loehr LR, Magnani JW, Murphy RA, Satterfield S, Newman AB, Marcus GM. The QT interval and risk of incident atrial fibrillation. Heart Rhythm. 2013 Oct; 10(10):1562-8. PMID: 23872693.
      View in: PubMed
    30. Byington RP, Furberg CD, Herrington DM, Herd JA, Hunninghake D, Lowery M, Riley W, Craven T, Chaput L, Ireland CC, Applegate WB. Effect of estrogen plus progestin on progression of carotid atherosclerosis in postmenopausal women with heart disease: HERS B-mode substudy. Arterioscler Thromb Vasc Biol. 2002 Oct 01; 22(10):1692-7. PMID: 12377751.
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    31. Somes GW, Kritchevsky SB, Shorr RI, Pahor M, Applegate WB. Body mass index, weight change, and death in older adults: the systolic hypertension in the elderly program. Am J Epidemiol. 2002 Jul 15; 156(2):132-8. PMID: 12117704.
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    32. Applegate WB. Elderly patients' adherence to statin therapy. JAMA. 2002 Jul 24-31; 288(4):495-7. PMID: 12132982.
      View in: PubMed
    33. Penninx BW, Rejeski WJ, Pandya J, Miller ME, Di Bari M, Applegate WB, Pahor M. Exercise and depressive symptoms: a comparison of aerobic and resistance exercise effects on emotional and physical function in older persons with high and low depressive symptomatology. J Gerontol B Psychol Sci Soc Sci. 2002 Mar; 57(2):P124-32. PMID: 11867660.
      View in: PubMed
    34. Di Bari M, Pahor M, Barnard M, Gades N, Graney M, Franse LV, Penninx BW, Marchionni N, Applegate WB. Evaluation and correction for a 'training effect' in the cognitive assessment of older adults. Neuroepidemiology. 2002 Mar-Apr; 21(2):87-92. PMID: 11901278.
      View in: PubMed
    35. Pahor M, Franse LV, Deitcher SR, Cushman WC, Johnson KC, Shorr RI, Kottke-Marchant K, Tracy RP, Somes GW, Applegate WB. Fosinopril versus amlodipine comparative treatments study: a randomized trial to assess effects on plasminogen activator inhibitor-1. Circulation. 2002 Jan 29; 105(4):457-61. PMID: 11815428.
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    36. Applegate WB. JAGS Approaches Middle Age with a Growth Spurt! J Am Geriatr Soc. 2002 Jan; 50(1):7-8. PMID: 12028239.
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    37. Penninx BW, Messier SP, Rejeski WJ, Williamson JD, DiBari M, Cavazzini C, Applegate WB, Pahor M. Physical exercise and the prevention of disability in activities of daily living in older persons with osteoarthritis. Arch Intern Med. 2001 Oct 22; 161(19):2309-16. PMID: 11606146.
      View in: PubMed
    38. Ferrucci L, Furberg CD, Penninx BW, DiBari M, Williamson JD, Guralnik JM, Chen JG, Applegate WB, Pahor M. Treatment of isolated systolic hypertension is most effective in older patients with high-risk profile. Circulation. 2001 Oct 16; 104(16):1923-6. PMID: 11602495.
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    39. Pahor M, Psaty BM, Alderman MH, Applegate WB, Furberg CD. Blood-pressure-lowering treatment. Lancet. 2001 Jul 14; 358(9276):152-3. PMID: 11469244.
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    40. Di Bari M, Pahor M, Franse LV, Shorr RI, Wan JY, Ferrucci L, Somes GW, Applegate WB. Dementia and disability outcomes in large hypertension trials: lessons learned from the systolic hypertension in the elderly program (SHEP) trial. Am J Epidemiol. 2001 Jan 01; 153(1):72-8. PMID: 11159149.
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    41. Pahor M, Psaty BM, Alderman MH, Applegate WB, Williamson JD, Cavazzini C, Furberg CD. Health outcomes associated with calcium antagonists compared with other first-line antihypertensive therapies: a meta-analysis of randomised controlled trials. Lancet. 2000 Dec 09; 356(9246):1949-54. PMID: 11130522.
      View in: PubMed
    42. Garg R, Elam MB, Crouse JR, Davis KB, Kennedy JW, Egan D, Herd JA, Hunninghake DB, Johnson WC, Kostis JB, Sheps DS, Applegate WB. Effective and safe modification of multiple atherosclerotic risk factors in patients with peripheral arterial disease. Am Heart J. 2000 Nov; 140(5):792-803. PMID: 11054628.
