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Clinical and Translational Science Institute

Keywords
Last Name

Laurence B. Givner, M.D.

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentPediatrics-Infect Disease
Address
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    Collapse Research 
    Collapse research activities and funding
    R29AI025019     (GIVNER, LAURENCE B)Aug 1, 1987 - Sep 30, 1992
    NIH/NIAID
    HYPERIMMUNE HUMAN IGG FOR TYPE III GROUP B STREPTOCOCCUS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Olarte L, Barson WJ, Bradley JS, Tan TQ, Lin PL, Romero JR, Givner LB, Hoffman JA, Hultén KG, Mason EO, Kaplan SL. Invasive Pneumococcal Disease in Infants Aged 0-60 Days in the United States in the 13-Valent Pneumococcal Conjugate Vaccine Era. J Pediatric Infect Dis Soc. 2018 Aug 17; 7(3):249-252. PMID: 28510699.
      View in: PubMed
    2. Russell TB, Rinker EK, Dillingham CS, Givner LB, McLean TW. Pneumocystis Jirovecii Pneumonia During Sirolimus Therapy for Kaposiform Hemangioendothelioma. Pediatrics. 2018 04; 141(Suppl 5):S421-S424. PMID: 29610164.
      View in: PubMed
    3. Olarte L, Kaplan SL, Barson WJ, Romero JR, Lin PL, Tan TQ, Hoffman JA, Bradley JS, Givner LB, Mason EO, Hultén KG. Invasive Serotype 35B Pneumococci Including an Expanding Serotype Switch Lineage. Emerg Infect Dis. 2018 02; 24(2):405. PMID: 29350161.
      View in: PubMed
    4. Olarte L, Romero J, Barson W, Bradley J, Lin PL, Givner L, Tan T, Hoffman J, Hultén KG, Mason EO, Kaplan SL. Osteoarticular Infections Caused by Streptococcus pneumoniae in Children in the Post-Pneumococcal Conjugate Vaccine Era. Pediatr Infect Dis J. 2017 Dec; 36(12):1201-1204. PMID: 28723870.
      View in: PubMed
    5. Olarte L, Barson WJ, Barson RM, Romero JR, Bradley JS, Tan TQ, Givner LB, Hoffman JA, Lin PL, Hultén KG, Mason EO, Kaplan SL. Pneumococcal Pneumonia Requiring Hospitalization in US Children in the 13-Valent Pneumococcal Conjugate Vaccine Era. Clin Infect Dis. 2017 Jun 15; 64(12):1699-1704. PMID: 28199482.
      View in: PubMed
    6. Nageswaran S, Donoghue N, Mitchell A, Givner LB. An Innovative Collaborative Model of Care for Undiagnosed Complex Medical Conditions. Pediatrics. 2017 05; 139(5). PMID: 28557741.
      View in: PubMed
    7. Olarte L, Lin PL, Barson WJ, Romero JR, Tan TQ, Givner LB, Hoffman JA, Bradley JS, Hultén KG, Mason EO, Kaplan SL. Invasive pneumococcal infections in children following transplantation in the pneumococcal conjugate vaccine era. Transpl Infect Dis. 2017 Feb; 19(1). PMID: 27862712.
      View in: PubMed
    8. Olarte L, Kaplan SL, Barson WJ, Romero JR, Lin PL, Tan TQ, Hoffman JA, Bradley JS, Givner LB, Mason EO, Hultén KG. Emergence of Multidrug-Resistant Pneumococcal Serotype 35B among Children in the United States. J Clin Microbiol. 2017 03; 55(3):724-734. PMID: 27847379.
      View in: PubMed
    9. Olarte L, Barson WJ, Barson RM, Lin PL, Romero JR, Tan TQ, Givner LB, Bradley JS, Hoffman JA, Hultén KG, Mason EO, Kaplan SL. Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Pneumococcal Meningitis in US Children. Clin Infect Dis. 2015 Sep 01; 61(5):767-75. PMID: 25972022.
      View in: PubMed
    10. McCrory MC, Moore BA, Nakagawa TA, Givner LB, Jason DR, Palavecino EL, Ajizian SJ. Disseminated mucormycosis in an adolescent with newly diagnosed diabetes mellitus. Pediatr Infect Dis J. 2014 Oct; 33(10):1094-6. PMID: 24830701.
      View in: PubMed
    11. Kaplan SL, Barson WJ, Lin PL, Romero JR, Bradley JS, Tan TQ, Hoffman JA, Givner LB, Mason EO. Early trends for invasive pneumococcal infections in children after the introduction of the 13-valent pneumococcal conjugate vaccine. Pediatr Infect Dis J. 2013 Mar; 32(3):203-7. PMID: 23558320.
