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Clinical and Translational Science Institute

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Last Name

Siobhan Marie Hoscheidt

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine - Gerontology
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    Siobhan Hoscheidt, Ph.D. is an Assistant Professor in the Department of Internal Medicine, Gerontology and Geriatrics, in the Sticht Center for Healthy Aging and Alzheimer’s Prevention. Dr. Hoscheidt is a cognitive neuroscientist, neuroimager, and expert in stress hormones, the impact of stress on brain health and memory function, and is an Alzheimer disease researcher. Dr. Hoscheidt received her Ph.D. from the University of Arizona under the mentorship of Dr. Lynn Nadel internationally renowned for his pivotal work on the critical role of the hippocampus in episodic memory and held postdoctoral fellowships at Duke University and the University of Wisconsin Hospital and Clinics in the Alzheimer’s Disease Research Center. Her research utilizes multimodal approaches such as structural and functional neuroimaging, fluid biomarkers, cognitive performance, genetics, metabolic health, and measures of stress to examine factors associated with increased risk for Alzheimer disease. At Wake Forest, Dr. Hoscheidt’s research program continues to utilize novel multimodal approaches to examine modifiable risk factors for pathological aging with a focus on developing clinical interventions to help minimize or ameliorate risk for Alzheimer disease.


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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Russell-Williams J, Jaroudi W, Perich T, Hoscheidt S, El Haj M, Moustafa AA. Mindfulness and meditation: treating cognitive impairment and reducing stress in dementia. Rev Neurosci. 2018 09 25; 29(7):791-804. PMID: 29466242.
      View in: PubMed
    2. Nicholas CR, Hoscheidt SM, Clark LR, Racine AM, Berman SE, Koscik RL, Maritza Dowling N, Asthana S, Christian BT, Sager MA, Johnson SC. Positive affect predicts cerebral glucose metabolism in late middle-aged adults. Soc Cogn Affect Neurosci. 2017 06 01; 12(6):993-1000. PMID: 28402542.
      View in: PubMed
    3. Fischer BL, Bacher R, Bendlin BB, Birdsill AC, Ly M, Hoscheidt SM, Chappell RJ, Mahoney JE, Gleason CE. An Examination of Brain Abnormalities and Mobility in Individuals with Mild Cognitive Impairment and Alzheimer's Disease. Front Aging Neurosci. 2017; 9:86. PMID: 28424612.
      View in: PubMed
    4. Clark LR, Berman SE, Rivera-Rivera LA, Hoscheidt SM, Darst BF, Engelman CD, Rowley HA, Carlsson CM, Asthana S, Turski P, Wieben O, Johnson SC. Macrovascular and microvascular cerebral blood flow in adults at risk for Alzheimer's disease. Alzheimers Dement (Amst). 2017; 7:48-55. PMID: 28239641.
      View in: PubMed
    5. Hoscheidt SM, Starks EJ, Oh JM, Zetterberg H, Blennow K, Krause RA, Gleason CE, Puglielli L, Atwood CS, Carlsson CM, Asthana S, Johnson SC, Bendlin BB. Insulin Resistance is Associated with Increased Levels of Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Reduced Memory Function in At-Risk Healthy Middle-Aged Adults. J Alzheimers Dis. 2016 04 12; 52(4):1373-83. PMID: 27079723.
      View in: PubMed
    6. Ly M, Adluru N, Destiche DJ, Lu SY, Oh JM, Hoscheidt SM, Alexander AL, Okonkwo OC, Rowley HA, Sager MA, Johnson SC, Bendlin BB. Fornix Microstructure and Memory Performance Is Associated with Altered Neural Connectivity during Episodic Recognition. J Int Neuropsychol Soc. 2016 Feb; 22(2):191-204. PMID: 26888616; PMCID: PMC4762064 [Available on 02/01/17].
    7. Melah KE, Lu SY, Hoscheidt SM, Alexander AL, Adluru N, Destiche DJ, Carlsson CM, Zetterberg H, Blennow K, Okonkwo OC, Gleason CE, Dowling NM, Bratzke LC, Rowley HA, Sager MA, Asthana S, Johnson SC, Bendlin BB. Cerebrospinal Fluid Markers of Alzheimer's Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer's Disease. J Alzheimers Dis. 2016; 50(3):873-86. PMID: 26836182; PMCID: PMC4760877.
    8. Hoscheidt SM, Kellawan JM, Berman SE, Rivera-Rivera LA, Krause RA, Oh JM, Beeri MS, Rowley HA, Wieben O, Carlsson CM, Asthana S, Johnson SC, Schrage WG, Bendlin BB. Insulin resistance is associated with lower arterial blood flow and reduced cortical perfusion in cognitively asymptomatic middle-aged adults. J Cereb Blood Flow Metab. 2017 Jun; 37(6):2249-2261. PMID: 27488909.
      View in: PubMed
    9. Starks EJ, Patrick O'Grady J, Hoscheidt SM, Racine AM, Carlsson CM, Zetterberg H, Blennow K, Okonkwo OC, Puglielli L, Asthana S, Dowling NM, Gleason CE, Anderson RM, Davenport-Sis NJ, DeRungs LM, Sager MA, Johnson SC, Bendlin BB. Insulin Resistance is Associated with Higher Cerebrospinal Fluid Tau Levels in Asymptomatic APOE?4 Carriers. J Alzheimers Dis. 2015; 46(2):525-33. PMID: 25812851; PMCID: PMC4583335.
    10. Hoscheidt SM, LaBar KS, Ryan L, Jacobs WJ, Nadel L. Encoding negative events under stress: high subjective arousal is related to accurate emotional memory despite misinformation exposure. Neurobiol Learn Mem. 2014 Jul; 112:237-47. PMID: 24055594.
      View in: PubMed
    11. Nadel L, Hoscheidt S, Ryan LR. Spatial cognition and the hippocampus: the anterior-posterior axis. J Cogn Neurosci. 2013 Jan; 25(1):22-8. PMID: 23198887.
      View in: PubMed
    12. Hoscheidt SM, Nadel L, Payne J, Ryan L. Hippocampal activation during retrieval of spatial context from episodic and semantic memory. Behav Brain Res. 2010 Oct 15; 212(2):121-32. PMID: 20385169.
      View in: PubMed
    13. Payne JD, Jackson ED, Hoscheidt S, Ryan L, Jacobs WJ, Nadel L. Stress administered prior to encoding impairs neutral but enhances emotional long-term episodic memories. Learn Mem. 2007 Dec; 14(12):861-8. PMID: 18086830; PMCID: PMC2151024.
    14. Payne JD, Jackson ED, Ryan L, Hoscheidt S, Jacobs JW, Nadel L. The impact of stress on neutral and emotional aspects of episodic memory. Memory. 2006 Jan; 14(1):1-16. PMID: 16423737.
      View in: PubMed
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