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Clinical and Translational Science Institute

Keywords
Last Name

Susan E. Appt, D.V.M.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentComparative Medicine
Address
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentCTSI

    TitleSection Head
    InstitutionWake Forest School of Medicine
    DepartmentPathology-Comparative Medicine


    Collapse Research 
    Collapse research activities and funding
    R01AG027847     (APPT, SUSAN E.)Sep 1, 2006 - Jul 31, 2014
    NIH/NIA
    Role of the Follicle-Depleted Ovary in the Pathogenesis of Chronic Diseases
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Atkins HM, Appt SE, Taylor RN, Torres-Mendoza Y, Lenk EE, Rosenthal NS, Caudell DL. Systemic Iron Deficiency in a Nonhuman Primate Model of Endometriosis. Comp Med. 2018 Aug 01; 68(4):298-307. PMID: 29871715.
      View in: PubMed
    2. Nagpal R, Shively CA, Appt SA, Register TC, Michalson KT, Vitolins MZ, Yadav H. Gut Microbiome Composition in Non-human Primates Consuming a Western or Mediterranean Diet. Front Nutr. 2018; 5:28. PMID: 29922651.
      View in: PubMed
    3. Justice JN, Silverstein-Metzler MG, Uberseder B, Appt SE, Clarkson TB, Register TC, Kritchevsky SB, Shively CA. Relationships of depressive behavior and sertraline treatment with walking speed and activity in older female nonhuman primates. Geroscience. 2017 12; 39(5-6):585-600. PMID: 29080976.
      View in: PubMed
    4. Silverstein-Metzler MG, Justice JN, Appt SE, Groban L, Kitzman DW, Carr JJ, Register TC, Shively CA. Long-term sertraline treatment and depression effects on carotid artery atherosclerosis in premenopausal female primates. Menopause. 2017 Oct; 24(10):1175-1184. PMID: 28609387.
      View in: PubMed
    5. Dhungana S, Carlson JE, Pathmasiri W, McRitchie S, Davis M, Sumner S, Appt SE. Impact of a western diet on the ovarian and serum metabolome. Maturitas. 2016 Oct; 92:134-142. PMID: 27621251.
      View in: PubMed
    6. Kuokkanen S, Polotsky AJ, Chosich J, Bradford AP, Jasinska A, Phang T, Santoro N, Appt SE. Corpus luteum as a novel target of weight changes that contribute to impaired female reproductive physiology and function. Syst Biol Reprod Med. 2016 Aug; 62(4):227-42. PMID: 27187064.
      View in: PubMed
    7. Silverstein-Metzler MG, Shively CA, Clarkson TB, Appt SE, Carr JJ, Kritchevsky SB, Jones SR, Register TC. Sertraline inhibits increases in body fat and carbohydrate dysregulation in adult female cynomolgus monkeys. Psychoneuroendocrinology. 2016 06; 68:29-38. PMID: 26939086.
      View in: PubMed
    8. Register TC, Appt SE, Clarkson TB. Atherosclerosis and Vascular Biologic Responses to Estrogens: Histologic, Immunohistochemical, Biochemical, and Molecular Methods. Methods Mol Biol. 2016; 1366:517-532. PMID: 26585161.
      View in: PubMed
    9. Register TC, Appt SE, Clarkson TB. Erratum to: Atherosclerosis and Vascular Biologic Responses to Estrogens: Histologic, Immunohistochemical, Biochemical, and Molecular Methods. Methods Mol Biol. 2016; 1366:E5. PMID: 29549626.
      View in: PubMed
    10. Appt SE. Myometrial artery calcification: significance for perimenopausal and postmenopausal women. Menopause. 2015 Dec; 22(12):1271-2. PMID: 26575112.
      View in: PubMed
    11. Bradford AP, Jones K, Kechris K, Chosich J, Montague M, Warren WC, May MC, Al-Safi Z, Kuokkanen S, Appt SE, Polotsky AJ. Joint MiRNA/mRNA expression profiling reveals changes consistent with development of dysfunctional corpus luteum after weight gain. PLoS One. 2015; 10(8):e0135163. PMID: 26258540.
      View in: PubMed
    12. Schnatz PF, Nudy M, Jiang X, Demko JE, Appt SE. Vitamin D deficiency and cardiovascular disease in postmenopausal women: contributions from human and nonhuman primate studies. Menopause. 2015 May; 22(5):554-63. PMID: 25563796.
      View in: PubMed
    13. Shively CA, Register TC, Appt SE, Clarkson TB. Effects of long-term sertraline treatment and depression on coronary artery atherosclerosis in premenopausal female primates. Psychosom Med. 2015 Apr; 77(3):267-78. PMID: 25829239.
