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Clinical and Translational Science Institute

Keywords
Last Name

Kounosuke Watabe, Ph.D.

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentCancer Biology
Address
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    Collapse Research 
    Collapse research activities and funding
    R15CA067290     (WATABE, KOUNOSUKE)Jun 20, 1995 - Jun 19, 1999
    NIH/NCI
    ROLES OF HEPATOCYTE GROWTH FACTOR IN TUMORIGENESIS
    Role: Principal Investigator

    R15CA079473     (WATABE, KOUNOSUKE)May 1, 2001 - Apr 30, 2005
    NIH/NCI
    TUMOR METASTASIS SUPPRESSOR GENE ON HUMAN CHROMOSOME 16
    Role: Principal Investigator

    R01CA124650     (WATABE, KOUNOSUKE)Sep 1, 2007 - Jul 31, 2014
    NIH/NCI
    Mechanism of tumor metastases suppression by Drg1
    Role: Principal Investigator

    R01CA129000     (WATABE, KOUNOSUKE)Sep 1, 2007 - Jul 31, 2014
    NIH/NCI
    Functional role of tumor metastases suppressor gene, KAl1, in tumor progression
    Role: Principal Investigator

    R01CA173499     (WATABE, KOUNOSUKE)Feb 11, 2014 - Jan 31, 2019
    NIH/NCI
    Roles of hyaluronic acid in cancer stem cell niche
    Role: Principal Investigator

    R01CA185650     (WATABE, KOUNOSUKE)Jan 7, 2016 - Nov 30, 2020
    NIH/NCI
    Role of inflammation and microRNA network in brain metastasis of breast cancer
    Role: Principal Investigator

    R01CA205067     (WATABE, KOUNOSUKE)Jan 1, 2017 - Dec 31, 2021
    NIH/NCI
    Roles of long-non-coding RNA, XIST, in brain metastasis of breast cancer
    Role: Principal Investigator

    R25CA229105     (WATABE, KOUNOSUKE)Sep 20, 2018 - Aug 31, 2023
    NIH/NCI
    Training program to promote diversity in cancer research
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Xing F, Liu Y, Wu SY, Wu K, Sharma S, Mo YY, Feng J, Sanders S, Jin G, Singh R, Vidi PA, Tyagi A, Chan MD, Ruiz J, Debinski W, Pasche BC, Lo HW, Metheny-Barlow LJ, D'Agostino RB, Watabe K. Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis. Cancer Res. 2018 Aug 01; 78(15):4316-4330. PMID: 30026327.
      View in: PubMed
    2. Hughes RT, McTyre ER, LeCompte M, Cramer CK, Munley MT, Laxton AW, Tatter SB, Ruiz J, Pasche B, Watabe K, Chan MD. Clinical Outcomes of Upfront Stereotactic Radiosurgery Alone for Patients With 5 to 15 Brain Metastases. Neurosurgery. 2018 Jul 06. PMID: 29982831.
      View in: PubMed
    3. Dohm A, McTyre ER, Okoukoni C, Henson A, Cramer CK, LeCompte MC, Ruiz J, Munley MT, Qasem S, Lo HW, Xing F, Watabe K, Laxton AW, Tatter SB, Chan MD. Staged Stereotactic Radiosurgery for Large Brain Metastases: Local Control and Clinical Outcomes of a One-Two Punch Technique. Neurosurgery. 2018 Jul 01; 83(1):114-121. PMID: 28973432.
      View in: PubMed
    4. Soike MH, McTyre ER, Hughes RT, Farris M, Cramer CK, LeCompte MC, Lanier CM, Ruiz J, Su J, Watabe K, Bourland JD, Munley MT, O'Neill S, Laxton AW, Tatter SB, Chan MD. Initial brain metastasis velocity: does the rate at which cancers first seed the brain affect outcomes? J Neurooncol. 2018 Sep; 139(2):461-467. PMID: 29740743.