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    43. O'Toole ML, Johnson KC, Satterfield S, Bush AJ, Koo WW, Klesges RC, Applegate WB. Do sweat calcium losses affect bone mass during firefighter training? J Occup Environ Med. 2000 Nov; 42(11):1054-9. PMID: 11094783.
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    44. Hsia J, Simon JA, Lin F, Applegate WB, Vogt MT, Hunninghake D, Carr M. Peripheral arterial disease in randomized trial of estrogen with progestin in women with coronary heart disease: the Heart and Estrogen/Progestin Replacement Study. Circulation. 2000 Oct 31; 102(18):2228-32. PMID: 11056097.
      View in: PubMed
    45. Chesney CM, Elam MB, Herd JA, Davis KB, Garg R, Hunninghake D, Kennedy JW, Applegate WB. Effect of niacin, warfarin, and antioxidant therapy on coagulation parameters in patients with peripheral arterial disease in the Arterial Disease Multiple Intervention Trial (ADMIT). Am Heart J. 2000 Oct; 140(4):631-6. PMID: 11011338.
      View in: PubMed
    46. Franse LV, Pahor M, Di Bari M, Shorr RI, Wan JY, Somes GW, Applegate WB. Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP). J Hypertens. 2000 Aug; 18(8):1149-54. PMID: 10954008.
      View in: PubMed
    47. Perry HM, Davis BR, Price TR, Applegate WB, Fields WS, Guralnik JM, Kuller L, Pressel S, Stamler J, Probstfield JL. Effect of treating isolated systolic hypertension on the risk of developing various types and subtypes of stroke: the Systolic Hypertension in the Elderly Program (SHEP). JAMA. 2000 Jul 26; 284(4):465-71. PMID: 10904510.
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    48. Pahor M, Psaty BM, Alderman MH, Applegate WB, Williamson JD, Furberg CD. Therapeutic benefits of ACE inhibitors and other antihypertensive drugs in patients with type 2 diabetes. Diabetes Care. 2000 Jul; 23(7):888-92. PMID: 10895836.
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    49. Chao D, Espeland MA, Farmer D, Register TC, Lenchik L, Applegate WB, Ettinger WH. Effect of voluntary weight loss on bone mineral density in older overweight women. J Am Geriatr Soc. 2000 Jul; 48(7):753-9. PMID: 10894313.
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    50. Franse LV, Pahor M, Di Bari M, Somes GW, Cushman WC, Applegate WB. Hypokalemia associated with diuretic use and cardiovascular events in the Systolic Hypertension in the Elderly Program. Hypertension. 2000 May; 35(5):1025-30. PMID: 10818057.
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    51. Johnson KC, Graney MJ, Applegate WB, Kitabchi AE, Runyan JW, Rutan GH. Does syndrome X exist in hypertensive elderly persons with impaired glycemic control? J Gerontol A Biol Sci Med Sci. 1999 Nov; 54(11):M571-6. PMID: 10619320.
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    52. Somes GW, Pahor M, Shorr RI, Cushman WC, Applegate WB. The role of diastolic blood pressure when treating isolated systolic hypertension. Arch Intern Med. 1999 Sep 27; 159(17):2004-9. PMID: 10510985.
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    53. Byington RP, Evans GW, Espeland MA, Applegate WB, Hunninghake DB, Probstfield J, Furberg CD. Effects of lovastatin and warfarin on early carotid atherosclerosis: sex-specific analyses. Asymptomatic Carotid Artery Progression Study (ACAPS) Research Group. Circulation. 1999 Jul 20; 100(3):e14-7. PMID: 10411862.
      View in: PubMed
    54. Espeland MA, Whelton PK, Kostis JB, Bahnson JL, Ettinger WH, Cutler JA, Appel LJ, Kumanyika S, Farmer D, Elam J, Wilson AC, Applegate WB. Predictors and mediators of successful long-term withdrawal from antihypertensive medications. TONE Cooperative Research Group. Trial of Nonpharmacologic Interventions in the Elderly. Arch Fam Med. 1999 May-Jun; 8(3):228-36. PMID: 10333818.
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    55. Pahor M, Elam MB, Garrison RJ, Kritchevsky SB, Applegate WB. Emerging noninvasive biochemical measures to predict cardiovascular risk. Arch Intern Med. 1999 Feb 08; 159(3):237-45. PMID: 9989535.
