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Clinical and Translational Science Institute

Keywords
Last Name

Steven J. Kridel, Ph.D.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentCancer Biology
Address
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentSurgical Sciences-Urology


    Collapse Research 
    Collapse research activities and funding
    F32AR008508     (KRIDEL, STEVEN J)Mar 29, 1998
    NIH/NIAMS
    BIOCHEMICAL ANALYSIS OF MELTRIN ALPHA IN MYOGENESIS
    Role: Principal Investigator

    T32CA079448     (KRIDEL, STEVEN J)Mar 15, 2000 - Aug 31, 2015
    NIH/NCI
    Training Program in Cancer Biology
    Role: Principal Investigator

    R01CA114104     (KRIDEL, STEVEN J)Sep 1, 2006 - Jul 31, 2011
    NIH/NCI
    Fatty acid synthase inhibitors and prostate cancer
    Role: Principal Investigator

    R01CA161503     (KRIDEL, STEVEN J)Jul 11, 2012 - Apr 30, 2017
    NIH/NCI
    NAD+ metabolism in prostate cancer
    Role: Principal Investigator

    R25CA229105     (WATABE, KOUNOSUKE)Sep 20, 2018 - Aug 31, 2023
    NIH/NCI
    Training program to promote diversity in cancer research
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Chmielewski JP, Bowlby SC, Wheeler FB, Shi L, Sui G, Davis AL, Howard TD, D'Agostino RB, Miller LD, Sirintrapun SJ, Cramer SD, Kridel SJ. CD38 Inhibits Prostate Cancer Metabolism and Proliferation by Reducing Cellular NAD+ Pools. Mol Cancer Res. 2018 Nov; 16(11):1687-1700. PMID: 30076241.
      View in: PubMed
    2. Jin G, Xu C, Zhang X, Long J, Rezaeian AH, Liu C, Furth ME, Kridel S, Pasche B, Bian XW, Lin HK. Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells. Nat Immunol. 2018 Jan; 19(1):29-40. PMID: 29242539.
      View in: PubMed
    3. Souchek JJ, Davis AL, Hill TK, Holmes MB, Qi B, Singh PK, Kridel SJ, Mohs AM. Combination Treatment with Orlistat-Containing Nanoparticles and Taxanes Is Synergistic and Enhances Microtubule Stability in Taxane-Resistant Prostate Cancer Cells. Mol Cancer Ther. 2017 09; 16(9):1819-1830. PMID: 28615298.
      View in: PubMed
    4. Wang J, Zhang X, Shi J, Cao P, Wan M, Zhang Q, Wang Y, Kridel SJ, Liu W, Xu J, Zhang Q, Sui G. Fatty acid synthase is a primary target of MiR-15a and MiR-16-1 in breast cancer. Oncotarget. 2016 Nov 29; 7(48):78566-78576. PMID: 27713175.
      View in: PubMed
    5. Coleman DT, Gray AL, Kridel SJ, Cardelli JA. Palmitoylation regulates the intracellular trafficking and stability of c-Met. Oncotarget. 2016 May 31; 7(22):32664-77. PMID: 27081699.
      View in: PubMed
    6. Hill TK, Davis AL, Wheeler FB, Kelkar SS, Freund EC, Lowther WT, Kridel SJ, Mohs AM. Development of a Self-Assembled Nanoparticle Formulation of Orlistat, Nano-ORL, with Increased Cytotoxicity against Human Tumor Cell Lines. Mol Pharm. 2016 Mar 07; 13(3):720-8. PMID: 26824142.
      View in: PubMed
    7. Zhang Q, Wan M, Shi J, Horita DA, Miller LD, Kute TE, Kridel SJ, Kulik G, Sui G. Yin Yang 1 promotes mTORC2-mediated AKT phosphorylation. J Mol Cell Biol. 2016 06; 8(3):232-43. PMID: 26762111.
      View in: PubMed
    8. Ritchie MK, Johnson LC, Clodfelter JE, Pemble CW, Fulp BE, Furdui CM, Kridel SJ, Lowther WT. Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE. J Biol Chem. 2016 Feb 12; 291(7):3520-30. PMID: 26663084.
      View in: PubMed
    9. Gao C, Wang N, Guo X, Ziegler JT, Taylor KD, Xiang AH, Hai Y, Kridel SJ, Nadler JL, Kandeel F, Raffel LJ, Chen YD, Norris JM, Rotter JI, Watanabe RM, Wagenknecht LE, Bowden DW, Speliotes EK, Goodarzi MO, Langefeld CD, Palmer ND. A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS). PLoS One. 2015; 10(11):e0134649. PMID: 26599207.
      View in: PubMed
    10. Suburu J, Shi L, Wu J, Wang S, Samuel M, Thomas MJ, Kock ND, Yang G, Kridel S, Chen YQ. Fatty acid synthase is required for mammary gland development and milk production during lactation. Am J Physiol Endocrinol Metab. 2014 May 15; 306(10):E1132-43. PMID: 24668799.
      View in: PubMed
