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Clinical and Translational Science Institute

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Last Name

Patricia E. Gallagher, Ph.D.

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentSurgery Hypertension
Address
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentCancer Biology


    Collapse Research 
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    R29CA047457     (GALLAGHER, PATRICIA E)Aug 15, 1987 - May 31, 1993
    NIH/NCI
    ENZYMATIC REPAIR OF CARCINOGENIC DAMAGE TO HUMAN DNA
    Role: Principal Investigator

    F33DK009208     (GALLAGHER, PATRICIA E)Jul 1, 1995
    NIH/NIDDK
    OXIDATIVE DNA REPAIR ENZYMES IN DAMAGED KIDNEY
    Role: Principal Investigator

    R01HL079498     (GALLAGHER, PATRICIA E)Aug 1, 2006 - May 31, 2011
    NIH/NHLBI
    Cellular Regulation of Angiotensin Converting Enzyme 2 (ACE2)
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wester A, Devocelle M, Tallant EA, Chappell MC, Gallagher PE, Paradisi F. Stabilization of Angiotensin-(1-7) by key substitution with a cyclic non-natural amino acid. Amino Acids. 2017 10; 49(10):1733-1742. PMID: 28744580.
      View in: PubMed
    2. Schaich CL, Grabenauer M, Thomas BF, Shaltout HA, Gallagher PE, Howlett AC, Diz DI. Medullary Endocannabinoids Contribute to the Differential Resting Baroreflex Sensitivity in Rats with Altered Brain Renin-Angiotensin System Expression. Front Physiol. 2016; 7:207. PMID: 27375489.
      View in: PubMed
    3. Willey JS, Bracey DN, Gallagher PE, Tallant EA, Wiggins WF, Callahan MF, Smith TL, Emory CL. Angiotensin-(1-7) Attenuates Skeletal Muscle Fibrosis and Stiffening in a Mouse Model of Extremity Sarcoma Radiation Therapy. J Bone Joint Surg Am. 2016 Jan 06; 98(1):48-55. PMID: 26738903.
      View in: PubMed
    4. Yamaleyeva LM, Chappell MC, Brosnihan KB, Anton L, Caudell DL, Shi S, McGee C, Pirro N, Gallagher PE, Taylor RN, Merrill DC, Mertz HL. Downregulation of apelin in the human placental chorionic villi from preeclamptic pregnancies. Am J Physiol Endocrinol Metab. 2015 Nov 15; 309(10):E852-60. PMID: 26394665.
      View in: PubMed
    5. Schaich CL, Shaltout HA, Grabenauer M, Thomas BF, Gallagher PE, Howlett AC, Diz DI. Alterations in the Medullary Endocannabinoid System Contribute to Age-related Impairment of Baroreflex Sensitivity. J Cardiovasc Pharmacol. 2015 May; 65(5):473-9. PMID: 25636077.
      View in: PubMed
    6. Suckow BD, Goodney PP, Nolan BW, Veeraswamy RK, Gallagher P, Cronenwett JL, Kraiss LW. Domains that Determine Quality of Life in Vascular Amputees. Ann Vasc Surg. 2015; 29(4):722-30. PMID: 25725279.
      View in: PubMed
    7. Brosnihan KB, Pulgar VM, Gallagher PE, Neves LA, Yamaleyeva LM. Local uterine Ang-(1-7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats. Reprod Biol Endocrinol. 2015 Jan 17; 13:5. PMID: 25596750.
      View in: PubMed
    8. Carver KA, Smith TL, Gallagher PE, Tallant EA. Angiotensin-(1-7) prevents angiotensin II-induced fibrosis in cremaster microvessels. Microcirculation. 2015 Jan; 22(1):19-27. PMID: 25079175.
      View in: PubMed
    9. Gallagher PE, Arter AL, Deng G, Tallant EA. Angiotensin-(1-7): a peptide hormone with anti-cancer activity. Curr Med Chem. 2014; 21(21):2417-23. PMID: 24524765.
      View in: PubMed
    10. Moore ED, Kooshki M, Metheny-Barlow LJ, Gallagher PE, Robbins ME. Angiotensin-(1-7) prevents radiation-induced inflammation in rat primary astrocytes through regulation of MAP kinase signaling. Free Radic Biol Med. 2013 Dec; 65:1060-1068. PMID: 24012919.
