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Clinical and Translational Science Institute

Keywords
Last Name

Lacey Renn McNally, Ph.D.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentCancer Biology
Address
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    Collapse Research 
    Collapse research activities and funding
    K99CA139050     (MCNALLY, LACEY R.)Jul 10, 2009 - Aug 30, 2011
    NIH/NCI
    KiSS1 treatment of pancreatic adenocarcinoma
    Role: Principal Investigator

    R00CA139050     (MCNALLY, LACEY R.)Sep 21, 2011 - Aug 31, 2014
    NIH/NCI
    KiSS1 treatment of pancreatic adenocarcinoma
    Role: Principal Investigator

    R01CA205941     (MCNALLY, LACEY R)Sep 1, 2016 - Feb 28, 2022
    NIH/NCI
    Non-invasive detection of tumor extracellular pH using multispectral optoacoustic tomography
    Role: Principal Investigator

    R01EB020125     (MCNALLY, LACEY R)Sep 15, 2016 - Jun 30, 2020
    NIH/NIBIB
    Theranostic nanoparticles for detection and treatment of pancreatic cancer
    Role: Principal Investigator

    R01CA212350     (MCNALLY, LACEY R)Jun 1, 2017 - May 31, 2022
    NIH/NCI
    Stroma targeted theranostic nanoparticles for pancreatic cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Samykutty A, Grizzle WE, Fouts BL, McNally MW, Chuong P, Thomas A, Chiba A, Otali D, Woloszynska A, Said N, Frederick PJ, Jasinski J, Liu J, McNally LR. Optoacoustic imaging identifies ovarian cancer using a microenvironment targeted theranostic wormhole mesoporous silica nanoparticle. Biomaterials. 2018 Nov; 182:114-126. PMID: 30118979.
      View in: PubMed
    2. Xiao TG, Weis JA, Gayzik FS, Thomas A, Chiba A, Gurcan MN, Topaloglu U, Samykutty A, McNally LR. Applying dynamic contrast enhanced MSOT imaging to intratumoral pharmacokinetic modeling. Photoacoustics. 2018 Sep; 11:28-35. PMID: 30105204.
      View in: PubMed
    3. Garza-Morales R, Gonzalez-Ramos R, Chiba A, Montes de Oca-Luna R, McNally LR, McMasters KM, Gomez-Gutierrez JG. Temozolomide Enhances Triple-Negative Breast Cancer Virotherapy In Vitro. Cancers (Basel). 2018 May 17; 10(5). PMID: 29772755.
      View in: PubMed
    4. Hupple CW, Morscher S, Burton NC, Pagel MD, McNally LR, Cárdenas-Rodríguez J. A light-fluence-independent method for the quantitative analysis of dynamic contrast-enhanced multispectral optoacoustic tomography (DCE MSOT). Photoacoustics. 2018 Jun; 10:54-64. PMID: 29988890.
      View in: PubMed
    5. Ramakrishnan S, Hu Q, Krishnan N, Wang D, Smit E, Granger V, Rak M, Attwood K, Johnson C, Morrison C, Pili R, Chatta G, Guru K, Gueron G, McNally L, Wang J, Woloszynska-Read A. Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer. Cell Death Dis. 2017 12 14; 8(12):3217. PMID: 29242529.
      View in: PubMed
    6. Bhutiani N, Grizzle WE, Galandiuk S, Otali D, Dryden GW, Egilmez NK, McNally LR. Noninvasive Imaging of Colitis Using Multispectral Optoacoustic Tomography. J Nucl Med. 2017 06; 58(6):1009-1012. PMID: 27908970.
      View in: PubMed
    7. Neves LF, Duan J, Voelker A, Khanal A, McNally L, Steinbach-Rankins J, Ceresa BP. Preparation and optimisation of anionic liposomes for delivery of small peptides and cDNA to human corneal epithelial cells. J Microencapsul. 2016 Jun; 33(4):391-9. PMID: 27530524; PMCID: PMC5033054 [Available on 08/10/17].
    8. Zeiderman MR, Morgan DE, Christein JD, Grizzle WE, McMasters KM, McNally LR. Acidic pH-targeted chitosan capped mesoporous silica coated gold nanorods facilitate detection of pancreatic tumors via multispectral optoacoustic tomography. ACS Biomater Sci Eng. 2016 Jul 11; 2(7):1108-1120. PMID: 28626793.
      View in: PubMed