      View in: PubMed
    5. Rimkus TK, Carpenter RL, Sirkisoon S, Zhu D, Pasche BC, Chan MD, Lesser GJ, Tatter SB, Watabe K, Debinski W, Lo HW. Truncated Glioma-Associated Oncogene Homolog 1 (tGLI1) Mediates Mesenchymal Glioblastoma via Transcriptional Activation of CD44. Cancer Res. 2018 May 15; 78(10):2589-2600. PMID: 29463580.
      View in: PubMed
    6. Sirkisoon SR, Carpenter RL, Rimkus T, Anderson A, Harrison A, Lange AM, Jin G, Watabe K, Lo HW. Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative breast cancers and HER2-enriched breast cancer. Oncogene. 2018 05; 37(19):2502-2514. PMID: 29449694.
      View in: PubMed
    7. Jimenez H, Blackman C, Lesser G, Debinski W, Chan M, Sharma S, Watabe K, Lo HW, Thomas A, Godwin D, Blackstock W, Mudry A, Posey J, O'Connor R, Brezovich I, Bonin K, Kim-Shapiro D, Barbault A, Pasche B. Use of non-ionizing electromagnetic fields for the treatment of cancer. Front Biosci (Landmark Ed). 2018 Jan 01; 23:284-297. PMID: 28930547.
      View in: PubMed
    8. Lanier CM, McTyre E, LeCompte M, Cramer CK, Hughes R, Watabe K, Lo HW, O'Neill S, Munley MT, Laxton AW, Tatter SB, Ruiz J, Chan MD. The number of prior lines of systemic therapy as a prognostic factor for patients with brain metastases treated with stereotactic radiosurgery: Results of a large single institution retrospective analysis. Clin Neurol Neurosurg. 2018 02; 165:24-28. PMID: 29289917.
      View in: PubMed
    9. LeCompte MC, McTyre E, Henson A, Farris M, Okoukoni C, Cramer CK, Triozzi P, Ruiz J, Watabe K, Lo HW, Munley MT, Laxton AW, Tatter SB, Zhou X, Chan M. Survival and Failure Outcomes Predicted by Brain Metastasis Volumetric Kinetics in Melanoma Patients Following Upfront Treatment with Stereotactic Radiosurgery Alone. Cureus. 2017 Dec 11; 9(12):e1934. PMID: 29464141.
      View in: PubMed
    10. Vallabhaneni KC, Penfornis P, Xing F, Hassler Y, Adams KV, Mo YY, Watabe K, Pochampally R. Stromal cell extracellular vesicular cargo mediated regulation of breast cancer cell metastasis via ubiquitin conjugating enzyme E2 N pathway. Oncotarget. 2017 Dec 15; 8(66):109861-109876. PMID: 29299114.
      View in: PubMed
    11. Alphonse-Sullivan N, Taksler GB, Lycan T, Weaver KE, McTyre ER, Shenker RF, Page BR, Isom S, Johnson A, Munley MT, Laxton AW, Tatter SB, Watabe K, Chan MD, Ruiz J. Sociodemographic predictors of patients with brain metastases treated with stereotactic radiosurgery. Oncotarget. 2017 Nov 24; 8(60):101005-101011. PMID: 29254141.
      View in: PubMed
    12. Wu K, Xing F, Wu SY, Watabe K. Extracellular vesicles as emerging targets in cancer: Recent development from bench to bedside. Biochim Biophys Acta Rev Cancer. 2017 Dec; 1868(2):538-563. PMID: 29054476.
      View in: PubMed
    13. Ayala-Peacock DN, Attia A, Braunstein SE, Ahluwalia MS, Hepel J, Chung C, Contessa J, McTyre E, Peiffer AM, Lucas JT, Isom S, Pajewski NM, Kotecha R, Stavas MJ, Page BR, Kleinberg L, Shen C, Taylor RB, Onyeuku NE, Hyde AT, Gorovets D, Chao ST, Corso C, Ruiz J, Watabe K, Tatter SB, Zadeh G, Chiang VLS, Fiveash JB, Chan MD. Prediction of new brain metastases after radiosurgery: validation and analysis of performance of a multi-institutional nomogram. J Neurooncol. 2017 Nov; 135(2):403-411. PMID: 28828698.
