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Clinical and Translational Science Institute

Keywords
Last Name

Mikhail A. Nikiforov, Ph.D.

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentCancer Biology
Address
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    Collapse Research 
    Collapse research activities and funding
    R01CA120244     (NIKIFOROV, MIKHAIL)Apr 1, 2006 - Nov 30, 2016
    NIH/NCI
    Oncogene c-Myc-dependent pathways in cutaneous melanoma03
    Role: Principal Investigator

    R01CA190533     (NIKIFOROV, MIKHAIL)Jul 10, 2015 - Jun 30, 2020
    NIH/NCI
    KLF9-TXNRD2 axis in melanoma progression and metastasis
    Role: Principal Investigator

    R21CA202162     (NIKIFOROV, MIKHAIL)Dec 1, 2015 - Nov 30, 2017
    NIH/NCI
    Melanoma suppressing functions of carcinoma oncogene FOXQ1
    Role: Principal Investigator

    R01CA193981     (NIKIFOROV, MIKHAIL)Dec 1, 2015 - Nov 30, 2020
    NIH/NCI
    KLF9-dependent pathways in multiple myeloma drug resistance
    Role: Principal Investigator

    R21CA220096     (NIKIFOROV, MIKHAIL)Aug 1, 2017 - Jul 31, 2020
    NIH/NCI
    Inhibition of MYC interactions with chromatin-remodeling factors as a novel anti-melanoma strategy
    Role: Principal Investigator

