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Clinical and Translational Science Institute

Keywords
Last Name

Khalil N. Bitar, Ph.D.

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentWF Institute for Regen Medicine
Address
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentInternal Medicine-Gastroenterology

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentPhysiology and Pharmacology


    Collapse Research 
    Collapse research activities and funding
    R01DK042876     (BITAR, KHALIL N)Jun 15, 1991 - Apr 30, 2013
    NIH/NIDDK
    Myogenic Control Mechanisms of Circular Muscle of the Rectosigmoid Colon
    Role: Principal Investigator

    R01DK057020     (BITAR, KHALIL N)Jun 1, 2001 - May 31, 2010
    NIH/NIDDK
    HSP27 Association with Thin Filaments in Colonic Muscle
    Role: Principal Investigator

    R01DK071614     (BITAR, KHALIL N)Feb 1, 2008 - Jan 31, 2014
    NIH/NIDDK
    Restoration of Fecal Continence in Aging IAS
    Role: Principal Investigator

    RC1DK087151     (BITAR, KHALIL N)Sep 30, 2009 - Jul 31, 2012
    NIH/NIDDK
    Implantation of physiologically functional bioengineered innervated IAS construct
    Role: Principal Investigator

    R42DK105593     (BITAR, KHALIL NAKHLE)Sep 23, 2015 - Aug 31, 2018
    NIH/NIDDK
    Implantation of Bioengineered Intrinsically Innervated Internal Anal Sphincter (BioSphincter) to Treat Fecal Incontinence
    Role: Principal Investigator