      View in: PubMed
    14. Wu SY, Watabe K. The roles of microglia/macrophages in tumor progression of brain cancer and metastatic disease. Front Biosci (Landmark Ed). 2017 06 01; 22:1805-1829. PMID: 28410147.
      View in: PubMed
    15. Carpenter RL, Sirkisoon S, Zhu D, Rimkus T, Harrison A, Anderson A, Paw I, Qasem S, Xing F, Liu Y, Chan M, Metheny-Barlow L, Pasche BC, Debinski W, Watabe K, Lo HW. Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth. Oncotarget. 2017 Sep 26; 8(43):73947-73963. PMID: 29088759.
      View in: PubMed
    16. Wang EC, Huang AJ, Huang KE, McTyre ER, Lo HW, Watabe K, Metheny-Barlow L, Laxton AW, Tatter SB, Strowd RE, Chan MD, Page BR. Leptomeningeal failure in patients with breast cancer receiving stereotactic radiosurgery for brain metastases. J Clin Neurosci. 2017 Sep; 43:6-10. PMID: 28511975.
      View in: PubMed
    17. Shenker RF, McTyre ER, Ruiz J, Weaver KE, Cramer C, Alphonse-Sullivan NK, Farris M, Petty WJ, Bonomi MR, Watabe K, Laxton AW, Tatter SB, Warren GW, Chan MD. The Effects of smoking status and smoking history on patients with brain metastases from lung cancer. Cancer Med. 2017 May; 6(5):944-952. PMID: 28401684.
      View in: PubMed
    18. McTyre ER, Johnson AG, Ruiz J, Isom S, Lucas JT, Hinson WH, Watabe K, Laxton AW, Tatter SB, Chan MD. Predictors of neurologic and nonneurologic death in patients with brain metastasis initially treated with upfront stereotactic radiosurgery without whole-brain radiation therapy. Neuro Oncol. 2017 04 01; 19(4):558-566. PMID: 27571883.
      View in: PubMed
    19. McTyre E, Helis CA, Farris M, Wilkins L, Sloan D, Hinson WH, Bourland JD, Dezarn WA, Munley MT, Watabe K, Xing F, Laxton AW, Tatter SB, Chan MD. Emerging Indications for Fractionated Gamma Knife Radiosurgery. Neurosurgery. 2017 02 01; 80(2):210-216. PMID: 28536486.
      View in: PubMed
    20. Farris M, McTyre ER, Cramer CK, Hughes R, Randolph DM, Ayala-Peacock DN, Bourland JD, Ruiz J, Watabe K, Laxton AW, Tatter SB, Zhou X, Chan MD. Brain Metastasis Velocity: A Novel Prognostic Metric Predictive of Overall Survival and Freedom From Whole-Brain Radiation Therapy After Distant Brain Failure Following Upfront Radiosurgery Alone. Int J Radiat Oncol Biol Phys. 2017 05 01; 98(1):131-141. PMID: 28586952.
      View in: PubMed
    21. Johnston H, McTyre ER, Cramer CK, Lesser GJ, Ruiz J, Bourland JD, Watabe K, Lo HW, Qasem S, Laxton AW, Tatter SB, Chan MD. Stereotactic radiosurgery in the treatment of brain metastases from gynecologic primary cancer. J Radiosurg SBRT. 2017; 5(1):55-61. PMID: 29296463.
      View in: PubMed
    22. Zhang X, Li CF, Zhang L, Wu CY, Han L, Jin G, Rezaeian AH, Han F, Liu C, Xu C, Xu X, Huang CY, Tsai FJ, Tsai CH, Watabe K, Lin HK. TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression. Mol Cell. 2016 11 17; 64(4):803-814. PMID: 27818144.
      View in: PubMed
    23. McKay WH, McTyre ER, Okoukoni C, Alphonse-Sullivan NK, Ruiz J, Munley MT, Qasem S, Lo HW, Xing F, Laxton AW, Tatter SB, Watabe K, Chan MD. Repeat stereotactic radiosurgery as salvage therapy for locally recurrent brain metastases previously treated with radiosurgery. J Neurosurg. 2017 Jul; 127(1):148-156. PMID: 27494815.
      View in: PubMed
    24. Sharma S, Xing F, Liu Y, Wu K, Said N, Pochampally R, Shiozawa Y, Lin HK, Balaji KC, Watabe K. Secreted Protein Acidic and Rich in Cysteine (SPARC) Mediates Metastatic Dormancy of Prostate Cancer in Bone. J Biol Chem. 2016 09 09; 291(37):19351-63. PMID: 27422817.
      View in: PubMed
    25. Xing F, Liu Y, Sharma S, Wu K, Chan MD, Lo HW, Carpenter RL, Metheny-Barlow LJ, Zhou X, Qasem SA, Pasche B, Watabe K. Activation of the c-Met Pathway Mobilizes an Inflammatory Network in the Brain Microenvironment to Promote Brain Metastasis of Breast Cancer. Cancer Res. 2016 09 01; 76(17):4970-80. PMID: 27364556.
      View in: PubMed
    26. Singh R, Gupta SC, Peng WX, Zhou N, Pochampally R, Atfi A, Watabe K, Lu Z, Mo YY. Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis. Cell Death Dis. 2016 06 09; 7(6):e2262. PMID: 27277684.
      View in: PubMed
    27. Haughton ME, Chan MD, Watabe K, Bonomi M, Debinski W, Lesser GJ, Ruiz J. Treatment of brain metastases of lung cancer in the era of precision medicine. Front Biosci (Elite Ed). 2016 Jan 01; 8:219-32. PMID: 26709658.
      View in: PubMed
    28. Ahmad O, Chan M, Savage P, Watabe K, Lo HW, Qasem S. Biology and treatment of metastasis of sarcoma to the brain. Front Biosci (Elite Ed). 2016 Jan 01; 8:233-44. PMID: 26709659.
      View in: PubMed
    29. Peng H, Tan H, Zhao W, Jin G, Sharma S, Xing F, Watabe K, Zhou X. Computational systems biology in cancer brain metastasis. Front Biosci (Schol Ed). 2016 Jan 01; 8:169-86. PMID: 26709906.
      View in: PubMed
    30. Wu K, Sharma S, Venkat S, Liu K, Zhou X, Watabe K. Non-coding RNAs in cancer brain metastasis. Front Biosci (Schol Ed). 2016 Jan 01; 8:187-202. PMID: 26709907.
      View in: PubMed
    31. Hughes RT, Black PJ, Page BR, Lucas JT, Qasem SA, Watabe K, Ruiz J, Laxton AW, Tatter SB, Debinski W, Chan MD. Local control of brain metastases after stereotactic radiosurgery: the impact of whole brain radiotherapy and treatment paradigm. J Radiosurg SBRT. 2016; 4(2):89-96. PMID: 29296433.
      View in: PubMed
    32. Gupta SC, Singh R, Asters M, Liu J, Zhang X, Pabbidi MR, Watabe K, Mo YY. Regulation of breast tumorigenesis through acid sensors. Oncogene. 2016 08 04; 35(31):4102-11. PMID: 26686084.
      View in: PubMed
    33. Carpenter RL, Paw I, Zhu H, Sirkisoon S, Xing F, Watabe K, Debinski W, Lo HW. The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis. Oncotarget. 2015 Sep 08; 6(26):22653-65. PMID: 26093087.
      View in: PubMed
    34. Johnson AG, Ruiz J, Hughes R, Page BR, Isom S, Lucas JT, McTyre ER, Houseknecht KW, Ayala-Peacock DN, Bourland DJ, Hinson WH, Laxton AW, Tatter SB, Debinski W, Watabe K, Chan MD. Impact of systemic targeted agents on the clinical outcomes of patients with brain metastases. Oncotarget. 2015 Aug 07; 6(22):18945-55. PMID: 26087184.
      View in: PubMed
    35. Kollareddy M, Dimitrova E, Vallabhaneni KC, Chan A, Le T, Chauhan KM, Carrero ZI, Ramakrishnan G, Watabe K, Haupt Y, Haupt S, Pochampally R, Boss GR, Romero DG, Radu CG, Martinez LA. Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities. Nat Commun. 2015 Jun 12; 6:7389. PMID: 26067754.
      View in: PubMed
    36. Liu Y, Sharma S, Watabe K. Roles of lncRNA in breast cancer. Front Biosci (Schol Ed). 2015 Jun 01; 7:94-108. PMID: 25961689.
      View in: PubMed
    37. Paw I, Carpenter RC, Watabe K, Debinski W, Lo HW. Mechanisms regulating glioma invasion. Cancer Lett. 2015 Jun 28; 362(1):1-7. PMID: 25796440.
      View in: PubMed
    38. Vallabhaneni KC, Penfornis P, Dhule S, Guillonneau F, Adams KV, Mo YY, Xu R, Liu Y, Watabe K, Vemuri MC, Pochampally R. Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins, and metabolites. Oncotarget. 2015 Mar 10; 6(7):4953-67. PMID: 25669974.
      View in: PubMed
    39. Wu K, Fukuda K, Xing F, Zhang Y, Sharma S, Liu Y, Chan MD, Zhou X, Qasem SA, Pochampally R, Mo YY, Watabe K. Roles of the cyclooxygenase 2 matrix metalloproteinase 1 pathway in brain metastasis of breast cancer. J Biol Chem. 2015 Apr 10; 290(15):9842-54. PMID: 25691572.
      View in: PubMed
    40. Xing F, Sharma S, Liu Y, Mo YY, Wu K, Zhang YY, Pochampally R, Martinez LA, Lo HW, Watabe K. miR-509 suppresses brain metastasis of breast cancer cells by modulating RhoC and TNF-a. Oncogene. 2015 Sep 10; 34(37):4890-900. PMID: 25659578.
      View in: PubMed
    41. Gupta SC, Singh R, Pochampally R, Watabe K, Mo YY. Acidosis promotes invasiveness of breast cancer cells through ROS-AKT-NF-?B pathway. Oncotarget. 2014 Dec 15; 5(23):12070-82. PMID: 25504433.
      View in: PubMed
    42. Singh R, Pochampally R, Watabe K, Lu Z, Mo YY. Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer. Mol Cancer. 2014 Nov 26; 13:256. PMID: 25428807.
      View in: PubMed
    43. Sharma S, Watabe K. Biomarkers and mechanisms associated with recurrent prostate cancer. Front Biosci (Landmark Ed). 2014 Jan 01; 19:339-51. PMID: 24389188.
      View in: PubMed
    44. Xing F, Wu K, Watabe K. MicroRNAs in cancer stem cells: new regulators of stemness. Curr Pharm Des. 2014; 20(33):5319-27. PMID: 24479802.
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    45. Espinoza I, Pochampally R, Xing F, Watabe K, Miele L. Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition. Onco Targets Ther. 2013 Sep 06; 6:1249-59. PMID: 24043949.
      View in: PubMed
    46. Xing F, Watabe K. miRNAs as biomarkers for brain metastasis of breast cancer. Biomark Med. 2013 Jun; 7(3):387-90. PMID: 23734799.
      View in: PubMed
    47. Xing F, Kobayashi A, Okuda H, Watabe M, Pai SK, Pandey PR, Hirota S, Wilber A, Mo YY, Moore BE, Liu W, Fukuda K, Iiizumi M, Sharma S, Liu Y, Wu K, Peralta E, Watabe K. Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain. EMBO Mol Med. 2013 Mar; 5(3):384-96. PMID: 23495140.
      View in: PubMed
    48. Okuda H, Xing F, Pandey PR, Sharma S, Watabe M, Pai SK, Mo YY, Iiizumi-Gairani M, Hirota S, Liu Y, Wu K, Pochampally R, Watabe K. miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4. Cancer Res. 2013 Feb 15; 73(4):1434-44. PMID: 23384942.
