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Clinical and Translational Science Institute

Keywords
Last Name

Herbert Lloyd Bonkovsky, M.D.

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentInt Med-Gastroenterology
Address
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    Collapse Research 
    Collapse research activities and funding
    R01HL036438     (BONKOVSKY, HERBERT L)Sep 1, 1985 - Nov 30, 1986
    NIH/NHLBI
    HEPATIC HEME, CYTOCHROME P-450 AND DRUG METABOLISM
    Role: Principal Investigator

    R01DK038825     (BONKOVSKY, HERBERT L)Jan 1, 1987 - Jun 30, 2011
    NIH/NIDDK
    Regulation of Hepatic Heme Metabolism
    Role: Principal Investigator

    N01DK092326     (BONKOVSKY, HERBERT L)May 1, 1999 - Apr 30, 2007
    NIH/NIDDK
    HEPATITIS C CLINICAL TRIAL-CLINICAL CENTERS
    Role: Principal Investigator

    U01DK065193     (PROTIVA, PETR)Sep 30, 2003 - Jun 30, 2009
    NIH/NIDDK
    Research Network for Drug-Induced Liver Disease
    Role: Co-Principal Investigator

    R15HL117199     (BONKOVSKY, HERBERT L)Feb 1, 2013 - Dec 31, 2015
    NIH/NHLBI
    Effect of Heme on mRNA and miRNA Profiles
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sendi H, Mead I, Wan M, Mehrab-Mohseni M, Koch K, Atala A, Bonkovsky HL, Bishop CE. miR-122 inhibition in a human liver organoid model leads to liver inflammation, necrosis, steatofibrosis and dysregulated insulin signaling. PLoS One. 2018; 13(7):e0200847. PMID: 30024933.
      View in: PubMed
    2. Church RJ, Kullak-Ublick GA, Aubrecht J, Bonkovsky HL, Chalasani N, Fontana RJ, Goepfert JC, Hackman F, King NMP, Kirby S, Kirby P, Marcinak J, Ormarsdottir S, Schomaker SJ, Schuppe-Koistinen I, Wolenski F, Arber N, Merz M, Sauer JM, Andrade RJ, van Bömmel F, Poynard T, Watkins PB. Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort. Hepatology. 2019 Feb; 69(2):760-773. PMID: 29357190.
      View in: PubMed
    3. Hines MC, Bonkovsky HL, Rudnick SR, Mhoon JT. Peripheral Neuropathy and the Ceruloplasmin Gene. Ann Intern Med. 2018 Jun 19; 168(12):894-895. PMID: 29482220.
      View in: PubMed
    4. Whritenour J, Ko M, Zong Q, Wang J, Tartaro K, Schneider P, Olson E, Van Volkenburg M, Serrano J, Hayashi P, Fontana R, Chalasani N, Bonkovsky HL. Development of a modified lymphocyte transformation test for diagnosing drug-induced liver injury associated with an adaptive immune response. J Immunotoxicol. 2017 12; 14(1):31-38. PMID: 28121193.
      View in: PubMed
    5. Bissell DM, Anderson KE, Bonkovsky HL. Porphyria. N Engl J Med. 2017 11 23; 377(21):2101. PMID: 29166231.
      View in: PubMed
    6. Wang B, Balwani M, Bonkovsky HL, Anderson KE, Bloomer JR, Bissell DM, Phillips JD, Desnick RJ. Reply. Hepatology. 2017 Nov 21. PMID: 29159969.
      View in: PubMed
    7. Ma J, Zeng S, Zhang Y, Deng G, Qu Y, Guo C, Yin L, Han Y, Cai C, Li Y, Wang G, Bonkovsky HL, Shen H. BMP4 promotes oxaliplatin resistance by an induction of epithelial-mesenchymal transition via MEK1/ERK/ELK1 signaling in hepatocellular carcinoma. Cancer Lett. 2017 12 28; 411:117-129. PMID: 28987388.
      View in: PubMed
    8. Balwani M, Wang B, Anderson KE, Bloomer JR, Bissell DM, Bonkovsky HL, Phillips JD, Desnick RJ. Acute hepatic porphyrias: Recommendations for evaluation and long-term management. Hepatology. 2017 10; 66(4):1314-1322. PMID: 28605040.
      View in: PubMed
    9. Bissell DM, Anderson KE, Bonkovsky HL. Porphyria. N Engl J Med. 2017 Aug 31; 377(9):862-872. PMID: 28854095.
      View in: PubMed
    10. Balwani M, Naik H, Anderson KE, Bissell DM, Bloomer J, Bonkovsky HL, Phillips JD, Overbey JR, Wang B, Singal AK, Liu LU, Desnick RJ. Clinical, Biochemical, and Genetic Characterization of North American Patients With Erythropoietic Protoporphyria and X-linked Protoporphyria. JAMA Dermatol. 2017 08 01; 153(8):789-796. PMID: 28614581.
      View in: PubMed
    11. Suzuki A, Barnhart H, Gu J, Bonkovsky HL, Tillmann HL, Fontana RJ, Kleiner DE. Associations of gender and a proxy of female menopausal status with histological features of drug-induced liver injury. Liver Int. 2017 11; 37(11):1723-1730. PMID: 28161910.
      View in: PubMed
    12. Bonkovsky HL, Kleiner DE, Gu J, Odin JA, Russo MW, Navarro VM, Fontana RJ, Ghabril MS, Barnhart H, Hoofnagle JH. Clinical presentations and outcomes of bile duct loss caused by drugs and herbal and dietary supplements. Hepatology. 2017 04; 65(4):1267-1277. PMID: 27981596.
      View in: PubMed
    13. Zeng S, Zhang Y, Ma J, Deng G, Qu Y, Guo C, Han Y, Yin L, Cai C, Li Y, Wang G, Bonkovsky HL, Shen H. BMP4 promotes metastasis of hepatocellular carcinoma by an induction of epithelial-mesenchymal transition via upregulating ID2. Cancer Lett. 2017 04 01; 390:67-76. PMID: 28093286.
      View in: PubMed
    14. Lane AM, McKay JT, Bonkovsky HL. Advances in the management of erythropoietic protoporphyria - role of afamelanotide. Appl Clin Genet. 2016; 9:179-189. PMID: 28003770.
      View in: PubMed
    15. Russo MW, Steuerwald N, Norton HJ, Anderson WE, Foureau D, Chalasani N, Fontana RJ, Watkins PB, Serrano J, Bonkovsky HL. Profiles of miRNAs in serum in severe acute drug induced liver injury and their prognostic significance. Liver Int. 2017 05; 37(5):757-764. PMID: 27860186.
      View in: PubMed
    16. Severson TJ, Besur S, Bonkovsky HL. Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review. World J Gastroenterol. 2016 Aug 07; 22(29):6742-56. PMID: 27547017.
      View in: PubMed
    17. deLemos AS, Ghabril M, Rockey DC, Gu J, Barnhart HX, Fontana RJ, Kleiner DE, Bonkovsky HL. Amoxicillin-Clavulanate-Induced Liver Injury. Dig Dis Sci. 2016 08; 61(8):2406-16. PMID: 27003146.
      View in: PubMed
    18. French JB, Bonacini M, Ghabril M, Foureau D, Bonkovsky HL. Hepatotoxicity Associated with the Use of Anti-TNF-a Agents. Drug Saf. 2016 Mar; 39(3):199-208. PMID: 26692395.
      View in: PubMed
    19. Gou EW, Balwani M, Bissell DM, Bloomer JR, Bonkovsky HL, Desnick RJ, Naik H, Phillips JD, Singal AK, Wang B, Keel S, Anderson KE. Pitfalls in Erythrocyte Protoporphyrin Measurement for Diagnosis and Monitoring of Protoporphyrias. Clin Chem. 2015 Dec; 61(12):1453-6. PMID: 26482161.
      View in: PubMed
    20. Wang G, Bonkovsky HL, de Lemos A, Burczynski FJ. Recent insights into the biological functions of liver fatty acid binding protein 1. J Lipid Res. 2015 Dec; 56(12):2238-47. PMID: 26443794.
      View in: PubMed
    21. Vera T, D'Agostino RB, Jordan JH, Whitlock MC, Meléndez GC, Lamar ZS, Porosnicu M, Bonkovsky HL, Poole LB, Hundley WG. Relation of Pre-anthracycline Serum Bilirubin Levels to Left Ventricular Ejection Fraction After Chemotherapy. Am J Cardiol. 2015 Dec 01; 116(11):1752-5. PMID: 26433273.
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    22. Bossi K, Lee J, Schmeltzer P, Holburton E, Groseclose G, Besur S, Hwang S, Bonkovsky HL. Homeostasis of iron and hepcidin in erythropoietic protoporphyria. Eur J Clin Invest. 2015 Oct; 45(10):1032-41. PMID: 26199063.
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    23. Kline JA, Steuerwald NM, Watts JA, Courtney M, Bonkovsky HL. Leukocyte expression of heme oxygenase-1 [hmox1] varies inversely with severity of tricuspid regurgitation in acute pulmonary embolism. Thromb Res. 2015 Oct; 136(4):769-74. PMID: 26337933.
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    24. O'Brien TR, Pfeiffer RM, Paquin A, Lang Kuhs KA, Chen S, Bonkovsky HL, Edlin BR, Howell CD, Kirk GD, Kuniholm MH, Morgan TR, Strickler HD, Thomas DL, Prokunina-Olsson L. Comparison of functional variants in IFNL4 and IFNL3 for association with HCV clearance. J Hepatol. 2015 Nov; 63(5):1103-10. PMID: 26186989.
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    25. Besur S, Schmeltzer P, Bonkovsky HL. Acute Porphyrias. J Emerg Med. 2015 Sep; 49(3):305-12. PMID: 26159905.
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    26. Langendonk JG, Balwani M, Anderson KE, Bonkovsky HL, Anstey AV, Bissell DM, Bloomer J, Edwards C, Neumann NJ, Parker C, Phillips JD, Lim HW, Hamzavi I, Deybach JC, Kauppinen R, Rhodes LE, Frank J, Murphy GM, Karstens FPJ, Sijbrands EJG, de Rooij FWM, Lebwohl M, Naik H, Goding CR, Wilson JHP, Desnick RJ. Afamelanotide for Erythropoietic Protoporphyria. N Engl J Med. 2015 Jul 02; 373(1):48-59. PMID: 26132941.
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    27. Foureau DM, Walling TL, Maddukuri V, Anderson W, Culbreath K, Kleiner DE, Ahrens WA, Jacobs C, Watkins PB, Fontana RJ, Chalasani N, Talwalkar J, Lee WM, Stolz A, Serrano J, Bonkovsky HL. Comparative analysis of portal hepatic infiltrating leucocytes in acute drug-induced liver injury, idiopathic autoimmune and viral hepatitis. Clin Exp Immunol. 2015 Apr; 180(1):40-51. PMID: 25418487.
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    28. Bonkovsky HL. On stress and the liver: a chicken and egg conundrum. Gastroenterology. 2015 May; 148(5):894-7. PMID: 25805419.
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    29. Chalasani N, Bonkovsky HL, Fontana R, Lee W, Stolz A, Talwalkar J, Reddy KR, Watkins PB, Navarro V, Barnhart H, Gu J, Serrano J. Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study. Gastroenterology. 2015 Jun; 148(7):1340-52.e7. PMID: 25754159.
      View in: PubMed
    30. Vuppalanchi R, Navarro V, Vega M, Bonkovsky HL, Seeff L, Serrano J. Herbal dietary supplement associated hepatotoxicity: an upcoming workshop and need for research. Gastroenterology. 2015 Mar; 148(3):480-2. PMID: 25579757.
      View in: PubMed
    31. Seeff LB, Bonkovsky HL, Navarro VJ, Wang G. Herbal products and the liver: a review of adverse effects and mechanisms. Gastroenterology. 2015 Mar; 148(3):517-532.e3. PMID: 25500423.
      View in: PubMed
    32. Besur S, Hou W, Schmeltzer P, Bonkovsky HL. Clinically important features of porphyrin and heme metabolism and the porphyrias. Metabolites. 2014 Nov 03; 4(4):977-1006. PMID: 25372274.