    R44DK105593     (BITAR, KHALIL N)Sep 23, 2015 - Aug 31, 2021
    NIH/NIDDK
    BioSphincter to Treat Fecal Incontinence. Phase 1/2 Clinical Trial. SBIR Phase IIB
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Bohl JL, Zakhem E, Bitar KN. Successful Treatment of Passive Fecal Incontinence in an Animal Model Using Engineered Biosphincters: A 3-Month Follow-Up Study. Stem Cells Transl Med. 2017 09; 6(9):1795-1802. PMID: 28678378.
      View in: PubMed
    2. Zakhem E, Tamburrini R, Orlando G, Koch KL, Bitar KN. Transplantation of a Human Tissue-Engineered Bowel in an Athymic Rat Model. Tissue Eng Part C Methods. 2017 11; 23(11):652-660. PMID: 28653858.
      View in: PubMed
    3. Zakhem E, El Bahrawy M, Orlando G, Bitar KN. Biomechanical properties of an implanted engineered tubular gut-sphincter complex. J Tissue Eng Regen Med. 2017 12; 11(12):3398-3407. PMID: 27882697.
      View in: PubMed
    4. Bitar KN, Zakhem E. Bioengineering the gut: future prospects of regenerative medicine. Nat Rev Gastroenterol Hepatol. 2016 09; 13(9):543-56. PMID: 27507104.
      View in: PubMed
    5. Rego SL, Zakhem E, Orlando G, Bitar KN. Bioengineered Human Pyloric Sphincters Using Autologous Smooth Muscle and Neural Progenitor Cells. Tissue Eng Part A. 2016 Jan; 22(1-2):151-60. PMID: 26563426.
      View in: PubMed
    6. Bitar KN, Zakhem E. Is bioengineering a possibility in gastrointestinal disorders? Expert Rev Gastroenterol Hepatol. 2015; 9(12):1463-5. PMID: 26523871.
      View in: PubMed
    7. Zakhem E, Bitar KN. Development of Chitosan Scaffolds with Enhanced Mechanical Properties for Intestinal Tissue Engineering Applications. J Funct Biomater. 2015 Oct 13; 6(4):999-1011. PMID: 26473937.
      View in: PubMed
    8. Rego SL, Zakhem E, Orlando G, Bitar KN. Bioengineering functional human sphincteric and non-sphincteric gastrointestinal smooth muscle constructs. Methods. 2016 Apr 15; 99:128-34. PMID: 26314281.
      View in: PubMed
    9. Zakhem E, Elbahrawy M, Orlando G, Bitar KN. Successful implantation of an engineered tubular neuromuscular tissue composed of human cells and chitosan scaffold. Surgery. 2015 Dec; 158(6):1598-608. PMID: 26096562.
      View in: PubMed
    10. Rego SL, Raghavan S, Zakhem E, Bitar KN. Enteric neural differentiation in innervated, physiologically functional, smooth muscle constructs is modulated by bone morphogenic protein 2 secreted by sphincteric smooth muscle cells. J Tissue Eng Regen Med. 2017 04; 11(4):1251-1261. PMID: 25926098.
      View in: PubMed
    11. Zakhem E, Rego SL, Raghavan S, Bitar KN. The appendix as a viable source of neural progenitor cells to functionally innervate bioengineered gastrointestinal smooth muscle tissues. Stem Cells Transl Med. 2015 Jun; 4(6):548-54. PMID: 25873745.
      View in: PubMed
    12. Bitar KN, Raghavan S. Stem cell therapy for GI neuromuscular disorders. Curr Gastroenterol Rep. 2014 Dec; 16(12):419. PMID: 25381632.
      View in: PubMed
    13. Whitehead WE, Rao SS, Lowry A, Nagle D, Varma M, Bitar KN, Bharucha AE, Hamilton FA. Treatment of fecal incontinence: state of the science summary for the National Institute of Diabetes and Digestive and Kidney Diseases workshop. Am J Gastroenterol. 2015 Jan; 110(1):138-46; quiz 147. PMID: 25331348.
      View in: PubMed
    14. Bitar KN. Regarding "Perianal implantation of bioengineered human internal anal sphincter constructs intrinsically innervated with human neural progenitor cells". Surgery. 2015 Jan; 157(1):178. PMID: 25154554.
      View in: PubMed
    15. Raghavan S, Bitar KN. The influence of extracellular matrix composition on the differentiation of neuronal subtypes in tissue engineered innervated intestinal smooth muscle sheets. Biomaterials. 2014 Aug; 35(26):7429-40. PMID: 24929617.
      View in: PubMed
