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Clinical and Translational Science Institute

Keywords
Last Name

Linda J. Metheny-Barlow, Ph.D.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentRadiation Oncology
Address
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentCancer Biology


    Collapse Research 
    Collapse research activities and funding
    R01CA112593     (METHENY-BARLOW, LINDA J)Sep 30, 2004 - Apr 30, 2014
    NIH/NCI
    PPARs and Radiation-induced Brain Injury
    Role: Principal Investigator

    R21CA115829     (METHENY-BARLOW, LINDA J)Jul 12, 2005 - Jun 30, 2008
    NIH/NCI
    Tumorigenic subversion of mural cells in breast cancer
    Role: Principal Investigator

    R01CA138727     (METHENY-BARLOW, LINDA J)Mar 1, 2009 - Jan 31, 2014
    NIH/NCI
    Regulation of Vascular Stabilization by Connexin 43
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Xing F, Liu Y, Wu SY, Wu K, Sharma S, Mo YY, Feng J, Sanders S, Jin G, Singh R, Vidi PA, Tyagi A, Chan MD, Ruiz J, Debinski W, Pasche BC, Lo HW, Metheny-Barlow LJ, D'Agostino RB, Watabe K. Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis. Cancer Res. 2018 Aug 01; 78(15):4316-4330. PMID: 30026327.
      View in: PubMed
    2. Andrews RN, Caudell DL, Metheny-Barlow LJ, Peiffer AM, Tooze JA, Bourland JD, Hampson RE, Deadwyler SA, Cline JM. Fibronectin Produced by Cerebral Endothelial and Vascular Smooth Muscle Cells Contributes to Perivascular Extracellular Matrix in Late-Delayed Radiation-Induced Brain Injury. Radiat Res. 2018 10; 190(4):361-373. PMID: 30016219.
      View in: PubMed
    3. Okoukoni C, McTyre ER, Ayala Peacock DN, Peiffer AM, Strowd R, Cramer C, Hinson WH, Rapp S, Metheny-Barlow L, Shaw EG, Chan MD. Hippocampal dose volume histogram predicts Hopkins Verbal Learning Test scores after brain irradiation. Adv Radiat Oncol. 2017 Oct-Dec; 2(4):624-629. PMID: 29204530.
      View in: PubMed
    4. Carpenter RL, Sirkisoon S, Zhu D, Rimkus T, Harrison A, Anderson A, Paw I, Qasem S, Xing F, Liu Y, Chan M, Metheny-Barlow L, Pasche BC, Debinski W, Watabe K, Lo HW. Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth. Oncotarget. 2017 Sep 26; 8(43):73947-73963. PMID: 29088759.
      View in: PubMed
    5. Wang EC, Huang AJ, Huang KE, McTyre ER, Lo HW, Watabe K, Metheny-Barlow L, Laxton AW, Tatter SB, Strowd RE, Chan MD, Page BR. Leptomeningeal failure in patients with breast cancer receiving stereotactic radiosurgery for brain metastases. J Clin Neurosci. 2017 Sep; 43:6-10. PMID: 28511975.
      View in: PubMed
    6. Andrews RN, Metheny-Barlow LJ, Peiffer AM, Hanbury DB, Tooze JA, Bourland JD, Hampson RE, Deadwyler SA, Cline JM. Cerebrovascular Remodeling and Neuroinflammation is a Late Effect of Radiation-Induced Brain Injury in Non-Human Primates. Radiat Res. 2017 05; 187(5):599-611. PMID: 28398880.
      View in: PubMed
    7. Xing F, Liu Y, Sharma S, Wu K, Chan MD, Lo HW, Carpenter RL, Metheny-Barlow LJ, Zhou X, Qasem SA, Pasche B, Watabe K. Activation of the c-Met Pathway Mobilizes an Inflammatory Network in the Brain Microenvironment to Promote Brain Metastasis of Breast Cancer. Cancer Res. 2016 09 01; 76(17):4970-80. PMID: 27364556.
      View in: PubMed
    8. Sirkisoon SR, Carpenter RL, Rimkus T, Miller L, Metheny-Barlow L, Lo HW. EGFR and HER2 signaling in breast cancer brain metastasis. Front Biosci (Elite Ed). 2016 Jan 01; 8:245-63. PMID: 26709660.
      View in: PubMed
    9. Devoid HM, McTyre ER, Page BR, Metheny-Barlow L, Ruiz J, Chan MD. Recent advances in radiosurgical management of brain metastases. Front Biosci (Schol Ed). 2016 Jan 01; 8:203-14. PMID: 26709908.
      View in: PubMed
    10. Choudhary M, Naczki C, Chen W, Barlow KD, Case LD, Metheny-Barlow LJ. Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation. BMC Cancer. 2015 May 23; 15:427. PMID: 26002762.
      View in: PubMed
    11. Wheeler KT, Payne V, D'Agostino RB, Walb MC, Munley MT, Metheny-Barlow LJ, Robbins ME. Impact of breathing 100% oxygen on radiation-induced cognitive impairment. Radiat Res. 2014 Nov; 182(5):580-5. PMID: 25338095.
      View in: PubMed
    12. Greene-Schloesser DM, Kooshki M, Payne V, D'Agostino RB, Wheeler KT, Metheny-Barlow LJ, Robbins ME. Cellular response of the rat brain to single doses of (137)Cs ? rays does not predict its response to prolonged 'biologically equivalent' fractionated doses. Int J Radiat Biol. 2014 Sep; 90(9):790-8. PMID: 24937374.