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    33. Sendi H, Mehrab-Mohseni M, Foureau DM, Ghosh S, Walling TL, Steuerwald N, Zamor PJ, Kaplan KJ, Jacobs C, Ahrens WA, Russo MW, Clemens MG, Schrum LW, Bonkovsky HL. MiR-122 decreases HCV entry into hepatocytes through binding to the 3' UTR of OCLN mRNA. Liver Int. 2015 Apr; 35(4):1315-23. PMID: 25302477.
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    34. Ghaziani T, Sendi H, Shahraz S, Zamor P, Bonkovsky HL. Hepatitis B and liver transplantation: molecular and clinical features that influence recurrence and outcome. World J Gastroenterol. 2014 Oct 21; 20(39):14142-55. PMID: 25339803.
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    35. Yazici C, Mutlu E, Bonkovsky HL, Russo MW. Risk factors for severe or fatal drug-induced liver injury from amoxicillin-clavulanic acid. Hepatol Res. 2015 Jun; 45(6):676-82. PMID: 25163514.
      View in: PubMed
    36. Navarro VJ, Barnhart H, Bonkovsky HL, Davern T, Fontana RJ, Grant L, Reddy KR, Seeff LB, Serrano J, Sherker AH, Stolz A, Talwalkar J, Vega M, Vuppalanchi R. Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network. Hepatology. 2014 Oct; 60(4):1399-408. PMID: 25043597.
      View in: PubMed
    37. Bonkovsky HL, Maddukuri VC, Yazici C, Anderson KE, Bissell DM, Bloomer JR, Phillips JD, Naik H, Peter I, Baillargeon G, Bossi K, Gandolfo L, Light C, Bishop D, Desnick RJ. Acute porphyrias in the USA: features of 108 subjects from porphyrias consortium. Am J Med. 2014 Dec; 127(12):1233-41. PMID: 25016127.
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    38. Thapar M, Bonkovsky HL. Indications for liver transplant and AASLD guidelines. Hepatology. 2015 Jan; 61(1):408. PMID: 24752818.
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    39. Chalasani NP, Hayashi PH, Bonkovsky HL, Navarro VJ, Lee WM, Fontana RJ. ACG Clinical Guideline: the diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol. 2014 Jul; 109(7):950-66; quiz 967. PMID: 24935270.
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    40. deLemos AS, Foureau DM, Jacobs C, Ahrens W, Russo MW, Bonkovsky HL. Drug-induced liver injury with autoimmune features. Semin Liver Dis. 2014 May; 34(2):194-204. PMID: 24879983.
      View in: PubMed
    41. Russo MW, Hoofnagle JH, Gu J, Fontana RJ, Barnhart H, Kleiner DE, Chalasani N, Bonkovsky HL. Spectrum of statin hepatotoxicity: experience of the drug-induced liver injury network. Hepatology. 2014 Aug; 60(2):679-86. PMID: 24700436.
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    42. Li T, Eheim AL, Klein S, Uschner FE, Smith AC, Brandon-Warner E, Ghosh S, Bonkovsky HL, Trebicka J, Schrum LW. Novel role of nuclear receptor Rev-erba in hepatic stellate cell activation: potential therapeutic target for liver injury. Hepatology. 2014 Jun; 59(6):2383-96. PMID: 24497272.
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    43. Bonacini M, Ghabril M, Bonkovsky HL. Hepatotoxicity of anti-TNF agents. Dig Dis Sci. 2014 May; 59(5):1070-1. PMID: 24652111.
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    44. Steuerwald NM, Foureau DM, Norton HJ, Zhou J, Parsons JC, Chalasani N, Fontana RJ, Watkins PB, Lee WM, Reddy KR, Stolz A, Talwalkar J, Davern T, Saha D, Bell LN, Barnhart H, Gu J, Serrano J, Bonkovsky HL. Profiles of serum cytokines in acute drug-induced liver injury and their prognostic significance. PLoS One. 2013; 8(12):e81974. PMID: 24386086.
      View in: PubMed
    45. Kleiner DE, Chalasani NP, Lee WM, Fontana RJ, Bonkovsky HL, Watkins PB, Hayashi PH, Davern TJ, Navarro V, Reddy R, Talwalkar JA, Stolz A, Gu J, Barnhart H, Hoofnagle JH. Hepatic histological findings in suspected drug-induced liver injury: systematic evaluation and clinical associations. Hepatology. 2014 Feb; 59(2):661-70. PMID: 24037963.
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    46. Hou W, Bonkovsky HL. Non-coding RNAs in hepatitis C-induced hepatocellular carcinoma: dysregulation and implications for early detection, diagnosis and therapy. World J Gastroenterol. 2013 Nov 28; 19(44):7836-45. PMID: 24307777.
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    47. Lee JG, McKinney KQ, Mougeot JL, Bonkovsky HL, Hwang SI. Proteomic strategy for probing complementary lethality of kinase inhibitors against pancreatic cancer. Proteomics. 2013 Dec; 13(23-24):3554-62. PMID: 24167056.
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    48. Thapar M, Russo MW, Bonkovsky HL. Statins and liver injury. Gastroenterol Hepatol (N Y). 2013 Sep; 9(9):605-6. PMID: 24729773.
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    49. Russo MW, Narang T, Eskind L, Hayes D, Casingal V, Purdum PP, Hanson JS, Ahrens W, Norton J, Bonkovsky H. Intravenous interferon administered during liver transplantation is not effective in preventing hepatitis C reinfection. Dig Dis Sci. 2013 Oct; 58(10):3010-6. PMID: 23812862.
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    50. Larion S, Caballes FR, Hwang SI, Lee JG, Rossman WE, Parsons J, Steuerwald N, Li T, Maddukuri V, Groseclose G, Finkielstein CV, Bonkovsky HL. Circadian rhythms in acute intermittent porphyria--a pilot study. Eur J Clin Invest. 2013 Jul; 43(7):727-39. PMID: 23650938.
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    51. Balwani M, Doheny D, Bishop DF, Nazarenko I, Yasuda M, Dailey HA, Anderson KE, Bissell DM, Bloomer J, Bonkovsky HL, Phillips JD, Liu L, Desnick RJ. Loss-of-function ferrochelatase and gain-of-function erythroid-specific 5-aminolevulinate synthase mutations causing erythropoietic protoporphyria and x-linked protoporphyria in North American patients reveal novel mutations and a high prevalence of X-linked protoporphyria. Mol Med. 2013 Apr 30; 19:26-35. PMID: 23364466.
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    52. Navarro VJ, Bonkovsky HL, Hwang SI, Vega M, Barnhart H, Serrano J. Catechins in dietary supplements and hepatotoxicity. Dig Dis Sci. 2013 Sep; 58(9):2682-90. PMID: 23625293.
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    53. Maddukuri VC, Russo MW, Ahrens WA, Emerson SU, Engle RE, Purcell RH, Thompson EB, Bonkovsky HL. Chronic hepatitis E with neurologic manifestations and rapid progression of liver fibrosis in a liver transplant recipient. Dig Dis Sci. 2013 Aug; 58(8):2413-6. PMID: 23512404.
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    54. Bonkovsky HL, Hou W, Steuerwald N, Tian Q, Li T, Parsons J, Hamilton A, Hwang S, Schrum L. Heme status affects human hepatic messenger RNA and microRNA expression. World J Gastroenterol. 2013 Mar 14; 19(10):1593-601. PMID: 23538684.
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    55. Fontana RJ, Hayashi P, Bonkovsky HL, Kleiner DE, Kochhar S, Gu J, Ghabril M. Presentation and outcomes with clinically apparent interferon beta hepatotoxicity. Dig Dis Sci. 2013 Jun; 58(6):1766-75. PMID: 23377559.
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    56. Ghabril M, Bonkovsky HL, Kum C, Davern T, Hayashi PH, Kleiner DE, Serrano J, Rochon J, Fontana RJ, Bonacini M. Liver injury from tumor necrosis factor-a antagonists: analysis of thirty-four cases. Clin Gastroenterol Hepatol. 2013 May; 11(5):558-564.e3. PMID: 23333219.
      View in: PubMed
    57. Prokunina-Olsson L, Muchmore B, Tang W, Pfeiffer RM, Park H, Dickensheets H, Hergott D, Porter-Gill P, Mumy A, Kohaar I, Chen S, Brand N, Tarway M, Liu L, Sheikh F, Astemborski J, Bonkovsky HL, Edlin BR, Howell CD, Morgan TR, Thomas DL, Rehermann B, Donnelly RP, O'Brien TR. A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. Nat Genet. 2013 Feb; 45(2):164-71. PMID: 23291588.
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    58. Ghosh S, Kaplan KJ, Schrum LW, Bonkovsky HL. Cytoskeletal proteins: shaping progression of hepatitis C virus-induced liver disease. Int Rev Cell Mol Biol. 2013; 302:279-319. PMID: 23351713.
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    59. Bonkovsky HL, Guo JT, Hou W, Li T, Narang T, Thapar M. Porphyrin and heme metabolism and the porphyrias. Compr Physiol. 2013 Jan; 3(1):365-401. PMID: 23720291.
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    60. Bonkovsky HL. Risk factors for porphyria cutanea tarda -the iron/HFE connection. Liver Int. 2013 Jan; 33(1):162. PMID: 23121614.
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    61. Urban TJ, Shen Y, Stolz A, Chalasani N, Fontana RJ, Rochon J, Ge D, Shianna KV, Daly AK, Lucena MI, Nelson MR, Molokhia M, Aithal GP, Floratos A, Pe'er I, Serrano J, Bonkovsky H, Davern TJ, Lee WM, Navarro VJ, Talwalkar JA, Goldstein DB, Watkins PB. Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs. Pharmacogenet Genomics. 2012 Nov; 22(11):784-95. PMID: 22968431.
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    62. McKinney KQ, Lee JG, Sindram D, Russo MW, Han DK, Bonkovsky HL, Hwang SI. Identification of differentially expressed proteins from primary versus metastatic pancreatic cancer cells using subcellular proteomics. Cancer Genomics Proteomics. 2012 Sep-Oct; 9(5):257-63. PMID: 22990105.
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    63. Chalasani N, Vuppalanchi R, Navarro V, Fontana R, Bonkovsky H, Barnhart H, Kleiner DE, Hoofnagle JH. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. Ann Intern Med. 2012 Jun 19; 156(12):857-60, W297-300. PMID: 22711078.
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    64. Lakner AM, Steuerwald NM, Walling TL, Ghosh S, Li T, McKillop IH, Russo MW, Bonkovsky HL, Schrum LW. Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis. Hepatology. 2012 Jul; 56(1):300-10. PMID: 22278637.
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    65. Thapar M, Covault J, Hesselbrock V, Bonkovsky HL. DNA methylation patterns in alcoholics and family controls. World J Gastrointest Oncol. 2012 Jun 15; 4(6):138-44. PMID: 22737275.
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    66. Hou W, Tian Q, Steuerwald NM, Schrum LW, Bonkovsky HL. The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes. Biochim Biophys Acta. 2012 Nov-Dec; 1819(11-12):1113-22. PMID: 22698995.
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    67. Ryan Caballes F, Sendi H, Bonkovsky HL. Hepatitis C, porphyria cutanea tarda and liver iron: an update. Liver Int. 2012 Jul; 32(6):880-93. PMID: 22510500.
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    68. Wang G, Zhang L, Bonkovsky HL. Chinese medicine for treatment of chronic hepatitis B. Chin J Integr Med. 2012 Apr; 18(4):253-5. PMID: 22457135.
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    69. Bell LN, Vuppalanchi R, Watkins PB, Bonkovsky HL, Serrano J, Fontana RJ, Wang M, Rochon J, Chalasani N. Serum proteomic profiling in patients with drug-induced liver injury. Aliment Pharmacol Ther. 2012 Mar; 35(5):600-12. PMID: 22403816.
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    70. Ellefson WM, Lakner AM, Hamilton A, McKillop IH, Bonkovsky HL, Steuerwald NM, Huet YM, Schrum LW. Neonatal androgenization exacerbates alcohol-induced liver injury in adult rats, an effect abrogated by estrogen. PLoS One. 2011; 6(12):e29463. PMID: 22206017.
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    71. Morishima C, Di Bisceglie AM, Rothman AL, Bonkovsky HL, Lindsay KL, Lee WM, Koziel MJ, Fontana RJ, Kim HY, Wright EC. Antigen-specific T lymphocyte proliferation decreases over time in advanced chronic hepatitis C. J Viral Hepat. 2012 Jun; 19(6):404-13. PMID: 22571902.