    16. Bitar KN, Zakhem E. Design strategies of biodegradable scaffolds for tissue regeneration. Biomed Eng Comput Biol. 2014; 6:13-20. PMID: 25288907.
      View in: PubMed
    17. Bitar KN, Raghavan S, Zakhem E. Tissue engineering in the gut: developments in neuromusculature. Gastroenterology. 2014 Jun; 146(7):1614-24. PMID: 24681129.
      View in: PubMed
    18. Gilmont RR, Raghavan S, Somara S, Bitar KN. Bioengineering of physiologically functional intrinsically innervated human internal anal sphincter constructs. Tissue Eng Part A. 2014 Jun; 20(11-12):1603-11. PMID: 24328537.
      View in: PubMed
    19. Raghavan S, Miyasaka EA, Gilmont RR, Somara S, Teitelbaum DH, Bitar KN. Perianal implantation of bioengineered human internal anal sphincter constructs intrinsically innervated with human neural progenitor cells. Surgery. 2014 Apr; 155(4):668-74. PMID: 24582493.
      View in: PubMed
    20. Zakhem E, Raghavan S, Bitar KN. Neo-innervation of a bioengineered intestinal smooth muscle construct around chitosan scaffold. Biomaterials. 2014 Feb; 35(6):1882-9. PMID: 24315576.
      View in: PubMed
    21. Raghavan S, Gilmont RR, Bitar KN. Neuroglial differentiation of adult enteric neuronal progenitor cells as a function of extracellular matrix composition. Biomaterials. 2013 Sep; 34(28):6649-58. PMID: 23746858.
      View in: PubMed
    22. Bitar KN, Zakhem E. Tissue engineering and regenerative medicine as applied to the gastrointestinal tract. Curr Opin Biotechnol. 2013 Oct; 24(5):909-15. PMID: 23583170.
      View in: PubMed
    23. Koch KL, Bitar KN, Fortunato JE. Tissue engineering for neuromuscular disorders of the gastrointestinal tract. World J Gastroenterol. 2012 Dec 21; 18(47):6918-25. PMID: 23322989.
      View in: PubMed
    24. Orlando G, Wood KJ, De Coppi P, Baptista PM, Binder KW, Bitar KN, Breuer C, Burnett L, Christ G, Farney A, Figliuzzi M, Holmes JH, Koch K, Macchiarini P, Mirmalek Sani SH, Opara E, Remuzzi A, Rogers J, Saul JM, Seliktar D, Shapira-Schweitzer K, Smith T, Solomon D, Van Dyke M, Yoo JJ, Zhang Y, Atala A, Stratta RJ, Soker S. Regenerative medicine as applied to general surgery. Ann Surg. 2012 May; 255(5):867-80. PMID: 22330032.
      View in: PubMed
    25. Zakhem E, Raghavan S, Gilmont RR, Bitar KN. Chitosan-based scaffolds for the support of smooth muscle constructs in intestinal tissue engineering. Biomaterials. 2012 Jun; 33(19):4810-7. PMID: 22483012.
      View in: PubMed
    26. Koga H, Sun X, Yang H, Nose K, Somara S, Bitar KN, Owyang C, Okawada M, Teitelbaum DH. Distraction-induced intestinal enterogenesis: preservation of intestinal function and lengthening after reimplantation into normal jejunum. Ann Surg. 2012 Feb; 255(2):302-10. PMID: 21997804.
      View in: PubMed
    27. Orlando G, Domínguez-Bendala J, Shupe T, Bergman C, Bitar KN, Booth C, Carbone M, Koch KL, Lerut JP, Neuberger JM, Petersen B, Ricordi C, Atala A, Stratta RJ, Soker S. Cell and organ bioengineering technology as applied to gastrointestinal diseases. Gut. 2013 May; 62(5):774-86. PMID: 22267591.
      View in: PubMed
    28. Bitar KN, Raghavan S. Intestinal tissue engineering: current concepts and future vision of regenerative medicine in the gut. Neurogastroenterol Motil. 2012 Jan; 24(1):7-19. PMID: 22188325.
      View in: PubMed
    29. Raghavan S, Gilmont RR, Miyasaka EA, Somara S, Srinivasan S, Teitelbaum DH, Bitar KN. Successful implantation of bioengineered, intrinsically innervated, human internal anal sphincter. Gastroenterology. 2011 Jul; 141(1):310-9. PMID: 21463628.
      View in: PubMed
    30. Somara S, Bashllari D, Gilmont RR, Bitar KN. Real-time dynamic movement of caveolin-1 during smooth muscle contraction of human colon and aged rat colon transfected with caveolin-1 cDNA. Am J Physiol Gastrointest Liver Physiol. 2011 Jun; 300(6):G1022-32. PMID: 21372166.
