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Clinical and Translational Science Institute

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Last Name

Linda J. Porrino, Ph.D.

TitleChair
InstitutionWake Forest School of Medicine
DepartmentPhysiology and Pharmacology
Address
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentCTSI

    TitleChair
    InstitutionWake Forest School of Medicine
    DepartmentPhysiology and Pharmacology


    Collapse Research 
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    R01DA007522     (PORRINO, LINDA J.)Dec 15, 1991 - Nov 30, 1997
    NIH/NIDA
    NEURO SUBSTRATES OF COCAINE INDUCED SENSITIZATION
    Role: Principal Investigator

    R01AA009291     (PORRINO, LINDA J.)May 1, 1992 - May 31, 2004
    NIH/NIAAA
    NEURAL SUBSTRATES OF THE ACUTE EFFECTS OF ETHANOL
    Role: Principal Investigator

    R01DA009085     (PORRINO, LINDA J.)Jul 1, 1995 - Mar 31, 2014
    NIH/NIDA
    Neurobiological Correlates of Cocaine Abuse
    Role: Principal Investigator

    R01AA012356     (PORRINO, LINDA J.)Aug 1, 1999 - Apr 30, 2004
    NIH/NIAAA
    TIME DEPENDENT EFFECTS OF ETHANOL ON CEREBRAL METABOLISM
    Role: Principal Investigator

    R01DA010230     (PORRINO, LINDA J.)Sep 15, 1999 - Aug 31, 2005
    NIH/NIDA
    REGIONAL BRAIN ACTIVATION DURING COCAINE ABSTINENCE
    Role: Principal Investigator

    R13DA018646     (PORRINO, LINDA J.)Jul 17, 2004 - Oct 31, 2004
    NIH/NIDA
    Conference--Scientific Approaches to Drug Addiction
    Role: Principal Investigator

    R01DA020074     (PORRINO, LINDA J.)Apr 10, 2006 - Dec 31, 2010
    NIH/NIDA
    Decision Making in Marijuana Users
    Role: Principal Investigator