      View in: PubMed
    12. Hulten KG, Kaplan SL, Lamberth LB, Barson WJ, Romero JR, Lin PL, Bradley JS, Givner LB, Tan TQ, Hoffman JA, Mason EO. Changes in Streptococcus pneumoniae serotype 19A invasive infections in children from 1993 to 2011. J Clin Microbiol. 2013 Apr; 51(4):1294-7. PMID: 23390277.
      View in: PubMed
    13. Fitzgerald CJ, Pranikoff TV, Ross GA, Mou S, Givner LB, Shetty AK. Purpura fulminans caused by community-associated methicillin-resistant Staphylococcus aureus. Am J Emerg Med. 2012 Jul; 30(6):1013.e1-4. PMID: 21641144.
      View in: PubMed
    14. Kobayashi D, Givner LB, Yeatts RP, Anthony EY, Shetty AK. Infantile orbital cellulitis secondary to community-associated methicillin-resistant Staphylococcus aureus. J AAPOS. 2011 Apr; 15(2):208-10. PMID: 21463961.
      View in: PubMed
    15. Green MC, Mason EO, Kaplan SL, Lamberth LB, Stovall SH, Givner LB, Bradley JS, Tan TQ, Barson WJ, Hoffman JA, Lin PL, Hulten KG. Increase in prevalence of Streptococcus pneumoniae serotype 6C at Eight Children's Hospitals in the United States from 1993 to 2009. J Clin Microbiol. 2011 Jun; 49(6):2097-101. PMID: 21450963.
      View in: PubMed
    16. Kaplan SL, Barson WJ, Lin PL, Stovall SH, Bradley JS, Tan TQ, Hoffman JA, Givner LB, Mason EO. Serotype 19A Is the most common serotype causing invasive pneumococcal infections in children. Pediatrics. 2010 Mar; 125(3):429-36. PMID: 20176669.
      View in: PubMed
    17. Stancil JM, Peters TR, Givner LB, Poehling KA. Potential impact of accelerating the primary dose of pneumococcal conjugate vaccine in infants. Arch Pediatr Adolesc Med. 2009 May; 163(5):422-5. PMID: 19414687.
      View in: PubMed
    18. Mian A, Becton D, Blackall DP, James SH, Berman DM, Owusu JA, Turner C, Givner LB, Shetty AK. Index of suspicion. Pediatr Rev. 2009 Apr; 30(4):139-45. PMID: 19339388.
      View in: PubMed
    19. Mason EO, Wald ER, Tan TQ, Schutze GE, Bradley JS, Barson WJ, Givner LB, Hoffman J, Kaplan SL. Recurrent systemic pneumococcal disease in children. Pediatr Infect Dis J. 2007 Jun; 26(6):480-4. PMID: 17529863.
      View in: PubMed
    20. Nageswaran S, Woods CR, Benjamin DK, Givner LB, Shetty AK. Orbital cellulitis in children. Pediatr Infect Dis J. 2006 Aug; 25(8):695-9. PMID: 16874168.
      View in: PubMed
    21. Null D, Pollara B, Dennehy PH, Steichen J, Sánchez PJ, Givner LB, Carlin D, Landry B, Top FH, Connor E. Safety and immunogenicity of palivizumab (Synagis) administered for two seasons. Pediatr Infect Dis J. 2005 Nov; 24(11):1021-3. PMID: 16282947.
      View in: PubMed
    22. Ross A, McLean TW, Farber R, Weaver RG, Chauvenet A, Givner LB, Shetty AK. Retinitis following varicella in a vaccinated child with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2005 Aug; 45(2):191-4. PMID: 15880424.
      View in: PubMed
    23. Givner LB, Mason EO, Tan TQ, Barson WJ, Schutze GE, Wald ER, Bradley JS, Hoffman J, Yogev R, Kaplan SL. Pneumococcal endocarditis in children. Clin Infect Dis. 2004 May 01; 38(9):1273-8. PMID: 15127340.
      View in: PubMed
    24. Kaplan SL, Mason EO, Wald ER, Schutze GE, Bradley JS, Tan TQ, Hoffman JA, Givner LB, Yogev R, Barson WJ. Decrease of invasive pneumococcal infections in children among 8 children's hospitals in the United States after the introduction of the 7-valent pneumococcal conjugate vaccine. Pediatrics. 2004 Mar; 113(3 Pt 1):443-9. PMID: 14993532.
