Loading...
Explore More at wakehealth.edu

Clinical and Translational Science Institute

Keywords
Last Name

David A. Ornelles, Ph.D.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentMicrobiology_Immunology
Address
vCardDownload vCard
    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentCancer Biology

    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentInstitute for Regenerative Medicine


    Collapse Research 
    Collapse research activities and funding
    R29AI035589     (ORNELLES, DAVID ARNOLD)Dec 1, 1994 - May 30, 2000
    NIH/NIAID
    ADENOVIRUS CONTROL OF MRNA TRANSPORT
    Role: Principal Investigator

    R01CA077342     (ORNELLES, DAVID ARNOLD)Apr 1, 1999 - Jan 31, 2011
    NIH/NCI
    NOVEL CELL CYCLE REGULATION BY ADENOVIRUS E1B 55K
    Role: Principal Investigator

    R01DC010051     (SWORDS, WILLIAM E)Apr 1, 2009 - Mar 31, 2019
    NIH/NIDCD
    Microbial interactions in otitis media
    Role: Co-Principal Investigator

    R01CA127621     (ORNELLES, DAVID ARNOLD)Apr 20, 2009 - Jan 31, 2014
    NIH/NCI
    Prenatal adenovirus infection, inhibition of DNA repair, and childhood leukemia
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Kaverina NV, Kadagidze ZG, Borovjagin AV, Karseladze AI, Kim CK, Lesniak MS, Miska J, Zhang P, Baryshnikova MA, Xiao T, Ornelles D, Cobbs C, Khramtsov A, Ulasov IV. Tamoxifen overrides autophagy inhibition in Beclin-1-deficient glioma cells and their resistance to adenovirus-mediated oncolysis via upregulation of PUMA and BAX. Oncogene. 2018 11; 37(46):6069-6082. PMID: 29991800.
      View in: PubMed
    2. Grayson KM, Blevins LK, Oliver MB, Ornelles DA, Swords WE, Alexander-Miller MA. Activation-dependent modulation of Streptococcus pneumoniae-mediated death in human lymphocytes. Pathog Dis. 2017 03 01; 75(2). PMID: 28158464.
      View in: PubMed
    3. Yacovone SK, Smelser AM, Macosko JC, Holzwarth G, Ornelles DA, Lyles DS. Migration of Nucleocapsids in Vesicular Stomatitis Virus-Infected Cells Is Dependent on both Microtubules and Actin Filaments. J Virol. 2016 07 01; 90(13):6159-70. PMID: 27122580.
      View in: PubMed
    4. Yacovone SK, Ornelles DA, Lyles DS. The border-to-border distribution method for analysis of cytoplasmic particles and organelles. Cell Tissue Res. 2016 Feb; 363(2):351-60. PMID: 26310140.
      View in: PubMed
    5. Ornelles DA, Gooding LR, Garnett-Benson C. Neonatal infection with species C adenoviruses confirmed in viable cord blood lymphocytes. PLoS One. 2015; 10(3):e0119256. PMID: 25764068.
      View in: PubMed
    6. Murrah KA, Turner RL, Pang B, Perez AC, Reimche JL, King LB, Wren J, Gandhi U, Swords WE, Ornelles DA. Replication of type 5 adenovirus promotes middle ear infection by Streptococcus pneumoniae in the chinchilla model of otitis media. Pathog Dis. 2015 Mar; 73(2):1-8. PMID: 25251686.
      View in: PubMed
    7. Turner RL, Groitl P, Dobner T, Ornelles DA. Adenovirus replaces mitotic checkpoint controls. J Virol. 2015 May; 89(9):5083-96. PMID: 25694601.
      View in: PubMed
    8. Turner RL, Wilkinson JC, Ornelles DA. E1B and E4 oncoproteins of adenovirus antagonize the effect of apoptosis inducing factor. Virology. 2014 May; 456-457:205-19. PMID: 24889240.
      View in: PubMed
    9. Furuse Y, Ornelles DA, Cullen BR. Persistently adenovirus-infected lymphoid cells express microRNAs derived from the viral VAI and especially VAII RNA. Virology. 2013 Dec; 447(1-2):140-5. PMID: 24210108.
      View in: PubMed
    10. Divers J, Núñez M, High KP, Murea M, Rocco MV, Ma L, Bowden DW, Hicks PJ, Spainhour M, Ornelles DA, Kleiboeker SB, Duncan K, Langefeld CD, Turner J, Freedman BI. JC polyoma virus interacts with APOL1 in African Americans with nondiabetic nephropathy. Kidney Int. 2013 Dec; 84(6):1207-13. PMID: 23677244.
      View in: PubMed
    11. Kute T, Stehle JR, Ornelles D, Walker N, Delbono O, Vaughn JP. Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2 positive breast cancer cells. Oncoimmunology. 2012 09 01; 1(6):810-821. PMID: 23162748.
      View in: PubMed
    12. Whitlock PW, Seyler TM, Parks GD, Ornelles DA, Smith TL, Van Dyke ME, Poehling GG. A novel process for optimizing musculoskeletal allograft tissue to improve safety, ultrastructural properties, and cell infiltration. J Bone Joint Surg Am. 2012 Aug 15; 94(16):1458-67. PMID: 22786867.
      View in: PubMed
    13. Murphy AM, Besmer DM, Moerdyk-Schauwecker M, Moestl N, Ornelles DA, Mukherjee P, Grdzelishvili VZ. Vesicular stomatitis virus as an oncolytic agent against pancreatic ductal adenocarcinoma. J Virol. 2012 Mar; 86(6):3073-87. PMID: 22238308.