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    56. Pahor M, Somes GW, Franse LV, Shorr RI, Applegate WB. Prevention of dementia: Syst-Eur trial. Lancet. 1999 Jan 16; 353(9148):235; author reply 236-7. PMID: 9923896.
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    57. Cummings SR, Black DM, Thompson DE, Applegate WB, Barrett-Connor E, Musliner TA, Palermo L, Prineas R, Rubin SM, Scott JC, Vogt T, Wallace R, Yates AJ, LaCroix AZ. Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial. JAMA. 1998 Dec 23-30; 280(24):2077-82. PMID: 9875874.
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    58. Blair SN, Applegate WB, Dunn AL, Ettinger WH, Haskell WL, King AC, Morgan TM, Shih JA, Simons-Morton DG. Activity Counseling Trial (ACT): rationale, design, and methods. Activity Counseling Trial Research Group. Med Sci Sports Exerc. 1998 Jul; 30(7):1097-106. PMID: 9662679.
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    59. Pahor M, Shorr RI, Somes GW, Cushman WC, Ferrucci L, Bailey JE, Elam JT, Applegate WB. Diuretic-based treatment and cardiovascular events in patients with mild renal dysfunction enrolled in the systolic hypertension in the elderly program. Arch Intern Med. 1998 Jun 22; 158(12):1340-5. PMID: 9645829.
      View in: PubMed
    60. Savage PJ, Pressel SL, Curb JD, Schron EB, Applegate WB, Black HR, Cohen J, Davis BR, Frost P, Smith W, Gonzalez N, Guthrie GP, Oberman A, Rutan G, Probstfield JL, Stamler J. Influence of long-term, low-dose, diuretic-based, antihypertensive therapy on glucose, lipid, uric acid, and potassium levels in older men and women with isolated systolic hypertension: The Systolic Hypertension in the Elderly Program. SHEP Cooperative Research Group. Arch Intern Med. 1998 Apr 13; 158(7):741-51. PMID: 9554680.
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    61. Chang CF, Kiser LJ, Bailey JE, Martins M, Gibson WC, Schaberg KA, Mirvis DM, Applegate WB. Tennessee's failed managed care program for mental health and substance abuse services. JAMA. 1998 Mar 18; 279(11):864-9. PMID: 9516002.
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    62. Whelton PK, Appel LJ, Espeland MA, Applegate WB, Ettinger WH, Kostis JB, Kumanyika S, Lacy CR, Johnson KC, Folmar S, Cutler JA. Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE). TONE Collaborative Research Group. JAMA. 1998 Mar 18; 279(11):839-46. PMID: 9515998.
      View in: PubMed
    63. Applegate WB. Quality of life during antihypertensive treatment. Lessons from the Systolic Hypertension in the Elderly Program. Am J Hypertens. 1998 Mar; 11(3 Pt 2):57S-61S. PMID: 9546039.
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    64. Applegate WB. Anti-hypertensive therapy reduced the incidence of stroke in older patients with isolated systolic hypertension. Evid Based Cardiovasc Med. 1998 Mar; 2(1):22. PMID: 16379786.
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    65. Shorr RI, Johnson KC, Wan JY, Sutton-Tyrrell K, Pahor M, Bailey JE, Applegate WB. The prognostic significance of asymptomatic carotid bruits in the elderly. J Gen Intern Med. 1998 Feb; 13(2):86-90. PMID: 9502367; PMCID: PMC1496903.
    66. Pahor M, Applegate WB. Recent advances. Geriatric medicine. BMJ. 1997 Oct 25; 315(7115):1071-4. PMID: 9366739; PMCID: PMC2127696.
    67. Kostis JB, Davis BR, Cutler J, Grimm RH, Berge KG, Cohen JD, Lacy CR, Perry HM, Blaufox MD, Wassertheil-Smoller S, Black HR, Schron E, Berkson DM, Curb JD, Smith WM, McDonald R, Applegate WB. Prevention of heart failure by antihypertensive drug treatment in older persons with isolated systolic hypertension. SHEP Cooperative Research Group. JAMA. 1997 Jul 16; 278(3):212-6. PMID: 9218667.
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    68. Applegate WB, Pahor M. Geriatric medicine. JAMA. 1997 Jun 18; 277(23):1863-4. PMID: 9185804.
