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Clinical and Translational Science Institute

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Last Name

Tao Ma, Ph.D.

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine - Gerontology
Address
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    Other Positions
    TitleAssistant Professor
    InstitutionWake Forest School of Medicine
    DepartmentNeurobiology and Anatomy


    Collapse Research 
    Collapse research activities and funding
    K99AG044469     (MA, TAO)Sep 1, 2013 - Jul 31, 2015
    NIH/NIA
    AMPK in Alzheimer's Disease-Associated Synaptic Failure and Memory Deficits
    Role: Principal Investigator

    R00AG044469     (MA, TAO)Sep 1, 2015 - Mar 31, 2018
    NIH/NIA
    AMPK in Alzheimer's Disease-Associated Synaptic Failure and Memory Deficits
    Role: Principal Investigator

    R01AG055581     (MA, TAO)Jul 15, 2017 - Apr 30, 2022
    NIH/NIA
    Isoform-specific roles of AMPK in synaptic failure and memory deficit in Alzheimer's Disease
    Role: Principal Investigator

    R01AG056622     (MA, TAO)Aug 1, 2017 - Apr 30, 2022
    NIH/NIA
    Role of protein synthesis in Alzheimers disease-associated impairments of synaptic plasticity and memory
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Zimmermann HR, Yang W, Beckelman BC, Kasica NP, Zhou X, Galli LD, Ryazanov AG, Ma T. Genetic removal of eIF2a kinase PERK in mice enables hippocampal L-LTP independent of mTORC1 activity. J Neurochem. 2018 Jul; 146(2):133-144. PMID: 29337352.
      View in: PubMed
    2. Ding H, Kiguchi N, Kishioka S, Ma T, Peters CM, Ko MC. Differential mRNA expression of neuroinflammatory modulators in the spinal cord and thalamus of type 2 diabetic monkeys. J Diabetes. 2018 Nov; 10(11):886-895. PMID: 29749036.
      View in: PubMed
    3. Day SM, Yang W, Ewin S, Zhou X, Ma T. Glucagon-like peptide-1 cleavage product GLP-1 (9-36) amide enhances hippocampal long-term synaptic plasticity in correlation with suppression of Kv4.2 expression and eEF2 phosphorylation. Hippocampus. 2017 12; 27(12):1264-1274. PMID: 28833775.
      View in: PubMed
    4. Beckelman BC, Day S, Zhou X, Donohue M, Gouras GK, Klann E, Keene CD, Ma T. Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease. J Alzheimers Dis. 2016 09 06; 54(2):669-78. PMID: 27567813.
      View in: PubMed
    5. Yang W, Zhou X, Zimmermann HR, Cavener DR, Klann E, Ma T. Repression of the eIF2a kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease. Neurobiol Aging. 2016 May; 41:19-24. PMID: 27103515.
      View in: PubMed
    6. Beckelman BC, Zhou X, Keene CD, Ma T. Impaired Eukaryotic Elongation Factor 1A Expression in Alzheimer's Disease. Neurodegener Dis. 2016; 16(1-2):39-43. PMID: 26551858.
      View in: PubMed
    7. Ma T, Chen Y, Vingtdeux V, Zhao H, Viollet B, Marambaud P, Klann E. Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid ß. J Neurosci. 2014 Sep 03; 34(36):12230-8. PMID: 25186765.
      View in: PubMed
    8. Ma T, Klann E. PERK: a novel therapeutic target for neurodegenerative diseases? Alzheimers Res Ther. 2014; 6(3):30. PMID: 25031640.
      View in: PubMed
    9. Trinh MA, Ma T, Kaphzan H, Bhattacharya A, Antion MD, Cavener DR, Hoeffer CA, Klann E. The eIF2a kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression. Learn Mem. 2014 Apr 16; 21(5):298-304. PMID: 24741110.
      View in: PubMed
    10. Kurinami H, Shimamura M, Ma T, Qian L, Koizumi K, Park L, Klann E, Manfredi G, Iadecola C, Zhou P. Prohibitin viral gene transfer protects hippocampal CA1 neurons from ischemia and ameliorates postischemic hippocampal dysfunction. Stroke. 2014 Apr; 45(4):1131-8. PMID: 24619393.