      View in: PubMed
    14. Zhang Y, Huang W, Ornelles DA, Gooding LR. Modeling adenovirus latency in human lymphocyte cell lines. J Virol. 2010 Sep; 84(17):8799-810. PMID: 20573817.
      View in: PubMed
    15. Spurgeon ME, Ornelles DA. The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection. J Virol. 2009 Oct; 83(19):9970-82. PMID: 19605483.
      View in: PubMed
    16. Nichols GJ, Schaack J, Ornelles DA. Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication. J Virol. 2009 Jun; 83(12):5987-98. PMID: 19321613.
      View in: PubMed
    17. Thomas MA, Broughton RS, Goodrum FD, Ornelles DA. E4orf1 limits the oncolytic potential of the E1B-55K deletion mutant adenovirus. J Virol. 2009 Mar; 83(6):2406-16. PMID: 19129452.
      View in: PubMed
    18. Henry CJ, Ornelles DA, Mitchell LM, Brzoza-Lewis KL, Hiltbold EM. IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17. J Immunol. 2008 Dec 15; 181(12):8576-84. PMID: 19050277.
      View in: PubMed
    19. Marshall LJ, Moore AC, Ohki M, Kitabayashi I, Patterson D, Ornelles DA. RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesis. J Virol. 2008 Jul; 82(13):6395-408. PMID: 18417565.
      View in: PubMed
    20. Ornelles DA, Broughton-Shepard RN, Goodrum FD. Analysis of adenovirus infections in synchronized cells. Methods Mol Med. 2007; 131:83-101. PMID: 17656777.
      View in: PubMed
    21. Hart LS, Ornelles D, Koumenis C. The adenoviral E4orf6 protein induces atypical apoptosis in response to DNA damage. J Biol Chem. 2007 Mar 02; 282(9):6061-7. PMID: 17172468.
      View in: PubMed
    22. Shapiro GS, Van Peursem C, Ornelles DA, Schaack J, DeGregori J. Recombinant adenoviral vectors can induce expression of p73 via the E4-orf6/7 protein. J Virol. 2006 Jun; 80(11):5349-60. PMID: 16699015.
      View in: PubMed
    23. Weitzman MD, Ornelles DA. Inactivating intracellular antiviral responses during adenovirus infection. Oncogene. 2005 Nov 21; 24(52):7686-96. PMID: 16299529.
      View in: PubMed
    24. Stracker TH, Lee DV, Carson CT, Araujo FD, Ornelles DA, Weitzman MD. Serotype-specific reorganization of the Mre11 complex by adenoviral E4orf3 proteins. J Virol. 2005 Jun; 79(11):6664-73. PMID: 15890904.
      View in: PubMed
    25. Xue Y, Johnson JS, Ornelles DA, Lieberman J, Engel DA. Adenovirus protein VII functions throughout early phase and interacts with cellular proteins SET and pp32. J Virol. 2005 Feb; 79(4):2474-83. PMID: 15681448.
      View in: PubMed
    26. Blanchette P, Cheng CY, Yan Q, Ketner G, Ornelles DA, Dobner T, Conaway RC, Conaway JW, Branton PE. Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53. Mol Cell Biol. 2004 Nov; 24(21):9619-29. PMID: 15485928.
      View in: PubMed
    27. Hart LS, Yannone SM, Naczki C, Orlando JS, Waters SB, Akman SA, Chen DJ, Ornelles D, Koumenis C. The adenovirus E4orf6 protein inhibits DNA double strand break repair and radiosensitizes human tumor cells in an E1B-55K-independent manner. J Biol Chem. 2005 Jan 14; 280(2):1474-81. PMID: 15507430.
      View in: PubMed
    28. Shepard RN, Ornelles DA. Diverse roles for E4orf3 at late times of infection revealed in an E1B 55-kilodalton protein mutant background. J Virol. 2004 Sep; 78(18):9924-35. PMID: 15331726.
      View in: PubMed
    29. McNees AL, Mahr JA, Ornelles D, Gooding LR. Postinternalization inhibition of adenovirus gene expression and infectious virus production in human T-cell lines. J Virol. 2004 Jul; 78(13):6955-66. PMID: 15194772.
      View in: PubMed
    30. Schaack J, Bennett ML, Colbert JD, Torres AV, Clayton GH, Ornelles D, Moorhead J. E1A and E1B proteins inhibit inflammation induced by adenovirus. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):3124-9. PMID: 14976240.
      View in: PubMed
    31. Shepard RN, Ornelles DA. E4orf3 is necessary for enhanced S-phase replication of cell cycle-restricted subgroup C adenoviruses. J Virol. 2003 Aug; 77(15):8593-5. PMID: 12857931.
      View in: PubMed
    32. Chastain-Moore AM, Roberts T, Trott DA, Newbold RF, Ornelles DA. An activity associated with human chromosome 21 permits nuclear colocalization of the adenovirus E1B-55K and E4orf6 proteins and promotes viral late gene expression. J Virol. 2003 Jul; 77(14):8087-98. PMID: 12829847.
      View in: PubMed
    33. Orlando JS, Ornelles DA. E4orf6 variants with separate abilities to augment adenovirus replication and direct nuclear localization of the E1B 55-kilodalton protein. J Virol. 2002 Feb; 76(3):1475-87. PMID: 11773420.
      View in: PubMed
    Ornelles's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _