Loading...
Explore More at wakehealth.edu

Clinical and Translational Science Institute

Keywords
Last Name

Kimberly Johnson Nelson, Ph.D.

TitleInstructor
InstitutionWake Forest School of Medicine
DepartmentStructural Biology
Address
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    F32GM074537     (NELSON, KIMBERLY J)Sep 1, 2005 - Aug 31, 2007
    NIH/NIGMS
    Profiling of cysteine sulfenic acids in redox signaling
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Bolduc JA, Nelson KJ, Haynes AC, Lee J, Reisz JA, Graff AH, Clodfelter JE, Parsonage D, Poole LB, Furdui CM, Lowther WT. Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins. J Biol Chem. 2018 07 27; 293(30):11901-11912. PMID: 29884768.
      View in: PubMed
    2. Keyes JD, Parsonage D, Yammani RD, Rogers LC, Kesty C, Furdui CM, Nelson KJ, Poole LB. Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals. Free Radic Biol Med. 2017 11; 112:534-543. PMID: 28843779.
      View in: PubMed
    3. Nelson KJ, Perkins A, Van Swearingen AED, Hartman S, Brereton AE, Parsonage D, Salsbury FR, Karplus PA, Poole LB. Experimentally Dissecting the Origins of Peroxiredoxin Catalysis. Antioxid Redox Signal. 2018 Mar 01; 28(7):521-536. PMID: 28375740.
      View in: PubMed
    4. Perkins A, Parsonage D, Nelson KJ, Ogba OM, Cheong PH, Poole LB, Karplus PA. Peroxiredoxin Catalysis at Atomic Resolution. Structure. 2016 Oct 04; 24(10):1668-1678. PMID: 27594682.
      View in: PubMed
    5. Poole LB, Nelson KJ. Distribution and Features of the Six Classes of Peroxiredoxins. Mol Cells. 2016 Jan; 39(1):53-9. PMID: 26810075.
      View in: PubMed
    6. Collins JA, Wood ST, Nelson KJ, Rowe MA, Carlson CS, Chubinskaya S, Poole LB, Furdui CM, Loeser RF. Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes. J Biol Chem. 2016 Mar 25; 291(13):6641-54. PMID: 26797130.
      View in: PubMed
    7. Randall L, Manta B, Nelson KJ, Santos J, Poole LB, Denicola A. Structural changes upon peroxynitrite-mediated nitration of peroxiredoxin 2; nitrated Prx2 resembles its disulfide-oxidized form. Arch Biochem Biophys. 2016 Jan 15; 590:101-108. PMID: 26612102.
      View in: PubMed
    8. Perkins A, Nelson KJ, Parsonage D, Poole LB, Karplus PA. Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling. Trends Biochem Sci. 2015 Aug; 40(8):435-45. PMID: 26067716.
      View in: PubMed
    9. Cunniff B, Newick K, Nelson KJ, Wozniak AN, Beuschel S, Leavitt B, Bhave A, Butnor K, Koenig A, Chouchani ET, James AM, Haynes AC, Lowther WT, Murphy MP, Shukla A, Heintz NH. Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma. PLoS One. 2015; 10(5):e0127310. PMID: 26011724.
      View in: PubMed
    10. Parsonage D, Nelson KJ, Ferrer-Sueta G, Alley S, Karplus PA, Furdui CM, Poole LB. Dissecting peroxiredoxin catalysis: separating binding, peroxidation, and resolution for a bacterial AhpC. Biochemistry. 2015 Feb 24; 54(7):1567-75. PMID: 25633283.
      View in: PubMed
    11. Klomsiri C, Rogers LC, Soito L, McCauley AK, King SB, Nelson KJ, Poole LB, Daniel LW. Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling. Free Radic Biol Med. 2014 Jun; 71:49-60. PMID: 24657741.
      View in: PubMed
    12. Perkins A, Nelson KJ, Williams JR, Parsonage D, Poole LB, Karplus PA. The sensitive balance between the fully folded and locally unfolded conformations of a model peroxiredoxin. Biochemistry. 2013 Dec 03; 52(48):8708-21. PMID: 24175952.
      View in: PubMed
    13. Taneja NK, Ganguly T, Bakaletz LO, Nelson KJ, Dubey P, Poole LB, Deora R. D-alanine modification of a protease-susceptible outer membrane component by the Bordetella pertussis dra locus promotes resistance to antimicrobial peptides and polymorphonuclear leukocyte-mediated killing. J Bacteriol. 2013 Nov; 195(22):5102-11. PMID: 24013634.