    R01DA020648     (PORRINO, LINDA J.)Jun 1, 2006 - Feb 28, 2014
    NIH/NIDA
    Early Exposure to Stimulants as a Risk Factor for Substance Abuse
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Wesley MJ, Lile JA, Fillmore MT, Porrino LJ. Neurophysiological capacity in a working memory task differentiates dependent from nondependent heavy drinkers and controls. Drug Alcohol Depend. 2017 06 01; 175:24-35. PMID: 28376413.
      View in: PubMed
    2. Gould RW, Czoty PW, Porrino LJ, Nader MA. Social Status in Monkeys: Effects of Social Confrontation on Brain Function and Cocaine Self-Administration. Neuropsychopharmacology. 2017 Apr; 42(5):1093-1102. PMID: 28025974.
      View in: PubMed
    3. Mayhugh RE, Moussa MN, Simpson SL, Lyday RG, Burdette JH, Porrino LJ, Laurienti PJ. Moderate-Heavy Alcohol Consumption Lifestyle in Older Adults Is Associated with Altered Central Executive Network Community Structure during Cognitive Task. PLoS One. 2016; 11(8):e0160214. PMID: 27494180.
      View in: PubMed
    4. Porrino LJ, Miller MD, Smith HR, Nader SH, Nader MA. Neural Correlates of Exposure to Cocaine Cues in Rhesus Monkeys: Modulation by the Dopamine Transporter. Biol Psychiatry. 2016 11 01; 80(9):702-710. PMID: 27059874.
      View in: PubMed
    5. Wesley MJ, Lile JA, Hanlon CA, Porrino LJ. Abnormal medial prefrontal cortex activity in heavy cannabis users during conscious emotional evaluation. Psychopharmacology (Berl). 2016 Mar; 233(6):1035-44. PMID: 26690589.
      View in: PubMed
    6. Smith HR, Beveridge TJ, Nader MA, Porrino LJ. Effects of abstinence from chronic cocaine self-administration on nonhuman primate dorsal and ventral noradrenergic bundle terminal field structures. Brain Struct Funct. 2016 06; 221(5):2703-15. PMID: 26013302.
      View in: PubMed
    7. Porrino LJ, Beveridge TJ, Smith HR, Nader MA. Functional consequences of cocaine expectation: findings in a non-human primate model of cocaine self-administration. Addict Biol. 2016 May; 21(3):519-29. PMID: 25684556; PMCID: PMC4537685 [Available on 05/01/17].
    8. Moussa MN, Simpson SL, Mayhugh RE, Grata ME, Burdette JH, Porrino LJ, Laurienti PJ. Long-term moderate alcohol consumption does not exacerbate age-related cognitive decline in healthy, community-dwelling older adults. Front Aging Neurosci. 2014; 6:341. PMID: 25601835; PMCID: PMC4283638.
    9. Gill KE, Chappell AM, Beveridge TJ, Porrino LJ, Weiner JL. Chronic methylphenidate treatment during early life is associated with greater ethanol intake in socially isolated rats. Alcohol Clin Exp Res. 2014 Aug; 38(8):2260-8. PMID: 25156616; PMCID: PMC4145615.
    10. Beveridge TJ, Smith HR, Nader SH, Nader MA, Porrino LJ. Functional consequences of cocaine re-exposure after discontinuation of cocaine availability. Neuropharmacology. 2014 Oct; 85:528-37. PMID: 24953829; PMCID: PMC4132869.
    11. Moussa MN, Wesley MJ, Porrino LJ, Hayasaka S, Bechara A, Burdette JH, Laurienti PJ. Age-related differences in advantageous decision making are associated with distinct differences in functional community structure. Brain Connect. 2014 Apr; 4(3):193-202. PMID: 24575804; PMCID: PMC3995120.
    12. Smith HR, Beveridge TJ, Nader MA, Porrino LJ. Regionally-specific alterations in myelin proteins in nonhuman primate white matter following prolonged cocaine self-administration. Drug Alcohol Depend. 2014 Apr 01; 137:143-7. PMID: 24529965; PMCID: PMC4000724.
    13. Calipari ES, Beveridge TJ, Jones SR, Porrino LJ. Withdrawal from extended-access cocaine self-administration results in dysregulated functional activity and altered locomotor activity in rats. Eur J Neurosci. 2013 Dec; 38(12):3749-57. PMID: 24118121; PMCID: PMC3865236.
    14. Martelle SE, Porrino LJ, Nader MA. Effects of chronic methylphenidate in adolescence on later methylphenidate self-administration in rhesus monkeys. Behav Pharmacol. 2013 Sep; 24(5-6):478-81. PMID: 23903242; PMCID: PMC4167420.
    15. Gill KE, Beveridge TJ, Smith HR, Porrino LJ. The effects of rearing environment and chronic methylphenidate administration on behavior and dopamine receptors in adolescent rats. Brain Res. 2013 Aug 21; 1527:67-78. PMID: 23806775; PMCID: PMC3775327.
    16. Hanlon CA, Beveridge TJ, Porrino LJ. Recovering from cocaine: insights from clinical and preclinical investigations. Neurosci Biobehav Rev. 2013 Nov; 37(9 Pt A):2037-46. PMID: 23628740; PMCID: PMC3935515.