      View in: PubMed
    11. Arnold AC, Gallagher PE, Diz DI. Brain renin-angiotensin system in the nexus of hypertension and aging. Hypertens Res. 2013 Jan; 36(1):5-13. PMID: 23076408.
      View in: PubMed
    12. Varagic J, Ahmad S, Voncannon JL, Moniwa N, Simington SW, Brosnihan BK, Gallagher PE, Habibi J, Sowers JR, Ferrario CM. Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats. J Hypertens. 2012 Sep; 30(9):1766-74. PMID: 22895019.
      View in: PubMed
    13. Nautiyal M, Katakam PV, Busija DW, Gallagher PE, Tallant EA, Chappell MC, Diz DI. Differences in oxidative stress status and expression of MKP-1 in dorsal medulla of transgenic rats with altered brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol. 2012 Oct 15; 303(8):R799-806. PMID: 22914751.
      View in: PubMed
    14. Garcia-Espinosa MA, Shaltout HA, Gallagher PE, Chappell MC, Diz DI. In vivo expression of angiotensin-(1-7) lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats. J Cardiovasc Pharmacol. 2012 Aug; 60(2):150-7. PMID: 22526299.
      View in: PubMed
    15. Yamaleyeva LM, Lindsey SH, Varagic J, Zhang LL, Gallagher PE, Chen AF, Chappell MC. Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat. J Cardiovasc Pharmacol. 2012 Jun; 59(6):529-38. PMID: 22370956.
      View in: PubMed
    16. Krishnan B, Torti FM, Gallagher PE, Tallant EA. Angiotensin-(1-7) reduces proliferation and angiogenesis of human prostate cancer xenografts with a decrease in angiogenic factors and an increase in sFlt-1. Prostate. 2013 Jan; 73(1):60-70. PMID: 22644934.
      View in: PubMed
    17. Krishnan B, Smith TL, Dubey P, Zapadka ME, Torti FM, Willingham MC, Tallant EA, Gallagher PE. Angiotensin-(1-7) attenuates metastatic prostate cancer and reduces osteoclastogenesis. Prostate. 2013 Jan; 73(1):71-82. PMID: 22644942.
      View in: PubMed
    18. McCollum LT, Gallagher PE, Tallant EA. Angiotensin-(1-7) abrogates mitogen-stimulated proliferation of cardiac fibroblasts. Peptides. 2012 Apr; 34(2):380-8. PMID: 22326709.
      View in: PubMed
    19. McCollum LT, Gallagher PE, Ann Tallant E. Angiotensin-(1-7) attenuates angiotensin II-induced cardiac remodeling associated with upregulation of dual-specificity phosphatase 1. Am J Physiol Heart Circ Physiol. 2012 Feb 01; 302(3):H801-10. PMID: 22140049.
      View in: PubMed
    20. Lindsey SH, Yamaleyeva LM, Brosnihan KB, Gallagher PE, Chappell MC. Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. Hypertension. 2011 Oct; 58(4):665-71. PMID: 21844484.
      View in: PubMed
    21. Gilliam-Davis S, Gallagher PE, Payne VS, Kasper SO, Tommasi EN, Westwood BM, Robbins ME, Chappell MC, Diz DI. Long-term systemic angiotensin II type 1 receptor blockade regulates mRNA expression of dorsomedial medulla renin-angiotensin system components. Physiol Genomics. 2011 Jul 14; 43(13):829-35. PMID: 21540301.
      View in: PubMed
    22. Gallagher PE, Cook K, Soto-Pantoja D, Menon J, Tallant EA. Angiotensin peptides and lung cancer. Curr Cancer Drug Targets. 2011 May; 11(4):394-404. PMID: 21395552.
      View in: PubMed
    23. Cook KL, Metheny-Barlow LJ, Tallant EA, Gallagher PE. Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. Cancer Res. 2010 Nov 01; 70(21):8319-28. PMID: 20837666.
      View in: PubMed
    24. Cohen JA, Lindsey SH, Pirro NT, Brosnihan KB, Gallagher PE, Chappell MC. Influence of estrogen depletion and salt loading on renal angiotensinogen expression in the mRen(2).Lewis strain. Am J Physiol Renal Physiol. 2010 Jul; 299(1):F35-42. PMID: 20462965.
