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Clinical and Translational Science Institute

Last Name

Victor Enrique Ortega, M.D.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine - Pulmonary
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    Collapse Research 
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    K08HL118128     (ORTEGA, VICTOR E)Jul 1, 2015 - Mar 31, 2018
    Effects of Rare Variants and Ancestry on Beta Agonist Response In Asthma
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Li X, Ortega VE, Ampleford EJ, Graham Barr R, Christenson SA, Cooper CB, Couper D, Dransfield MT, Han MLK, Hansel NN, Hoffman EA, Kanner RE, Kleerup EC, Martinez FJ, Paine R, Woodruff PG, Hawkins GA, Bleecker ER, Meyers DA. Genome-wide association study of lung function and clinical implication in heavy smokers. BMC Med Genet. 2018 Aug 01; 19(1):134. PMID: 30068317.
      View in: PubMed
    2. Lima JJ, Castro M, King TS, Lang JE, Ortega VE, Peters SP, Denlinger LC, Israel E, Sorkness CA, Wechsler ME, Wenzel SE, Smith LJ. Association of free vitamin D3 concentrations and asthma treatment failures in the VIDA Trial. Ann Allergy Asthma Immunol. 2018 Oct; 121(4):444-450.e1. PMID: 29908319.
      View in: PubMed
    3. Labaki WW, Xia M, Murray S, Curtis JL, Barr RG, Bhatt SP, Bleecker ER, Hansel NN, Cooper CB, Dransfield MT, Wells JM, Hoffman EA, Kanner RE, Paine R, Ortega VE, Peters SP, Krishnan JA, Bowler RP, Couper DJ, Woodruff PG, Martinez FJ, Martinez CH, Han MK. NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort. Respir Med. 2018 07; 140:87-93. PMID: 29957287.
      View in: PubMed
    4. Ortega VE. Picking the Right Fruit: Intersecting Chronic Obstructive Pulmonary Disease Genome-Wide Association Study Discoveries with Epigenetics. Am J Respir Crit Care Med. 2018 May 15; 197(10):1237-1239. PMID: 29425467.
      View in: PubMed
    5. Khoury O, Barrios C, Ortega V, Atala A, Murphy SV. Immunomodulatory Cell Therapy to Target Cystic Fibrosis Inflammation. Am J Respir Cell Mol Biol. 2018 Jan; 58(1):12-20. PMID: 28707978.
      View in: PubMed
    6. Hastie AT, Martinez FJ, Curtis JL, Doerschuk CM, Hansel NN, Christenson S, Putcha N, Ortega VE, Li X, Barr RG, Carretta EE, Couper DJ, Cooper CB, Hoffman EA, Kanner RE, Kleerup E, O'Neal WK, Paine R, Peters SP, Alexis NE, Woodruff PG, Han MK, Meyers DA, Bleecker ER. Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort. Lancet Respir Med. 2017 12; 5(12):956-967. PMID: 29146301.
      View in: PubMed
    7. Cardet JC, Louisias M, King TS, Castro M, Codispoti CD, Dunn R, Engle L, Giles BL, Holguin F, Lima JJ, Long D, Lugogo N, Nyenhuis S, Ortega VE, Ramratnam S, Wechsler ME, Israel E, Phipatanakul W. Income is an independent risk factor for worse asthma outcomes. J Allergy Clin Immunol. 2018 Feb; 141(2):754-760.e3. PMID: 28535964.
      View in: PubMed
    8. Himes BE, Ortega VE. Making progress toward understanding the genetic architecture of asthma in the most affected US ethnic group. Eur Respir J. 2017 05; 49(5). PMID: 28461304.
      View in: PubMed
    9. Celedón JC, Burchard EG, Schraufnagel D, Castillo-Salgado C, Schenker M, Balmes J, Neptune E, Cummings KJ, Holguin F, Riekert KA, Wisnivesky JP, Garcia JGN, Roman J, Kittles R, Ortega VE, Redline S, Mathias R, Thomas A, Samet J, Ford JG. An American Thoracic Society/National Heart, Lung, and Blood Institute Workshop Report: Addressing Respiratory Health Equality in the United States. Ann Am Thorac Soc. 2017 May; 14(5):814-826. PMID: 28459618.
      View in: PubMed
    10. Ortega VE, Pecchiari M. Understanding at-risk subgroups for lung function impairment in life-long nonsmokers with a1-antitrypsin deficiency. Eur Respir J. 2017 03; 49(3). PMID: 28356380.
      View in: PubMed
    11. Ortega VE, Torgerson DG. On a Collision Course: The Electronic Medical Record and Genetic Studies of Asthma. Am J Respir Crit Care Med. 2017 02 15; 195(4):412-414. PMID: 28199158.