      View in: PubMed
    25. Hoffman JA, Mason EO, Schutze GE, Tan TQ, Barson WJ, Givner LB, Wald ER, Bradley JS, Yogev R, Kaplan SL. Streptococcus pneumoniae infections in the neonate. Pediatrics. 2003 Nov; 112(5):1095-102. PMID: 14595052.
      View in: PubMed
    26. Givner LB. Periorbital versus orbital cellulitis. Pediatr Infect Dis J. 2002 Dec; 21(12):1157-8. PMID: 12488668.
      View in: PubMed
    27. Shetty AK, Beaty MW, McGuirt WF, Woods CR, Givner LB. Kimura's disease: a diagnostic challenge. Pediatrics. 2002 Sep; 110(3):e39. PMID: 12205289.
      View in: PubMed
    28. Tan TQ, Mason EO, Wald ER, Barson WJ, Schutze GE, Bradley JS, Givner LB, Yogev R, Kim KS, Kaplan SL. Clinical characteristics of children with complicated pneumonia caused by Streptococcus pneumoniae. Pediatrics. 2002 Jul; 110(1 Pt 1):1-6. PMID: 12093940.
      View in: PubMed
    29. Schutze GE, Mason EO, Barson WJ, Kim KS, Wald ER, Givner LB, Tan TQ, Bradley JS, Yogev R, Kaplan SL. Invasive pneumococcal infections in children with asplenia. Pediatr Infect Dis J. 2002 Apr; 21(4):278-82. PMID: 12075756.
      View in: PubMed
    30. Kaplan SL, Mason EO, Wald E, Tan TQ, Schutze GE, Bradley JS, Givner LB, Kim KS, Yogev R, Barson WJ. Six year multicenter surveillance of invasive pneumococcal infections in children. Pediatr Infect Dis J. 2002 Feb; 21(2):141-7. PMID: 11840082.
      View in: PubMed
    31. Orlicek SL, Abramson JS, Woods CR, Givner LB. Obturator internus muscle abscess in children. J Pediatr Orthop. 2001 Nov-Dec; 21(6):744-8. PMID: 11675547.
      View in: PubMed
    32. Schutze GE, Mason EO, Wald ER, Barson WJ, Bradley JS, Tan TQ, Kim KS, Givner LB, Yogev R, Kaplan SL. Pneumococcal infections in children after transplantation. Clin Infect Dis. 2001 Jul 01; 33(1):16-21. PMID: 11389489.
      View in: PubMed
    33. Kaplan SL, Mason EO, Barson WJ, Tan TQ, Schutze GE, Bradley JS, Givner LB, Kim KS, Yogev R, Wald ER. Outcome of invasive infections outside the central nervous system caused by Streptococcus pneumoniae isolates nonsusceptible to ceftriazone in children treated with beta-lactam antibiotics. Pediatr Infect Dis J. 2001 Apr; 20(4):392-6. PMID: 11332663.
      View in: PubMed
    34. Givner LB, Mason EO, Barson WJ, Tan TQ, Wald ER, Schutze GE, Kim KS, Bradley JS, Yogev R, Kaplan SL. Pneumococcal facial cellulitis in children. Pediatrics. 2000 Nov; 106(5):E61. PMID: 11061798.
      View in: PubMed
    35. Kaplan SL, Mason EO, Wald ER, Kim KS, Givner LB, Bradley JS, Barson WJ, Tan TQ, Schutze GE, Yogev R. Pneumococcal mastoiditis in children. Pediatrics. 2000 Oct; 106(4):695-9. PMID: 11015510.
      View in: PubMed
    36. Bitzan MM, Nagaraj SK, Georgitis JW, Givner LB, Lorentz WB, Iskandar SS. Staphylococcus aureus pneumonia, hyponatremia, hypertension, proteinuria, and hematuria in a 14-year-old boy. Am J Kidney Dis. 2000 Feb; 35(2):354-9. PMID: 10676740.
      View in: PubMed
    37. Abramson JS, Givner LB. Rocky Mountain spotted fever. Pediatr Infect Dis J. 1999 Jun; 18(6):539-40. PMID: 10391185.
      View in: PubMed
    38. Givner LB. Monoclonal antibodies against respiratory syncytial virus. Pediatr Infect Dis J. 1999 Jun; 18(6):541-2. PMID: 10391187.
      View in: PubMed
    39. Tan TQ, Mason EO, Barson WJ, Wald ER, Schutze GE, Bradley JS, Arditi M, Givner LB, Yogev R, Kim KS, Kaplan SL. Clinical characteristics and outcome of children with pneumonia attributable to penicillin-susceptible and penicillin-nonsusceptible Streptococcus pneumoniae. Pediatrics. 1998 Dec; 102(6):1369-75. PMID: 9832571.