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    69. Johnson KC, Graney MJ, Applegate WB, Kitabchi AE, Runyan JW, Shorr RI. Prevalence of undiagnosed non-insulin-dependent diabetes mellitus and impaired glucose tolerance in a cohort of older persons with hypertension. J Am Geriatr Soc. 1997 Jun; 45(6):695-700. PMID: 9180662.
      View in: PubMed
    70. Stamler J, Applegate WB, Cohen JD, Cutler JA, Whelton PK. More on dietary sodium and blood pressure. JAMA. 1997 May 28; 277(20):1594-6. PMID: 9168287.
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    71. Elam MB, Cushman W, Applegate WB, Heimberg M. Recent developments in coronary heart disease prevention: the Scandinavian and west of Scotland studies. Tenn Med. 1997 May; 90(5):189-92. PMID: 9130876.
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    72. Applegate WB, Rich MW, Cheitlin MD. Integrating geriatrics into cardiology training programs. J Am Geriatr Soc. 1997 May; 45(5):641-2. PMID: 9158592.
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    73. Applegate WB, Graney MJ. Overlapping publications. J Am Geriatr Soc. 1997 Feb; 45(2):249. PMID: 9064303.
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    74. Santanello NC, Barber BL, Applegate WB, Elam J, Curtis C, Hunninghake DB, Gordon DJ. Effect of pharmacologic lipid lowering on health-related quality of life in older persons: results from the Cholesterol Reduction in Seniors Program (CRISP) Pilot Study. J Am Geriatr Soc. 1997 Jan; 45(1):8-14. PMID: 8994481.
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    75. Applegate WB. Evolution of our understanding of the importance of elevated systolic blood pressure. Tenn Med. 1997 Jan; 90(1):24-6. PMID: 8997159.
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    76. Applegate WB, Furberg CD, Byington RP, Grimm R. The Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS) JAMA. 1997 Jan 22-29; 277(4):297; author reply 297-8. PMID: 9002488.
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    77. Curb JD, Pressel SL, Cutler JA, Savage PJ, Applegate WB, Black H, Camel G, Davis BR, Frost PH, Gonzalez N, Guthrie G, Oberman A, Rutan GH, Stamler J. Effect of diuretic-based antihypertensive treatment on cardiovascular disease risk in older diabetic patients with isolated systolic hypertension. Systolic Hypertension in the Elderly Program Cooperative Research Group. JAMA. 1996 Dec 18; 276(23):1886-92. PMID: 8968014.
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    78. Applegate WB. Rationale and safety of angiotensin converting enzyme inhibitor combination with calcium channel blockers. Am J Hypertens. 1996 Dec; 9(12 Pt 2):192S. PMID: 8968433.
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    79. Whelton PK, Cohen JD, Applegate WB. Dietary sodium and blood pressure. JAMA. 1996 Nov 13; 276(18):1467-8; author reply 1469-70. PMID: 8903250.
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    80. Espeland MA, Kumanyika S, Kostis JB, Algire J, Applegate WB, Ettinger W, Whelton PK, Bahnson J. Antihypertensive medication use among recruits for the Trial of Nonpharmacologic Interventions in the Elderly (TONE). J Am Geriatr Soc. 1996 Oct; 44(10):1183-9. PMID: 8855996.
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    81. Applegate WB, Sowers JR. Elevated systolic blood pressure: increased cardiovascular risk and rationale for treatment. Am J Med. 1996 Sep 30; 101(3A):3S-9S. PMID: 8876470.
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    82. Garrison RJ, Klesges LM, Applegate WB. Improving dietary patterns and physical activity levels among children and adolescents. JAMA. 1996 Jul 17; 276(3):195. PMID: 8667557.
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    83. Klesges RC, Ward KD, Shelton ML, Applegate WB, Cantler ED, Palmieri GM, Harmon K, Davis J. Changes in bone mineral content in male athletes. Mechanisms of action and intervention effects. JAMA. 1996 Jul 17; 276(3):226-30. PMID: 8667568.
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    84. Applegate WB, Cohen JD, Wolfson P, Davis A, Green S. Evaluation of blood pressure response to the combination of enalapril (single dose) and diltiazem ER (four different doses) in systemic hypertension. Am J Cardiol. 1996 Jul 01; 78(1):51-5. PMID: 8712118.
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    85. Applegate WB, Burns R. Geriatric medicine. JAMA. 1996 Jun 19; 275(23):1812-3. PMID: 8642724.