    11. Odens H, Lowther T, Kridel S, Watts L, Filipponi L, Schmitt J. Inhibition of the thioesterase activity of human fatty acid synthase by 1,4- and 9,10-diones. Chem Pharm Bull (Tokyo). 2014; 62(9):933-6. PMID: 25177021.
      View in: PubMed
    12. Deford-Watts LM, Mintz A, Kridel SJ. The potential of ¹¹C-acetate PET for monitoring the Fatty acid synthesis pathway in Tumors. Curr Pharm Biotechnol. 2013; 14(3):300-12. PMID: 23597406.
      View in: PubMed
    13. Bowlby SC, Thomas MJ, D'Agostino RB, Kridel SJ. Nicotinamide phosphoribosyl transferase (Nampt) is required for de novo lipogenesis in tumor cells. PLoS One. 2012; 7(6):e40195. PMID: 22768255.
      View in: PubMed
    14. Scott KE, Wheeler FB, Davis AL, Thomas MJ, Ntambi JM, Seals DF, Kridel SJ. Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis. PLoS One. 2012; 7(1):e29761. PMID: 22238651.
      View in: PubMed
    15. Berquin IM, Edwards IJ, Kridel SJ, Chen YQ. Polyunsaturated fatty acid metabolism in prostate cancer. Cancer Metastasis Rev. 2011 Dec; 30(3-4):295-309. PMID: 22015690.
      View in: PubMed
    16. Pandya H, Gibo DM, Garg S, Kridel S, Debinski W. An interleukin 13 receptor a 2-specific peptide homes to human Glioblastoma multiforme xenografts. Neuro Oncol. 2012 Jan; 14(1):6-18. PMID: 21946118.
      View in: PubMed
    17. Little JL, Wheeler FB, Koumenis C, Kridel SJ. Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death. Mol Cancer Ther. 2008 Dec; 7(12):3816-24. PMID: 19074856.
      View in: PubMed
    18. Fels DR, Ye J, Segan AT, Kridel SJ, Spiotto M, Olson M, Koong AC, Koumenis C. Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways. Cancer Res. 2008 Nov 15; 68(22):9323-30. PMID: 19010906.
      View in: PubMed
    19. Vavere AL, Kridel SJ, Wheeler FB, Lewis JS. 1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer. J Nucl Med. 2008 Feb; 49(2):327-34. PMID: 18199615.
      View in: PubMed
    20. Little JL, Kridel SJ. Fatty acid synthase activity in tumor cells. Subcell Biochem. 2008; 49:169-94. PMID: 18751912.
      View in: PubMed
    21. Chen YQ, Edwards IJ, Kridel SJ, Thornburg T, Berquin IM. Dietary fat-gene interactions in cancer. Cancer Metastasis Rev. 2007 Dec; 26(3-4):535-51. PMID: 17849170.
      View in: PubMed
    22. Kridel SJ, Lowther WT, Pemble CW. Fatty acid synthase inhibitors: new directions for oncology. Expert Opin Investig Drugs. 2007 Nov; 16(11):1817-29. PMID: 17970640.
      View in: PubMed
    23. Lally BE, Geiger GA, Kridel S, Arcury-Quandt AE, Robbins ME, Kock ND, Wheeler K, Peddi P, Georgakilas A, Kao GD, Koumenis C. Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library. Cancer Res. 2007 Sep 15; 67(18):8791-9. PMID: 17875720.
      View in: PubMed
    24. Pemble CW, Johnson LC, Kridel SJ, Lowther WT. Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat. Nat Struct Mol Biol. 2007 Aug; 14(8):704-9. PMID: 17618296.
      View in: PubMed
    25. Little JL, Wheeler FB, Fels DR, Koumenis C, Kridel SJ. Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells. Cancer Res. 2007 Feb 01; 67(3):1262-9. PMID: 17283163.
      View in: PubMed
    26. Kridel SJ, Axelrod F, Rozenkrantz N, Smith JW. Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. Cancer Res. 2004 Mar 15; 64(6):2070-5. PMID: 15026345.
      View in: PubMed
    27. Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A, Smith JW, Liddington RC, Lipton SA. S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science. 2002 Aug 16; 297(5584):1186-90. PMID: 12183632.
      View in: PubMed
    28. Kridel SJ, Sawai H, Ratnikov BI, Chen EI, Li W, Godzik A, Strongin AY, Smith JW. A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases. J Biol Chem. 2002 Jun 28; 277(26):23788-93. PMID: 11959855.
      View in: PubMed
    29. Chen EI, Kridel SJ, Howard EW, Li W, Godzik A, Smith JW. A unique substrate recognition profile for matrix metalloproteinase-2. J Biol Chem. 2002 Feb 08; 277(6):4485-91. PMID: 11694539.
      View in: PubMed
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