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Clinical and Translational Science Institute

Keywords
Last Name

Lindsay M. Reynolds

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentPHS-Epidemiology
Address
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    Collapse Biography 
    Collapse education and training
    Appalachian State University, Boone, NCB.S.2007Applied physics; minors: biology, chemistry, mathematics
    University of California - San Francisco, San Francisco, CAPh.D.2012Pharmacogenomics; genetic epidemiology

    Collapse Overview 
    Collapse overview
    Dr. Reynolds' research aims to better understand how aging and environmental exposures (including smoking and diet) are related to disease etiology, and to identify biomarkers and potential targets for early disease detection and intervention strategies. Dr. Reynolds has cross-discipline training in applied physics, chemistry, biology, and genetic epidemiology, and currently integrates functional genomic datasets with environmental and clinical characteristics collected in large cohort studies.


    Collapse Research 
    Collapse research activities and funding
    R03AG056959     (REYNOLDS, LINDSAY M)Sep 1, 2017 - May 31, 2019
    NIH/NIA
    Nutrigenomics of Cardiometabolic Health in Older Adults
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Wan M, Bennett BD, Pittman GS, Campbell MR, Reynolds LM, Porter DK, Crowl CL, Wang X, Su D, Englert NA, Thompson IJ, Liu Y, Bell DA. Identification of Smoking-Associated Differentially Methylated Regions Using Reduced Representation Bisulfite Sequencing and Cell type-Specific Enhancer Activation and Gene Expression. Environ Health Perspect. 2018 04 27; 126(4):047015. PMID: 29706059.
      View in: PubMed
    2. Stokes A, Collins JM, Berry KM, Reynolds LM, Fetterman JL, Rodriguez CJ, Siegel MB, Benjamin EJ. Electronic Cigarette Prevalence and Patterns of Use in Adults with a History of Cardiovascular Disease in the United States. J Am Heart Assoc. 2018 Apr 26; 7(9). PMID: 29700041.
      View in: PubMed
    3. Reynolds LM, Howard TD, Ruczinski I, Kanchan K, Seeds MC, Mathias RA, Chilton FH. Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression. PLoS One. 2018; 13(3):e0194610. PMID: 29590160.
      View in: PubMed
    4. Berry KM, Reynolds LM, Collins JM, Siegel MB, Fetterman JL, Hamburg NM, Bhatnagar A, Benjamin EJ, Stokes A. E-cigarette initiation and associated changes in smoking cessation and reduction: the Population Assessment of Tobacco and Health Study, 2013-2015. Tob Control. 2018 Mar 24. PMID: 29574448.
      View in: PubMed
    5. Reynolds LM, Lohman K, Pittman GS, Barr RG, Chi GC, Kaufman J, Wan M, Bell DA, Blaha MJ, Rodriguez CJ, Liu Y. Tobacco exposure-related alterations in DNA methylation and gene expression in human monocytes: the Multi-Ethnic Study of Atherosclerosis (MESA). Epigenetics. 2017; 12(12):1092-1100. PMID: 29166816.
      View in: PubMed
    6. Chilton FH, Dutta R, Reynolds LM, Sergeant S, Mathias RA, Seeds MC. Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases. Nutrients. 2017 Oct 25; 9(11). PMID: 29068398.
      View in: PubMed
    7. Tibuakuu M, Kamimura D, Kianoush S, DeFilippis AP, Al Rifai M, Reynolds LM, White WB, Butler KR, Mosley TH, Turner ST, Kullo IJ, Hall ME, Blaha MJ. The association between cigarette smoking and inflammation: The Genetic Epidemiology Network of Arteriopathy (GENOA) study. PLoS One. 2017; 12(9):e0184914. PMID: 28922371.
      View in: PubMed
    8. Liu Y, Reynolds LM, Ding J, Hou L, Lohman K, Young T, Cui W, Huang Z, Grenier C, Wan M, Stunnenberg HG, Siscovick D, Hou L, Psaty BM, Rich SS, Rotter JI, Kaufman JD, Burke GL, Murphy S, Jacobs DR, Post W, Hoeschele I, Bell DA, Herrington D, Parks JS, Tracy RP, McCall CE, Stein JH. Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis. Nat Commun. 2017 08 30; 8(1):393. PMID: 28855511.
      View in: PubMed
    9. Taylor J, Reynolds L, Hou L, Lohman K, Cui W, Kritchevsky S, McCall C, Liu Y. Transcriptomic profiles of aging in naïve and memory CD4+ cells from mice. Immun Ageing. 2017; 14:15. PMID: 28642803.
      View in: PubMed
    10. Reynolds LM, Magid HS, Chi GC, Lohman K, Barr RG, Kaufman JD, Hoeschele I, Blaha MJ, Navas-Acien A, Liu Y. Secondhand Tobacco Smoke Exposure Associations With DNA Methylation of the Aryl Hydrocarbon Receptor Repressor. Nicotine Tob Res. 2017 Apr 01; 19(4):442-451. PMID: 27613907.
      View in: PubMed
    11. Chi GC, Liu Y, MacDonald JW, Barr RG, Donohue KM, Hensley MD, Hou L, McCall CE, Reynolds LM, Siscovick DS, Kaufman JD. Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Environ Health. 2016 12 01; 15(1):119. PMID: 27903268.