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    72. Nguyen HT, Torian U, Faulk K, Mather K, Engle RE, Thompson E, Bonkovsky HL, Emerson SU. A naturally occurring human/hepatitis E recombinant virus predominates in serum but not in faeces of a chronic hepatitis E patient and has a growth advantage in cell culture. J Gen Virol. 2012 Mar; 93(Pt 3):526-30. PMID: 22113007.
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    73. Fontana RJ, Litman HJ, Dienstag JL, Bonkovsky HL, Su G, Sterling RK, Lok AS. YKL-40 genetic polymorphisms and the risk of liver disease progression in patients with advanced fibrosis due to chronic hepatitis C. Liver Int. 2012 Apr; 32(4):665-74. PMID: 22103814.
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    74. Lee YY, McKinney KQ, Ghosh S, Iannitti DA, Martinie JB, Caballes FR, Russo MW, Ahrens WA, Lundgren DH, Han DK, Bonkovsky HL, Hwang SI. Subcellular tissue proteomics of hepatocellular carcinoma for molecular signature discovery. J Proteome Res. 2011 Nov 04; 10(11):5070-83. PMID: 21913717.
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    75. Hwang SI, Lee YY, Park JO, Norton HJ, Clemens E, Schrum LW, Bonkovsky HL. Effects of a single dose of oral iron on hepcidin concentrations in human urine and serum analyzed by a robust LC-MS/MS method. Clin Chim Acta. 2011 Nov 20; 412(23-24):2241-7. PMID: 21867695.
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    76. O'Bryan JM, Potts JA, Bonkovsky HL, Mathew A, Rothman AL. Extended interferon-alpha therapy accelerates telomere length loss in human peripheral blood T lymphocytes. PLoS One. 2011; 6(8):e20922. PMID: 21829595.
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    77. Rakoski MO, Brown MB, Fontana RJ, Bonkovsky HL, Brunt EM, Goodman ZD, Lok AS, Omary MB. Mallory-Denk bodies are associated with outcomes and histologic features in patients with chronic hepatitis C. Clin Gastroenterol Hepatol. 2011 Oct; 9(10):902-909.e1. PMID: 21782771.
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    78. O'Brien TR, Everhart JE, Morgan TR, Lok AS, Chung RT, Shao Y, Shiffman ML, Dotrang M, Sninsky JJ, Bonkovsky HL, Pfeiffer RM. An IL28B genotype-based clinical prediction model for treatment of chronic hepatitis C. PLoS One. 2011; 6(7):e20904. PMID: 21760886.
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    79. Ghosh S, Ahrens WA, Phatak SU, Hwang S, Schrum LW, Bonkovsky HL. Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. J Viral Hepat. 2011 Oct; 18(10):e568-77. PMID: 21914078.
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    80. Panov A, Kubalik N, Zinchenko N, Hemendinger R, Dikalov S, Bonkovsky HL. Respiration and ROS production in brain and spinal cord mitochondria of transgenic rats with mutant G93a Cu/Zn-superoxide dismutase gene. Neurobiol Dis. 2011 Oct; 44(1):53-62. PMID: 21745570.
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    81. Dienstag JL, Ghany MG, Morgan TR, Di Bisceglie AM, Bonkovsky HL, Kim HY, Seeff LB, Szabo G, Wright EC, Sterling RK, Everson GT, Lindsay KL, Lee WM, Lok AS, Morishima C, Stoddard AM, Everhart JE. A prospective study of the rate of progression in compensated, histologically advanced chronic hepatitis C. Hepatology. 2011 Aug; 54(2):396-405. PMID: 21520194.
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    82. Tian Q, Li T, Hou W, Zheng J, Schrum LW, Bonkovsky HL. Lon peptidase 1 (LONP1)-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells. J Biol Chem. 2011 Jul 29; 286(30):26424-30. PMID: 21659532.
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    83. Lakner AM, Bonkovsky HL, Schrum LW. microRNAs: fad or future of liver disease. World J Gastroenterol. 2011 May 28; 17(20):2536-42. PMID: 21633658.
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    84. Mehrab-Mohseni M, Sendi H, Steuerwald N, Ghosh S, Schrum LW, Bonkovsky HL. Legalon-SIL downregulates HCV core and NS5A in human hepatocytes expressing full-length HCV. World J Gastroenterol. 2011 Apr 07; 17(13):1694-700. PMID: 21483629.
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    85. Di Bisceglie AM, Stoddard AM, Dienstag JL, Shiffman ML, Seeff LB, Bonkovsky HL, Morishima C, Wright EC, Snow KK, Lee WM, Fontana RJ, Morgan TR, Ghany MG. Excess mortality in patients with advanced chronic hepatitis C treated with long-term peginterferon. Hepatology. 2011 Apr; 53(4):1100-8. PMID: 21480316.
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    86. Li T, Bonkovsky HL, Guo JT. Structural analysis of heme proteins: implications for design and prediction. BMC Struct Biol. 2011 Mar 03; 11:13. PMID: 21371326.
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    87. Lambrecht RW, Sterling RK, Naishadham D, Stoddard AM, Rogers T, Morishima C, Morgan TR, Bonkovsky HL. Iron levels in hepatocytes and portal tract cells predict progression and outcomes of patients with advanced chronic hepatitis C. Gastroenterology. 2011 May; 140(5):1490-500.e3. PMID: 21335007.
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    88. Panov AV, Kubalik N, Zinchenko N, Ridings DM, Radoff DA, Hemendinger R, Brooks BR, Bonkovsky HL. Metabolic and functional differences between brain and spinal cord mitochondria underlie different predisposition to pathology. Am J Physiol Regul Integr Comp Physiol. 2011 Apr; 300(4):R844-54. PMID: 21248309.
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    89. Fontana RJ, Sanyal AJ, Ghany MG, Bonkovsky HL, Morgan TR, Litman HJ, Reid AE, Lee WM, Naishadham D. Development and progression of portal hypertensive gastropathy in patients with chronic hepatitis C. Am J Gastroenterol. 2011 May; 106(5):884-93. PMID: 21139575.
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    90. Lok AS, Everhart JE, Wright EC, Di Bisceglie AM, Kim HY, Sterling RK, Everson GT, Lindsay KL, Lee WM, Bonkovsky HL, Dienstag JL, Ghany MG, Morishima C, Morgan TR. Maintenance peginterferon therapy and other factors associated with hepatocellular carcinoma in patients with advanced hepatitis C. Gastroenterology. 2011 Mar; 140(3):840-9; quiz e12. PMID: 21129375.
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    91. Phatak P, Brissot P, Wurster M, Adams PC, Bonkovsky HL, Gross J, Malfertheiner P, McLaren GD, Niederau C, Piperno A, Powell LW, Russo MW, Stoelzel U, Stremmel W, Griffel L, Lynch N, Zhang Y, Pietrangelo A. A phase 1/2, dose-escalation trial of deferasirox for the treatment of iron overload in HFE-related hereditary hemochromatosis. Hepatology. 2010 Nov; 52(5):1671-779. PMID: 20814896.
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    92. Vuppalanchi R, Hayashi PH, Chalasani N, Fontana RJ, Bonkovsky H, Saxena R, Kleiner D, Hoofnagle JH. Duloxetine hepatotoxicity: a case-series from the drug-induced liver injury network. Aliment Pharmacol Ther. 2010 Nov; 32(9):1174-83. PMID: 20815829.
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    93. Steuerwald NM, Parsons JC, Bennett K, Bates TC, Bonkovsky HL. Parallel microRNA and mRNA expression profiling of (genotype 1b) human hepatoma cells expressing hepatitis C virus. Liver Int. 2010 Nov; 30(10):1490-504. PMID: 20825557.
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    94. Morgan TR, Ghany MG, Kim HY, Snow KK, Shiffman ML, De Santo JL, Lee WM, Di Bisceglie AM, Bonkovsky HL, Dienstag JL, Morishima C, Lindsay KL, Lok AS. Outcome of sustained virological responders with histologically advanced chronic hepatitis C. Hepatology. 2010 Sep; 52(3):833-44. PMID: 20564351.
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    95. McKinney KQ, Lee YY, Choi HS, Groseclose G, Iannitti DA, Martinie JB, Russo MW, Lundgren DH, Han DK, Bonkovsky HL, Hwang SI. Discovery of putative pancreatic cancer biomarkers using subcellular proteomics. J Proteomics. 2011 Jan 01; 74(1):79-88. PMID: 20807598.
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    96. Panov AV, Vavilin VA, Lyakhovich VV, Brooks BR, Bonkovsky HL. Effect of bovine serum albumin on mitochondrial respiration in the brain and liver of mice and rats. Bull Exp Biol Med. 2010 Aug; 149(2):187-90. PMID: 21113488.
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    97. Fontana RJ, Dienstag JL, Bonkovsky HL, Sterling RK, Naishadham D, Goodman ZD, Lok AS, Wright EC, Su GL. Serum fibrosis markers are associated with liver disease progression in non-responder patients with chronic hepatitis C. Gut. 2010 Oct; 59(10):1401-9. PMID: 20675691.
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    98. Bonkovsky HL, Lambrecht RW, Naishadham D. Genetic variations in heme oxygenase-1 and chronic hepatitis. Hepatology. 2010 Jul; 52(1):400-1. PMID: 20232486.
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    99. Hou W, Tian Q, Zheng J, Bonkovsky HL. MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins. Hepatology. 2010 May; 51(5):1494-504. PMID: 20127796.
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    100. Seeff LB, Everson GT, Morgan TR, Curto TM, Lee WM, Ghany MG, Shiffman ML, Fontana RJ, Di Bisceglie AM, Bonkovsky HL, Dienstag JL. Complication rate of percutaneous liver biopsies among persons with advanced chronic liver disease in the HALT-C trial. Clin Gastroenterol Hepatol. 2010 Oct; 8(10):877-83. PMID: 20362695.
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    101. Pierucci-Lagha A, Covault J, Bonkovsky HL, Feinn R, Abreu C, Sterling RK, Fontana RJ, Kranzler HR. A functional serotonin transporter gene polymorphism and depressive effects associated with interferon-alpha treatment. Psychosomatics. 2010 Mar-Apr; 51(2):137-48. PMID: 20332289.
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    102. Zhang L, Wang G, Hou W, Li P, Dulin A, Bonkovsky HL. Contemporary clinical research of traditional Chinese medicines for chronic hepatitis B in China: an analytical review. Hepatology. 2010 Feb; 51(2):690-8. PMID: 20101751.
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    103. Everhart JE, Wright EC, Goodman ZD, Dienstag JL, Hoefs JC, Kleiner DE, Ghany MG, Mills AS, Nash SR, Govindarajan S, Rogers TE, Greenson JK, Brunt EM, Bonkovsky HL, Morishima C, Litman HJ. Prognostic value of Ishak fibrosis stage: findings from the hepatitis C antiviral long-term treatment against cirrhosis trial. Hepatology. 2010 Feb; 51(2):585-94. PMID: 20101752.
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    104. Snow KK, Bonkovsky HL, Fontana RJ, Kim HY, Sterling RK, Di Bisceglie AM, Morgan TR, Dienstag JL, Ghany MG. Changes in quality of life and sexual health are associated with low-dose peginterferon therapy and disease progression in patients with chronic hepatitis C. Aliment Pharmacol Ther. 2010 Apr; 31(7):719-34. PMID: 20070284.
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    105. Goodman ZD, Stoddard AM, Bonkovsky HL, Fontana RJ, Ghany MG, Morgan TR, Wright EC, Brunt EM, Kleiner DE, Shiffman ML, Everson GT, Lindsay KL, Dienstag JL, Morishima C. Fibrosis progression in chronic hepatitis C: morphometric image analysis in the HALT-C trial. Hepatology. 2009 Dec; 50(6):1738-49. PMID: 19824074.
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    106. Rustgi VK, Lee WM, Lawitz E, Gordon SC, Afdhal N, Poordad F, Bonkovsky HL, Bengtsson L, Chandorkar G, Harding M, McNair L, Aalyson M, Alam J, Kauffman R, Gharakhanian S, McHutchison JG. Merimepodib, pegylated interferon, and ribavirin in genotype 1 chronic hepatitis C pegylated interferon and ribavirin nonresponders. Hepatology. 2009 Dec; 50(6):1719-26. PMID: 19852040.
