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Clinical and Translational Science Institute

Keywords
Last Name

Shannon Lynn Macauley-Rambach, Ph.D.

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine - Gerontology
Address
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    Collapse Biography 
    Collapse education and training
    Middlebury CollegeB.A.1999Biology & Psychology
    Washington UniversityPh.D.2009Neuroscience
    Washington UniversityFellowship2011Internal Medicine
    Washington UniversityFellowship2015Neurology

    Collapse Overview 
    Collapse overview
    Shannon L. Macauley, PhD is an Assistant Professor of Internal Medicine in the Section on Gerontology and Geriatric Medicine at Wake Forest University School of Medicine. She is also a member of the Sticht Center on Aging and Alzheimer’s Prevention and the Center for Diabetes, Obesity, and Metabolism. The main focus of Dr. Macauley’s work is to understand diseases of the central nervous system (CNS) and how secondary mechanisms, such altered CNS metabolism, impact neuronal health and function. Her work is focused in two main areas: 1) the interplay between Alzheimer’s disease (AD) and type-2-diabetes (T2D) and 2) the understanding and treatment of lysosomal storage diseases (LSDs). As it relates to the relationship between AD and T2D, the Macauley lab uses mouse models to understand how metabolic perturbations, either systemically or within the brain, affect the progression of AD-related pathology, such as the production, clearance, and aggregation of amyloid-beta (Aß) or tau. She uses a variety of methods, including glucose clamps, in vivo microdialysis, and neuroimaging techniques to study the acute effects of metabolic challenges on Aß dynamics within the brain’s interstitial fluid (ISF) as well as chronic studies to investigate what metabolic factors impact the progression of AD-related pathology and functional deficits. Ultimately, the goal is to leverage these findings as therapeutic targets for treating neurodegenerative disorders.


    Collapse Research 
    Collapse research activities and funding
    F31NS056718     (MACAULEY-RAMBACH, SHANNON L)May 1, 2007 - Apr 30, 2010
    NIH/NINDS
    Cellular Pathology of Batten Disease
    Role: Principal Investigator

         (MACAULEY-RAMBACH, SHANNON)Jan 1, 2010 - Sep 15, 2011
    Batten Disease Support & Research Association Research Award
    Activated astrocytes as therapeutic targets in INCL
    Role: Principal Investigator

    F32NS080320     (MACAULEY-RAMBACH, SHANNON L)Apr 1, 2013 - Mar 31, 2016
    NIH/NINDS
    Effects of Altered Glucose Utilization on AB Levels and Functional Connectivity
    Role: Principal Investigator

         (MACAULEY-RAMBACH, SHANNON L)Apr 1, 2015 - Mar 30, 2016
    DONOR'S CURE - NEW VISION AWARD
    Targeting the link between Alzheimer’s disease and diabetes with KATP channel modulators
    Role: Principal Investigator

         (MACAULEY-RAMBACH, SHANNON & BAUER, ADAM)Apr 1, 2016 - Mar 30, 2018
    McDonnell Center for Systems Neuroscience
    Mapping glucose utilization in a mouse model of beta amyloidosis
    Role: Co-Principal Investigator