      View in: PubMed
    12. Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T, Elks CE, Aslibekyan S, Moreno-Macias H, Smith JA, Brody JA, Dhingra R, Yousefi P, Pankow JS, Kunze S, Shah SH, McRae AF, Lohman K, Sha J, Absher DM, Ferrucci L, Zhao W, Demerath EW, Bressler J, Grove ML, Huan T, Liu C, Mendelson MM, Yao C, Kiel DP, Peters A, Wang-Sattler R, Visscher PM, Wray NR, Starr JM, Ding J, Rodriguez CJ, Wareham NJ, Irvin MR, Zhi D, Barrdahl M, Vineis P, Ambatipudi S, Uitterlinden AG, Hofman A, Schwartz J, Colicino E, Hou L, Vokonas PS, Hernandez DG, Singleton AB, Bandinelli S, Turner ST, Ware EB, Smith AK, Klengel T, Binder EB, Psaty BM, Taylor KD, Gharib SA, Swenson BR, Liang L, DeMeo DL, O'Connor GT, Herceg Z, Ressler KJ, Conneely KN, Sotoodehnia N, Kardia SL, Melzer D, Baccarelli AA, van Meurs JB, Romieu I, Arnett DK, Ong KK, Liu Y, Waldenberger M, Deary IJ, Fornage M, Levy D, London SJ. Epigenetic Signatures of Cigarette Smoking. Circ Cardiovasc Genet. 2016 Oct; 9(5):436-447. PMID: 27651444.
      View in: PubMed
    13. Reynolds LM, Wan M, Ding J, Taylor JR, Lohman K, Su D, Bennett BD, Porter DK, Gimple R, Pittman GS, Wang X, Howard TD, Siscovick D, Psaty BM, Shea S, Burke GL, Jacobs DR, Rich SS, Hixson JE, Stein JH, Stunnenberg H, Barr RG, Kaufman JD, Post WS, Hoeschele I, Herrington DM, Bell DA, Liu Y. DNA Methylation of the Aryl Hydrocarbon Receptor Repressor Associations With Cigarette Smoking and Subclinical Atherosclerosis. Circ Cardiovasc Genet. 2015 Oct; 8(5):707-16. PMID: 26307030; PMCID: PMC4618776 [Available on 10/01/16].
    14. Ding J, Reynolds LM, Zeller T, Müller C, Lohman K, Nicklas BJ, Kritchevsky SB, Huang Z, de la Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR, Post W, Tracy RP, Wild PS, Blankenberg S, Hoeschele I, Herrington D, McCall CE, Liu Y. Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease. Diabetes. 2015 Oct; 64(10):3464-74. PMID: 26153245; PMCID: PMC4587646 [Available on 10/01/16].
    15. Reynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR, Hoeschele I, McCall CE, Kritchevsky SB, Herrington D, Tracy RP, Liu Y. Transcriptomic profiles of aging in purified human immune cells. BMC Genomics. 2015 Apr 22; 16:333. PMID: 25898983; PMCID: PMC4417516.
    16. Reynolds LM, Taylor JR, Ding J, Lohman K, Johnson C, Siscovick D, Burke G, Post W, Shea S, Jacobs DR, Stunnenberg H, Kritchevsky SB, Hoeschele I, McCall CE, Herrington D, Tracy RP, Liu Y. Age-related variations in the methylome associated with gene expression in human monocytes and T cells. Nat Commun. 2014 Nov 18; 5:5366. PMID: 25404168; PMCID: PMC4280798.
    17. Peloso GM, Auer PL, Bis JC, Voorman A, Morrison AC, Stitziel NO, Brody JA, Khetarpal SA, Crosby JR, Fornage M, Isaacs A, Jakobsdottir J, Feitosa MF, Davies G, Huffman JE, Manichaikul A, Davis B, Lohman K, Joon AY, Smith AV, Grove ML, Zanoni P, Redon V, Demissie S, Lawson K, Peters U, Carlson C, Jackson RD, Ryckman KK, Mackey RH, Robinson JG, Siscovick DS, Schreiner PJ, Mychaleckyj JC, Pankow JS, Hofman A, Uitterlinden AG, Harris TB, Taylor KD, Stafford JM, Reynolds LM, Marioni RE, Dehghan A, Franco OH, Patel AP, Lu Y, Hindy G, Gottesman O, Bottinger EP, Melander O, Orho-Melander M, Loos RJ, Duga S, Merlini PA, Farrall M, Goel A, Asselta R, Girelli D, Martinelli N, Shah SH, Kraus WE, Li M, Rader DJ, Reilly MP, McPherson R, Watkins H, Ardissino D, Zhang Q, Wang J, Tsai MY, Taylor HA, Correa A, Griswold ME, Lange LA, Starr JM, Rudan I, Eiriksdottir G, Launer LJ, Ordovas JM, Levy D, Chen YD, Reiner AP, Hayward C, Polasek O, Deary IJ, Borecki IB, Liu Y, Gudnason V, Wilson JG, van Duijn CM, Kooperberg C, Rich SS, Psaty BM, Rotter JI, O'Donnell CJ, Rice K, Boerwinkle E, Kathiresan S, Cupples LA. Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. Am J Hum Genet. 2014 Feb 06; 94(2):223-32. PMID: 24507774.
      View in: PubMed
    18. Liu Y, Ding J, Reynolds LM, Lohman K, Register TC, De La Fuente A, Howard TD, Hawkins GA, Cui W, Morris J, Smith SG, Barr RG, Kaufman JD, Burke GL, Post W, Shea S, McCall CE, Siscovick D, Jacobs DR, Tracy RP, Herrington DM, Hoeschele I. Methylomics of gene expression in human monocytes. Hum Mol Genet. 2013 Dec 15; 22(24):5065-74. PMID: 23900078.
      View in: PubMed
    19. Divaris K, Monda KL, North KE, Olshan AF, Reynolds LM, Hsueh WC, Lange EM, Moss K, Barros SP, Weyant RJ, Liu Y, Newman AB, Beck JD, Offenbacher S. Exploring the genetic basis of chronic periodontitis: a genome-wide association study. Hum Mol Genet. 2013 Jun 01; 22(11):2312-24. PMID: 23459936; PMCID: PMC3652417.
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