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    107. Hou W, Tian Q, Zheng J, Bonkovsky HL. Zinc mesoporphyrin induces rapid proteasomal degradation of hepatitis C nonstructural 5A protein in human hepatoma cells. Gastroenterology. 2010 May; 138(5):1909-19. PMID: 19909748.
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    108. Freedman ND, Everhart JE, Lindsay KL, Ghany MG, Curto TM, Shiffman ML, Lee WM, Lok AS, Di Bisceglie AM, Bonkovsky HL, Hoefs JC, Dienstag JL, Morishima C, Abnet CC, Sinha R. Coffee intake is associated with lower rates of liver disease progression in chronic hepatitis C. Hepatology. 2009 Nov; 50(5):1360-9. PMID: 19676128.
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    109. Lok AS, Sterling RK, Everhart JE, Wright EC, Hoefs JC, Di Bisceglie AM, Morgan TR, Kim HY, Lee WM, Bonkovsky HL, Dienstag JL. Des-gamma-carboxy prothrombin and alpha-fetoprotein as biomarkers for the early detection of hepatocellular carcinoma. Gastroenterology. 2010 Feb; 138(2):493-502. PMID: 19852963.
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    110. Russo MW, Scobey M, Bonkovsky HL. Drug-induced liver injury associated with statins. Semin Liver Dis. 2009 Nov; 29(4):412-22. PMID: 19826975.
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    111. Hou WH, Rossi L, Shan Y, Zheng JY, Lambrecht RW, Bonkovsky HL. Iron increases HMOX1 and decreases hepatitis C viral expression in HCV-expressing cells. World J Gastroenterol. 2009 Sep 28; 15(36):4499-510. PMID: 19777608.
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    112. Ghany MG, Lok AS, Everhart JE, Everson GT, Lee WM, Curto TM, Wright EC, Stoddard AM, Sterling RK, Di Bisceglie AM, Bonkovsky HL, Morishima C, Morgan TR, Dienstag JL. Predicting clinical and histologic outcomes based on standard laboratory tests in advanced chronic hepatitis C. Gastroenterology. 2010 Jan; 138(1):136-46. PMID: 19766643.
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    113. Sendi H, Mehrab-Mohseni M, Shahraz S, Norder H, Alavian SM, Noorinayer B, Zali MR, Pumpens P, Bonkovsky HL, Magnius LO. CTL escape mutations of core protein are more frequent in strains of HBeAg negative patients with low levels of HBV DNA. J Clin Virol. 2009 Nov; 46(3):259-64. PMID: 19748824.
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    114. Shiffman ML, Morishima C, Dienstag JL, Lindsay KL, Hoefs JC, Lee WM, Wright EC, Naishadham D, Everson GT, Lok AS, Di Bisceglie AM, Bonkovsky HL, Ghany MG. Effect of HCV RNA suppression during peginterferon alfa-2a maintenance therapy on clinical outcomes in the HALT-C trial. Gastroenterology. 2009 Dec; 137(6):1986-94. PMID: 19747918.
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    115. Lok AS, Everhart JE, Chung RT, Kim HY, Everson GT, Hoefs JC, Greenson JK, Sterling RK, Lindsay KL, Lee WM, Di Bisceglie AM, Bonkovsky HL, Ghany MG, Morishima C. Evolution of hepatic steatosis in patients with advanced hepatitis C: results from the hepatitis C antiviral long-term treatment against cirrhosis (HALT-C) trial. Hepatology. 2009 Jun; 49(6):1828-37. PMID: 19291787.
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    116. Welzel TM, Morgan TR, Bonkovsky HL, Naishadham D, Pfeiffer RM, Wright EC, Hutchinson AA, Crenshaw AT, Bashirova A, Carrington M, Dotrang M, Sterling RK, Lindsay KL, Fontana RJ, Lee WM, Di Bisceglie AM, Ghany MG, Gretch DR, Chanock SJ, Chung RT, O'Brien TR. Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial. Hepatology. 2009 Jun; 49(6):1847-58. PMID: 19434718.
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    117. Everhart JE, Lok AS, Kim HY, Morgan TR, Lindsay KL, Chung RT, Bonkovsky HL, Ghany MG. Weight-related effects on disease progression in the hepatitis C antiviral long-term treatment against cirrhosis trial. Gastroenterology. 2009 Aug; 137(2):549-57. PMID: 19445938.
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    118. Panov A, Schonfeld P, Dikalov S, Hemendinger R, Bonkovsky HL, Brooks BR. The neuromediator glutamate, through specific substrate interactions, enhances mitochondrial ATP production and reactive oxygen species generation in nonsynaptic brain mitochondria. J Biol Chem. 2009 May 22; 284(21):14448-56. PMID: 19304986.
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    119. Fontana RJ, Watkins PB, Bonkovsky HL, Chalasani N, Davern T, Serrano J, Rochon J. Drug-Induced Liver Injury Network (DILIN) prospective study: rationale, design and conduct. Drug Saf. 2009; 32(1):55-68. PMID: 19132805.
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    120. Di Bisceglie AM, Shiffman ML, Everson GT, Lindsay KL, Everhart JE, Wright EC, Lee WM, Lok AS, Bonkovsky HL, Morgan TR, Ghany MG, Morishima C, Snow KK, Dienstag JL. Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon. N Engl J Med. 2008 Dec 04; 359(23):2429-41. PMID: 19052125.
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    121. Fontana RJ, Bonkovsky HL, Naishadham D, Dienstag JL, Sterling RK, Lok AS, Su GL. Serum fibrosis marker levels decrease after successful antiviral treatment in chronic hepatitis C patients with advanced fibrosis. Clin Gastroenterol Hepatol. 2009 Feb; 7(2):219-26. PMID: 19068241.
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    122. Lok AS, Seeff LB, Morgan TR, di Bisceglie AM, Sterling RK, Curto TM, Everson GT, Lindsay KL, Lee WM, Bonkovsky HL, Dienstag JL, Ghany MG, Morishima C, Goodman ZD. Incidence of hepatocellular carcinoma and associated risk factors in hepatitis C-related advanced liver disease. Gastroenterology. 2009 Jan; 136(1):138-48. PMID: 18848939.
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    123. Chalasani N, Fontana RJ, Bonkovsky HL, Watkins PB, Davern T, Serrano J, Yang H, Rochon J. Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. Gastroenterology. 2008 Dec; 135(6):1924-34, 1934.e1-4. PMID: 18955056.
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    124. Zheng J, Shan Y, Lambrecht RW, Donohue SE, Bonkovsky HL. Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin. Mol Cell Biochem. 2008 Dec; 319(1-2):153-61. PMID: 18719978.
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    125. Phatak PD, Bonkovsky HL, Kowdley KV. Hereditary hemochromatosis: time for targeted screening. Ann Intern Med. 2008 Aug 19; 149(4):270-2. PMID: 18711158.
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    126. Bonifaz V, Shan Y, Lambrecht RW, Donohue SE, Moschenross D, Bonkovsky HL. Effects of silymarin on hepatitis C virus and haem oxygenase-1 gene expression in human hepatoma cells. Liver Int. 2009 Mar; 29(3):366-73. PMID: 18694403.
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    127. Bonkovsky HL, Tice AD, Yapp RG, Bodenheimer HC, Monto A, Rossi SJ, Sulkowski MS. Efficacy and safety of peginterferon alfa-2a/ribavirin in methadone maintenance patients: randomized comparison of direct observed therapy and self-administration. Am J Gastroenterol. 2008 Nov; 103(11):2757-65. PMID: 18684176.
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    128. Thapar M, Bonkovsky HL. The diagnosis and management of erythropoietic protoporphyria. Gastroenterol Hepatol (N Y). 2008 Aug; 4(8):561-6. PMID: 21960936.
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    129. Bonkovsky HL, Siao P, Roig Z, Hedley-Whyte ET, Flotte TJ. Case records of the Massachusetts General Hospital. Case 20-2008. A 57-year-old woman with abdominal pain and weakness after gastric bypass surgery. N Engl J Med. 2008 Jun 26; 358(26):2813-25. PMID: 18579817.
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    130. Morgan TR, Lambrecht RW, Bonkovsky HL, Chung RT, Naishadham D, Sterling RK, Fontana RJ, Lee WM, Ghany MG, Wright EC, O'Brien TR. DNA polymorphisms and response to treatment in patients with chronic hepatitis C: results from the HALT-C trial. J Hepatol. 2008 Oct; 49(4):548-56. PMID: 18619701.
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    131. Zheng J, Tian Q, Hou W, Watts JA, Schrum LW, Bonkovsky HL. Tissue-specific expression of ALA synthase-1 and heme oxygenase-1 and their expression in livers of rats chronically exposed to ethanol. FEBS Lett. 2008 Jun 11; 582(13):1829-34. PMID: 18472004.
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    132. Fontana RJ, Goodman ZD, Dienstag JL, Bonkovsky HL, Naishadham D, Sterling RK, Su GL, Ghosh M, Wright EC. Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis C. Hepatology. 2008 Mar; 47(3):789-98. PMID: 18175357.
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    133. Hou W, Shan Y, Zheng J, Lambrecht RW, Donohue SE, Bonkovsky HL. Zinc mesoporphyrin induces rapid and marked degradation of the transcription factor Bach1 and up-regulates HO-1. Biochim Biophys Acta. 2008 Mar; 1779(3):195-203. PMID: 18325350.
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    134. Venkataraman K, Lee YM, Michaud J, Thangada S, Ai Y, Bonkovsky HL, Parikh NS, Habrukowich C, Hla T. Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. Circ Res. 2008 Mar 28; 102(6):669-76. PMID: 18258856.
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    135. Lindsay KL, Morishima C, Wright EC, Dienstag JL, Shiffman ML, Everson GT, Lok AS, Bonkovsky HL, Lee WM, Morgan TR, Ghany MG. Blunted cytopenias and weight loss: new correlates of virologic null response to re-treatment of chronic hepatitis C. Clin Gastroenterol Hepatol. 2008 Feb; 6(2):234-41. PMID: 18237873.
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    136. Seeff LB, Curto TM, Szabo G, Everson GT, Bonkovsky HL, Dienstag JL, Shiffman ML, Lindsay KL, Lok AS, Di Bisceglie AM, Lee WM, Ghany MG. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Hepatology. 2008 Feb; 47(2):605-12. PMID: 18157835.
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    137. Desai TK, Jamil LH, Balasubramaniam M, Koff R, Bonkovsky HL. Phlebotomy improves therapeutic response to interferon in patients with chronic hepatitis C: a meta-analysis of six prospective randomized controlled trials. Dig Dis Sci. 2008 Mar; 53(3):815-22. PMID: 17846887.
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    138. Shan Y, Zheng J, Lambrecht RW, Bonkovsky HL. Reciprocal effects of micro-RNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytes. Gastroenterology. 2007 Oct; 133(4):1166-74. PMID: 17919492.
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    139. Sjogren MH, Sjogren R, Lyons MF, Ryan M, Santoro J, Smith C, Reddy KR, Bonkovsky H, Huntley B, Faris-Young S. Antiviral response of HCV genotype 1 to consensus interferon and ribavirin versus pegylated interferon and ribavirin. Dig Dis Sci. 2007 Jun; 52(6):1540-7. PMID: 17406822.
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    140. Ghaziani T, Alavian SM, Zali MR, Shahraz S, Agah M, Jensen KP, Ansari S, Sendi H, Lambrecht RW, Covault J, Bonkovsky HL. Serum measures of iron status and HFE gene mutations in patients with hepatitis B virus infection. Hepatol Res. 2007 Mar; 37(3):172-8. PMID: 17362299.
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    141. Immenschuh S, Shan Y, Kroll H, Santoso S, Wössmann W, Bein G, Bonkovsky HL. Marked hyperbilirubinemia associated with the heme oxygenase-1 gene promoter microsatellite polymorphism in a boy with autoimmune hemolytic anemia. Pediatrics. 2007 Mar; 119(3):e764-7. PMID: 17325212.
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    142. Lambrecht RW, Thapar M, Bonkovsky HL. Genetic aspects of porphyria cutanea tarda. Semin Liver Dis. 2007 Feb; 27(1):99-108. PMID: 17295179.