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    86. Wassertheil-Smoller S, Applegate WB, Berge K, Chang CJ, Davis BR, Grimm R, Kostis J, Pressel S, Schron E. Change in depression as a precursor of cardiovascular events. SHEP Cooperative Research Group (Systoloc Hypertension in the elderly). Arch Intern Med. 1996 Mar 11; 156(5):553-61. PMID: 8604962.
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    87. Mirvis DM, Chang CF, Hall CJ, Zaar GT, Applegate WB. TennCare--health system reform for Tennessee. JAMA. 1995 Oct 18; 274(15):1235-41. PMID: 7563515.
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    88. Hughes TA, Elam MB, Applegate WB, Bond MG, Hughes SM, Wang X, Tolley EA, Bittle JB, Stentz FB, Kang ES. Postprandial lipoprotein responses in hypertriglyceridemic subjects with and without cardiovascular disease. Metabolism. 1995 Aug; 44(8):1082-98. PMID: 7637651.
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    89. Manolio TA, Cutler JA, Furberg CD, Psaty BM, Whelton PK, Applegate WB. Trends in pharmacologic management of hypertension in the United States. Arch Intern Med. 1995 Apr 24; 155(8):829-37. PMID: 7717791.
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    90. Probstfield J, Applegate WB. Prospective meta-analysis: ahoy! A clinical trial? J Am Geriatr Soc. 1995 Apr; 43(4):452-3. PMID: 7706639.
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    91. Appel LJ, Espeland M, Whelton PK, Dolecek T, Kumanyika S, Applegate WB, Ettinger WH, Kostis JB, Wilson AC, Lacy C, et al. Trial of Nonpharmacologic Intervention in the Elderly (TONE). Design and rationale of a blood pressure control trial. Ann Epidemiol. 1995 Mar; 5(2):119-29. PMID: 7795830.
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    92. Yamamoto ME, Applegate WB, Klag MJ, Borhani NO, Cohen JD, Kirchner KA, Lakatos E, Sacks FM, Taylor JO, Hennekens CH. Lack of blood pressure effect with calcium and magnesium supplementation in adults with high-normal blood pressure. Results from Phase I of the Trials of Hypertension Prevention (TOHP). Trials of Hypertension Prevention (TOHP) Collaborative Research Group. Ann Epidemiol. 1995 Mar; 5(2):96-107. PMID: 7795837.
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    93. Johnson JA, Akers WS, Miller ST, Applegate WB. Lymphocyte beta 2-receptor activity, metoprolol kinetics, and response to metoprolol in hypertensive black men. Pharmacotherapy. 1995 Mar-Apr; 15(2):150-7. PMID: 7624261.
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    94. Davis CE, Applegate WB, Gordon DJ, Curtis RC, McCormick M. An empirical evaluation of the placebo run-in. Control Clin Trials. 1995 Feb; 16(1):41-50. PMID: 7743788.
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    95. Applegate WB, Pressel S, Wittes J, Luhr J, Shekelle RB, Camel GH, Greenlick MR, Hadley E, Moye L, Perry HM, et al. Impact of the treatment of isolated systolic hypertension on behavioral variables. Results from the systolic hypertension in the elderly program. Arch Intern Med. 1994 Oct 10; 154(19):2154-60. PMID: 7944835.
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    96. Furberg CD, Adams HP, Applegate WB, Byington RP, Espeland MA, Hartwell T, Hunninghake DB, Lefkowitz DS, Probstfield J, Riley WA, et al. Effect of lovastatin on early carotid atherosclerosis and cardiovascular events. Asymptomatic Carotid Artery Progression Study (ACAPS) Research Group. Circulation. 1994 Oct; 90(4):1679-87. PMID: 7734010.
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    97. Ram CV, Ames RP, Applegate WB, Burris JF, Davidov ME, Mroczek WJ. Double-blind comparison of amlodipine and hydrochlorothiazide in patients with mild to moderate hypertension. Clin Cardiol. 1994 May; 17(5):251-6. PMID: 8004839.
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    98. Sacks FM, Hebert P, Appel LJ, Borhani NO, Applegate WB, Cohen JD, Cutler JA, Kirchner KA, Kuller LH, Roth KJ, et al. Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the Trials of Hypertension Prevention. J Hypertens. 1994 Feb; 12(2):209-13. PMID: 8021472.