      View in: PubMed
    40. Bradley JS, Kaplan SL, Tan TQ, Barson WJ, Arditi M, Schutze GE, Wald ER, Givner LB, Mason EO. Pediatric pneumococcal bone and joint infections. The Pediatric Multicenter Pneumococcal Surveillance Study Group (PMPSSG). Pediatrics. 1998 Dec; 102(6):1376-82. PMID: 9832572.
      View in: PubMed
    41. Arditi M, Mason EO, Bradley JS, Tan TQ, Barson WJ, Schutze GE, Wald ER, Givner LB, Kim KS, Yogev R, Kaplan SL. Three-year multicenter surveillance of pneumococcal meningitis in children: clinical characteristics, and outcome related to penicillin susceptibility and dexamethasone use. Pediatrics. 1998 Nov; 102(5):1087-97. PMID: 9794939.
      View in: PubMed
    42. Kaplan SL, Mason EO, Barson WJ, Wald ER, Arditi M, Tan TQ, Schutze GE, Bradley JS, Givner LB, Kim KS, Yogev R. Three-year multicenter surveillance of systemic pneumococcal infections in children. Pediatrics. 1998 Sep; 102(3 Pt 1):538-45. PMID: 9738174.
      View in: PubMed
    43. O'Shea TM, Sevick MA, Givner LB. Costs and benefits of respiratory syncytial virus immunoglobulin to prevent hospitalization for lower respiratory tract illness in very low birth weight infants. Pediatr Infect Dis J. 1998 Jul; 17(7):587-93. PMID: 9686723.
      View in: PubMed
    44. Givner LB. Invasive disease due to group A beta-hemolytic streptococci: continued occurrence in children in North Carolina. South Med J. 1998 Apr; 91(4):333-7. PMID: 9563422.
      View in: PubMed
    45. Subramanian KN, Weisman LE, Rhodes T, Ariagno R, Sánchez PJ, Steichen J, Givner LB, Jennings TL, Top FH, Carlin D, Connor E. Safety, tolerance and pharmacokinetics of a humanized monoclonal antibody to respiratory syncytial virus in premature infants and infants with bronchopulmonary dysplasia. MEDI-493 Study Group. Pediatr Infect Dis J. 1998 Feb; 17(2):110-5. PMID: 9493805.
      View in: PubMed
    46. Givner LB, Gray L, O'Shea TM. Antibodies to tumor necrosis factor-alpha: use as adjunctive therapy in established group B streptococcal disease in newborn rats. Pediatr Res. 1995 Oct; 38(4):551-4. PMID: 8559608.
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    47. Ford JG, Yeatts RP, Givner LB. Orbital cellulitis, subperiosteal abscess, sinusitis, and septicemia caused b Arcanobacterium haemolyticum. Am J Ophthalmol. 1995 Aug; 120(2):261-2. PMID: 7639318.
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    48. Abramson JS, O'Shea TM, Ratledge DL, Lawless MR, Givner LB. Development of a vaccine tracking system to improve the rate of age-appropriate primary immunization in children of lower socioeconomic status. J Pediatr. 1995 Apr; 126(4):583-6. PMID: 7699537.
      View in: PubMed
    49. Woods CR, Smith AL, Wasilauskas BL, Campos J, Givner LB. Invasive disease caused by Neisseria meningitidis relatively resistant to penicillin in North Carolina. J Infect Dis. 1994 Aug; 170(2):453-6. PMID: 8035036.
      View in: PubMed
    50. Givner LB, Woods CR, Abramson JS. The practice of pediatrics in the era of vaccines effective against Haemophilus influenzae type b. Pediatrics. 1994 Apr; 93(4):680-1. PMID: 8134231.
      View in: PubMed
    51. Ernest JM, Givner LB. A prospective, randomized, placebo-controlled trial of penicillin in preterm premature rupture of membranes. Am J Obstet Gynecol. 1994 Feb; 170(2):516-21. PMID: 8116706.
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    52. Abramson JS, Givner LB, Woods CR. Bismuth in infants with watery diarrhea. N Engl J Med. 1993 Dec 02; 329(23):1742; author reply 1743. PMID: 8232479.
      View in: PubMed
    53. Givner LB, Kaplan SL. Meningitis due to Staphylococcus aureus in children. Clin Infect Dis. 1993 Jun; 16(6):766-71. PMID: 8329508.
      View in: PubMed
    54. Givner LB, Nagaraj SK. Hyperimmune human IgG or recombinant human granulocyte-macrophage colony-stimulating factor as adjunctive therapy for group B streptococcal sepsis in newborn rats. J Pediatr. 1993 May; 122(5 Pt 1):774-9. PMID: 8496760.