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    143. Lok AS, Everhart JE, Chung RT, Padmanabhan L, Greenson JK, Shiffman ML, Everson GT, Lindsay KL, Bonkovsky HL, Di Bisceglie AM, Lee WM, Morgan TR, Ghany MG, Morishima C. Hepatic steatosis in hepatitis C: comparison of diabetic and nondiabetic patients in the hepatitis C antiviral long-term treatment against cirrhosis trial. Clin Gastroenterol Hepatol. 2007 Feb; 5(2):245-54. PMID: 17296533.
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    144. Everson GT, Hoefs JC, Seeff LB, Bonkovsky HL, Naishadham D, Shiffman ML, Kahn JA, Lok AS, Di Bisceglie AM, Lee WM, Dienstag JL, Ghany MG, Morishima C. Impact of disease severity on outcome of antiviral therapy for chronic hepatitis C: Lessons from the HALT-C trial. Hepatology. 2006 Dec; 44(6):1675-84. PMID: 17133499.
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    145. Bonkovsky HL, Snow KK, Malet PF, Back-Madruga C, Fontana RJ, Sterling RK, Kulig CC, Di Bisceglie AM, Morgan TR, Dienstag JL, Ghany MG, Gretch DR. Health-related quality of life in patients with chronic hepatitis C and advanced fibrosis. J Hepatol. 2007 Mar; 46(3):420-31. PMID: 17196293.
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    146. Shiffman ML, Ghany MG, Morgan TR, Wright EC, Everson GT, Lindsay KL, Lok AS, Bonkovsky HL, Di Bisceglie AM, Lee WM, Dienstag JL, Gretch DR. Impact of reducing peginterferon alfa-2a and ribavirin dose during retreatment in patients with chronic hepatitis C. Gastroenterology. 2007 Jan; 132(1):103-12. PMID: 17241864.
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    147. Shan Y, Lambrecht RW, Donohue SE, Bonkovsky HL. Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin. FASEB J. 2006 Dec; 20(14):2651-3. PMID: 17065227.
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    148. Alla V, Abraham J, Siddiqui J, Raina D, Wu GY, Chalasani NP, Bonkovsky HL. Autoimmune hepatitis triggered by statins. J Clin Gastroenterol. 2006 Sep; 40(8):757-61. PMID: 16940892.
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    149. Bonkovsky HL, Naishadham D, Lambrecht RW, Chung RT, Hoefs JC, Nash SR, Rogers TE, Banner BF, Sterling RK, Donovan JA, Fontana RJ, Di Bisceglie AM, Ghany MG, Morishima C. Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C. Gastroenterology. 2006 Nov; 131(5):1440-51. PMID: 17101320.
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    150. Morishima C, Morgan TR, Everhart JE, Wright EC, Shiffman ML, Everson GT, Lindsay KL, Lok AS, Bonkovsky HL, Di Bisceglie AM, Lee WM, Dienstag JL, Ghany MG, Gretch DR. HCV RNA detection by TMA during the hepatitis C antiviral long-term treatment against cirrhosis (Halt-C) trial. Hepatology. 2006 Aug; 44(2):360-7. PMID: 16871570.
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    151. Javaid A, Bonkovsky HL. Hepatotoxicity due to extracts of Chinese green tea (Camellia sinensis): a growing concern. J Hepatol. 2006 Aug; 45(2):334-5; author reply 335-6. PMID: 16793166.
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    152. Anderson KE, Bonkovsky HL, Bloomer JR, Shedlofsky SI. Reconstitution of hematin for intravenous infusion. Ann Intern Med. 2006 Apr 04; 144(7):537-8. PMID: 16585674.
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    153. Morishima C, Polyak SJ, Ray R, Doherty MC, Di Bisceglie AM, Malet PF, Bonkovsky HL, Sullivan DG, Gretch DR, Rothman AL, Koziel MJ, Lindsay KL. Hepatitis C virus-specific immune responses and quasi-species variability at baseline are associated with nonresponse to antiviral therapy during advanced hepatitis C. J Infect Dis. 2006 Apr 01; 193(7):931-40. PMID: 16518754.
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    154. Ghaziani T, Shan Y, Lambrecht RW, Donohue SE, Pietschmann T, Bartenschlager R, Bonkovsky HL. HCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells. J Hepatol. 2006 Jul; 45(1):5-12. PMID: 16530877.
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    155. Bonkovsky HL. Hepatotoxicity associated with supplements containing Chinese green tea (Camellia sinensis). Ann Intern Med. 2006 Jan 03; 144(1):68-71. PMID: 16389263.
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    156. McGuire BM, Bonkovsky HL, Carithers RL, Chung RT, Goldstein LI, Lake JR, Lok AS, Potter CJ, Rand E, Voigt MD, Davis PR, Bloomer JR. Liver transplantation for erythropoietic protoporphyria liver disease. Liver Transpl. 2005 Dec; 11(12):1590-6. PMID: 16315313.
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    157. Kolluri S, Sadlon TJ, May BK, Bonkovsky HL. Haem repression of the housekeeping 5-aminolaevulinic acid synthase gene in the hepatoma cell line LMH. Biochem J. 2005 Nov 15; 392(Pt 1):173-80. PMID: 16033334.
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    158. Alla V, Bonkovsky HL. Iron in nonhemochromatotic liver disorders. Semin Liver Dis. 2005 Nov; 25(4):461-72. PMID: 16315139.
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    159. Bonkovsky HL, Salek J. No role of the -2518 promoter polymorphism of monocyte chemotactic protein-1 in chronic hepatitis C. Gastroenterology. 2005 Oct; 129(4):1361-2. PMID: 16230097.
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    160. Di Bisceglie AM, Sterling RK, Chung RT, Everhart JE, Dienstag JL, Bonkovsky HL, Wright EC, Everson GT, Lindsay KL, Lok AS, Lee WM, Morgan TR, Ghany MG, Gretch DR. Serum alpha-fetoprotein levels in patients with advanced hepatitis C: results from the HALT-C Trial. J Hepatol. 2005 Sep; 43(3):434-41. PMID: 16136646.
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    161. Lok AS, Ghany MG, Goodman ZD, Wright EC, Everson GT, Sterling RK, Everhart JE, Lindsay KL, Bonkovsky HL, Di Bisceglie AM, Lee WM, Morgan TR, Dienstag JL, Morishima C. Predicting cirrhosis in patients with hepatitis C based on standard laboratory tests: results of the HALT-C cohort. Hepatology. 2005 Aug; 42(2):282-92. PMID: 15986415.
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    162. Polyak SJ, Sullivan DG, Austin MA, Dai JY, Shuhart MC, Lindsay KL, Bonkovsky HL, Di Bisceglie AM, Lee WM, Morishima C, Gretch DR. Comparison of amplification enzymes for Hepatitis C Virus quasispecies analysis. Virol J. 2005 Apr 22; 2:41. PMID: 15847697.
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    163. Anderson KE, Bloomer JR, Bonkovsky HL, Kushner JP, Pierach CA, Pimstone NR, Desnick RJ. Recommendations for the diagnosis and treatment of the acute porphyrias. Ann Intern Med. 2005 Mar 15; 142(6):439-50. PMID: 15767622.
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    164. Rothman AL, Morishima C, Bonkovsky HL, Polyak SJ, Ray R, Di Bisceglie AM, Lindsay KL, Malet PF, Chang M, Gretch DR, Sullivan DG, Bhan AK, Wright EC, Koziel MJ. Associations among clinical, immunological, and viral quasispecies measurements in advanced chronic hepatitis C. Hepatology. 2005 Mar; 41(3):617-25. PMID: 15726656.
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    165. Shan Y, Lambrecht RW, Bonkovsky HL. Association of hepatitis C virus infection with serum iron status: analysis of data from the third National Health and Nutrition Examination Survey. Clin Infect Dis. 2005 Mar 15; 40(6):834-41. PMID: 15736017.
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    166. Giuggio VM, Bonkovsky HL, Rothman AL. Evolution of the intrahepatic T cell repertoire during chronic hepatitis C virus infection. Viral Immunol. 2005; 18(1):179-89. PMID: 15802962.
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    167. Siddiqui J, Jaffe PE, Aziz K, Forouhar F, Sheppard R, Covault J, Bonkovsky HL. Fatal air and bile embolism after percutaneous liver biopsy and ERCP. Gastrointest Endosc. 2005 Jan; 61(1):153-7. PMID: 15672079.
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    168. Bonkovsky HL. Neurovisceral porphyrias: what a hematologist needs to know. Hematology Am Soc Hematol Educ Program. 2005; 24-30. PMID: 16304355.
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    169. Sendi H, Ghaziani T, Zali MR, Adibi P, Agah M, Jazayeri M, Shahraz S, Magnius L, Bonkovsky HL. Hemochromatosis mutations in Iranians with hepatitis B virus infection. Clin Infect Dis. 2005 Feb 01; 40(3):e19-21. PMID: 15668853.
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    170. Chemmanur AT, Bonkovsky HL. Hepatic porphyrias: diagnosis and management. Clin Liver Dis. 2004 Nov; 8(4):807-38, viii. PMID: 15464657.
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    171. Lee WM, Dienstag JL, Lindsay KL, Lok AS, Bonkovsky HL, Shiffman ML, Everson GT, Di Bisceglie AM, Morgan TR, Ghany MG, Morishima C, Wright EC, Everhart JE. Evolution of the HALT-C Trial: pegylated interferon as maintenance therapy for chronic hepatitis C in previous interferon nonresponders. Control Clin Trials. 2004 Oct; 25(5):472-92. PMID: 15465617.
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    172. Shan Y, Lambrecht RW, Ghaziani T, Donohue SE, Bonkovsky HL. Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS. J Biol Chem. 2004 Dec 10; 279(50):51769-74. PMID: 15465821.
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    173. Shan Y, Lambrecht RW, Bonkovsky HL. Identification of key elements that are responsible for heme-mediated induction of the avian heme oxygenase-1 gene. Biochim Biophys Acta. 2004 Aug 12; 1679(2):87-94. PMID: 15297142.
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    174. Shiffman ML, Di Bisceglie AM, Lindsay KL, Morishima C, Wright EC, Everson GT, Lok AS, Morgan TR, Bonkovsky HL, Lee WM, Dienstag JL, Ghany MG, Goodman ZD, Everhart JE. Peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior treatment. Gastroenterology. 2004 Apr; 126(4):1015-23; discussion 947. PMID: 15057741.
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    175. Fernandez M, Bonkovsky HL. Vascular endothelial growth factor increases heme oxygenase-1 protein expression in the chick embryo chorioallantoic membrane. Br J Pharmacol. 2003 Jun; 139(3):634-40. PMID: 12788823.
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    176. Bonkovsky HL, Lambrecht RW, Shan Y. Iron as a co-morbid factor in nonhemochromatotic liver disease. Alcohol. 2003 Jun; 30(2):137-44. PMID: 12957298.
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    177. Bonkovsky HL. Optimal management of nonalcoholic fatty liver/steatohepatitis. J Clin Gastroenterol. 2003 Mar; 36(3):193-5. PMID: 12590226.
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    178. Bonkovsky HL, Troy N, McNeal K, Banner BF, Sharma A, Obando J, Mehta S, Koff RS, Liu Q, Hsieh CC. Iron and HFE or TfR1 mutations as comorbid factors for development and progression of chronic hepatitis C. J Hepatol. 2002 Dec; 37(6):848-54. PMID: 12445428.
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    179. Agrawal S, Bonkovsky HL. Management of nonalcoholic steatohepatitis: an analytic review. J Clin Gastroenterol. 2002 Sep; 35(3):253-61. PMID: 12192203.
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    180. Bonkovsky HL, Azar R, Bird S, Szabo G, Banner B. Severe cholestatic hepatitis caused by thiazolidinediones: risks associated with substituting rosiglitazone for troglitazone. Dig Dis Sci. 2002 Jul; 47(7):1632-7. PMID: 12141828.
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    181. Rolfs A, Bonkovsky HL, Kohlroser JG, McNeal K, Sharma A, Berger UV, Hediger MA. Intestinal expression of genes involved in iron absorption in humans. Am J Physiol Gastrointest Liver Physiol. 2002 Apr; 282(4):G598-607. PMID: 11897618.
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    182. Lambrecht RW, Bonkovsky HL. Hemochromatosis and porphyria. Semin Gastrointest Dis. 2002 Apr; 13(2):109-19. PMID: 12064861.
