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Clinical and Translational Science Institute

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Last Name

J. Mark Cline, D.V.M., Ph.D.

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentComparative Medicine
Address
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentCTSI

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentRadiation Oncology


    Collapse Research 
    Collapse research activities and funding
    T32RR007009     (CLINE, J. MARK)Jul 1, 1982 - May 31, 2013
    NIH/NCRR
    Laboratory Animal &Comparative Medicine Training
    Role: Principal Investigator

    T32OD010957     (CLINE, J. MARK)Jul 1, 1982 - Mar 31, 2018
    NIH
    Laboratory Animal & Comparative Medicine Training
    Role: Principal Investigator

    R01AT000639     (CLINE, J. MARK)Sep 18, 2000 - Jun 30, 2013
    NIH/NCCIH
    SOY AND ESTROGEN INTERACTIONS IN THE BREAST
    Role: Principal Investigator

    R03CA103111     (CLINE, J. MARK)Sep 8, 2003 - Aug 31, 2006
    NIH/NCI
    Effects of Dietary Soy on Biomarkers in Prostate Cancer
    Role: Principal Investigator

    T35RR025836     (CLINE, J. MARK)Apr 1, 2009 - Mar 31, 2014
    NIH/NCRR
    Summer Veterinary Student Research Fellows at Wake Forest University
    Role: Principal Investigator

    T35OD010946     (KAVANAGH, KYLIE)Apr 1, 2009 - Mar 31, 2019
    NIH
    Summer Veterinary Student Research Fellows at Wake Forest University
    Role: Co-Principal Investigator