    9. McNally LR, Mezera M, Morgan DE, Frederick PJ, Yang ES, Eltoum IE, Grizzle WE. Current and Emerging Clinical Applications of Multispectral Optoacoustic Tomography (MSOT) in Oncology. Clin Cancer Res. 2016 07 15; 22(14):3432-9. PMID: 27208064.
      View in: PubMed
    10. Liu M, Luo F, Ding C, Albeituni S, Hu X, Ma Y, Cai Y, McNally L, Sanders MA, Jain D, Kloecker G, Bousamra M, Zhang HG, Higashi RM, Lane AN, Fan TW, Yan J. Correction: Dectin-1 Activation by a Natural Product ß-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype. J Immunol. 2016 05 01; 196(9):3968. PMID: 27183653.
      View in: PubMed
    11. Gurka MK, Pender D, Chuong P, Fouts BL, Sobelov A, McNally MW, Mezera M, Woo SY, McNally LR. Identification of pancreatic tumors in vivo with ligand-targeted, pH responsive mesoporous silica nanoparticles by multispectral optoacoustic tomography. J Control Release. 2016 06 10; 231:60-7. PMID: 26763377.
      View in: PubMed
    12. Yin W, Kimbrough CW, Gomez-Gutierrez JG, Burns CT, Chuong P, Grizzle WE, McNally LR. Tumor specific liposomes improve detection of pancreatic adenocarcinoma in vivo using optoacoustic tomography. J Nanobiotechnology. 2015 Dec 01; 13:90. PMID: 26627455; PMCID: PMC4665906.
    13. Liu M, Luo F, Ding C, Albeituni S, Hu X, Ma Y, Cai Y, McNally L, Sanders MA, Jain D, Kloecker G, Bousamra M, Zhang HG, Higashi RM, Lane AN, Fan TW, Yan J. Dectin-1 Activation by a Natural Product ß-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype. J Immunol. 2015 Nov 15; 195(10):5055-65. PMID: 26453753; PMCID: PMC4637216 [Available on 11/15/16].
    14. Kimbrough CW, Khanal A, Zeiderman M, Khanal BR, Burton NC, McMasters KM, Vickers SM, Grizzle WE, McNally LR. Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-Low Insertion Peptide Probes In Vivo. Clin Cancer Res. 2015 Oct 15; 21(20):4576-85. PMID: 26124201; PMCID: PMC4609270 [Available on 10/15/16].
    15. Kimbrough CW, Hudson S, Khanal A, Egger ME, McNally LR. Orthotopic pancreatic tumors detected by optoacoustic tomography using Syndecan-1. J Surg Res. 2015 Jan; 193(1):246-54. PMID: 25439222; PMCID: PMC4268324.
    16. Walker LR, Ryu JS, Perkins E, McNally LR, Raucher D. Fusion of cell-penetrating peptides to thermally responsive biopolymer improves tumor accumulation of p21 peptide in a mouse model of pancreatic cancer. Drug Des Devel Ther. 2014; 8:1649-58. PMID: 25336913; PMCID: PMC4199967.
    17. Hudson SV, Huang JS, Yin W, Albeituni S, Rush J, Khanal A, Yan J, Ceresa BP, Frieboes HB, McNally LR. Targeted noninvasive imaging of EGFR-expressing orthotopic pancreatic cancer using multispectral optoacoustic tomography. Cancer Res. 2014 Nov 01; 74(21):6271-9. PMID: 25217521; PMCID: PMC4216771.
    18. Egger ME, McNally LR, Nitz J, McMasters KM, Gomez-Gutierrez JG. Adenovirus-mediated FKHRL1/TM sensitizes melanoma cells to apoptosis induced by temozolomide. Hum Gene Ther Clin Dev. 2014 Sep; 25(3):186-95. PMID: 25238278; PMCID: PMC4227438.
    19. Egger M, McNally L, Nitz J, McMasters KM, Gomez-Gutierrez JG. Adenovirus-mediated FKHRL1/TM sensitizes melanoma cells to apoptosis induced by temozolomide. Hum Gene Ther Clin Dev. 2014 Aug 20. PMID: 25141261.
      View in: PubMed
    20. Frieboes HB, Huang JS, Yin WC, McNally LR. Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy. JOP. 2014 Mar 10; 15(2):189-97. PMID: 24618445.
      View in: PubMed
    21. Zeiderman MR, Egger ME, Kimbrough CW, England CG, Dupre TV, McMasters KM, McNally LR. Targeting of BRAF resistant melanoma via extracellular matrix metalloproteinase inducer receptor. J Surg Res. 2014 Jul; 190(1):111-8. PMID: 24655664; PMCID: PMC4576881.