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    183. Shan Y, Pepe J, Lambrecht RW, Bonkovsky HL. Mapping of the chick heme oxygenase-1 proximal promoter for responsiveness to metalloporphyrins. Arch Biochem Biophys. 2002 Mar 15; 399(2):159-66. PMID: 11888201.
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    184. Do KD, Banner BF, Katz E, Szymanski IO, Bonkovsky HL. Benefits of chronic plasmapheresis and intravenous heme-albumin in erythropoietic protoporphyria after orthotopic liver transplantation. Transplantation. 2002 Feb 15; 73(3):469-72. PMID: 11884947.
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    185. Bonkovsky HL. Iron as a comorbid factor in chronic viral hepatitis. Am J Gastroenterol. 2002 Jan; 97(1):1-4. PMID: 11808931.
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    186. Tian W, Bonkovsky HL, Shibahara S, Cohen DM. Urea and hypertonicity increase expression of heme oxygenase-1 in murine renal medullary cells. Am J Physiol Renal Physiol. 2001 Nov; 281(5):F983-91. PMID: 11592956.
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    187. Mehta S, Levey JM, Bonkovsky HL. Extrahepatic manifestations of infection with hepatitis C virus. Clin Liver Dis. 2001 Nov; 5(4):979-1008. PMID: 11685805.
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    188. Gildemeister OS, Pepe JA, Lambrecht RW, Bonkovsky HL. Induction of heme oxygenase-1 by phenylarsine oxide. Studies in cultured primary liver cells. Mol Cell Biochem. 2001 Oct; 226(1-2):17-26. PMID: 11768235.
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    189. Bonkovsky HL, Stefancyk D, McNeal K, Banner BF, Liu Q, Zucker GM, Israel J, Stagias J, Colker J. Comparative effects of different doses of ribavirin plus interferon-alpha2b for therapy of chronic hepatitis C: results of a controlled, randomized trial. Dig Dis Sci. 2001 Oct; 46(10):2051-9. PMID: 11680575.
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    190. Fernandez M, Lambrecht RW, Bonkovsky HL. Increased heme oxygenase activity in splanchnic organs from portal hypertensive rats: role in modulating mesenteric vascular reactivity. J Hepatol. 2001 Jun; 34(6):812-7. PMID: 11451163.
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    191. Bonkovsky HL, Mehta S. Hepatitis C: a review and update. J Am Acad Dermatol. 2001 Feb; 44(2):159-82. PMID: 11174373.
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    192. Banner BF, Savas L, Zivny J, Tortorelli K, Bonkovsky HL. Ubiquitin as a marker of cell injury in nonalcoholic steatohepatitis. Am J Clin Pathol. 2000 Dec; 114(6):860-6. PMID: 11338474.
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    193. Bonkovsky HL, Davidoff A, Stark DD. Hepatic iron concentration and total body iron stores in thalassemia major. N Engl J Med. 2000 Nov 30; 343(22):1656; author reply 1657. PMID: 11184988.
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    194. Szabo G, Katz E, Bonkovsky HL. Management of recurrent hepatitis C after liver transplantation: a concise review. Am J Gastroenterol. 2000 Sep; 95(9):2164-70. PMID: 11007212.
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    195. Childs S, Weinstein BM, Mohideen MA, Donohue S, Bonkovsky H, Fishman MC. Zebrafish dracula encodes ferrochelatase and its mutation provides a model for erythropoietic protoporphyria. Curr Biol. 2000 Aug 24; 10(16):1001-4. PMID: 10985389.
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    196. Shan Y, Pepe J, Lu TH, Elbirt KK, Lambrecht RW, Bonkovsky HL. Induction of the heme oxygenase-1 gene by metalloporphyrins. Arch Biochem Biophys. 2000 Aug 15; 380(2):219-27. PMID: 10933875.
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    197. Bonkovsky HL, Woolley JM. Outcomes research in chronic viral hepatitis C: effects of interferon therapy. Can J Gastroenterol. 2000 Jul-Aug; 14 Suppl B:21B-29B. PMID: 10938501.
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    198. Di Bisceglie AM, Bonkovsky HL, Chopra S, Flamm S, Reddy RK, Grace N, Killenberg P, Hunt C, Tamburro C, Tavill AS, Ferguson R, Krawitt E, Banner B, Bacon BR. Iron reduction as an adjuvant to interferon therapy in patients with chronic hepatitis C who have previously not responded to interferon: a multicenter, prospective, randomized, controlled trial. Hepatology. 2000 Jul; 32(1):135-8. PMID: 10869301.
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    199. Lu TH, Shan Y, Pepe J, Lambrecht RW, Bonkovsky HL. Upstream regulatory elements in chick heme oxygenase-1 promoter: a study in primary cultures of chick embryo liver cells. Mol Cell Biochem. 2000 Jun; 209(1-2):17-27. PMID: 10942197.
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    200. Bonkovsky HL, Lambrecht RW. Iron-induced liver injury. Clin Liver Dis. 2000 May; 4(2):409-29, vi-vii. PMID: 11232198.
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    201. Fontana RJ, Israel J, LeClair P, Banner BF, Tortorelli K, Grace N, Levine RA, Fiarman G, Thiim M, Tavill AS, Bonkovsky HL. Iron reduction before and during interferon therapy of chronic hepatitis C: results of a multicenter, randomized, controlled trial. Hepatology. 2000 Mar; 31(3):730-6. PMID: 10706565.
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    202. Kohlroser J, Mathai J, Reichheld J, Banner BF, Bonkovsky HL. Hepatotoxicity due to troglitazone: report of two cases and review of adverse events reported to the United States Food and Drug Administration. Am J Gastroenterol. 2000 Jan; 95(1):272-6. PMID: 10638596.
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    203. Shan Y, Lambrecht RW, Hong Lu T, Bonkovsky HL. Effects of phenylarsine oxide on expression of heme oxygenase-1 reporter constructs in transiently transfected cultures of chick embryo liver cells. Arch Biochem Biophys. 1999 Dec 15; 372(2):224-9. PMID: 10600159.
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    204. Lambrecht RW, Gildemeister OS, Pepe JA, Tortorelli KD, Williams A, Bonkovsky HL. Effects of antidepressants and benzodiazepine-type anxiolytic agents on hepatic porphyrin accumulation in primary cultures of chick embryo liver cells. J Pharmacol Exp Ther. 1999 Dec; 291(3):1150-5. PMID: 10565836.
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    205. Kolluri S, Elbirt KK, Bonkovsky HL. Heme biosynthesis in a chicken hepatoma cell line (LMH): comparison with primary chick embryo liver cells (CELC). Biochim Biophys Acta. 1999 Nov 16; 1472(3):658-67. PMID: 10564780.
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    206. Lambrecht RW, Gildemeister OS, Williams A, Pepe JA, Tortorelli KD, Bonkovsky HL. Effects of selected antihypertensives and analgesics on hepatic porphyrin accumulation: implications for clinical porphyria. Biochem Pharmacol. 1999 Sep 01; 58(5):887-96. PMID: 10449201.
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    207. Bonkovsky HL, Jawaid Q, Tortorelli K, LeClair P, Cobb J, Lambrecht RW, Banner BF. Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis. J Hepatol. 1999 Sep; 31(3):421-9. PMID: 10488699.
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    208. Mathai J, Shimoda K, Banner BF, Mori M, Bonkovsky HL, Barnard GF. IFN-alpha receptor mRNA expression in a United States sample with predominantly genotype 1a/I chronic hepatitis C liver biopsies correlates with response to IFN therapy. J Interferon Cytokine Res. 1999 Sep; 19(9):1011-8. PMID: 10505743.
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    209. Elbirt KK, Bonkovsky HL. Heme oxygenase: recent advances in understanding its regulation and role. Proc Assoc Am Physicians. 1999 Sep-Oct; 111(5):438-47. PMID: 10519165.
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    210. Bonkovsky HL, Rubin RB, Cable EE, Davidoff A, Rijcken TH, Stark DD. Hepatic iron concentration: noninvasive estimation by means of MR imaging techniques. Radiology. 1999 Jul; 212(1):227-34. PMID: 10405746.
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    211. Fernandez M, Bonkovsky HL. Increased heme oxygenase-1 gene expression in liver cells and splanchnic organs from portal hypertensive rats. Hepatology. 1999 Jun; 29(6):1672-9. PMID: 10347107.
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    212. Reichheld JH, Katz E, Banner BF, Szymanski IO, Saltzman JR, Bonkovsky HL. The value of intravenous heme-albumin and plasmapheresis in reducing postoperative complications of orthotopic liver transplantation for erythropoietic protoporphyria. Transplantation. 1999 Mar 27; 67(6):922-8. PMID: 10199745.
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    213. Bonkovsky HL, Obando JV. Role of HFE gene mutations in liver diseases other than hereditary hemochromatosis. Curr Gastroenterol Rep. 1999 Feb-Mar; 1(1):30-7. PMID: 10980924.
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    214. Bonkovsky HL, Woolley JM. Reduction of health-related quality of life in chronic hepatitis C and improvement with interferon therapy. The Consensus Interferon Study Group. Hepatology. 1999 Jan; 29(1):264-70. PMID: 9862876.
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    215. Giuggio VM, Bonkovsky HL, Smith J, Rothman AL. Inefficient recognition of autologous viral sequences by intrahepatic hepatitis C virus-specific cytotoxic T lymphocytes in chronically infected subjects. Virology. 1998 Nov 10; 251(1):132-40. PMID: 9813209.
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    216. Banner BF, Karamitsios N, Smith L, Bonkovsky HL. Enhanced phenotypic expression of alpha-1-antitrypsin deficiency in an MZ heterozygote with chronic hepatitis C. Am J Gastroenterol. 1998 Sep; 93(9):1541-5. PMID: 9732941.
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    217. Kiefer CR, McKenney JB, Trainor JF, Lambrecht RW, Bonkovsky HL, Lifshitz LM, Valeri CR, Snyder LM. Porphyrin loading of lipofuscin granules in inflamed striated muscle. Am J Pathol. 1998 Sep; 153(3):703-8. PMID: 9736020.
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    218. Shimoda K, Begum NA, Shibuta K, Mori M, Bonkovsky HL, Banner BF, Barnard GF. Interleukin-8 and hIRH (SDF1-alpha/PBSF) mRNA expression and histological activity index in patients with chronic hepatitis C. Hepatology. 1998 Jul; 28(1):108-15. PMID: 9657103.
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    219. Bonkovsky HL, Poh-Fitzpatrick M, Pimstone N, Obando J, Di Bisceglie A, Tattrie C, Tortorelli K, LeClair P, Mercurio MG, Lambrecht RW. Porphyria cutanea tarda, hepatitis C, and HFE gene mutations in North America. Hepatology. 1998 Jun; 27(6):1661-9. PMID: 9620340.
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    220. Elbirt KK, Whitmarsh AJ, Davis RJ, Bonkovsky HL. Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. Role of mitogen-activated protein kinases. J Biol Chem. 1998 Apr 10; 273(15):8922-31. PMID: 9535875.
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    221. Kalman DR, Bonkovsky HL. Management of acute attacks in the porphyrias. Clin Dermatol. 1998 Mar-Apr; 16(2):299-306. PMID: 9554242.
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    222. Lu TH, Lambrecht RW, Pepe J, Shan Y, Kim T, Bonkovsky HL. Molecular cloning, characterization, and expression of the chicken heme oxygenase-1 gene in transfected primary cultures of chick embryo liver cells. Gene. 1998 Jan 30; 207(2):177-86. PMID: 9511760.
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    223. Bonkovsky HL, Barnard GF. Diagnosis of porphyric syndromes: a practical approach in the era of molecular biology. Semin Liver Dis. 1998; 18(1):57-65. PMID: 9516679.
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    224. Kowdley KV, Trainer TD, Saltzman JR, Pedrosa M, Krawitt EL, Knox TA, Susskind K, Pratt D, Bonkovsky HL, Grace ND, Kaplan MM. Utility of hepatic iron index in American patients with hereditary hemochromatosis: a multicenter study. Gastroenterology. 1997 Oct; 113(4):1270-7. PMID: 9322522.
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    225. Banner BF, Allan C, Savas L, Baker S, Barnard G, Bonkovsky HL. Inflammatory markers in chronic hepatitis C. Virchows Arch. 1997 Sep; 431(3):181-7. PMID: 9334839.