    G20OD020291     (CLINE, J. MARK)Jul 1, 2015 - Jun 30, 2016
    NIH
    Enhanced Imaging Resources for Clinical Care of Research Animals
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Cline JM, Dugan G, Bourland JD, Perry DL, Stitzel JD, Weaver AA, Jiang C, Tovmasyan A, Owzar K, Spasojevic I, Batinic-Haberle I, Vujaskovic Z. Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation. Antioxidants (Basel). 2018 Mar 07; 7(3). PMID: 29518913.
      View in: PubMed
    2. Joe RM, Flores A, Doche ME, Cline JM, Clutter ES, Vander PB, Riedel H, Argetsinger LS, Carter-Su C. Phosphorylation of the Unique C-Terminal Tail of the Alpha Isoform of the Scaffold Protein SH2B1 Controls the Ability of SH2B1a To Enhance Nerve Growth Factor Function. Mol Cell Biol. 2018 03 15; 38(6). PMID: 29229648.
      View in: PubMed
    3. Andrews RN, Metheny-Barlow LJ, Peiffer AM, Hanbury DB, Tooze JA, Bourland JD, Hampson RE, Deadwyler SA, Cline JM. Cerebrovascular Remodeling and Neuroinflammation is a Late Effect of Radiation-Induced Brain Injury in Non-Human Primates. Radiat Res. 2017 05; 187(5):599-611. PMID: 28398880.
      View in: PubMed
    4. Hanbury DB, Peiffer AM, Dugan G, Andrews RN, Cline JM. Long-Term Cognitive Functioning in Single-Dose Total-Body Gamma-Irradiated Rhesus Monkeys ( Macaca mulatta ). Radiat Res. 2016 Nov; 186(5):447-454. PMID: 27740889.
      View in: PubMed
    5. DeBo RJ, Lees CJ, Dugan GO, Caudell DL, Michalson KT, Hanbury DB, Kavanagh K, Cline JM, Register TC. Late Effects of Total-Body Gamma Irradiation on Cardiac Structure and Function in Male Rhesus Macaques. Radiat Res. 2016 07; 186(1):55-64. PMID: 27333082.
      View in: PubMed
    6. Dewi FN, Wood CE, Willson CJ, Register TC, Lees CJ, Howard TD, Huang Z, Murphy SK, Tooze JA, Chou JW, Miller LD, Cline JM. Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques. Cancer Prev Res (Phila). 2016 05; 9(5):385-95. PMID: 27006379.
      View in: PubMed
    7. Willson CJ, Herbert RA, Cline JM. Hormone Receptor Expression in Spontaneous Uterine Adenocarcinoma in Fischer 344 Rats. Toxicol Pathol. 2015 Aug; 43(6):865-71. PMID: 26157037.
      View in: PubMed
    8. DeBo RJ, Register TC, Caudell DL, Sempowski GD, Dugan G, Gray S, Owzar K, Jiang C, Bourland JD, Chao NJ, Cline JM. Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques. Int J Radiat Biol. 2015 Jun; 91(6):510-8. PMID: 25786585.
      View in: PubMed
    9. Kavanagh K, Dendinger MD, Davis AT, Register TC, DeBo R, Dugan G, Cline JM. Type 2 Diabetes is a Delayed Late Effect of Whole-Body Irradiation in Nonhuman Primates. Radiat Res. 2015 Apr; 183(4):398-406. PMID: 25811716.
      View in: PubMed
    10. Fang X, Gyabaah K, Nickkholgh B, Cline JM, Balaji KC. Novel In Vivo model for combinatorial fluorescence labeling in mouse prostate. Prostate. 2015 Jun 15; 75(9):988-1000. PMID: 25753731.
      View in: PubMed
    11. Hanbury DB, Robbins ME, Bourland JD, Wheeler KT, Peiffer AM, Mitchell EL, Daunais JB, Deadwyler SA, Cline JM. Pathology of fractionated whole-brain irradiation in rhesus monkeys ( Macaca mulatta ). Radiat Res. 2015 Mar; 183(3):367-74. PMID: 25688996.
      View in: PubMed
    12. Maglic D, Stovall DB, Cline JM, Fry EA, Mallakin A, Taneja P, Caudell DL, Willingham MC, Sui G, Inoue K. DMP1ß, a splice isoform of the tumour suppressor DMP1 locus, induces proliferation and progression of breast cancer. J Pathol. 2015 May; 236(1):90-102. PMID: 25537728.
      View in: PubMed
    13. Williams JK, Eckman D, Dean A, Moradi M, Allickson J, Cline JM, Yoo JJ, Atala A. The dose-effect safety profile of skeletal muscle precursor cell therapy in a dog model of intrinsic urinary sphincter deficiency. Stem Cells Transl Med. 2015 Mar; 4(3):286-94. PMID: 25637189.
      View in: PubMed