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    99. Miller ST, Applegate WB, Elam JT, Graney MJ. Influence of diagnostic classification on outcomes and charges in geriatric assessment and rehabilitation. J Am Geriatr Soc. 1994 Jan; 42(1):11-5. PMID: 8277105.
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    100. Sacks FM, Hebert P, Appel LJ, Borhani NO, Applegate WB, Cohen JD, Cutler JA, Kirchner KA, Kuller LH, Roth KJ, et al. The effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the Trials of Hypertension Prevention. Trials of Hypertension Prevention Collaborative Research Group. J Hypertens Suppl. 1994; 12(7):S23-31. PMID: 7769501.
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    101. Pool PE, Applegate WB, Woehler T, Sandall P, Cady WJ. A randomized, controlled trial comparing diltiazem, hydrochlorothiazide, and their combination in the therapy of essential hypertension. Pharmacotherapy. 1993 Sep-Oct; 13(5):487-93. PMID: 8247917.
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    102. Applegate WB. Ankle/arm blood pressure index. A useful test for clinical practice? JAMA. 1993 Jul 28; 270(4):497-8. PMID: 8320792.
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    103. Burns R, Nichols LO, Graney MJ, Applegate WB. Mortality in a public and a private hospital compared: the severity of antecedent disorders in Medicare patients. Am J Public Health. 1993 Jul; 83(7):966-71. PMID: 8328618; PMCID: PMC1694782.
    104. Applegate WB. Managing the older patient with hypertension. Am J Hypertens. 1993 Jul; 6(7 Pt 2):277S-282S. PMID: 8398012.
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    105. Paton RN, Graney MJ, Elam JT, Applegate WB. Prediction of elder caregiver burden. J Tenn Med Assoc. 1993 Feb; 86(2):53-6. PMID: 8426455.
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    106. Applegate WB, Rutan GH. Advances in management of hypertension in older persons. J Am Geriatr Soc. 1992 Nov; 40(11):1164-74. PMID: 1401705.
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    107. Applegate WB. The relative importance of focusing on elevations of systolic vs diastolic blood pressure. A definitive answer at last. Arch Intern Med. 1992 Oct; 152(10):1969-71. PMID: 1417368.
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    108. Riley WA, Barnes RW, Applegate WB, Dempsey R, Hartwell T, Davis VG, Bond MG, Furberg CD. Reproducibility of noninvasive ultrasonic measurement of carotid atherosclerosis. The Asymptomatic Carotid Artery Plaque Study. Stroke. 1992 Aug; 23(8):1062-8. PMID: 1636178.
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    109. Applegate WB. The hypertensive patient. Not just a number. Postgrad Med. 1992 Jul; 92(1):237-44. PMID: 1614934.
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    110. Applegate WB, Miller ST, Elam JT, Cushman WC, el Derwi D, Brewer A, Graney MJ. Nonpharmacologic intervention to reduce blood pressure in older patients with mild hypertension. Arch Intern Med. 1992 Jun; 152(6):1162-6. PMID: 1599343.
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    111. Whelton PK, Hebert PR, Cutler J, Applegate WB, Eberlein KA, Klag MJ, Keough ME, Hamill S, Borhani NO, Hollis J, et al. Baseline characteristics of participants in phase I of the Trials of Hypertension Prevention. Ann Epidemiol. 1992 May; 2(3):295-310. PMID: 1342280.
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    112. Applegate WB. High blood pressure treatment in the elderly. Clin Geriatr Med. 1992 Feb; 8(1):103-17. PMID: 1576569.
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    113. Miller ST, Elam JT, Graney MJ, Applegate WB. Discrepancies in recording systolic blood pressure of elderly persons by ambulatory blood pressure monitor. Am J Hypertens. 1992 Jan; 5(1):16-21. PMID: 1736929.
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    114. Applegate WB. Systolic hypertension in older persons. Adv Intern Med. 1992; 37:37-54. PMID: 1558003.
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    115. Applegate WB, Davis BR, Black HR, Smith WM, Miller ST, Burlando AJ. Prevalence of postural hypotension at baseline in the Systolic Hypertension in the Elderly Program (SHEP) cohort. J Am Geriatr Soc. 1991 Nov; 39(11):1057-64. PMID: 1753042.
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    116. Applegate WB, Graney MJ, Miller ST, Elam JT. Impact of a geriatric assessment unit on subsequent health care charges. Am J Public Health. 1991 Oct; 81(10):1302-6. PMID: 1928529; PMCID: PMC1405339.