    R01CA224434     (NIKIFOROV, MIKHAIL)May 15, 2018 - Apr 30, 2023
    NIH/NCI
    GMPS-GMPR axis melanoma progression and therapy
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Fink EE, Moparthy S, Bagati A, Bianchi-Smiraglia A, Lipchick BC, Wolff DW, Roll MV, Wang J, Liu S, Bakin AV, Kandel ES, Lee AH, Nikiforov MA. XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response. Cell Rep. 2018 Oct 02; 25(1):212-223.e4. PMID: 30282030.
      View in: PubMed
    2. Bianchi-Smiraglia A, Bagati A, Fink EE, Affronti HC, Lipchick BC, Moparthy S, Long MD, Rosario SR, Lightman SM, Moparthy K, Wolff DW, Yun DH, Han Z, Polechetti A, Roll MV, Gitlin II, Leonova KI, Rowsam AM, Kandel ES, Gudkov AV, Bergsagel PL, Lee KP, Smiraglia DJ, Nikiforov MA. Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma. J Clin Invest. 2018 Oct 01; 128(10):4682-4696. PMID: 30198908.
      View in: PubMed
    3. Bagati A, Bianchi-Smiraglia A, Moparthy S, Kolesnikova K, Fink EE, Lipchick BC, Kolesnikova M, Jowdy P, Polechetti A, Mahpour A, Ross J, Wawrzyniak JA, Yun DH, Paragh G, Kozlova NI, Berman AE, Wang J, Liu S, Nemeth MJ, Nikiforov MA. Melanoma Suppressor Functions of the Carcinoma Oncogene FOXQ1. Cell Rep. 2017 Sep 19; 20(12):2820-2832. PMID: 28930679.
      View in: PubMed
    4. Bianchi-Smiraglia A, Rana MS, Foley CE, Paul LM, Lipchick BC, Moparthy S, Moparthy K, Fink EE, Bagati A, Hurley E, Affronti HC, Bakin AV, Kandel ES, Smiraglia DJ, Feltri ML, Sousa R, Nikiforov MA. Internally ratiometric fluorescent sensors for evaluation of intracellular GTP levels and distribution. Nat Methods. 2017 Oct; 14(10):1003-1009. PMID: 28869758.
      View in: PubMed
    5. Fink EE, Mannava S, Bagati A, Bianchi-Smiraglia A, Nair JR, Moparthy K, Lipchick BC, Drokov M, Utley A, Ross J, Mendeleeva LP, Savchenko VG, Lee KP, Nikiforov MA. Mitochondrial thioredoxin reductase regulates major cytotoxicity pathways of proteasome inhibitors in multiple myeloma cells. Leukemia. 2016 Jan; 30(1):104-11. PMID: 26205085.
      View in: PubMed
    6. Bianchi-Smiraglia A, Wawrzyniak JA, Bagati A, Marvin EK, Ackroyd J, Moparthy S, Bshara W, Fink EE, Foley CE, Morozevich GE, Berman AE, Shewach DS, Nikiforov MA. Pharmacological targeting of guanosine monophosphate synthase suppresses melanoma cell invasion and tumorigenicity. Cell Death Differ. 2015 Nov; 22(11):1858-64. PMID: 25909885.
      View in: PubMed
    7. Zucker SN, Fink EE, Bagati A, Mannava S, Bianchi-Smiraglia A, Bogner PN, Wawrzyniak JA, Foley C, Leonova KI, Grimm MJ, Moparthy K, Ionov Y, Wang J, Liu S, Sexton S, Kandel ES, Bakin AV, Zhang Y, Kaminski N, Segal BH, Nikiforov MA. Nrf2 amplifies oxidative stress via induction of Klf9. Mol Cell. 2014 Mar 20; 53(6):916-928. PMID: 24613345.
      View in: PubMed
    8. Wawrzyniak JA, Bianchi-Smiraglia A, Bshara W, Mannava S, Ackroyd J, Bagati A, Omilian AR, Im M, Fedtsova N, Miecznikowski JC, Moparthy KC, Zucker SN, Zhu Q, Kozlova NI, Berman AE, Hoek KS, Gudkov AV, Shewach DS, Morrison CD, Nikiforov MA. A purine nucleotide biosynthesis enzyme guanosine monophosphate reductase is a suppressor of melanoma invasion. Cell Rep. 2013 Oct 31; 5(2):493-507. PMID: 24139804.
      View in: PubMed
    9. Mannava S, Moparthy KC, Wheeler LJ, Natarajan V, Zucker SN, Fink EE, Im M, Flanagan S, Burhans WC, Zeitouni NC, Shewach DS, Mathews CK, Nikiforov MA. Depletion of deoxyribonucleotide pools is an endogenous source of DNA damage in cells undergoing oncogene-induced senescence. Am J Pathol. 2013 Jan; 182(1):142-51. PMID: 23245831.
      View in: PubMed
    10. Mannava S, Moparthy KC, Wheeler LJ, Leonova KI, Wawrzyniak JA, Bianchi-Smiraglia A, Berman AE, Flanagan S, Shewach DS, Zeitouni NC, Gudkov AV, Mathews CK, Nikiforov MA. Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion. Aging (Albany NY). 2012 Dec; 4(12):917-22. PMID: 23249808.
      View in: PubMed
    11. Bianchi-Smiraglia A, Nikiforov MA. Controversial aspects of oncogene-induced senescence. Cell Cycle. 2012 Nov 15; 11(22):4147-51. PMID: 23095636.
      View in: PubMed
    12. Mannava S, Zhuang D, Nair JR, Bansal R, Wawrzyniak JA, Zucker SN, Fink EE, Moparthy KC, Hu Q, Liu S, Boise LH, Lee KP, Nikiforov MA. KLF9 is a novel transcriptional regulator of bortezomib- and LBH589-induced apoptosis in multiple myeloma cells. Blood. 2012 Feb 09; 119(6):1450-8. PMID: 22144178.
      View in: PubMed
    13. Noubissi FK, Nikiforov MA, Colburn N, Spiegelman VS. Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions. Genes Cancer. 2010 Oct; 1(10):1074-82. PMID: 21779431.
      View in: PubMed
    14. Flanagan SA, Krokosky CM, Mannava S, Nikiforov MA, Shewach DS. MLH1 deficiency enhances radiosensitization with 5-fluorodeoxyuridine by increasing DNA mismatches. Mol Pharmacol. 2008 Sep; 74(3):863-71. PMID: 18535288.
      View in: PubMed
    15. Mannava S, Grachtchouk V, Wheeler LJ, Im M, Zhuang D, Slavina EG, Mathews CK, Shewach DS, Nikiforov MA. Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells. Cell Cycle. 2008 Aug; 7(15):2392-400. PMID: 18677108.
      View in: PubMed
    16. Nikiforov MA, Riblett M, Tang WH, Gratchouck V, Zhuang D, Fernandez Y, Verhaegen M, Varambally S, Chinnaiyan AM, Jakubowiak AJ, Soengas MS. Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition. Proc Natl Acad Sci U S A. 2007 Dec 04; 104(49):19488-93. PMID: 18042711.
      View in: PubMed
    17. Denoyelle C, Abou-Rjaily G, Bezrookove V, Verhaegen M, Johnson TM, Fullen DR, Pointer JN, Gruber SB, Su LD, Nikiforov MA, Kaufman RJ, Bastian BC, Soengas MS. Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. Nat Cell Biol. 2006 Oct; 8(10):1053-63. PMID: 16964246.
      View in: PubMed
    18. Nikiforov MA, Popov N, Kotenko I, Henriksson M, Cole MD. The Mad and Myc basic domains are functionally equivalent. J Biol Chem. 2003 Mar 28; 278(13):11094-9. PMID: 12538578.
      View in: PubMed
    19. Nikiforov MA, Chandriani S, O'Connell B, Petrenko O, Kotenko I, Beavis A, Sedivy JM, Cole MD. A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism. Mol Cell Biol. 2002 Aug; 22(16):5793-800. PMID: 12138190.
      View in: PubMed
    20. Nikiforov MA, Chandriani S, Park J, Kotenko I, Matheos D, Johnsson A, McMahon SB, Cole MD. TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins. Mol Cell Biol. 2002 Jul; 22(14):5054-63. PMID: 12077335.
      View in: PubMed
    21. Gurova KV, Kwek SS, Koman IE, Komarov AP, Kandel E, Nikiforov MA, Gudkov AV. Apoptosis inhibitor as a suppressor of tumor progression: expression of Bcl-2 eliminates selective advantages for p53-deficient cells in the tumor. Cancer Biol Ther. 2002 Jan-Feb; 1(1):39-44. PMID: 12170763.
      View in: PubMed
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