    14. Dugan G, O'Donnell L, Hanbury DB, Cline JM, Caudell DL. Assessment of Multiplate platelet aggregometry using citrate, heparin or hirudin in Rhesus macaques. Platelets. 2015; 26(8):730-5. PMID: 25549285.
      View in: PubMed
    15. Pearce LR, Joe R, Doche ME, Su HW, Keogh JM, Henning E, Argetsinger LS, Bochukova EG, Cline JM, Garg S, Saeed S, Shoelson S, O'Rahilly S, Barroso I, Rui L, Farooqi IS, Carter-Su C. Functional characterization of obesity-associated variants involving the a and ß isoforms of human SH2B1. Endocrinology. 2014 Sep; 155(9):3219-26. PMID: 24971614.
      View in: PubMed
    16. Hernandez-Ramon EE, Sandoval NA, John K, Cline JM, Wood CE, Woodward RA, Poirier MC. Tamoxifen-DNA adduct formation in monkey and human reproductive organs. Carcinogenesis. 2014 May; 35(5):1172-6. PMID: 24501327.
      View in: PubMed
    17. Sharma A, Fonseca LL, Rajani C, Yanagida JK, Endo Y, Cline JM, Stone JC, Ji J, Ramos JW, Lorenzo PS. Targeted deletion of RasGRP1 impairs skin tumorigenesis. Carcinogenesis. 2014 May; 35(5):1084-91. PMID: 24464785.
      View in: PubMed
    18. Down JD, Medhora M, Jackson IL, Cline JM, Vujaskovic Z. Do variations in mast cell hyperplasia account for differences in radiation-induced lung injury among different mouse strains, rats and nonhuman primates? Radiat Res. 2013 Aug; 180(2):216-21. PMID: 23819595.
      View in: PubMed
    19. Ethun KF, Wood CE, Cline JM, Register TC, Appt SE, Clarkson TB. Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model. Menopause. 2013 Jul; 20(7):777-84. PMID: 23793168.
      View in: PubMed
    20. Dewi FN, Wood CE, Lees CJ, Willson CJ, Register TC, Tooze JA, Franke AA, Cline JM. Dietary soy effects on mammary gland development during the pubertal transition in nonhuman primates. Cancer Prev Res (Phila). 2013 Aug; 6(8):832-42. PMID: 23771522.
      View in: PubMed
    21. Hassan S, Karpova Y, Baiz D, Yancey D, Pullikuth A, Flores A, Register T, Cline JM, D'Agostino R, Danial N, Datta SR, Kulik G. Behavioral stress accelerates prostate cancer development in mice. J Clin Invest. 2013 Feb; 123(2):874-86. PMID: 23348742.
      View in: PubMed
    22. Wood CE, Branstetter D, Jacob AP, Cline JM, Register TC, Rohrbach K, Huang LY, Borgerink H, Dougall WC. Progestin effects on cell proliferation pathways in the postmenopausal mammary gland. Breast Cancer Res. 2013; 15(4):R62. PMID: 23938070.
      View in: PubMed
    23. Doche ME, Bochukova EG, Su HW, Pearce LR, Keogh JM, Henning E, Cline JM, Saeed S, Dale A, Cheetham T, Barroso I, Argetsinger LS, O'Rahilly S, Rui L, Carter-Su C, Farooqi IS. Human SH2B1 mutations are associated with maladaptive behaviors and obesity. J Clin Invest. 2012 Dec; 122(12):4732-6. PMID: 23160192.
      View in: PubMed
    24. Ethun KF, Wood CE, Register TC, Cline JM, Appt SE, Clarkson TB. Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeys. Menopause. 2012 Nov; 19(11):1242-52. PMID: 23103754.
      View in: PubMed
    25. Sasseville VG, Mansfield KG, Mankowski JL, Tremblay C, Terio KA, Mätz-Rensing K, Gruber-Dujardin E, Delaney MA, Schmidt LD, Liu D, Markovits JE, Owston M, Harbison C, Shanmukhappa S, Miller AD, Kaliyaperumal S, Assaf BT, Kattenhorn L, Macri SC, Simmons HA, Baldessari A, Sharma P, Courtney C, Bradley A, Cline JM, Reindel JF, Hutto DL, Montali RJ, Lowenstine LJ. Meeting report: Spontaneous lesions and diseases in wild, captive-bred, and zoo-housed nonhuman primates and in nonhuman primate species used in drug safety studies. Vet Pathol. 2012 Nov; 49(6):1057-69. PMID: 23135296.
      View in: PubMed
    26. Davis VL, Shaikh F, Gallagher KM, Villegas M, Rea SL, Cline JM, Hughes CL. Inhibition of Neu-induced mammary carcinogenesis in transgenic mice expressing ER?3, a dominant negative estrogen receptor a variant. Horm Cancer. 2012 Dec; 3(5-6):227-39. PMID: 22968785.
      View in: PubMed