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    226. Jiang Z, Liu Y, Savas L, Smith L, Bonkovsky H, Baker S, Banner B. Frequency and distribution of DNA fragmentation as a marker of cell death in chronic liver diseases. Virchows Arch. 1997 Sep; 431(3):189-94. PMID: 9334840.
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    227. Bonkovsky HL. Therapy of hepatitis C: other options. Hepatology. 1997 Sep; 26(3 Suppl 1):143S-151S. PMID: 9305680.
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    228. Hahn M, Gildemeister OS, Krauss GL, Pepe JA, Lambrecht RW, Donohue S, Bonkovsky HL. Effects of new anticonvulsant medications on porphyrin synthesis in cultured liver cells: potential implications for patients with acute porphyria. Neurology. 1997 Jul; 49(1):97-106. PMID: 9222176.
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    229. Lu TH, Pepe JA, Gildemeister OS, Tyrrell RM, Bonkovsky HL. Regulation of expression of the human heme oxygenase-1 gene in transfected chick embryo liver cell cultures. Biochim Biophys Acta. 1997 Jun 26; 1352(3):293-302. PMID: 9224953.
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    230. Cable EE, Gildemeister OS, Pepe JA, Lambrecht RW, Bonkovsky HL. Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: evidence against a stress-mediated response. Mol Cell Biochem. 1997 Apr; 169(1-2):13-20. PMID: 9089626.
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    231. Bonkovsky HL, Banner BF, Rothman AL. Iron and chronic viral hepatitis. Hepatology. 1997 Mar; 25(3):759-68. PMID: 9049232.
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    232. Hahn M, Bonkovsky HL. Multiple chemical sensitivity syndrome and porphyria. A note of caution and concern. Arch Intern Med. 1997 Feb 10; 157(3):281-5. PMID: 9040294.
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    233. Bonkovsky HL, Gildemeister OS, Pepe JA, Lambrecht RW, Hrkal Z. Haemopexin and uptake of haem by liver cells. Eur J Clin Chem Clin Biochem. 1996 Nov; 34(11):931-2. PMID: 8960469.
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    234. Bonkovsky HL, Ponka P, Bacon BR, Drysdale J, Grace ND, Tavill AS. An update on iron metabolism: summary of the Fifth International Conference on Disorders of Iron Metabolism. Hepatology. 1996 Sep; 24(3):718-29. PMID: 8781349.
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    235. Cable EE, Gildemeister OS, Pepe JA, Donohue SE, Lambrecht RW, Bonkovsky HL. Hepatic 5-aminolevulinic acid synthase mRNA stability is modulated by inhibitors of heme biosynthesis and by metalloporphyrins. Eur J Biochem. 1996 Aug 15; 240(1):112-7. PMID: 8797843.
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    236. Banner BF, Allan C, Smith L, Savas L, Bonkovsky HL. Effect of interferon therapy on bile duct inflammation in hepatitis C. Virchows Arch. 1996 Jul; 428(4-5):253-9. PMID: 8764934.
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    237. Gabis KK, Gildemeister OS, Pepe JA, Lambrecht RW, Bonkovsky HL. Induction of heme oxygenase-1 in LMH cells. Comparison of LMH cells to primary cultures of chick embryo liver cells. Biochim Biophys Acta. 1996 May 21; 1290(1):113-20. PMID: 8645700.
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    238. Bonkovsky HL, Banner BF, Lambrecht RW, Rubin RB. Iron in liver diseases other than hemochromatosis. Semin Liver Dis. 1996 Feb; 16(1):65-82. PMID: 8723325.
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    239. Bonkovsky HL, Clifford BD, Smith LJ, Allan C, Banner B. High-dose interferon-alpha 2b for re-treatment of nonresponders or relapsing patients with chronic hepatitis C. A controlled randomized trial. Dig Dis Sci. 1996 Jan; 41(1):149-54. PMID: 8565748.
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    240. Lu TH, Pepe J, Lambrecht RW, Bonkovsky HL. Regulation of metallothionein gene expression. Studies in transfected primary cultures of chick embryo liver cells. Biochimie. 1996; 78(4):236-44. PMID: 8874798.
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    241. Rubin RB, Barton AL, Banner BF, Bonkovsky HL. Iron and chronic viral hepatitis: emerging evidence for an important interaction. Dig Dis. 1995 Jul-Aug; 13(4):223-38. PMID: 8521608.
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    242. Bonkovsky HL, Liang TJ, Hasegawa K, Banner B. Chronic leukocytoclastic vasculitis complicating HBV infection. Possible role of mutant forms of HBV in pathogenesis and persistence of disease. J Clin Gastroenterol. 1995 Jul; 21(1):42-7. PMID: 7560833.
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    243. Barton AL, Banner BF, Cable EE, Bonkovsky HL. Distribution of iron in the liver predicts the response of chronic hepatitis C infection to interferon therapy. Am J Clin Pathol. 1995 Apr; 103(4):419-24. PMID: 7537017.
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    244. Banner BF, Barton AL, Cable EE, Smith L, Bonkovsky HL. A detailed analysis of the Knodell score and other histologic parameters as predictors of response to interferon therapy in chronic hepatitis C. Mod Pathol. 1995 Apr; 8(3):232-8. PMID: 7542385.
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    245. Clifford BD, Donahue D, Smith L, Cable E, Luttig B, Manns M, Bonkovsky HL. High prevalence of serological markers of autoimmunity in patients with chronic hepatitis C. Hepatology. 1995 Mar; 21(3):613-9. PMID: 7533120.
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    246. Levey JM, Romain PL, Bonkovsky HL. Putting the freeze on hepatitis C virus-associated mixed cryoglobulinemia. Hepatology. 1995 Feb; 21(2):594-7. PMID: 7843735.
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    247. Russo SM, Pepe JA, Donohue S, Cable EE, Lambrecht RW, Bonkovsky HL. Tissue distribution of zinc-mesoporphyrin in rats: relationship to inhibition of heme oxygenase. J Pharmacol Exp Ther. 1995 Feb; 272(2):766-74. PMID: 7853192.
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    248. Cable EE, Pepe JA, Donohue SE, Lambrecht RW, Bonkovsky HL. Effects of mifepristone (RU-486) on heme metabolism and cytochromes P-450 in cultured chick embryo liver cells, possible implications for acute porphyria. Eur J Biochem. 1994 Oct 15; 225(2):651-7. PMID: 7957180.
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    249. Barnard GF, Jafri IH, Banner BF, Bonkovsky HL. Colonic mucosal appearance of Tangier disease in a new patient. Gastrointest Endosc. 1994 Sep-Oct; 40(5):628-30. PMID: 7988831.
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    250. Sinclair PR, Bement WJ, Healey JF, Gorman N, Sinclair JF, Bonkovsky HL, Liem HH, Muller-Eberhard U. Effects of hemopexin on heme-mediated repression of 5-aminolevulinate synthase and induction of heme oxygenase in cultured hepatocytes. Hepatology. 1994 Sep; 20(3):741-6. PMID: 8076930.
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    251. Pinnix IB, Guzman GS, Bonkovsky HL, Zaki SR, Kinkade JM. The post-translational processing of myeloperoxidase is regulated by the availability of heme. Arch Biochem Biophys. 1994 Aug 01; 312(2):447-58. PMID: 8037458.
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    252. Cable EE, Pepe JA, Karamitsios NC, Lambrecht RW, Bonkovsky HL. Differential effects of metalloporphyrins on messenger RNA levels of delta-aminolevulinate synthase and heme oxygenase. Studies in cultured chick embryo liver cells. J Clin Invest. 1994 Aug; 94(2):649-54. PMID: 8040318.
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    253. Russo SM, Pepe JA, Cable EE, Lambrecht RW, Bonkovsky HL. Repression of ALA synthase by heme and zinc-mesoporphyrin in a chick embryo liver cell culture model of acute porphyria. Eur J Clin Invest. 1994 Jun; 24(6):406-15. PMID: 7957494.
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    254. Bonkovsky HL, Kane RE, Jones DP, Galinsky RE, Banner B. Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition: evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency. Hepatology. 1994 May; 19(5):1141-8. PMID: 8175135.
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    255. Lambrecht RW, Cable JW, Pepe JA, Bonkovsky HL. 3,5,5-Trimethylhexanoylferrocene induction of heme oxygenase activity in normal hepatocytes. Biochem Pharmacol. 1994 Apr 29; 47(9):1669-76. PMID: 8185682.
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    256. Levey JM, Banner B, Darrah J, Bonkovsky HL. Inflammatory cloacogenic polyp: three cases and literature review. Am J Gastroenterol. 1994 Mar; 89(3):438-41. PMID: 8122661.
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    257. Nompleggi DJ, Bonkovsky HL. Nutritional supplementation in chronic liver disease: an analytical review. Hepatology. 1994 Feb; 19(2):518-33. PMID: 8294109.
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    258. Levey JM, Bjornsson B, Banner B, Kuhns M, Malhotra R, Whitman N, Romain PL, Cropley TG, Bonkovsky HL. Mixed cryoglobulinemia in chronic hepatitis C infection. A clinicopathologic analysis of 10 cases and review of recent literature. Medicine (Baltimore). 1994 Jan; 73(1):53-67. PMID: 8309362.
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    259. Cable JW, Cable EE, Bonkovsky HL. Induction of heme oxygenase in intestinal epithelial cells: studies in Caco-2 cell cultures. Mol Cell Biochem. 1993 Dec 08; 129(1):93-8. PMID: 8177232.
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    260. Bonkovsky HL. Advances in understanding and treating 'the little imitator,' acute porphyria. Gastroenterology. 1993 Aug; 105(2):590-4. PMID: 8335213.
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    261. Srivastva KK, Cable EE, Bonkovsky HL. Purifying nascent mRNA from nuclear run-on assays using guanidinium isothiocyanate. Biotechniques. 1993 Aug; 15(2):226-7. PMID: 8373584.
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    262. Cable EE, Cable JW, Bonkovsky HL. Repression of hepatic delta-aminolevulinate synthase by heme and metalloporphyrins: relationship to inhibition of heme oxygenase. Hepatology. 1993 Jul; 18(1):119-27. PMID: 8325603.
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    263. Srivastava KK, Cable EE, Donohue SE, Bonkovsky HL. Molecular basis for heme-dependent induction of heme oxygenase in primary cultures of chick embryo hepatocytes. Demonstration of acquired refractoriness to heme. Eur J Biochem. 1993 May 01; 213(3):909-17. PMID: 8504830.
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    264. Merrill AH, Wang E, LaRocque R, Mullins RE, Morgan ET, Hargrove JL, Bonkovsky HL, Popova IA. Differences in glycogen, lipids, and enzymes in livers from rats flown on COSMOS 2044. J Appl Physiol (1985). 1992 Aug; 73(2 Suppl):142S-147S. PMID: 1526942.
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    265. Bonkovsky HL, Cable EE, Cable JW, Donohue SE, White EC, Greene YJ, Lambrecht RW, Srivastava KK, Arnold WN. Porphyrogenic properties of the terpenes camphor, pinene, and thujone (with a note on historic implications for absinthe and the illness of Vincent van Gogh). Biochem Pharmacol. 1992 Jun 09; 43(11):2359-68. PMID: 1610401.
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    266. Cable EE, Healey JF, Greene Y, Evans CO, Bonkovsky HL. Synergistic induction of delta-aminolevulinate synthase by glutethimide and iron: relationship to the synergistic induction of heme oxygenase. Biochim Biophys Acta. 1991 Nov 15; 1080(3):245-51. PMID: 1954232.
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    267. Greene YJ, Healey JF, Bonkovsky HL. Immunochemical studies of haem oxygenase. Preparation and characterization of antibodies to chick liver haem oxygenase and their use in detecting and quantifying amounts of haem oxygenase protein. Biochem J. 1991 Nov 01; 279 ( Pt 3):849-54. PMID: 1953681.
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    268. Bonkovsky HL, Fiellin DA, Smith GS, Slaker DP, Simon D, Galambos JT. A randomized, controlled trial of treatment of alcoholic hepatitis with parenteral nutrition and oxandrolone. I. Short-term effects on liver function. Am J Gastroenterol. 1991 Sep; 86(9):1200-8. PMID: 1909085.
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    269. Bonkovsky HL, Singh RH, Jafri IH, Fiellin DA, Smith GS, Simon D, Cotsonis GA, Slaker DP. A randomized, controlled trial of treatment of alcoholic hepatitis with parenteral nutrition and oxandrolone. II. Short-term effects on nitrogen metabolism, metabolic balance, and nutrition. Am J Gastroenterol. 1991 Sep; 86(9):1209-18. PMID: 1909086.