      View in: PubMed
    12. Mathias RA, Taub MA, Gignoux CR, Fu W, Musharoff S, O'Connor TD, Vergara C, Torgerson DG, Pino-Yanes M, Shringarpure SS, Huang L, Rafaels N, Boorgula MP, Johnston HR, Ortega VE, Levin AM, Song W, Torres R, Padhukasahasram B, Eng C, Mejia-Mejia DA, Ferguson T, Qin ZS, Scott AF, Yazdanbakhsh M, Wilson JG, Marrugo J, Lange LA, Kumar R, Avila PC, Williams LK, Watson H, Ware LB, Olopade C, Olopade O, Oliveira R, Ober C, Nicolae DL, Meyers D, Mayorga A, Knight-Madden J, Hartert T, Hansel NN, Foreman MG, Ford JG, Faruque MU, Dunston GM, Caraballo L, Burchard EG, Bleecker E, Araujo MI, Herrera-Paz EF, Gietzen K, Grus WE, Bamshad M, Bustamante CD, Kenny EE, Hernandez RD, Beaty TH, Ruczinski I, Akey J, Barnes KC. A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome. Nat Commun. 2016 10 11; 7:12522. PMID: 27725671.
      View in: PubMed
    13. Ortega VE, Celedón JC. The Advent of High-Throughput Sequencing Studies of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 06 15; 193(12):1323-4. PMID: 27304235; PMCID: PMC4910894 [Available on 06/15/17].
    14. Ortega VE, Kumar R. The Effect of Ancestry and Genetic Variation on Lung Function Predictions: What Is "Normal" Lung Function in Diverse Human Populations? Curr Allergy Asthma Rep. 2015 Apr; 15(4):16. PMID: 26130473.
      View in: PubMed
    15. Ortega VE. Predictive genetic profiles for ß-agonist therapy in asthma. A future under construction. Am J Respir Crit Care Med. 2015 Mar 01; 191(5):494-6. PMID: 25723819.
      View in: PubMed
    16. Ortega VE, Meyers DA, Bleecker ER. Asthma pharmacogenetics and the development of genetic profiles for personalized medicine. Pharmgenomics Pers Med. 2015; 8:9-22. PMID: 25691813; PMCID: PMC4325626.
    17. Ortega VE, Meyers DA. Implications of population structure and ancestry on asthma genetic studies. Curr Opin Allergy Clin Immunol. 2014 Oct; 14(5):381-9. PMID: 25153337; PMCID: PMC4278361.
    18. Ortega VE, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Busse WW, Castro M, Chardon D, Erzurum SC, Israel E, Montealegre F, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting ß agonist treatment in a multiethnic asthma population: a genetic study. Lancet Respir Med. 2014 Mar; 2(3):204-13. PMID: 24621682; PMCID: PMC4053167.
    19. Ortega VE, Meyers DA. Pharmacogenetics: implications of race and ethnicity on defining genetic profiles for personalized medicine. J Allergy Clin Immunol. 2014 Jan; 133(1):16-26. PMID: 24369795; PMCID: PMC3933289.
    20. Miller SM, Ortega VE. Pharmacogenetics and the development of personalized approaches for combination therapy in asthma. Curr Allergy Asthma Rep. 2013 Oct; 13(5):443-52. PMID: 23912588; PMCID: PMC3878163.
    21. Ortega VE, Wechsler ME. Asthma pharmacogenetics: responding to the call for a personalized approach. Curr Opin Allergy Clin Immunol. 2013 Aug; 13(4):399-409. PMID: 23799335.
      View in: PubMed
    22. Hastie AT, Moore WC, Li H, Rector BM, Ortega VE, Pascual RM, Peters SP, Meyers DA, Bleecker ER. Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects. J Allergy Clin Immunol. 2013 Jul; 132(1):72-80. PMID: 23706399; PMCID: PMC3704048.
    23. Ortega VE, Peters SP. Beta-2 adrenergic agonists: focus on safety and benefits versus risks. Curr Opin Pharmacol. 2010 Jun; 10(3):246-53. PMID: 20452285.
      View in: PubMed
    24. Ortega VE, Hawkins GA, Peters SP, Bleecker ER. Pharmacogenetics of the beta 2-adrenergic receptor gene. Immunol Allergy Clin North Am. 2007 Nov; 27(4):665-84; vii. PMID: 17996583; PMCID: PMC2736101.
    25. Penn RB, Ortega VE, Bleecker ER. A Roadmap to functional genomics. Physiol Genomics. 2007 Jun 19; 30(1):82-8. PMID: 17327496.
      View in: PubMed
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