      View in: PubMed
    14. Nelson KJ, Parsonage D, Karplus PA, Poole LB. Evaluating peroxiredoxin sensitivity toward inactivation by peroxide substrates. Methods Enzymol. 2013; 527:21-40. PMID: 23830624.
      View in: PubMed
    15. Perkins A, Gretes MC, Nelson KJ, Poole LB, Karplus PA. Mapping the active site helix-to-strand conversion of CxxxxC peroxiredoxin Q enzymes. Biochemistry. 2012 Sep 25; 51(38):7638-50. PMID: 22928725.
      View in: PubMed
    16. Reeves SA, Parsonage D, Nelson KJ, Poole LB. Kinetic and thermodynamic features reveal that Escherichia coli BCP is an unusually versatile peroxiredoxin. Biochemistry. 2011 Oct 18; 50(41):8970-81. PMID: 21910476.
      View in: PubMed
    17. Poole LB, Hall A, Nelson KJ. Overview of peroxiredoxins in oxidant defense and redox regulation. Curr Protoc Toxicol. 2011 Aug; Chapter 7:Unit7.9. PMID: 21818754.
      View in: PubMed
    18. Nelson KJ, Parsonage D. Measurement of peroxiredoxin activity. Curr Protoc Toxicol. 2011 Aug; Chapter 7:Unit7.10. PMID: 21818753.
      View in: PubMed
    19. Nelson KJ, Knutson ST, Soito L, Klomsiri C, Poole LB, Fetrow JS. Analysis of the peroxiredoxin family: using active-site structure and sequence information for global classification and residue analysis. Proteins. 2011 Mar; 79(3):947-64. PMID: 21287625.
      View in: PubMed
    20. Soito L, Williamson C, Knutson ST, Fetrow JS, Poole LB, Nelson KJ. PREX: PeroxiRedoxin classification indEX, a database of subfamily assignments across the diverse peroxiredoxin family. Nucleic Acids Res. 2011 Jan; 39(Database issue):D332-7. PMID: 21036863.
      View in: PubMed
    21. Parsonage D, Desrosiers DC, Hazlett KR, Sun Y, Nelson KJ, Cox DL, Radolf JD, Poole LB. Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum. Proc Natl Acad Sci U S A. 2010 Apr 06; 107(14):6240-5. PMID: 20304799.
      View in: PubMed
    22. Nelson KJ, Klomsiri C, Codreanu SG, Soito L, Liebler DC, Rogers LC, Daniel LW, Poole LB. Use of dimedone-based chemical probes for sulfenic acid detection methods to visualize and identify labeled proteins. Methods Enzymol. 2010; 473:95-115. PMID: 20513473.
      View in: PubMed
    23. Klomsiri C, Nelson KJ, Bechtold E, Soito L, Johnson LC, Lowther WT, Ryu SE, King SB, Furdui CM, Poole LB. Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins. Methods Enzymol. 2010; 473:77-94. PMID: 20513472.
      View in: PubMed
    24. Nelson KJ, Parsonage D, Hall A, Karplus PA, Poole LB. Cysteine pK(a) values for the bacterial peroxiredoxin AhpC. Biochemistry. 2008 Dec 02; 47(48):12860-8. PMID: 18986167.
      View in: PubMed
    25. Poole LB, Nelson KJ. Discovering mechanisms of signaling-mediated cysteine oxidation. Curr Opin Chem Biol. 2008 Feb; 12(1):18-24. PMID: 18282483.
      View in: PubMed
    26. Nelson KJ, Day AE, Zeng BB, King SB, Poole LB. Isotope-coded, iodoacetamide-based reagent to determine individual cysteine pK(a) values by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Biochem. 2008 Apr 15; 375(2):187-95. PMID: 18162165.
      View in: PubMed
    27. Poole LB, Klomsiri C, Knaggs SA, Furdui CM, Nelson KJ, Thomas MJ, Fetrow JS, Daniel LW, King SB. Fluorescent and affinity-based tools to detect cysteine sulfenic acid formation in proteins. Bioconjug Chem. 2007 Nov-Dec; 18(6):2004-17. PMID: 18030992.
      View in: PubMed
    28. Michalek RD, Nelson KJ, Holbrook BC, Yi JS, Stridiron D, Daniel LW, Fetrow JS, King SB, Poole LB, Grayson JM. The requirement of reversible cysteine sulfenic acid formation for T cell activation and function. J Immunol. 2007 Nov 15; 179(10):6456-67. PMID: 17982034.
      View in: PubMed
    Nelson's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description