      View in: PubMed
    14. Meléndez GC, Register TC, Appt SE, Clarkson TB, Franke AA, Kaplan JR. Beneficial effects of soy supplementation on postmenopausal atherosclerosis are dependent on pretreatment stage of plaque progression. Menopause. 2015 Mar; 22(3):289-96. PMID: 25072952.
      View in: PubMed
    15. Silverstein MG, Kaplan JR, Appt SE, Register TC, Shively CA. Effect of soy isoflavones on thyroid hormones in intact and ovariectomized cynomolgus monkeys (Macaca fascicularis). Menopause. 2014 Oct; 21(10):1136-42. PMID: 24618766.
      View in: PubMed
    16. Eyster KM, Appt S, Chalpe A, Mark-Kappeler CJ, Register TC, Clarkson TB. Effects of estradiol on transcriptional profiles in atherosclerotic iliac arteries in ovariectomized cynomolgus macaques. Menopause. 2014 Feb; 21(2):143-52. PMID: 23760433.
      View in: PubMed
    17. Atkins HM, Willson CJ, Silverstein M, Jorgensen M, Floyd E, Kaplan JR, Appt SE. Characterization of ovarian aging and reproductive senescence in vervet monkeys (Chlorocebus aethiops sabaeus). Comp Med. 2014 Feb; 64(1):55-62. PMID: 24512962.
      View in: PubMed
    18. Clarkson TB, Ethun KF, Pajewski NM, Golden D, Floyd E, Appt SE. Effects of bazedoxifene, conjugated equine estrogens, and a tissue-selective estrogen complex containing both bazedoxifene and conjugated equine estrogens on cerebral artery atherosclerosis in postmenopausal monkeys. Menopause. 2014 Jan; 21(1):8-14. PMID: 23676638.
      View in: PubMed
    19. Stephens SM, Pau FK, Yalcinkaya TM, May MC, Berga SL, Post MD, Appt SE, Polotsky AJ. Assessing the pulsatility of luteinizing hormone in female vervet monkeys (Chlorocebus aethiops sabaeus). Comp Med. 2013 Oct; 63(5):432-8. PMID: 24210020.
      View in: PubMed
    20. Ethun KF, Wood CE, Cline JM, Register TC, Appt SE, Clarkson TB. Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model. Menopause. 2013 Jul; 20(7):777-84. PMID: 23793168.
      View in: PubMed
    21. Sophonsritsuk A, Appt SE, Clarkson TB, Shively CA, Espeland MA, Register TC. Differential effects of estradiol on carotid artery inflammation when administered early versus late after surgical menopause. Menopause. 2013 May; 20(5):540-7. PMID: 23615645.
      View in: PubMed
    22. Clarkson TB, Ethun KF, Chen H, Golden D, Floyd E, Appt SE. Effects of bazedoxifene alone and with conjugated equine estrogens on coronary and peripheral artery atherosclerosis in postmenopausal monkeys. Menopause. 2013 Mar; 20(3):274-81. PMID: 23435024.
      View in: PubMed
    23. Clarkson TB, Meléndez GC, Appt SE. Timing hypothesis for postmenopausal hormone therapy: its origin, current status, and future. Menopause. 2013 Mar; 20(3):342-53. PMID: 23435033.
      View in: PubMed
    24. Kundu MC, May MC, Chosich J, Bradford AP, Lasley B, Gee N, Santoro N, Appt SE, Polotsky AJ. Assessment of luteal function in the vervet monkey as a means to develop a model for obesity-related reproductive phenotype. Syst Biol Reprod Med. 2013 Apr; 59(2):74-81. PMID: 23278149.
      View in: PubMed
    25. Appt SE, Chen H, Clarkson TB, Kaplan JR. Premenopausal antimüllerian hormone concentration is associated with subsequent atherosclerosis. Menopause. 2012 Dec; 19(12):1353-9. PMID: 22929037.
      View in: PubMed
    26. Ethun KF, Wood CE, Register TC, Cline JM, Appt SE, Clarkson TB. Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeys. Menopause. 2012 Nov; 19(11):1242-52. PMID: 23103754.
      View in: PubMed
    27. Schnatz PF, Vila-Wright S, Jiang X, Register TC, Kaplan JR, Clarkson TB, Appt SE. The association between plasma 25-hydroxyvitamin D3 concentrations, C-reactive protein levels, and coronary artery atherosclerosis in postmenopausal monkeys. Menopause. 2012 Oct; 19(10):1074-80. PMID: 22713861.