      View in: PubMed
    55. Baker CJ, Melish ME, Hall RT, Casto DT, Vasan U, Givner LB. Intravenous immune globulin for the prevention of nosocomial infection in low-birth-weight neonates. The Multicenter Group for the Study of Immune Globulin in Neonates. N Engl J Med. 1992 Jul 23; 327(4):213-9. PMID: 1614462.
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    56. Wheeler JG, Givner LB. Therapeutic use of recombinant human granulocyte-macrophage colony-stimulating factor in neonatal rats with type III group B streptococcal sepsis. J Infect Dis. 1992 May; 165(5):938-41. PMID: 1533238.
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    57. Givner LB. Arcanobacterium haemolyticum sepsis and Epstein-Barr virus infection. Pediatr Infect Dis J. 1992 May; 11(5):417-8. PMID: 1321407.
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    58. Sherertz RJ, Gledhill KS, Hampton KD, Pfaller MA, Givner LB, Abramson JS, Dillard RG. Outbreak of Candida bloodstream infections associated with retrograde medication administration in a neonatal intensive care unit. J Pediatr. 1992 Mar; 120(3):455-61. PMID: 1538298.
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    59. Givner LB, Baker CJ. Pooled human IgG hyperimmune for type III group B streptococci: evaluation against multiple strains in vitro and in experimental disease. J Infect Dis. 1991 May; 163(5):1141-5. PMID: 2019763.
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    60. Givner LB, Abramson JS, Wasilauskas B. Apparent increase in the incidence of invasive group A beta-hemolytic streptococcal disease in children. J Pediatr. 1991 Mar; 118(3):341-6. PMID: 1999773.
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    61. Givner LB. Human immunoglobulins for intravenous use: comparison of available preparations for group B streptococcal antibody levels, opsonic activity, and efficacy in animal models. Pediatrics. 1990 Dec; 86(6):955-62. PMID: 2123536.
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    62. Ernest JM, Givner LB, Pool R. Intrapartum hepatitis B screening in a low-risk population. Am J Obstet Gynecol. 1990 Sep; 163(3):978-80. PMID: 2403177.
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    63. Abramson JS, Givner LB. Should tetracycline be contraindicated for therapy of presumed Rocky Mountain spotted fever in children less than 9 years of age? Pediatrics. 1990 Jul; 86(1):123-4. PMID: 2359669.
      View in: PubMed
    64. Givner LB, Abramson JS, Wasilauskas B. Meningitis due to Haemophilus influenzae type b resistant to ampicillin and chloramphenicol. Rev Infect Dis. 1989 Mar-Apr; 11(2):329-34. PMID: 2649966.
      View in: PubMed
    65. Abramson JS, Givner LB, Thompson JN. Possible role of tonsillectomy and adenoidectomy in children with recurrent fever and tonsillopharyngitis. Pediatr Infect Dis J. 1989 Feb; 8(2):119-20. PMID: 2704602.
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    66. Givner LB, Edwards MS, Baker CJ. A polyclonal human IgG preparation hyperimmune for type III, group B Streptococcus: in vitro opsonophagocytic activity and efficacy in experimental models. J Infect Dis. 1988 Oct; 158(4):724-30. PMID: 3049837.
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    67. Givner LB, Baker CJ. The prevention and treatment of neonatal group B streptococcal infections. Adv Pediatr Infect Dis. 1988; 3:65-90. PMID: 3061395.
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    68. Givner LB, McGehee D, Taber LH, Stein F, Sumaya CV. Sinusitis, orbital cellulitis and polymicrobial bacteremia in a patient with primary Epstein-Barr virus infection. Pediatr Infect Dis. 1984 May-Jun; 3(3):254-6. PMID: 6739327.
      View in: PubMed
    69. Bush JK, Givner LB, Whitaker SH, Anderson DC, Percy AK. Necrotizing fasciitis of the parapharyngeal space with carotid artery occlusion and acute hemiplegia. Pediatrics. 1984 Mar; 73(3):343-7. PMID: 6701058.
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    70. Givner LB, Luddy RE, Schwartz AD. Etiology of osteomyelitis in patients with major sickle hemoglobinopathies. J Pediatr. 1981 Sep; 99(3):411-3. PMID: 7264796.
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    71. Givner LB, Rennels MB, Woodward CL, Huang SW. Chlamydia trachomatis infection in infant delivered by cesarean section. Pediatrics. 1981 Sep; 68(3):420-1. PMID: 7279471.
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