      View in: PubMed
    11. Ma T. GSK3 in Alzheimer's disease: mind the isoforms. J Alzheimers Dis. 2014; 39(4):707-10. PMID: 24254703.
      View in: PubMed
    12. Zhou X, Zhang J, Chen Y, Ma T, Wang Y, Wang J, Zhang Z. Aggravated cognitive and brain functional impairment in mild cognitive impairment patients with type 2 diabetes: a resting-state functional MRI study. J Alzheimers Dis. 2014; 41(3):925-35. PMID: 24705547.
      View in: PubMed
    13. Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, DiMarchi RD, Tschöp MH. Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. Sci Transl Med. 2013 Oct 30; 5(209):209ra151. PMID: 24174327.
      View in: PubMed
    14. Ma T, Trinh MA, Wexler AJ, Bourbon C, Gatti E, Pierre P, Cavener DR, Klann E. Suppression of eIF2a kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci. 2013 Sep; 16(9):1299-305. PMID: 23933749.
      View in: PubMed
    15. Hoeffer CA, Santini E, Ma T, Arnold EC, Whelan AM, Wong H, Pierre P, Pelletier J, Klann E. Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation. J Neurophysiol. 2013 Jan; 109(1):68-76. PMID: 23054596.
      View in: PubMed
    16. Ma T, Du X, Pick JE, Sui G, Brownlee M, Klann E. Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice. J Neurosci. 2012 Oct 03; 32(40):13701-8. PMID: 23035082.
      View in: PubMed
    17. Ma T, Tzavaras N, Tsokas P, Landau EM, Blitzer RD. Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of glycogen synthetase kinase-3. J Neurosci. 2011 Nov 30; 31(48):17537-46. PMID: 22131415.
      View in: PubMed
    18. Ma T, Klann E. Amyloid ß: linking synaptic plasticity failure to memory disruption in Alzheimer's disease. J Neurochem. 2012 Jan; 120 Suppl 1:140-8. PMID: 22122128.
      View in: PubMed
    19. Yang WZ, Guo JY, Li Y, An F, Zhang YQ, Ma T. [Transurethral resection of the prostate for urinary retention after seed implantation for prostate cancer: report of 2 cases]. Zhonghua Nan Ke Xue. 2011 Nov; 17(11):1011-3. PMID: 22141273.
      View in: PubMed
    20. Ma T, Hoeffer CA, Wong H, Massaad CA, Zhou P, Iadecola C, Murphy MP, Pautler RG, Klann E. Amyloid ß-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide. J Neurosci. 2011 Apr 13; 31(15):5589-95. PMID: 21490199.
      View in: PubMed
    21. Ma T, Hoeffer CA, Capetillo-Zarate E, Yu F, Wong H, Lin MT, Tampellini D, Klann E, Blitzer RD, Gouras GK. Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease. PLoS One. 2010 Sep 20; 5(9). PMID: 20862226.
      View in: PubMed
    22. Tampellini D, Rahman N, Gallo EF, Huang Z, Dumont M, Capetillo-Zarate E, Ma T, Zheng R, Lu B, Nanus DM, Lin MT, Gouras GK. Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations. J Neurosci. 2009 Aug 05; 29(31):9704-13. PMID: 19657023.
      View in: PubMed
    23. Tsokas P, Grace EA, Chan P, Ma T, Sealfon SC, Iyengar R, Landau EM, Blitzer RD. Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation. J Neurosci. 2005 Jun 15; 25(24):5833-43. PMID: 15958750.
      View in: PubMed
    24. Ma T, Qi QH, Xu J, Dong ZL, Yang WX. Signal pathways involved in emodin-induced contraction of smooth muscle cells from rat colon. World J Gastroenterol. 2004 May 15; 10(10):1476-9. PMID: 15133857.
      View in: PubMed
    25. Ma T, Qi QH, Yang WX, Xu J, Dong ZL. Contractile effects and intracellular Ca2+ signalling induced by emodin in circular smooth muscle cells of rat colon. World J Gastroenterol. 2003 Aug; 9(8):1804-7. PMID: 12918125.
      View in: PubMed
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