    17. Cousijn J, Wiers RW, Ridderinkhof KR, van den Brink W, Veltman DJ, Porrino LJ, Goudriaan AE. Individual differences in decision making and reward processing predict changes in cannabis use: a prospective functional magnetic resonance imaging study. Addict Biol. 2013 Nov; 18(6):1013-23. PMID: 22994937.
      View in: PubMed
    18. Porrino LJ, Hampson RE, Opris I, Deadwyler SA. Acute cocaine induced deficits in cognitive performance in rhesus macaque monkeys treated with baclofen. Psychopharmacology (Berl). 2013 Jan; 225(1):105-14. PMID: 22836369; PMCID: PMC3801229.
    19. Gill KE, Pierre PJ, Daunais J, Bennett AJ, Martelle S, Gage HD, Swanson JM, Nader MA, Porrino LJ. Chronic treatment with extended release methylphenidate does not alter dopamine systems or increase vulnerability for cocaine self-administration: a study in nonhuman primates. Neuropsychopharmacology. 2012 Nov; 37(12):2555-65. PMID: 22805600; PMCID: PMC3473324.
    20. Taber KH, Black DN, Porrino LJ, Hurley RA. Neuroanatomy of dopamine: reward and addiction. J Neuropsychiatry Clin Neurosci. 2012; 24(1):1-4. PMID: 22450608.
      View in: PubMed
    21. Gould RW, Porrino LJ, Nader MA. Nonhuman primate models of addiction and PET imaging: dopamine system dysregulation. Curr Top Behav Neurosci. 2012; 11:25-44. PMID: 22020537; PMCID: PMC3831150.
    22. Hanlon CA, Dufault DL, Wesley MJ, Porrino LJ. Elevated gray and white matter densities in cocaine abstainers compared to current users. Psychopharmacology (Berl). 2011 Dec; 218(4):681-92. PMID: 21691942; PMCID: PMC3197798.
    23. Hanlon CA, Wesley MJ, Stapleton JR, Laurienti PJ, Porrino LJ. The association between frontal-striatal connectivity and sensorimotor control in cocaine users. Drug Alcohol Depend. 2011 Jun 01; 115(3):240-3. PMID: 21193273; PMCID: PMC3499027.
    24. Wesley MJ, Hanlon CA, Porrino LJ. Poor decision-making by chronic marijuana users is associated with decreased functional responsiveness to negative consequences. Psychiatry Res. 2011 Jan 30; 191(1):51-9. PMID: 21145211; PMCID: PMC3125637.
    25. Hampson RE, Porrino LJ, Opris I, Stanford T, Deadwyler SA. Effects of cocaine rewards on neural representations of cognitive demand in nonhuman primates. Psychopharmacology (Berl). 2011 Jan; 213(1):105-18. PMID: 20865250; PMCID: PMC3126099.
    26. Fridberg DJ, Queller S, Ahn WY, Kim W, Bishara AJ, Busemeyer JR, Porrino L, Stout JC. Cognitive Mechanisms Underlying Risky Decision-Making in Chronic Cannabis Users. J Math Psychol. 2010 Feb 01; 54(1):28-38. PMID: 20419064.
      View in: PubMed
    27. Hanlon CA, Wesley MJ, Roth AJ, Miller MD, Porrino LJ. Loss of laterality in chronic cocaine users: an fMRI investigation of sensorimotor control. Psychiatry Res. 2010 Jan 30; 181(1):15-23. PMID: 19959345; PMCID: PMC2794910.
    28. Hanlon CA, Wesley MJ, Porrino LJ. Loss of functional specificity in the dorsal striatum of chronic cocaine users. Drug Alcohol Depend. 2009 Jun 01; 102(1-3):88-94. PMID: 19264428; PMCID: PMC3124239.
    29. Beveridge TJ, Gill KE, Hanlon CA, Porrino LJ. Review. Parallel studies of cocaine-related neural and cognitive impairment in humans and monkeys. Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12; 363(1507):3257-66. PMID: 18640916; PMCID: PMC2607331.
    30. Beveridge TJ, Smith HR, Nader MA, Porrino LJ. Abstinence from chronic cocaine self-administration alters striatal dopamine systems in rhesus monkeys. Neuropsychopharmacology. 2009 Apr; 34(5):1162-71. PMID: 18769473; PMCID: PMC3845090.
    31. Smith HR, Porrino LJ. The comparative distributions of the monoamine transporters in the rodent, monkey, and human amygdala. Brain Struct Funct. 2008 Sep; 213(1-2):73-91. PMID: 18283492.
      View in: PubMed
    32. Deadwyler SA, Porrino L, Siegel JM, Hampson RE. Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates. J Neurosci. 2007 Dec 26; 27(52):14239-47. PMID: 18160631.
      View in: PubMed
    33. Porrino LJ, Smith HR, Nader MA, Beveridge TJ. The effects of cocaine: a shifting target over the course of addiction. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Nov 15; 31(8):1593-600. PMID: 17900777; PMCID: PMC2211431.
    34. Beveridge TJ, Smith HR, Daunais JB, Nader MA, Porrino LJ. Chronic cocaine self-administration is associated with altered functional activity in the temporal lobes of non human primates. Eur J Neurosci. 2006 Jun; 23(11):3109-18. PMID: 16820001.
      View in: PubMed