    K01AG050719     (MACAULEY-RAMBACH, SHANNON L)Apr 1, 2016 - Mar 31, 2021
    NIH/NIA
    Effects of Hyperglycemia on Neuronal Activity, Cerebral Metabolism, and Amyloid-beta Levels
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Arnold SE, Arvanitakis Z, Macauley-Rambach SL, Koenig AM, Wang HY, Ahima RS, Craft S, Gandy S, Buettner C, Stoeckel LE, Holtzman DM, Nathan DM. Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums. Nat Rev Neurol. 2018 Mar; 14(3):168-181. PMID: 29377010.
      View in: PubMed
    2. Ju YS, Ooms SJ, Sutphen C, Macauley SL, Zangrilli MA, Jerome G, Fagan AM, Mignot E, Zempel JM, Claassen JAHR, Holtzman DM. Slow wave sleep disruption increases cerebrospinal fluid amyloid-ß levels. Brain. 2017 Aug 01; 140(8):2104-2111. PMID: 28899014.
      View in: PubMed
    3. Stanley M, Macauley SL, Caesar EE, Koscal LJ, Moritz W, Robinson GO, Roh J, Keyser J, Jiang H, Holtzman DM. The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-ß in Young and Old APP/PS1 Mice. J Neurosci. 2016 11 16; 36(46):11704-11715. PMID: 27852778.
      View in: PubMed
    4. Harris RA, Tindale L, Lone A, Singh O, Macauley SL, Stanley M, Holtzman DM, Bartha R, Cumming RC. Aerobic Glycolysis in the Frontal Cortex Correlates with Memory Performance in Wild-Type Mice But Not the APP/PS1 Mouse Model of Cerebral Amyloidosis. J Neurosci. 2016 Feb 10; 36(6):1871-8. PMID: 26865611.
      View in: PubMed
    5. Macauley SL, Stanley M, Caesar EE, Yamada SA, Raichle ME, Perez R, Mahan TE, Sutphen CL, Holtzman DM. Hyperglycemia modulates extracellular amyloid-ß concentrations and neuronal activity in vivo. J Clin Invest. 2015 Jun; 125(6):2463-7. PMID: 25938784.
      View in: PubMed
    6. Macauley SL, Wozniak DF, Kielar C, Tan Y, Cooper JD, Sands MS. Cerebellar pathology and motor deficits in the palmitoyl protein thioesterase 1-deficient mouse. Exp Neurol. 2009 May; 217(1):124-35. PMID: 19416667.
      View in: PubMed
    7. Macauley SL, Sidman RL, Schuchman EH, Taksir T, Stewart GR. Neuropathology of the acid sphingomyelinase knockout mouse model of Niemann-Pick A disease including structure-function studies associated with cerebellar Purkinje cell degeneration. Exp Neurol. 2008 Dec; 214(2):181-92. PMID: 18778708.
      View in: PubMed
    8. Lin D, Donsante A, Macauley S, Levy B, Vogler C, Sands MS. Central nervous system-directed AAV2/5-mediated gene therapy synergizes with bone marrow transplantation in the murine model of globoid-cell leukodystrophy. Mol Ther. 2007 Jan; 15(1):44-52. PMID: 17164774.
      View in: PubMed
    9. Kielar C, Maddox L, Bible E, Pontikis CC, Macauley SL, Griffey MA, Wong M, Sands MS, Cooper JD. Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis. Neurobiol Dis. 2007 Jan; 25(1):150-62. PMID: 17046272.
      View in: PubMed
    10. Griffey M, Macauley SL, Ogilvie JM, Sands MS. AAV2-mediated ocular gene therapy for infantile neuronal ceroid lipofuscinosis. Mol Ther. 2005 Sep; 12(3):413-21. PMID: 15979943.
      View in: PubMed
    11. Passini MA, Macauley SL, Huff MR, Taksir TV, Bu J, Wu IH, Piepenhagen PA, Dodge JC, Shihabuddin LS, O'Riordan CR, Schuchman EH, Stewart GR. AAV vector-mediated correction of brain pathology in a mouse model of Niemann-Pick A disease. Mol Ther. 2005 May; 11(5):754-62. PMID: 15851014.
      View in: PubMed
    12. Shihabuddin LS, Numan S, Huff MR, Dodge JC, Clarke J, Macauley SL, Yang W, Taksir TV, Parsons G, Passini MA, Gage FH, Stewart GR. Intracerebral transplantation of adult mouse neural progenitor cells into the Niemann-Pick-A mouse leads to a marked decrease in lysosomal storage pathology. J Neurosci. 2004 Nov 24; 24(47):10642-51. PMID: 15564580.
      View in: PubMed
    13. Sleat DE, Wiseman JA, El-Banna M, Kim KH, Mao Q, Price S, Macauley SL, Sidman RL, Shen MM, Zhao Q, Passini MA, Davidson BL, Stewart GR, Lobel P. A mouse model of classical late-infantile neuronal ceroid lipofuscinosis based on targeted disruption of the CLN2 gene results in a loss of tripeptidyl-peptidase I activity and progressive neurodegeneration. J Neurosci. 2004 Oct 13; 24(41):9117-26. PMID: 15483130.
      View in: PubMed
    14. Macauley SL, Horsch AD, Oterdoom M, Zheng MH, Stewart GR. The effects of transforming growth factor-beta2 on dopaminergic graft survival. Cell Transplant. 2004; 13(3):245-52. PMID: 15191162.
      View in: PubMed
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