      View in: PubMed
    31. Miyasaka EA, Raghavan S, Gilmont RR, Mittal K, Somara S, Bitar KN, Teitelbaum DH. In vivo growth of a bioengineered internal anal sphincter: comparison of growth factors for optimization of growth and survival. Pediatr Surg Int. 2011 Feb; 27(2):137-43. PMID: 21046117.
      View in: PubMed
    32. Raghavan S, Lam MT, Foster LL, Gilmont RR, Somara S, Takayama S, Bitar KN. Bioengineered three-dimensional physiological model of colonic longitudinal smooth muscle in vitro. Tissue Eng Part C Methods. 2010 Oct; 16(5):999-1009. PMID: 20001822.
      View in: PubMed
    33. Somara S, Gilmont RR, Varadarajan S, Bitar KN. Phosphorylated HSP20 modulates the association of thin-filament binding proteins: caldesmon with tropomyosin in colonic smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2010 Nov; 299(5):G1164-76. PMID: 20829522.
      View in: PubMed
    34. Raghavan S, Miyasaka EA, Hashish M, Somara S, Gilmont RR, Teitelbaum DH, Bitar KN. Successful implantation of physiologically functional bioengineered mouse internal anal sphincter. Am J Physiol Gastrointest Liver Physiol. 2010 Aug; 299(2):G430-9. PMID: 20558766.
      View in: PubMed
    35. Hashish M, Raghavan S, Somara S, Gilmont RR, Miyasaka E, Bitar KN, Teitelbaum DH. Surgical implantation of a bioengineered internal anal sphincter. J Pediatr Surg. 2010 Jan; 45(1):52-8. PMID: 20105579.
      View in: PubMed
    36. Somara S, Gilmont R, Bitar KN. Role of thin-filament regulatory proteins in relaxation of colonic smooth muscle contraction. Am J Physiol Gastrointest Liver Physiol. 2009 Nov; 297(5):G958-66. PMID: 20501443.
      View in: PubMed
    37. Deng H, Hershenson MB, Lei J, Bitar KN, Fingar DC, Solway J, Bentley JK. p70 Ribosomal S6 kinase is required for airway smooth muscle cell size enlargement but not increased contractile protein expression. Am J Respir Cell Mol Biol. 2010 Jun; 42(6):744-52. PMID: 19648476.
      View in: PubMed
    38. Somara S, Gilmont RR, Dennis RG, Bitar KN. Bioengineered internal anal sphincter derived from isolated human internal anal sphincter smooth muscle cells. Gastroenterology. 2009 Jul; 137(1):53-61. PMID: 19328796.
      View in: PubMed
    39. Bentley JK, Deng H, Linn MJ, Lei J, Dokshin GA, Fingar DC, Bitar KN, Henderson WR, Hershenson MB. Airway smooth muscle hyperplasia and hypertrophy correlate with glycogen synthase kinase-3(beta) phosphorylation in a mouse model of asthma. Am J Physiol Lung Cell Mol Physiol. 2009 Feb; 296(2):L176-84. PMID: 19011050.
      View in: PubMed
    40. Somara S, Bitar KN. Direct association of calponin with specific domains of PKC-alpha. Am J Physiol Gastrointest Liver Physiol. 2008 Dec; 295(6):G1246-54. PMID: 18948438.
      View in: PubMed
    41. Gilmont RR, Somara S, Bitar KN. VIP induces PKA-mediated rapid and sustained phosphorylation of HSP20. Biochem Biophys Res Commun. 2008 Oct 31; 375(4):552-6. PMID: 18725196.
      View in: PubMed
    42. Deng H, Dokshin GA, Lei J, Goldsmith AM, Bitar KN, Fingar DC, Hershenson MB, Bentley JK. Inhibition of glycogen synthase kinase-3beta is sufficient for airway smooth muscle hypertrophy. J Biol Chem. 2008 Apr 11; 283(15):10198-207. PMID: 18252708.
      View in: PubMed
    43. Huebner M, Margulies RU, Fenner DE, Ashton-Miller JA, Bitar KN, DeLancey JO. Age effects on internal anal sphincter thickness and diameter in nulliparous females. Dis Colon Rectum. 2007 Sep; 50(9):1405-11. PMID: 17665265.
      View in: PubMed
    44. Somara S, Gilmont RR, Martens JR, Bitar KN. Ectopic expression of caveolin-1 restores physiological contractile response of aged colonic smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2007 Jul; 293(1):G240-9. PMID: 17431219.
      View in: PubMed