    22. England CG, Priest T, Zhang G, Sun X, Patel DN, McNally LR, van Berkel V, Gobin AM, Frieboes HB. Enhanced penetration into 3D cell culture using two and three layered gold nanoparticles. Int J Nanomedicine. 2013; 8:3603-17. PMID: 24124360; PMCID: PMC3794839.
    23. Lee JJ, Huang J, England CG, McNally LR, Frieboes HB. Predictive modeling of in vivo response to gemcitabine in pancreatic cancer. PLoS Comput Biol. 2013; 9(9):e1003231. PMID: 24068909; PMCID: PMC3777914.
    24. Egger ME, Huang JS, Yin W, McMasters KM, McNally LR. Inhibition of autophagy with chloroquine is effective in melanoma. J Surg Res. 2013 Sep; 184(1):274-81. PMID: 23706562.
      View in: PubMed
    25. Kerr EH, Frederick PJ, Egger ME, Stockard CR, Sellers J, DellaManna D, Oelschlager DK, Amm HM, Eltoum IE, Straughn JM, Buchsbaum DJ, Grizzle WE, McNally LR. Lung resistance-related protein (LRP) expression in malignant ascitic cells as a prognostic marker for advanced ovarian serous carcinoma. Ann Surg Oncol. 2013 Sep; 20(9):3059-65. PMID: 23525731.
      View in: PubMed
    26. Bevis KS, McNally LR, Sellers JC, Della Manna D, Londoño Joshi A, Amm H, Straughn JM, Buchsbaum DJ. Anti-tumor activity of an anti-DR5 monoclonal antibody, TRA-8, in combination with taxane/platinum-based chemotherapy in an ovarian cancer model. Gynecol Oncol. 2011 Apr; 121(1):193-9. PMID: 21211830.
      View in: PubMed
    27. McNally LR, Welch DR, Beck BH, Stafford LJ, Long JW, Sellers JC, Huang ZQ, Grizzle WE, Stockard CR, Nash KT, Buchsbaum DJ. KISS1 over-expression suppresses metastasis of pancreatic adenocarcinoma in a xenograft mouse model. Clin Exp Metastasis. 2010 Dec; 27(8):591-600. PMID: 20844932; PMCID: PMC2975384.
    28. Borovjagin AV, McNally LR, Wang M, Curiel DT, MacDougall MJ, Zinn KR. Noninvasive monitoring of mRFP1- and mCherry-labeled oncolytic adenoviruses in an orthotopic breast cancer model by spectral imaging. Mol Imaging. 2010 Apr; 9(2):59-75. PMID: 20236604; PMCID: PMC2952450.
    29. Dean NR, Newman JR, Helman EE, Zhang W, Safavy S, Weeks DM, Cunningham M, Snyder LA, Tang Y, Yan L, McNally LR, Buchsbaum DJ, Rosenthal EL. Anti-EMMPRIN monoclonal antibody as a novel agent for therapy of head and neck cancer. Clin Cancer Res. 2009 Jun 15; 15(12):4058-65. PMID: 19509148; PMCID: PMC2796106.
    30. Skipper JB, McNally LR, Rosenthal EL, Wang W, Buchsbaum DJ. In vivo efficacy of marimastat and chemoradiation in head and neck cancer xenografts. ORL J Otorhinolaryngol Relat Spec. 2009; 71(1):1-5. PMID: 18931526; PMCID: PMC2700630.
    31. Kim H, Morgan DE, Buchsbaum DJ, Zeng H, Grizzle WE, Warram JM, Stockard CR, McNally LR, Long JW, Sellers JC, Forero A, Zinn KR. Early therapy evaluation of combined anti-death receptor 5 antibody and gemcitabine in orthotopic pancreatic tumor xenografts by diffusion-weighted magnetic resonance imaging. Cancer Res. 2008 Oct 15; 68(20):8369-76. PMID: 18922909; PMCID: PMC2597015.
    32. McNally LR, Henk WG, Cooper RK. Chromosomal localization of a proinsulin transgene in Japanese quail by laser pressure catapulting. Transgenic Res. 2006 Aug; 15(4):427-33. PMID: 16906443.
      View in: PubMed
    33. Sokolova YY, McNally LR, Fuxa JR, Vinson SB. Spore morphotypes of Thelohania solenopsae (microsporidia) described microscopically and confirmed by PCR of individual spores microdissected from smears by position ablative laser microbeam microscopy. Microbiology. 2004 May; 150(Pt 5):1261-70. PMID: 15133089.
      View in: PubMed
    34. Sokolova YY, McNally LR, Fuxa JR. PCR-based analysis of spores isolated from smears by laser pressure catapult microdissection confirms genetic identity of spore morphotypes of the microsporidian Thelohania solenopsae. J Eukaryot Microbiol. 2003; 50 Suppl:584-5. PMID: 14736173.
      View in: PubMed
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