      View in: PubMed
    25. Trask AJ, Groban L, Westwood BM, Varagic J, Ganten D, Gallagher PE, Chappell MC, Ferrario CM. Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. Am J Hypertens. 2010 Jun; 23(6):687-93. PMID: 20300067.
      View in: PubMed
    26. Varagic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CM. Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Ther Adv Cardiovasc Dis. 2010 Feb; 4(1):17-25. PMID: 19946038.
      View in: PubMed
    27. Petty WJ, Miller AA, McCoy TP, Gallagher PE, Tallant EA, Torti FM. Phase I and pharmacokinetic study of angiotensin-(1-7), an endogenous antiangiogenic hormone. Clin Cancer Res. 2009 Dec 01; 15(23):7398-404. PMID: 19920106.
      View in: PubMed
    28. Arnold AC, Shaltout HA, Gallagher PE, Diz DI. Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus. Hypertension. 2009 Nov; 54(5):1001-8. PMID: 19770402.
      View in: PubMed
    29. Anton L, Merrill DC, Neves LA, Diz DI, Corthorn J, Valdes G, Stovall K, Gallagher PE, Moorefield C, Gruver C, Brosnihan KB. The uterine placental bed Renin-Angiotensin system in normal and preeclamptic pregnancy. Endocrinology. 2009 Sep; 150(9):4316-25. PMID: 19520788.
      View in: PubMed
    30. Soto-Pantoja DR, Menon J, Gallagher PE, Tallant EA. Angiotensin-(1-7) inhibits tumor angiogenesis in human lung cancer xenografts with a reduction in vascular endothelial growth factor. Mol Cancer Ther. 2009 Jun; 8(6):1676-83. PMID: 19509262.
      View in: PubMed
    31. Lindsey SH, Cohen JA, Brosnihan KB, Gallagher PE, Chappell MC. Chronic treatment with the G protein-coupled receptor 30 agonist G-1 decreases blood pressure in ovariectomized mRen2.Lewis rats. Endocrinology. 2009 Aug; 150(8):3753-8. PMID: 19372194.
      View in: PubMed
    32. Greenberg SJ, Gallagher PE. The great contribution: Index Medicus, Index-Catalogue, and IndexCat. J Med Libr Assoc. 2009 Apr; 97(2):108-13. PMID: 19404501.
      View in: PubMed
    33. Gallagher PE, Ferrario CM, Tallant EA. Regulation of ACE2 in cardiac myocytes and fibroblasts. Am J Physiol Heart Circ Physiol. 2008 Dec; 295(6):H2373-9. PMID: 18849338.
      View in: PubMed
    34. Gallagher PE, Ferrario CM, Tallant EA. MAP kinase/phosphatase pathway mediates the regulation of ACE2 by angiotensin peptides. Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1169-74. PMID: 18768926.
      View in: PubMed
    35. Diz DI, Garcia-Espinosa MA, Gallagher PE, Ganten D, Ferrario CM, Averill DB. Angiotensin-(1-7) and baroreflex function in nucleus tractus solitarii of (mRen2)27 transgenic rats. J Cardiovasc Pharmacol. 2008 Jun; 51(6):542-8. PMID: 18475201.
      View in: PubMed
    36. Diz DI, Garcia-Espinosa MA, Gegick S, Tommasi EN, Ferrario CM, Ann Tallant E, Chappell MC, Gallagher PE. Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats. Exp Physiol. 2008 May; 93(5):694-700. PMID: 18356558.
      View in: PubMed
    37. Jessup JA, Brosnihan KB, Gallagher PE, Chappell MC, Ferrario CM. Differential effect of low dose thiazides on the Renin Angiotensin system in genetically hypertensive and normotensive rats. J Am Soc Hypertens. 2008 Mar-Apr; 2(2):106-15. PMID: 19343087.
      View in: PubMed
    38. Anton L, Merrill DC, Neves LA, Stovall K, Gallagher PE, Diz DI, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Activation of local chorionic villi angiotensin II levels but not angiotensin (1-7) in preeclampsia. Hypertension. 2008 Apr; 51(4):1066-72. PMID: 18259034.