    45. Somara S, Bitar KN. Phosphorylated HSP27 modulates the association of phosphorylated caldesmon with tropomyosin in colonic smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2006 Oct; 291(4):G630-9. PMID: 16627824.
      View in: PubMed
    46. Goldsmith AM, Bentley JK, Zhou L, Jia Y, Bitar KN, Fingar DC, Hershenson MB. Transforming growth factor-beta induces airway smooth muscle hypertrophy. Am J Respir Cell Mol Biol. 2006 Feb; 34(2):247-54. PMID: 16239645.
      View in: PubMed
    47. Patil SB, Bitar KN. RhoA- and PKC-alpha-mediated phosphorylation of MYPT and its association with HSP27 in colonic smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2006 Jan; 290(1):G83-95. PMID: 16179599.
      View in: PubMed
    48. Bitar KN. Aging and Gi smooth muscle fecal incontinence: Is bioengineering an option. Exp Gerontol. 2005 Aug-Sep; 40(8-9):643-9. PMID: 15970414.
      View in: PubMed
    49. Pang H, Bitar KN. Direct association of RhoA with specific domains of PKC-alpha. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C982-93. PMID: 15930143.
      View in: PubMed
    50. Hecker L, Baar K, Dennis RG, Bitar KN. Development of a three-dimensional physiological model of the internal anal sphincter bioengineered in vitro from isolated smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2005 Aug; 289(2):G188-96. PMID: 15774939.
      View in: PubMed
    51. Bitar KN, Patil SB. Aging and gastrointestinal smooth muscle. Mech Ageing Dev. 2004 Dec; 125(12):907-10. PMID: 15563937.
      View in: PubMed
    52. Somara S, Pang H, Bitar KN. Agonist-induced association of tropomyosin with protein kinase Calpha in colonic smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2005 Feb; 288(2):G268-76. PMID: 15486343.
      View in: PubMed
    53. Patil SB, Tsunoda Y, Pawar MD, Bitar KN. Translocation and association of ROCK-II with RhoA and HSP27 during contraction of rabbit colon smooth muscle cells. Biochem Biophys Res Commun. 2004 Jun 18; 319(1):95-102. PMID: 15158447.
      View in: PubMed
    54. Xin X, Hou YT, Li L, Schmiedlin-Ren P, Christman GM, Cheng HL, Bitar KN, Zimmermann EM. IGF-I increases IGFBP-5 and collagen alpha1(I) mRNAs by the MAPK pathway in rat intestinal smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2004 May; 286(5):G777-83. PMID: 15068962.
      View in: PubMed
    55. Somara S, Bitar KN. Tropomyosin interacts with phosphorylated HSP27 in agonist-induced contraction of smooth muscle. Am J Physiol Cell Physiol. 2004 Jun; 286(6):C1290-301. PMID: 14749215.
      View in: PubMed
    56. Patil SB, Pawar MD, Bitar KN. Direct association and translocation of PKC-alpha with calponin. Am J Physiol Gastrointest Liver Physiol. 2004 Jun; 286(6):G954-63. PMID: 14726309.
      View in: PubMed
    57. Patil SB, Pawar MD, Bitar KN. Phosphorylated HSP27 essential for acetylcholine-induced association of RhoA with PKCalpha. Am J Physiol Gastrointest Liver Physiol. 2004 Apr; 286(4):G635-44. PMID: 14592945.
      View in: PubMed
    58. Bitar KN. Function of gastrointestinal smooth muscle: from signaling to contractile proteins. Am J Med. 2003 Aug 18; 115 Suppl 3A:15S-23S. PMID: 12928070.
      View in: PubMed
    59. Cao W, Sohn UD, Bitar KN, Behar J, Biancani P, Harnett KM. MAPK mediates PKC-dependent contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2003 Jul; 285(1):G86-95. PMID: 12799309.
      View in: PubMed
    60. Bitar KN. Aging and neural control of the GI tract: V. Aging and gastrointestinal smooth muscle: from signal transduction to contractile proteins. Am J Physiol Gastrointest Liver Physiol. 2003 Jan; 284(1):G1-7. PMID: 12488230.
      View in: PubMed
    61. Bitar KN. HSP27 phosphorylation and interaction with actin-myosin in smooth muscle contraction. Am J Physiol Gastrointest Liver Physiol. 2002 May; 282(5):G894-903. PMID: 11960785.
      View in: PubMed
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