    35. Beveridge TJ, Smith HR, Nader MA, Porrino LJ. Effects of chronic cocaine self-administration on norepinephrine transporters in the nonhuman primate brain. Psychopharmacology (Berl). 2005 Aug; 180(4):781-8. PMID: 15739079.
      View in: PubMed
    36. Porrino LJ, Daunais JB, Rogers GA, Hampson RE, Deadwyler SA. Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates. PLoS Biol. 2005 Sep; 3(9):e299. PMID: 16104830; PMCID: PMC1188239.
    37. O'Connor KA, Porrino LJ, Davies HM, Childers SR. Time-dependent changes in receptor/G-protein coupling in rat brain following chronic monoamine transporter blockade. J Pharmacol Exp Ther. 2005 May; 313(2):510-7. PMID: 15644432; PMCID: PMC4353408.
    38. Grobin AC, VanDoren MJ, Porrino LJ, Morrow AL. Cortical 3 alpha-hydroxy-5 alpha-pregnan-20-one levels after acute administration of Delta 9-tetrahydrocannabinol, cocaine and morphine. Psychopharmacology (Berl). 2005 May; 179(3):544-50. PMID: 15619118.
      View in: PubMed
    39. Beveridge TJ, Smith HR, Nader MA, Porrino LJ. Functional effects of cocaine self-administration in primate brain regions regulating cardiovascular function. Neurosci Lett. 2004 Nov 11; 370(2-3):201-5. PMID: 15488323.
      View in: PubMed
    40. Whitlow CT, Liguori A, Livengood LB, Hart SL, Mussat-Whitlow BJ, Lamborn CM, Laurienti PJ, Porrino LJ. Long-term heavy marijuana users make costly decisions on a gambling task. Drug Alcohol Depend. 2004 Oct 05; 76(1):107-11. PMID: 15380295.
      View in: PubMed
    41. Porrino LJ, Lyons D, Smith HR, Daunais JB, Nader MA. Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains. J Neurosci. 2004 Apr 07; 24(14):3554-62. PMID: 15071103.
      View in: PubMed
    42. Howlett AC, Breivogel CS, Childers SR, Deadwyler SA, Hampson RE, Porrino LJ. Cannabinoid physiology and pharmacology: 30 years of progress. Neuropharmacology. 2004; 47 Suppl 1:345-58. PMID: 15464149.
      View in: PubMed
    43. Porrino LJ, Daunais JB, Smith HR, Nader MA. The expanding effects of cocaine: studies in a nonhuman primate model of cocaine self-administration. Neurosci Biobehav Rev. 2004 Jan; 27(8):813-20. PMID: 15019430.
      View in: PubMed
    44. Macey DJ, Rice WN, Freedland CS, Whitlow CT, Porrino LJ. Patterns of functional activity associated with cocaine self-administration in the rat change over time. Psychopharmacology (Berl). 2004 Apr; 172(4):384-92. PMID: 14668974.
      View in: PubMed
    45. Whitlow CT, Freedland CS, Porrino LJ. Functional consequences of the repeated administration of Delta9-tetrahydrocannabinol in the rat. Drug Alcohol Depend. 2003 Aug 20; 71(2):169-77. PMID: 12927655.
      View in: PubMed
    46. Freedland CS, Whitlow CT, Smith HR, Porrino LJ. Functional consequences of the acute administration of the cannabinoid receptor antagonist, SR141716A, in cannabinoid-naive and -tolerant animals: a quantitative 2-[14C]deoxyglucose study. Brain Res. 2003 Feb 07; 962(1-2):169-79. PMID: 12543468.
      View in: PubMed
    47. Macey DJ, Smith HR, Nader MA, Porrino LJ. Chronic cocaine self-administration upregulates the norepinephrine transporter and alters functional activity in the bed nucleus of the stria terminalis of the rhesus monkey. J Neurosci. 2003 Jan 01; 23(1):12-6. PMID: 12514195.
      View in: PubMed
    48. Porrino LJ, Lyons D, Miller MD, Smith HR, Friedman DP, Daunais JB, Nader MA. Metabolic mapping of the effects of cocaine during the initial phases of self-administration in the nonhuman primate. J Neurosci. 2002 Sep 01; 22(17):7687-94. PMID: 12196592.
      View in: PubMed
    49. Freedland CS, Whitlow CT, Miller MD, Porrino LJ. Dose-dependent effects of Delta9-tetrahydrocannabinol on rates of local cerebral glucose utilization in rat. Synapse. 2002 Aug; 45(2):134-42. PMID: 12112406.
      View in: PubMed
    50. Nader MA, Daunais JB, Moore T, Nader SH, Moore RJ, Smith HR, Friedman DP, Porrino LJ. Effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys: initial and chronic exposure. Neuropsychopharmacology. 2002 Jul; 27(1):35-46. PMID: 12062905.
      View in: PubMed
    51. Weiss F, Porrino LJ. Behavioral neurobiology of alcohol addiction: recent advances and challenges. J Neurosci. 2002 May 01; 22(9):3332-7. PMID: 11978808.
      View in: PubMed
    52. Whitlow CT, Freedland CS, Porrino LJ. Metabolic mapping of the time-dependent effects of delta 9-tetrahydrocannabinol administration in the rat. Psychopharmacology (Berl). 2002 May; 161(2):129-36. PMID: 11981592.
      View in: PubMed
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