      View in: PubMed
    49. Zhang A, Zhou N, Huang J, Liu Q, Fukuda K, Ma D, Lu Z, Bai C, Watabe K, Mo YY. The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage. Cell Res. 2013 Mar; 23(3):340-50. PMID: 23208419.
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    50. Pandey PR, Liu W, Xing F, Fukuda K, Watabe K. Anti-cancer drugs targeting fatty acid synthase (FAS). Recent Pat Anticancer Drug Discov. 2012 May 01; 7(2):185-97. PMID: 22338595.
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    51. Liu W, Xing F, Iiizumi-Gairani M, Okuda H, Watabe M, Pai SK, Pandey PR, Hirota S, Kobayashi A, Mo YY, Fukuda K, Li Y, Watabe K. N-myc downstream regulated gene 1 modulates Wnt-ß-catenin signalling and pleiotropically suppresses metastasis. EMBO Mol Med. 2012 Feb; 4(2):93-108. PMID: 22246988.
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    52. Yoshioka S, King ML, Ran S, Okuda H, MacLean JA, McAsey ME, Sugino N, Brard L, Watabe K, Hayashi K. WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/ß-catenin pathway. Mol Cancer Res. 2012 Mar; 10(3):469-82. PMID: 22232518.
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    53. Fukuda K, Kobayashi A, Watabe K. The role of tumor-associated macrophage in tumor progression. Front Biosci (Schol Ed). 2012 Jan 01; 4:787-98. PMID: 22202090.
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    54. Kobayashi A, Okuda H, Xing F, Pandey PR, Watabe M, Hirota S, Pai SK, Liu W, Fukuda K, Chambers C, Wilber A, Watabe K. Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone. J Exp Med. 2011 Dec 19; 208(13):2641-55. PMID: 22124112.
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    55. Okuda H, Kobayashi A, Xia B, Watabe M, Pai SK, Hirota S, Xing F, Liu W, Pandey PR, Fukuda K, Modur V, Ghosh A, Wilber A, Watabe K. Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells. Cancer Res. 2012 Jan 15; 72(2):537-47. PMID: 22113945.
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    56. Liu W, Iiizumi-Gairani M, Okuda H, Kobayashi A, Watabe M, Pai SK, Pandey PR, Xing F, Fukuda K, Modur V, Hirota S, Suzuki K, Chiba T, Endo M, Sugai T, Watabe K. KAI1 gene is engaged in NDRG1 gene-mediated metastasis suppression through the ATF3-NFkappaB complex in human prostate cancer. J Biol Chem. 2011 May 27; 286(21):18949-59. PMID: 21454613.
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    57. Pandey PR, Okuda H, Watabe M, Pai SK, Liu W, Kobayashi A, Xing F, Fukuda K, Hirota S, Sugai T, Wakabayashi G, Koeda K, Kashiwaba M, Suzuki K, Chiba T, Endo M, Fujioka T, Tanji S, Mo YY, Cao D, Wilber AC, Watabe K. Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase. Breast Cancer Res Treat. 2011 Nov; 130(2):387-98. PMID: 21188630.
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    58. Cabarcas S, Watabe K, Schramm L. Inhibition of U6 snRNA Transcription by PTEN. Online J Biol Sci. 2010 Sep 30; 10(3):114-125. PMID: 21479160.
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    59. Liu W, Furuta E, Shindo K, Watabe M, Xing F, Pandey PR, Okuda H, Pai SK, Murphy LL, Cao D, Mo YY, Kobayashi A, Iiizumi M, Fukuda K, Xia B, Watabe K. Cacalol, a natural sesquiterpene, induces apoptosis in breast cancer cells by modulating Akt-SREBP-FAS signaling pathway. Breast Cancer Res Treat. 2011 Jul; 128(1):57-68. PMID: 20665104.