    117. Elam JT, Graney MJ, Beaver T, el Derwi D, Applegate WB, Miller ST. Comparison of subjective ratings of function with observed functional ability of frail older persons. Am J Public Health. 1991 Sep; 81(9):1127-30. PMID: 1951822; PMCID: PMC1405654.
    118. Rubenstein LZ, Applegate WB, Burton JR, Hyer K, Pawlson LG, Winograd CH. Medicare reimbursement for geriatric assessment: report of the American Geriatrics Society Ad Hoc Committee on Geriatrics Assessment. J Am Geriatr Soc. 1991 Sep; 39(9):926-31. PMID: 1885868.
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    119. Applegate WB, Phillips HL, Schnaper H, Shepherd AM, Schocken D, Luhr JC, Koch GG, Park GD. A randomized controlled trial of the effects of three antihypertensive agents on blood pressure control and quality of life in older women. Arch Intern Med. 1991 Sep; 151(9):1817-23. PMID: 1888248.
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    120. Jahnigen DW, Applegate WB, Cohen HJ, Epstein A, Granger C, Hogan D, Kennedy R, Lazaroff A. Working group recommendations: research on content and efficacy of geriatric evaluation and management interventions. J Am Geriatr Soc. 1991 Sep; 39(9 Pt 2):42S-44S. PMID: 1885877.
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    121. Satterfield S, Cutler JA, Langford HG, Applegate WB, Borhani NO, Brittain E, Cohen JD, Kuller LH, Lasser NL, Oberman A, et al. Trials of hypertension prevention. Phase I design. Ann Epidemiol. 1991 Aug; 1(5):455-71. PMID: 1669525.
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    122. Borhani NO, Applegate WB, Cutler JA, Davis BR, Furberg CD, Lakatos E, Page L, Perry HM, Smith WM, Probstfield JL. Systolic Hypertension in the Elderly Program (SHEP). Part 1: Rationale and design. Hypertension. 1991 Mar; 17(3 Suppl):II2-15. PMID: 1999373.
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    123. Applegate WB, Borhani N, DeQuattro V, Kaihlanen PM, Oishi S, Due DL, Sirgo MA. Comparison of labetalol versus enalapril as monotherapy in elderly patients with hypertension: results of 24-hour ambulatory blood pressure monitoring. Am J Med. 1991 Feb; 90(2):198-205. PMID: 1996588.
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    124. Applegate WB, Byington RP. MIDAS, the Multicenter Isradipine/Diuretic Atherosclerosis Study. Design features and baseline data. Am J Hypertens. 1991 Feb; 4(2 Pt 2):114S-117S. PMID: 1827000.
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    125. Applegate WB, Hughes JP, Vander Zwaag R. Case-control study of coronary heart disease risk factors in the elderly. J Clin Epidemiol. 1991; 44(4-5):409-15. PMID: 2010784.
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    126. Applegate WB, Curb JD. Designing and executing randomized clinical trials involving elderly persons. J Am Geriatr Soc. 1990 Aug; 38(8):943-50. PMID: 2387959.
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    127. Applegate WB, Miller ST, Graney MJ, Elam JT, Burns R, Akins DE. A randomized, controlled trial of a geriatric assessment unit in a community rehabilitation hospital. N Engl J Med. 1990 May 31; 322(22):1572-8. PMID: 2186276.
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    128. Rosmarin PC, Applegate WB, Somes GW. Coffee consumption and blood pressure: a randomized, crossover clinical trial. J Gen Intern Med. 1990 May-Jun; 5(3):211-3. PMID: 2095747.
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    129. Applegate WB, Blass JP, Williams TF. Instruments for the functional assessment of older patients. N Engl J Med. 1990 Apr 26; 322(17):1207-14. PMID: 2183053.
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    130. Rosmarin PC, Applegate WB, Somes GW. Coffee consumption and serum lipids: a randomized, crossover clinical trial. Am J Med. 1990 Apr; 88(4):349-56. PMID: 2183599.
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    131. Applegate WB, Miller ST. Choice of antihypertensive medication regimen. Clin Geriatr Med. 1989 Nov; 5(4):803-11. PMID: 2691066.
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    132. Applegate WB. Hypertension in elderly patients. Ann Intern Med. 1989 Jun 01; 110(11):901-15. PMID: 2655523.