    27. Dewi FN, Wood CE, Lampe JW, Hullar MA, Franke AA, Golden DL, Adams MR, Cline JM. Endogenous and exogenous equol are antiestrogenic in reproductive tissues of apolipoprotein e-null mice. J Nutr. 2012 Oct; 142(10):1829-35. PMID: 22933749.
      View in: PubMed
    28. Clafshenkel WP, King TL, Kotlarczyk MP, Cline JM, Foster WG, Davis VL, Witt-Enderby PA. Morinda citrifolia (Noni) Juice Augments Mammary Gland Differentiation and Reduces Mammary Tumor Growth in Mice Expressing the Unactivated c-erbB2 Transgene. Evid Based Complement Alternat Med. 2012; 2012:487423. PMID: 22619689.
      View in: PubMed
    29. Johnson NA, Ho A, Cline JM, Hughes CL, Foster WG, Davis VL. Accelerated mammary tumor onset in a HER2/Neu mouse model exposed to DDT metabolites locally delivered to the mammary gland. Environ Health Perspect. 2012 Aug; 120(8):1170-6. PMID: 22514210.
      View in: PubMed
    30. Wu M, Shi L, Cimic A, Romero L, Sui G, Lees CJ, Cline JM, Seals DF, Sirintrapun JS, McCoy TP, Liu W, Kim JW, Hawkins GA, Peehl DM, Xu J, Cramer SD. Suppression of Tak1 promotes prostate tumorigenesis. Cancer Res. 2012 Jun 01; 72(11):2833-43. PMID: 22467172.
      View in: PubMed
    31. Hulchiy M, Zhang H, Cline JM, Hirschberg AL, Sahlin L. Effects of long-term tibolone treatment on nuclear sex steroid hormone receptors and G-protein-coupled estrogen receptor-1 expression in the macaque uterus. Menopause. 2012 Mar; 19(3):332-8. PMID: 22027943.
      View in: PubMed
    32. Wood CE, Boue SM, Collins-Burow BM, Rhodes LV, Register TC, Cline JM, Dewi FN, Burow ME. Glyceollin-elicited soy protein consumption induces distinct transcriptional effects as compared to standard soy protein. J Agric Food Chem. 2012 Jan 11; 60(1):81-6. PMID: 22126086.
      View in: PubMed
    33. Stute P, Sielker S, Wood CE, Register TC, Lees CJ, Dewi FN, Williams JK, Wagner JD, Stefenelli U, Cline JM. Life stage differences in mammary gland gene expression profile in non-human primates. Breast Cancer Res Treat. 2012 Jun; 133(2):617-34. PMID: 22037779.
      View in: PubMed
    34. Ethun KF, Cline JM, Appt SE. Endocrine profile of an ovariectomized cynomolgus monkey (Macaca fascicularis) with a supernumerary ovary. Comp Med. 2011 Oct; 61(5):462-6. PMID: 22330356.
      View in: PubMed
    35. Zhang H, von Schoultz B, Cline JM, Sahlin L. Distribution of cyclooxygenases 1 and 2 in the uterus and breast of cynomolgus monkeys-effects of hormone treatment. Menopause. 2011 Sep; 18(9):1001-9. PMID: 21540754.
      View in: PubMed
    36. The role of soy isoflavones in menopausal health: report of The North American Menopause Society/Wulf H. Utian Translational Science Symposium in Chicago, IL (October 2010). Menopause. 2011 Jul; 18(7):732-53. PMID: 21685820.
      View in: PubMed
    37. Hill GD, Moore AB, Kissling GE, Flagler ND, Ney E, Cline JM, Dixon D. Effects of hormonally active agents on steroid hormone receptor expression and cell proliferation in the myometrium of ovariectomized macaques. Toxicol Pathol. 2011 Apr; 39(3):508-15. PMID: 21411722.
      View in: PubMed
    38. Robbins ME, Bourland JD, Cline JM, Wheeler KT, Deadwyler SA. A model for assessing cognitive impairment after fractionated whole-brain irradiation in nonhuman primates. Radiat Res. 2011 Apr; 175(4):519-25. PMID: 21275607.
      View in: PubMed
    39. Wood CE, Tannehill-Gregg SH, Chen Z, Doorslaer Kv, Nelson DR, Cline JM, Burk RD. Novel betapapillomavirus associated with hand and foot papillomas in a cynomolgus macaque. Vet Pathol. 2011 May; 48(3):731-6. PMID: 20921322.
      View in: PubMed
    40. Mazurkiewicz-Munoz AM, Argetsinger LS, Kouadio JL, Stensballe A, Jensen ON, Cline JM, Carter-Su C. Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor. Mol Cell Biol. 2006 Jun; 26(11):4052-62. PMID: 16705159.
      View in: PubMed
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