      View in: PubMed
    28. Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE. Coronary artery vitamin D receptor expression and plasma concentrations of 25-hydroxyvitamin D: their association with atherosclerosis. Menopause. 2012 Sep; 19(9):967-73. PMID: 22617336.
      View in: PubMed
    29. Schnatz PF, Marakovits KA, O'Sullivan DM, Ethun K, Clarkson TB, Appt SE. Response to an adequate dietary intake of vitamin D3 modulates the effect of estrogen therapy on bone density. J Womens Health (Larchmt). 2012 Aug; 21(8):858-64. PMID: 22691032.
      View in: PubMed
    30. Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE. The quantification of vitamin D receptors in coronary arteries and their association with atherosclerosis. Maturitas. 2012 Oct; 73(2):143-7. PMID: 22542390.
      View in: PubMed
    31. Eyster KM, Appt SE, Mark-Kappeler CJ, Chalpe A, Register TC, Clarkson TB. Gene expression signatures differ with extent of atherosclerosis in monkey iliac artery. Menopause. 2011 Oct; 18(10):1087-95. PMID: 21646924.
      View in: PubMed
    32. Ethun KF, Cline JM, Appt SE. Endocrine profile of an ovariectomized cynomolgus monkey (Macaca fascicularis) with a supernumerary ovary. Comp Med. 2011 Oct; 61(5):462-6. PMID: 22330356.
      View in: PubMed
    33. Schnatz PF, Nudy M, O'Sullivan DM, Ethun K, Appt SE, Clarkson TB. Identification of a mechanism for increased cardiovascular risk among individuals with low vitamin D concentrations. Menopause. 2011 Sep; 18(9):994-1000. PMID: 21593696.
      View in: PubMed
    34. Hamilton RT, Rettberg JR, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. Hippocampal responsiveness to 17ß-estradiol and equol after long-term ovariectomy: implication for a therapeutic window of opportunity. Brain Res. 2011 Mar 16; 1379:11-22. PMID: 21241683.
      View in: PubMed
    35. Rettberg JR, Hamilton RT, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeys. Brain Res. 2011 Mar 16; 1379:23-33. PMID: 21238431.
      View in: PubMed
    36. Appt SE, Clarkson TB, Hoyer PB, Kock ND, Goode AK, May MC, Persyn JT, Vail NK, Ethun KF, Chen H, Sen N, Kaplan JR. Experimental induction of reduced ovarian reserve in a nonhuman primate model (Macaca fascicularis). Comp Med. 2010 Oct; 60(5):380-8. PMID: 21262124.
      View in: PubMed
    37. Appt SE, Chen H, Goode AK, Hoyer PB, Clarkson TB, Adams MR, Wilson ME, Franke AA, Kaplan JR. The effect of diet and cardiovascular risk on ovarian aging in cynomolgus monkeys (Macaca fascicularis). Menopause. 2010 Jul; 17(4):741-8. PMID: 20458254.
      View in: PubMed
    38. Jones JC, Appt SE, Werre SR, Tan JC, Kaplan JR. Validation of multi-detector computed tomography as a non-invasive method for measuring ovarian volume in macaques (Macaca fascicularis). Am J Primatol. 2010 Jun; 72(6):530-8. PMID: 20131358.
      View in: PubMed
    39. Appt SE, Ethun KF. Reproductive aging and risk for chronic disease: Insights from studies of nonhuman primates. Maturitas. 2010 Sep; 67(1):7-14. PMID: 20430541.
      View in: PubMed
    40. Appt SE, Clarkson TB, Chen H, Adams MR, Christian PJ, Hoyer PB, Wilson ME, Kaplan JR. Serum antimüllerian hormone predicts ovarian reserve in a monkey model. Menopause. 2009 May-Jun; 16(3):597-601. PMID: 19188851.
      View in: PubMed
    41. Muhammad FS, Goode AK, Kock ND, Arifin EA, Cline JM, Adams MR, Hoyer PB, Christian PJ, Isom S, Kaplan JR, Appt SE. Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes. Comp Med. 2009 Feb; 59(1):46-59. PMID: 19295054.
      View in: PubMed
    42. Walker SE, Register TC, Appt SE, Adams MR, Clarkson TB, Chen H, Isom S, Franke AA, Kaplan JR. Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burden. Menopause. 2008 Sep-Oct; 15(5):950-7. PMID: 18427358.
      View in: PubMed
    43. Appt SE, Törmälä R, Franke AA, Mikkola TS, Tikkanen MJ, Ylikorkala O, Clarkson TB. Soy-tibolone combination - effect on lipids in postmenopausal monkeys and women. Maturitas. 2008 Jul-Aug; 60(3-4):216-22. PMID: 18687539.