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    133. Applegate WB. Therapeutic choices for the older hypertensive patient. J Natl Med Assoc. 1989 Apr; 81 Suppl:25-9. PMID: 2738960; PMCID: PMC2625779.
    134. Probstfield JL, Applegate WB, Borhani NO, Curb JD, Cutler JA, Davis BR, Furberg CD, Hawkins CM, Lakatos E, Page LB, et al. The Systolic Hypertension in the Elderly Program (SHEP): an intervention trial on isolated systolic hypertension. SHEP Cooperative Research Group. Clin Exp Hypertens A. 1989; 11(5-6):973-89. PMID: 2676266.
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    135. Elam JT, Graney MJ, Applegate WB, Miller ST, Freeman JM, Wood TO, Gettlefinger TC. Functional outcome one year following cataract surgery in elderly persons. J Gerontol. 1988 Sep; 43(5):M122-6. PMID: 3418032.
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    136. Miller ST, Graney MJ, Elam JT, Applegate WB, Freeman JM. Predictions of outcomes from cataract surgery in elderly persons. Ophthalmology. 1988 Aug; 95(8):1125-9. PMID: 3231453.
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    137. Burris JF, Ames RP, Applegate WB, Ram CV, Davidov ME, Mroczek WJ. Double-blind comparison of amlodipine and hydrochlorothiazide in patients with mild to moderate hypertension. J Cardiovasc Pharmacol. 1988; 12 Suppl 7:S98-102. PMID: 2467140.
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    138. Applegate WB, Miller ST, Elam JT, Freeman JM, Wood TO, Gettlefinger TC. Impact of cataract surgery with lens implantation on vision and physical function in elderly patients. JAMA. 1987 Feb 27; 257(8):1064-6. PMID: 3806895.
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    139. Applegate WB. Use of assessment instruments in clinical settings. J Am Geriatr Soc. 1987 Jan; 35(1):45-50. PMID: 3794146.
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    140. Perry CB, Applegate WB. Medical paternalism and patient self-determination. J Am Geriatr Soc. 1985 May; 33(5):353-9. PMID: 3989201.
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    141. Miller ST, Applegate WB, Perry C. Clinical trials in elderly persons. J Am Geriatr Soc. 1985 Feb; 33(2):91-2. PMID: 3968376.
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    142. Applegate WB, Carper ER, Kahn SE, Westbrook L, Linton M, Baker MG, Runyan JW. Comparison of the use of reserpine versus alpha-methyldopa for second step treatment of hypertension in the elderly. J Am Geriatr Soc. 1985 Feb; 33(2):109-15. PMID: 3968365.
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    143. Applegate WB, Graves S, Collins T, Vander Zwaag R, Akins D. Acute myocardial infarction in elderly patients. South Med J. 1984 Sep; 77(9):1127-9. PMID: 6484679.
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    144. Applegate WB, Dismuke SE, Runyan JW. Treatment of hypertension in the elderly: a time for caution? J Am Geriatr Soc. 1984 Jan; 32(1):21-3. PMID: 6361107.
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    145. Applegate WB, Akins D, Vander Zwaag R, Thoni K, Baker MG. A geriatric rehabilitation and assessment unit in a community hospital. J Am Geriatr Soc. 1983 Apr; 31(4):206-10. PMID: 6833696.
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    146. Applegate WB, Vander Zwaag R, Dismuke SE, Runyan JW. Control of systolic blood pressure in elderly black patients. J Am Geriatr Soc. 1982 Jun; 30(6):391-6. PMID: 7077021.
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    147. Applegate WB, Runyan JW, Brasfield L, Williams ML, Konigsberg C, Fouche C. Analysis of the 1980 heat wave in Memphis. J Am Geriatr Soc. 1981 Aug; 29(8):337-42. PMID: 7264123.
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    148. Spector MH, Applegate WB, Olmstead SJ, DiVasto PV, Skipper B. Assessment of attitudes toward mass screening for colorectal cancer and polyps. Prev Med. 1981 Jan; 10(1):105-9. PMID: 7232341.
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    149. Lyle CB, Applegate WB, Citron DS, Williams OD. Practice habits in a group of eight internists. Ann Intern Med. 1976 May; 84(5):594-601. PMID: 1275366.
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    150. Levy RC, Applegate WB. Student-community health projects. How to win friends without influencing people. JAMA. 1972 May 22; 220(8):1113-5. PMID: 5067512.
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