      View in: PubMed
    39. Brosnihan KB, Hodgin JB, Smithies O, Maeda N, Gallagher P. Tissue-specific regulation of ACE/ACE2 and AT1/AT2 receptor gene expression by oestrogen in apolipoprotein E/oestrogen receptor-alpha knock-out mice. Exp Physiol. 2008 May; 93(5):658-64. PMID: 18192335.
      View in: PubMed
    40. Neves LA, Stovall K, Joyner J, Vald├ęs G, Gallagher PE, Ferrario CM, Merrill DC, Brosnihan KB. ACE2 and ANG-(1-7) in the rat uterus during early and late gestation. Am J Physiol Regul Integr Comp Physiol. 2008 Jan; 294(1):R151-61. PMID: 17977916.
      View in: PubMed
    41. Yamaleyeva LM, Pendergrass KD, Pirro NT, Gallagher PE, Groban L, Chappell MC. Ovariectomy is protective against renal injury in the high-salt-fed older mRen2. Lewis rat. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2064-71. PMID: 17630347.
      View in: PubMed
    42. Menon J, Soto-Pantoja DR, Callahan MF, Cline JM, Ferrario CM, Tallant EA, Gallagher PE. Angiotensin-(1-7) inhibits growth of human lung adenocarcinoma xenografts in nude mice through a reduction in cyclooxygenase-2. Cancer Res. 2007 Mar 15; 67(6):2809-15. PMID: 17363603.
      View in: PubMed
    43. Sakima A, Averill DB, Kasper SO, Jackson L, Ganten D, Ferrario CM, Gallagher PE, Diz DI. Baroreceptor reflex regulation in anesthetized transgenic rats with low glia-derived angiotensinogen. Am J Physiol Heart Circ Physiol. 2007 Mar; 292(3):H1412-9. PMID: 17085537.
      View in: PubMed
    44. Yamaleyeva LM, Gallagher PE, Vinsant S, Chappell MC. Discoordinate regulation of renal nitric oxide synthase isoforms in ovariectomized mRen2. Lewis rats. Am J Physiol Regul Integr Comp Physiol. 2007 Feb; 292(2):R819-26. PMID: 17023669.
      View in: PubMed
    45. Whaley-Connell AT, Chowdhury NA, Hayden MR, Stump CS, Habibi J, Wiedmeyer CE, Gallagher PE, Tallant EA, Cooper SA, Link CD, Ferrario C, Sowers JR. Oxidative stress and glomerular filtration barrier injury: role of the renin-angiotensin system in the Ren2 transgenic rat. Am J Physiol Renal Physiol. 2006 Dec; 291(6):F1308-14. PMID: 16788142.
      View in: PubMed
    46. Jessup JA, Gallagher PE, Averill DB, Brosnihan KB, Tallant EA, Chappell MC, Ferrario CM. Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2166-72. PMID: 16766648.
      View in: PubMed
    47. Tallant EA, Ferrario CM, Gallagher PE. Cardioprotective role for angiotensin-(1-7) and angiotensin converting enzyme 2 in the heart. Future Cardiol. 2006 May; 2(3):335-42. PMID: 19804091.
      View in: PubMed
    48. Ferrario CM, Jessup J, Gallagher PE, Averill DB, Brosnihan KB, Ann Tallant E, Smith RD, Chappell MC. Effects of renin-angiotensin system blockade on renal angiotensin-(1-7) forming enzymes and receptors. Kidney Int. 2005 Nov; 68(5):2189-96. PMID: 16221218.
      View in: PubMed
    49. Albright CD, Klem E, Shah AA, Gallagher P. Breast cancer cell-targeted oxidative stress: enhancement of cancer cell uptake of conjugated linoleic acid, activation of p53, and inhibition of proliferation. Exp Mol Pathol. 2005 Oct; 79(2):118-25. PMID: 15992797.
      View in: PubMed
    50. Gallagher PE, Chappell MC, Ferrario CM, Tallant EA. Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes. Am J Physiol Cell Physiol. 2006 Feb; 290(2):C420-6. PMID: 16176966.
      View in: PubMed
    51. Kasper SO, Carter CS, Ferrario CM, Ganten D, Ferder LF, Sonntag WE, Gallagher PE, Diz DI. Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems. Physiol Genomics. 2005 Nov 17; 23(3):311-7. PMID: 16131528.