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    60. Furuta E, Okuda H, Kobayashi A, Watabe K. Metabolic genes in cancer: their roles in tumor progression and clinical implications. Biochim Biophys Acta. 2010 Apr; 1805(2):141-52. PMID: 20122995.
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    61. Xing F, Saidou J, Watabe K. Cancer associated fibroblasts (CAFs) in tumor microenvironment. Front Biosci (Landmark Ed). 2010 Jan 01; 15:166-79. PMID: 20036813.
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    62. Pandey PR, Saidou J, Watabe K. Role of myoepithelial cells in breast tumor progression. Front Biosci (Landmark Ed). 2010 Jan 01; 15:226-36. PMID: 20036817.
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    63. Wang C, Rajput S, Watabe K, Liao DF, Cao D. Acetyl-CoA carboxylase-a as a novel target for cancer therapy. Front Biosci (Schol Ed). 2010 Jan 01; 2:515-26. PMID: 20036965.
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    64. Jajoo S, Mukherjea D, Watabe K, Ramkumar V. Adenosine A(3) receptor suppresses prostate cancer metastasis by inhibiting NADPH oxidase activity. Neoplasia. 2009 Nov; 11(11):1132-45. PMID: 19881949.
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    65. Wang C, Yan R, Luo D, Watabe K, Liao DF, Cao D. Aldo-keto reductase family 1 member B10 promotes cell survival by regulating lipid synthesis and eliminating carbonyls. J Biol Chem. 2009 Sep 25; 284(39):26742-8. PMID: 19643728.
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    66. Peng S, Wu H, Mo YY, Watabe K, Pauza ME. c-Maf increases apoptosis in peripheral CD8 cells by transactivating Caspase 6. Immunology. 2009 Jun; 127(2):267-78. PMID: 19476513.
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    67. Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, Elble R, Watabe K, Mo YY. p53 represses c-Myc through induction of the tumor suppressor miR-145. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):3207-12. PMID: 19202062.
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    68. Iiizumi M, Bandyopadhyay S, Pai SK, Watabe M, Hirota S, Hosobe S, Tsukada T, Miura K, Saito K, Furuta E, Liu W, Xing F, Okuda H, Kobayashi A, Watabe K. RhoC promotes metastasis via activation of the Pyk2 pathway in prostate cancer. Cancer Res. 2008 Sep 15; 68(18):7613-20. PMID: 18794150.
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    69. Iiizumi M, Liu W, Pai SK, Furuta E, Watabe K. Drug development against metastasis-related genes and their pathways: a rationale for cancer therapy. Biochim Biophys Acta. 2008 Dec; 1786(2):87-104. PMID: 18692117.
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    70. Kobayashi A, Watabe K. Critical role of ADAM15 in tumor progression: targeting multiple factors for metastasis promotion. Future Oncol. 2008 Jun; 4(3):351-4. PMID: 18518760.
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    71. Furuta E, Pai SK, Zhan R, Bandyopadhyay S, Watabe M, Mo YY, Hirota S, Hosobe S, Tsukada T, Miura K, Kamada S, Saito K, Iiizumi M, Liu W, Ericsson J, Watabe K. Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1. Cancer Res. 2008 Feb 15; 68(4):1003-11. PMID: 18281474.
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    72. Liu W, Bagaitkar J, Watabe K. Roles of AKT signal in breast cancer. Front Biosci. 2007 May 01; 12:4011-9. PMID: 17485354.
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    73. Mohinta S, Wu H, Chaurasia P, Watabe K. Wnt pathway and breast cancer. Front Biosci. 2007 May 01; 12:4020-33. PMID: 17485355.
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    74. Iiizumi M, Mohinta S, Bandyopadhyay S, Watabe K. Tumor-endothelial cell interactions: therapeutic potential. Microvasc Res. 2007 Sep-Nov; 74(2-3):114-20. PMID: 17498748.
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    75. Iiizumi M, Bandyopadhyay S, Watabe K. Interaction of Duffy antigen receptor for chemokines and KAI1: a critical step in metastasis suppression. Cancer Res. 2007 Feb 15; 67(4):1411-4. PMID: 17308076.