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    270. Steinberg KK, Bonkovsky HL, Caudill SP, Bernhardt RK, Hawkins M. Osteocalcin and bone alkaline phosphatase in the serum of women with liver disease. Ann Clin Lab Sci. 1991 Sep-Oct; 21(5):305-14. PMID: 1952779.
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    271. Bonkovsky HL, Healey JF, Lourie AN, Gerron GG. Intravenous heme-albumin in acute intermittent porphyria: evidence for repletion of hepatic hemoproteins and regulatory heme pools. Am J Gastroenterol. 1991 Aug; 86(8):1050-6. PMID: 1713408.
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    272. Bonkovsky HL. Activation of the hepatocarcinogen aflatoxin B1 by forms of human hepatic cytochromes P-450: some do and some don't. Hepatology. 1991 May; 13(5):1003-5. PMID: 1903123.
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    273. Evans CO, Healey JF, Greene Y, Bonkovsky HL. Cloning, sequencing and expression of cDNA for chick liver haem oxygenase. Comparison of avian and mammalian cDNAs and deduced proteins. Biochem J. 1991 Feb 01; 273 ( Pt 3):659-66. PMID: 1996964.
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    274. Bonkovsky HL. Iron and the liver. Am J Med Sci. 1991 Jan; 301(1):32-43. PMID: 1847276.
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    275. Van de Water J, Ansari AA, Surh CD, Coppel R, Roche T, Bonkovsky H, Kaplan M, Gershwin ME. Evidence for the targeting by 2-oxo-dehydrogenase enzymes in the T cell response of primary biliary cirrhosis. J Immunol. 1991 Jan 01; 146(1):89-94. PMID: 1984455.
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    276. Bonkovsky HL, Slaker DP, Bills EB, Wolf DC. Usefulness and limitations of laboratory and hepatic imaging studies in iron-storage disease. Gastroenterology. 1990 Oct; 99(4):1079-91. PMID: 2394329.
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    277. Bonkovsky HL, Hawkins M, Steinberg K, Hersh T, Galambos JT, Henderson JM, Millikan WJ, Galloway JR. Prevalence and prediction of osteopenia in chronic liver disease. Hepatology. 1990 Aug; 12(2):273-80. PMID: 2391068.
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    278. Yoshida T, Bonkovsky H, Ansari A, Danner D. Antibodies against mitochondrial dehydrogenase complexes in primary biliary cirrhosis. Gastroenterology. 1990 Jul; 99(1):187-94. PMID: 2188870.
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    279. Bonkovsky HL, Weber R, Aaron L. Four-hour measurement of urinary iron excretion after deferoxine treatment: a rapid, simple method for study of iron excretion. Am J Gastroenterol. 1990 May; 85(5):554-7. PMID: 2337058.
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    280. Bonkovsky HL, Healey JF, Pohl J. Purification and characterization of heme oxygenase from chick liver. Comparison of the avian and mammalian enzymes. Eur J Biochem. 1990 Apr 20; 189(1):155-66. PMID: 2158889.
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    281. Cable E, Greene Y, Healey J, Evans CO, Bonkovsky H. Mechanism of synergistic induction of hepatic heme oxygenase by glutethimide and iron: studies in cultured chick embryo liver cells. Biochem Biophys Res Commun. 1990 Apr 16; 168(1):176-81. PMID: 2327996.
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    282. Chawla RK, Wolf DC, Kutner MH, Bonkovsky HL. Choline may be an essential nutrient in malnourished patients with cirrhosis. Gastroenterology. 1989 Dec; 97(6):1514-20. PMID: 2511054.
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    283. Bonkovsky HL. Mechanism of iron potentiation of hepatic uroporphyria: studies in cultured chick embryo liver cells. Hepatology. 1989 Sep; 10(3):354-64. PMID: 2759551.
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    284. Lincoln BC, Aw TY, Bonkovsky HL. Heme catabolism in cultured hepatocytes: evidence that heme oxygenase is the predominant pathway and that a proportion of synthesized heme is converted rapidly to biliverdin. Biochim Biophys Acta. 1989 Jul 21; 992(1):49-58. PMID: 2752038.
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    285. Bonkovsky HL, Bonkovsky ML, Anderson PB, Rothstein RI, Erkkinen JF. Atenolol for prevention of rebleeding from esophageal varices in hepatic cirrhosis: results of a controlled, randomized pilot study. Am J Gastroenterol. 1989 Jun; 84(6):681-3. PMID: 2658555.
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    286. Sinclair P, Frezza J, Sinclair J, Bement W, Haugen S, Healey J, Bonkovsky H. Immunochemical detection of different isoenzymes of cytochrome P-450 induced in chick hepatocyte cultures. Biochem J. 1989 Feb 15; 258(1):237-45. PMID: 2930511.
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    287. Bloomer JR, Bonkovsky HL. The porphyrias. Dis Mon. 1989 Jan; 35(1):1-54. PMID: 2645098.
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    288. Lincoln BC, Alvarado A, Setty N, Bonkovsky HL. Tryptophan 2,3-dioxygenase in chick embryo hepatocytes: studies in ovo and in culture. Proc Soc Exp Biol Med. 1988 Jul; 188(3):308-15. PMID: 3393544.
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    289. Lincoln BC, Mayer A, Bonkovsky HL. Microassay of heme oxygenase by high-performance liquid chromatography: application to assay of needle biopsies of human liver. Anal Biochem. 1988 May 01; 170(2):485-90. PMID: 3394947.
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    290. Bonkovsky HL, Hartle DK, Mellen BG, Kutner M, Galambos JT. Plasma concentrations of immunoreactive atrial natriuretic peptide in hospitalized cirrhotic and noncirrhotic patients: evidence for a role of deficient atrial natriuretic peptide in pathogenesis of cirrhotic ascites. Am J Gastroenterol. 1988 May; 83(5):531-5. PMID: 2966574.
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    291. Lincoln BC, Healey JF, Bonkovsky HL. Regulation of hepatic haem metabolism. Disparate mechanisms of induction of haem oxygenase by drugs and metals. Biochem J. 1988 Feb 15; 250(1):189-96. PMID: 3355510.
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    292. Shedlofsky SI, Sinclair PR, Bonkovsky HL, Healey JF, Swim AT, Robinson JM. Haem synthesis from exogenous 5-aminolaevulinate in cultured chick-embryo hepatocytes. Effects of inducers of cytochromes P-450. Biochem J. 1987 Nov 15; 248(1):229-36. PMID: 3435440.
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    293. Bonkovsky HL, Healey JF, Lincoln B, Bacon BR, Bishop DF, Elder GH. Hepatic heme synthesis in a new model of experimental hemochromatosis: studies in rats fed finely divided elemental iron. Hepatology. 1987 Nov-Dec; 7(6):1195-203. PMID: 3679087.
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    294. Simon DM, McCain JR, Bonkovsky HL, Wells JO, Hartle DK, Galambos JT. Effects of therapeutic paracentesis on systemic and hepatic hemodynamics and on renal and hormonal function. Hepatology. 1987 May-Jun; 7(3):423-9. PMID: 3570154.
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    295. Bonkovsky HL, Sinclair PR, Bement WJ, Lambrecht RW, Sinclair JF. Role of cytochrome P-450 in porphyria caused by halogenated aromatic compounds. Ann N Y Acad Sci. 1987; 514:96-112. PMID: 3327440.
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    296. Bonkovsky HL, Lincoln B, Healey JF, Ou LC, Sinclair PR, Muller-Eberhard U. Hepatic heme and drug metabolism in rats with chronic mountain sickness. Am J Physiol. 1986 Oct; 251(4 Pt 1):G467-74. PMID: 3094379.
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    297. Sinclair PR, Bement WJ, Bonkovsky HL, Lambrecht RW, Frezza JE, Sinclair JF, Urquhart AJ, Elder GH. Uroporphyrin accumulation produced by halogenated biphenyls in chick-embryo hepatocytes. Reversal of the accumulation by piperonyl butoxide. Biochem J. 1986 Jul 01; 237(1):63-71. PMID: 3026315.
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    298. Bacon BR, Healey JF, Brittenham GM, Park CH, Nunnari J, Tavill AS, Bonkovsky HL. Hepatic microsomal function in rats with chronic dietary iron overload. Gastroenterology. 1986 Jun; 90(6):1844-53. PMID: 3009259.
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    299. Bonkovsky HL, Wood SG, Howell SK, Sinclair PR, Lincoln B, Healey JF, Sinclair JF. High-performance liquid chromatographic separation and quantitation of tetrapyrroles from biological materials. Anal Biochem. 1986 May 15; 155(1):56-64. PMID: 3717559.
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    300. Bonkovsky HL, Blanchette PL, Schned AR. Severe liver injury due to phenelzine with unique hepatic deposition of extracellular material. Am J Med. 1986 Apr; 80(4):689-92. PMID: 3963046.
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    301. Sinclair JF, Zaitlin LM, Smith EL, Howell SK, Bonkovsky HL, Sinclair PR. Induction of 5-aminolaevulinate synthase by two- to five-carbon alcohols in cultured chick-embryo hepatocytes. Relationship to induction of cytochrome P-450. Biochem J. 1986 Mar 01; 234(2):405-11. PMID: 3718476.
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    302. Bonkovsky HL, Schned AR. Fatal liver failure in protoporphyria. Synergism between ethanol excess and the genetic defect. Gastroenterology. 1986 Jan; 90(1):191-201. PMID: 3940245.
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    303. Sinclair PR, Sinclair JF, Bement WJ, Lambrecht RW, Bonkovsky HL. Induction of porphyria in cultured chick-embryo hepatocytes by halogenated aromatic compounds. IARC Sci Publ. 1986; (77):535-42. PMID: 3596754.
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    304. Elder GH, Urquhart AJ, De Salamanca RE, Munoz JJ, Bonkovsky HL. Immunoreactive uroporphyrinogen decarboxylase in the liver in porphyria cutanea tarda. Lancet. 1985 Aug 03; 2(8449):229-33. PMID: 2862415.
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    305. Bonkovsky HL, Healey JF, Sinclair PR, Sinclair JF. Conversion of 5-aminolaevulinate into haem by homogenates of human liver. Comparison with rat and chick-embryo liver homogenates. Biochem J. 1985 May 01; 227(3):893-901. PMID: 4004804.
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    306. Bonkovsky HL, Hauri HP, Marti U, Gasser R, Meyer UA. Cytochrome P450 of small intestinal epithelial cells. Immunochemical characterization of the increase in cytochrome P450 caused by phenobarbital. Gastroenterology. 1985 Feb; 88(2):458-67. PMID: 3965334.
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    307. Sinclair PR, Bement WJ, Bonkovsky HL, Sinclair JF. Inhibition of uroporphyrinogen decarboxylase by halogenated biphenyls in chick hepatocyte cultures. Essential role for induction of cytochrome P-448. Biochem J. 1984 Sep 15; 222(3):737-48. PMID: 6435605.
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    308. Bonkovsky HL, Sinclair JF, Healey JF, Sinclair PR, Smith EL. Formation of cytochrome P-450 containing haem or cobalt-protoporphyrin in liver homogenates of rats treated with phenobarbital and allylisopropylacetamide. Biochem J. 1984 Sep 01; 222(2):453-62. PMID: 6477526.
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    309. Bonkovsky HL, Mitchell WJ, Healey JF. Effect of hemochromatosis on hepatic cytochrome P450 and antipyrine metabolism in humans. Clin Chem. 1984 Aug; 30(8):1430-1. PMID: 6744621.
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    310. Shedlofsky SI, Sinclair PR, Sinclair JF, Bonkovsky HL. Increased glutathione in cultured hepatocytes associated with induction of cytochrome P-450. Lack of effect of glutathione depletion on induction of cytochrome P-450 and delta-aminolevulinate synthase. Biochem Pharmacol. 1984 May 01; 33(9):1487-91. PMID: 6375680.
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    311. Bonkovsky HL, Healey JF, Bement WJ, Sinclair PR, Sinclair JF, Shedlofsky SI. Effect of uroporphyrin on the spectral measurement of cytochrome P450. Biochem Pharmacol. 1984 Feb 01; 33(3):499-502. PMID: 6704169.
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