      View in: PubMed
    52. Sakima A, Averill DB, Gallagher PE, Kasper SO, Tommasi EN, Ferrario CM, Diz DI. Impaired heart rate baroreflex in older rats: role of endogenous angiotensin-(1-7) at the nucleus tractus solitarii. Hypertension. 2005 Aug; 46(2):333-40. PMID: 16009784.
      View in: PubMed
    53. Tallant EA, Ferrario CM, Gallagher PE. Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor. Am J Physiol Heart Circ Physiol. 2005 Oct; 289(4):H1560-6. PMID: 15951342.
      View in: PubMed
    54. Ferrario CM, Jessup J, Chappell MC, Averill DB, Brosnihan KB, Tallant EA, Diz DI, Gallagher PE. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation. 2005 May 24; 111(20):2605-10. PMID: 15897343.
      View in: PubMed
    55. Igase M, Strawn WB, Gallagher PE, Geary RL, Ferrario CM. Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) expression in the aorta of spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2005 Sep; 289(3):H1013-9. PMID: 15833808.
      View in: PubMed
    56. Richmond RS, Tallant EA, Gallagher PE, Ferrario CM, Strawn WB. Angiotensin II stimulates arachidonic acid release from bone marrow stromal cells. J Renin Angiotensin Aldosterone Syst. 2004 Dec; 5(4):176-82. PMID: 15803435.
      View in: PubMed
    57. Gallagher PE, Tallant EA. Inhibition of human lung cancer cell growth by angiotensin-(1-7). Carcinogenesis. 2004 Nov; 25(11):2045-52. PMID: 15284177.
      View in: PubMed
    58. Strawn WB, Richmond RS, Ann Tallant E, Gallagher PE, Ferrario CM. Renin-angiotensin system expression in rat bone marrow haematopoietic and stromal cells. Br J Haematol. 2004 Jul; 126(1):120-6. PMID: 15198742.
      View in: PubMed
    59. Ishiyama Y, Gallagher PE, Averill DB, Tallant EA, Brosnihan KB, Ferrario CM. Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors. Hypertension. 2004 May; 43(5):970-6. PMID: 15007027.
      View in: PubMed
    60. Modrall JG, Sadjadi J, Brosnihan KB, Gallagher PE, Yu CH, Kramer GL, Bernstein KE, Chappell MC. Depletion of tissue angiotensin-converting enzyme differentially influences the intrarenal and urinary expression of angiotensin peptides. Hypertension. 2004 Apr; 43(4):849-53. PMID: 14981053.
      View in: PubMed
    61. Sampath D, Discafani CM, Loganzo F, Beyer C, Liu H, Tan X, Musto S, Annable T, Gallagher P, Rios C, Greenberger LM. MAC-321, a novel taxane with greater efficacy than paclitaxel and docetaxel in vitro and in vivo. Mol Cancer Ther. 2003 Sep; 2(9):873-84. PMID: 14555706.
      View in: PubMed
    62. Chappell MC, Gallagher PE, Averill DB, Ferrario CM, Brosnihan KB. Estrogen or the AT1 antagonist olmesartan reverses the development of profound hypertension in the congenic mRen2. Lewis rat. Hypertension. 2003 Oct; 42(4):781-6. PMID: 12874087.
      View in: PubMed
    63. Diz DI, Jessup JA, Westwood BM, Bosch SM, Vinsant S, Gallagher PE, Averill DB. Angiotensin peptides as neurotransmitters/neuromodulators in the dorsomedial medulla. Clin Exp Pharmacol Physiol. 2002 May-Jun; 29(5-6):473-82. PMID: 12010195.
      View in: PubMed
    64. Gallagher PE, Allen TY, Wyer PC. How to find evidence when you need it, part 3: a clinician's guide to MEDLINE: tricks and special skills. Ann Emerg Med. 2002 May; 39(5):547-51. PMID: 11973563.
      View in: PubMed
    65. Gallagher PE, Allen TY, Wyer PC. How to find evidence when you need it, part 2: a clinician's guide to MEDLINE: the basics. Ann Emerg Med. 2002 Apr; 39(4):436-40. PMID: 11919532.
      View in: PubMed
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