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    76. Bandyopadhyay S, Wang Y, Zhan R, Pai SK, Watabe M, Iiizumi M, Furuta E, Mohinta S, Liu W, Hirota S, Hosobe S, Tsukada T, Miura K, Takano Y, Saito K, Commes T, Piquemal D, Hai T, Watabe K. The tumor metastasis suppressor gene Drg-1 down-regulates the expression of activating transcription factor 3 in prostate cancer. Cancer Res. 2006 Dec 15; 66(24):11983-90. PMID: 17178897.
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    77. Furuta E, Bandyopadhyay S, Iiizumi M, Mohinta S, Zhan R, Watabe K. The role of tumor metastasis suppressors in cancers of breast and prostate. Front Biosci. 2006 Sep 01; 11:2845-60. PMID: 16720356.
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    78. Bandyopadhyay S, Zhan R, Chaudhuri A, Watabe M, Pai SK, Hirota S, Hosobe S, Tsukada T, Miura K, Takano Y, Saito K, Pauza ME, Hayashi S, Wang Y, Mohinta S, Mashimo T, Iiizumi M, Furuta E, Watabe K. Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression. Nat Med. 2006 Aug; 12(8):933-8. PMID: 16862154.
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    79. Bandyopadhyay S, Zhan R, Wang Y, Pai SK, Hirota S, Hosobe S, Takano Y, Saito K, Furuta E, Iiizumi M, Mohinta S, Watabe M, Chalfant C, Watabe K. Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells. Cancer Res. 2006 Jun 01; 66(11):5934-40. PMID: 16740734.
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    80. Malafa MP, Fokum FD, Andoh J, Neitzel LT, Bandyopadhyay S, Zhan R, Iiizumi M, Furuta E, Horvath E, Watabe K. Vitamin E succinate suppresses prostate tumor growth by inducing apoptosis. Int J Cancer. 2006 May 15; 118(10):2441-7. PMID: 16380976.
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    81. Bandyopadhyay S, Pai SK, Watabe M, Gross SC, Hirota S, Hosobe S, Tsukada T, Miura K, Saito K, Markwell SJ, Wang Y, Huggenvik J, Pauza ME, Iiizumi M, Watabe K. FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis. Oncogene. 2005 Aug 11; 24(34):5389-95. PMID: 15897909.
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    82. Furuta E, Yamamoto K, Tatebe D, Watabe K, Kitayama T, Utsumi R. Targeting protein homodimerization: a novel drug discovery system. FEBS Lett. 2005 Apr 11; 579(10):2065-70. PMID: 15811319.
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    83. Bandyopadhyay S, Pai SK, Hirota S, Hosobe S, Tsukada T, Miura K, Takano Y, Saito K, Commes T, Piquemal D, Watabe M, Gross S, Wang Y, Huggenvik J, Watabe K. PTEN up-regulates the tumor metastasis suppressor gene Drg-1 in prostate and breast cancer. Cancer Res. 2004 Nov 01; 64(21):7655-60. PMID: 15520163.
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    84. Bandyopadhyay S, Pai SK, Hirota S, Hosobe S, Takano Y, Saito K, Piquemal D, Commes T, Watabe M, Gross SC, Wang Y, Ran S, Watabe K. Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression. Oncogene. 2004 Jul 22; 23(33):5675-81. PMID: 15184886.
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    85. Bandyopadhyay S, Pai SK, Gross SC, Hirota S, Hosobe S, Miura K, Saito K, Commes T, Hayashi S, Watabe M, Watabe K. The Drg-1 gene suppresses tumor metastasis in prostate cancer. Cancer Res. 2003 Apr 15; 63(8):1731-6. PMID: 12702552.
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    86. Gross SC, Goodarzi G, Watabe M, Bandyopadhyay S, Pai SK, Watabe K. Antineoplastic activity of Solidago virgaurea on prostatic tumor cells in an SCID mouse model. Nutr Cancer. 2002; 43(1):76-81. PMID: 12467138.
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