      View in: PubMed
    44. Wood CE, Hester JM, Appt SE, Geisinger KR, Cline JM. Estrogen effects on epithelial proliferation and benign proliferative lesions in the postmenopausal primate mammary gland. Lab Invest. 2008 Sep; 88(9):938-48. PMID: 18607345.
      View in: PubMed
    45. Appt SE. Peer review and reflection continues forever. Fertil Steril. 2008 Apr; 89(4):1034-5. PMID: 18325504.
      View in: PubMed
    46. Törmälä R, Appt S, Clarkson TB, Groop PH, Rönnback M, Ylikorkala O, Mikkola TS. Equol production capability is associated with favorable vascular function in postmenopausal women using tibolone; no effect with soy supplementation. Atherosclerosis. 2008 May; 198(1):174-8. PMID: 17961576.
      View in: PubMed
    47. Jones JC, Appt SE, Bourland JD, Hoyer PB, Clarkson TB, Kaplan JR. Multidetector computed tomographic morphology of ovaries in cynomolgus macaques (Macaca fascicularis). J Am Assoc Lab Anim Sci. 2007 Sep; 46(5):54-63. PMID: 17877330.
      View in: PubMed
    48. Appt SE, Kaplan JR, Clarkson TB, Cline JM, Christian PJ, Hoyer PB. Destruction of primordial ovarian follicles in adult cynomolgus macaques after exposure to 4-vinylcyclohexene diepoxide: a nonhuman primate model of the menopausal transition. Fertil Steril. 2006 Oct; 86(4 Suppl):1210-6. PMID: 16952357.
      View in: PubMed
    49. Stroud FC, Appt SE, Wilson ME, Franke AA, Adams MR, Kaplan JR. Concentrations of isoflavones in macaques consuming standard laboratory monkey diet. J Am Assoc Lab Anim Sci. 2006 Jul; 45(4):20-3. PMID: 16884174.
      View in: PubMed
    50. Wood CE, Appt SE, Clarkson TB, Franke AA, Lees CJ, Doerge DR, Cline JM. Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys. Biol Reprod. 2006 Sep; 75(3):477-86. PMID: 16723506.
      View in: PubMed
    51. Appt SE, Clarkson TB, Lees CJ, Anthony MS. Low dose estrogens inhibit coronary artery atherosclerosis in postmenopausal monkeys. Maturitas. 2006 Sep 20; 55(2):187-94. PMID: 16574351.
      View in: PubMed
    52. Wood CE, Clarkson TB, Appt SE, Franke AA, Boue SM, Burow ME, McCoy T, Cline JM. Effects of soybean glyceollins and estradiol in postmenopausal female monkeys. Nutr Cancer. 2006; 56(1):74-81. PMID: 17176220.
      View in: PubMed
    53. Badeau M, Tikkanen MJ, Appt SE, Adlercreutz H, Clarkson TB, Hoikkala A, Wähälä K, Mikkola TS. Determination of plasma genistein fatty acid esters following administration of genistein or genistein 4'7-O-dioleate in monkeys. Biochim Biophys Acta. 2005 Dec 30; 1738(1-3):115-20. PMID: 16326136.
      View in: PubMed
    54. Clarkson TB, Appt SE. Controversies about HRT--lessons from monkey models. Maturitas. 2005 May 16; 51(1):64-74. PMID: 15883111.
      View in: PubMed
    55. Pazol K, Kaplan JR, Abbott D, Appt SE, Wilson ME. Practical measurement of total and bioavailable estradiol in female macaques. Clin Chim Acta. 2004 Feb; 340(1-2):117-26. PMID: 14734203.
      View in: PubMed
    56. Appt SE. Usefulness of the monkey model to investigate the role soy in postmenopausal women's health. ILAR J. 2004; 45(2):200-11. PMID: 15111739.
      View in: PubMed
    57. Clarkson TB, Appt SE. MPA and postmenopausal coronary artery atherosclerosis revisited. Steroids. 2003 Nov; 68(10-13):941-51. PMID: 14667987.
      View in: PubMed
    58. Blair RM, Appt SE, Franke AA, Clarkson TB. Treatment with antibiotics reduces plasma equol concentration in cynomolgus monkeys (Macaca fascicularis). J Nutr. 2003 Jul; 133(7):2262-7. PMID: 12840190.
      View in: PubMed
    59. Blair RM, Appt SE, Bennetau-Pelissero C, Clarkson TB, Anthony MS, Lamothe V, Potter SM. Dietary soy and soy isoflavones have gender-specific effects on plasma lipids and isoflavones in golden Syrian f(1)b hybrid hamsters. J Nutr. 2002 Dec; 132(12):3585-91. PMID: 12468592.
      View in: PubMed
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