      View in: PubMed
    13. Greene-Schloesser D, Payne V, Peiffer AM, Hsu FC, Riddle DR, Zhao W, Chan MD, Metheny-Barlow L, Robbins ME. The peroxisomal proliferator-activated receptor (PPAR) a agonist, fenofibrate, prevents fractionated whole-brain irradiation-induced cognitive impairment. Radiat Res. 2014 Jan; 181(1):33-44. PMID: 24397438.
      View in: PubMed
    14. Moore ED, Kooshki M, Wheeler KT, Metheny-Barlow LJ, Robbins ME. Differential expression of Homer1a in the hippocampus and cortex likely plays a role in radiation-induced brain injury. Radiat Res. 2014 Jan; 181(1):21-32. PMID: 24377717.
      View in: PubMed
    15. Moore ED, Kooshki M, Metheny-Barlow LJ, Gallagher PE, Robbins ME. Angiotensin-(1-7) prevents radiation-induced inflammation in rat primary astrocytes through regulation of MAP kinase signaling. Free Radic Biol Med. 2013 Dec; 65:1060-1068. PMID: 24012919.
      View in: PubMed
    16. Vincent A, Lesser G, Brown D, Vern-Gross T, Metheny-Barlow L, Lawrence J, Chan M. Prolonged regression of metastatic leptomeningeal breast cancer that has failed conventional therapy: a case report and review of the literature. J Breast Cancer. 2013 Mar; 16(1):122-6. PMID: 23593093.
      View in: PubMed
    17. Vern-Gross TZ, Lawrence JA, Case LD, McMullen KP, Bourland JD, Metheny-Barlow LJ, Ellis TL, Tatter SB, Shaw EG, Urbanic JJ, Chan MD. Breast cancer subtype affects patterns of failure of brain metastases after treatment with stereotactic radiosurgery. J Neurooncol. 2012 Dec; 110(3):381-8. PMID: 23001361.
      View in: PubMed
    18. Buchanan CF, Szot CS, Wilson TD, Akman S, Metheny-Barlow LJ, Robertson JL, Freeman JW, Rylander MN. Cross-talk between endothelial and breast cancer cells regulates reciprocal expression of angiogenic factors in vitro. J Cell Biochem. 2012 Apr; 113(4):1142-51. PMID: 22095586.
      View in: PubMed
    19. Barlow KD, Sanders AM, Soker S, Ergun S, Metheny-Barlow LJ. Pericytes on the tumor vasculature: jekyll or hyde? Cancer Microenviron. 2013 Apr; 6(1):1-17. PMID: 22467426.
      View in: PubMed
    20. Cook KL, Metheny-Barlow LJ, Tallant EA, Gallagher PE. Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. Cancer Res. 2010 Nov 01; 70(21):8319-28. PMID: 20837666.
      View in: PubMed
    21. Metheny-Barlow LJ, Li LY. Vascular endothelial growth inhibitor (VEGI), an endogenous negative regulator of angiogenesis. Semin Ophthalmol. 2006 Jan-Mar; 21(1):49-58. PMID: 16517446.
      View in: PubMed
    22. Ramljak D, Romanczyk LJ, Metheny-Barlow LJ, Thompson N, Knezevic V, Galperin M, Ramesh A, Dickson RB. Pentameric procyanidin from Theobroma cacao selectively inhibits growth of human breast cancer cells. Mol Cancer Ther. 2005 Apr; 4(4):537-46. PMID: 15827326.
      View in: PubMed
    23. Li LY, Barlow KD, Metheny-Barlow LJ. Angiopoietins and Tie2 in health and disease. Pediatr Endocrinol Rev. 2005 Mar; 2(3):399-408. PMID: 16429117.
      View in: PubMed
    24. Metheny-Barlow LJ, Tian S, Hayes AJ, Li LY. Direct chemotactic action of angiopoietin-1 on mesenchymal cells in the presence of VEGF. Microvasc Res. 2004 Nov; 68(3):221-30. PMID: 15501241.
      View in: PubMed
    25. Metheny-Barlow LJ, Li LY. The enigmatic role of angiopoietin-1 in tumor angiogenesis. Cell Res. 2003 Oct; 13(5):309-17. PMID: 14672554.
      View in: PubMed
    26. Tian S, Hayes AJ, Metheny-Barlow LJ, Li LY. Stabilization of breast cancer xenograft tumour neovasculature by angiopoietin-1. Br J Cancer. 2002 Feb 12; 86(4):645-51. PMID: 11870550.
      View in: PubMed
    27. Yu J, Tian S, Metheny-Barlow L, Chew LJ, Hayes AJ, Pan H, Yu GL, Li LY. Modulation of endothelial cell growth arrest and apoptosis by vascular endothelial growth inhibitor. Circ Res. 2001 Dec 07; 89(12):1161-7. PMID: 11739281.
      View in: PubMed
    28. Marrogi A, Pass HI, Khan M, Metheny-Barlow LJ, Harris CC, Gerwin BI. Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): in vitro antiproliferative effects of a COX-2 inhibitor. Cancer Res. 2000 Jul 15; 60(14):3696-700. PMID: 10919635.
      View in: PubMed
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