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Clinical and Translational Science Institute

Keywords
Last Name

Evgeny Budygin, Ph.D.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentNeurobiology and Anatomy
Address
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    Collapse Research 
    Collapse research activities and funding
    R03AA014686     (BUDYGIN, EVGENY ALEXANDER)Aug 1, 2004 - Jul 31, 2007
    NIH/NIAAA
    Effects of Ethanol Exposure on Mesolimbic Dopamine
    Role: Principal Investigator

    K01DA021634     (BUDYGIN, EVGENY ALEXANDER)Aug 1, 2006 - Jun 30, 2012
    NIH/NIDA
    The role of dopamine mechanisms in the development of addiction to cocaine
    Role: Principal Investigator

    R21AA020564     (BUDYGIN, EVGENY ALEXANDER)May 1, 2012 - Apr 30, 2014
    NIH/NIAAA
    Dopamine Release Patterns in Alcohol-drinking Behavior: An Optogenetic Study
    Role: Principal Investigator

    R01AA022449     (BUDYGIN, EVGENY ALEXANDER)Jun 1, 2014 - May 31, 2019
    NIH/NIAAA
    Real-Time Accumbal Dopamine Signaling and Ethanol Drinking Behavior
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Leo D, Sukhanov I, Zoratto F, Illiano P, Caffino L, Sanna F, Messa G, Emanuele M, Esposito A, Dorofeikova M, Budygin EA, Mus L, Efimova EV, Niello M, Espinoza S, Sotnikova TD, Hoener MC, Laviola G, Fumagalli F, Adriani W, Gainetdinov RR. Pronounced Hyperactivity, Cognitive Dysfunctions, and BDNF Dysregulation in Dopamine Transporter Knock-out Rats. J Neurosci. 2018 Feb 21; 38(8):1959-1972. PMID: 29348190.
      View in: PubMed
    2. Deal AL, Konstantopoulos JK, Weiner JL, Budygin EA. Exploring the consequences of social defeat stress and intermittent ethanol drinking on dopamine dynamics in the rat nucleus accumbens. Sci Rep. 2018 01 10; 8(1):332. PMID: 29321525.
      View in: PubMed
    3. McHenry JA, Otis JM, Rossi MA, Robinson JE, Kosyk O, Miller NW, McElligott ZA, Budygin EA, Rubinow DR, Stuber GD. Corrigendum: Hormonal gain control of a medial preoptic area social reward circuit. Nat Neurosci. 2017 09 28; 20(10):1427-1430. PMID: 28949330.
      View in: PubMed
    4. Illiano P, Bass CE, Fichera L, Mus L, Budygin EA, Sotnikova TD, Leo D, Espinoza S, Gainetdinov RR. Recombinant Adeno-Associated Virus-mediated rescue of function in a mouse model of Dopamine Transporter Deficiency Syndrome. Sci Rep. 2017 04 18; 7:46280. PMID: 28417953.
      View in: PubMed
    5. McHenry JA, Otis JM, Rossi MA, Robinson JE, Kosyk O, Miller NW, McElligott ZA, Budygin EA, Rubinow DR, Stuber GD. Hormonal gain control of a medial preoptic area social reward circuit. Nat Neurosci. 2017 Mar; 20(3):449-458. PMID: 28135243.
      View in: PubMed
    6. Budygin EA, Oleson EB, Lee YB, Blume LC, Bruno MJ, Howlett AC, Thompson AC, Bass CE. Acute Depletion of D2 Receptors from the Rat Substantia Nigra Alters Dopamine Kinetics in the Dorsal Striatum and Drug Responsivity. Front Behav Neurosci. 2016; 10:248. PMID: 28154530.
      View in: PubMed
    7. Mikhailova MA, Bass CE, Grinevich VP, Chappell AM, Deal AL, Bonin KD, Weiner JL, Gainetdinov RR, Budygin EA. Optogenetically-induced tonic dopamine release from VTA-nucleus accumbens projections inhibits reward consummatory behaviors. Neuroscience. 2016 10 01; 333:54-64. PMID: 27421228.
      View in: PubMed
    8. Fox ME, Mikhailova MA, Bass CE, Takmakov P, Gainetdinov RR, Budygin EA, Wightman RM. Cross-hemispheric dopamine projections have functional significance. Proc Natl Acad Sci U S A. 2016 06 21; 113(25):6985-90. PMID: 27298371; PMCID: PMC4922155 [Available on 12/21/16].
    9. Efimova EV, Gainetdinov RR, Budygin EA, Sotnikova TD. Dopamine transporter mutant animals: a translational perspective. J Neurogenet. 2016 03; 30(1):5-15. PMID: 27276191; PMCID: PMC4902158 [Available on 03/01/17].
    10. Adamah-Biassi EB, Almonte AG, Blagovechtchenski E, Grinevich VP, Weiner JL, Bonin KD, Budygin EA. Real time adenosine fluctuations detected with fast-scan cyclic voltammetry in the rat striatum and motor cortex. J Neurosci Methods. 2015 Dec 30; 256:56-62. PMID: 26310181.
      View in: PubMed
    11. Gompf HS, Budygin EA, Fuller PM, Bass CE. Targeted genetic manipulations of neuronal subtypes using promoter-specific combinatorial AAVs in wild-type animals. Front Behav Neurosci. 2015; 9:152. PMID: 26190981; PMCID: PMC4488755.
    12. Park J, Bucher ES, Budygin EA, Wightman RM. Norepinephrine and dopamine transmission in 2 limbic regions differentially respond to acute noxious stimulation. Pain. 2015 Feb; 156(2):318-27. PMID: 25599453; PMCID: PMC4299949.
    13. Budygin EA, Weiner JL. Exploring the Neurochemical Basis of Alcohol Addiction-Related Behaviors: Translational Research. Transl Biomed. 2015; 6(Suppl Spec). PMID: 26770883.
      View in: PubMed
    14. Maex R, Grinevich VP, Grinevich V, Budygin E, Bencherif M, Gutkin B. Understanding the role a7 nicotinic receptors play in dopamine efflux in nucleus accumbens. ACS Chem Neurosci. 2014 Oct 15; 5(10):1032-40. PMID: 25147933; PMCID: PMC4198061.
    15. Bass CE, Grinevich VP, Gioia D, Day-Brown JD, Bonin KD, Stuber GD, Weiner JL, Budygin EA. Optogenetic stimulation of VTA dopamine neurons reveals that tonic but not phasic patterns of dopamine transmission reduce ethanol self-administration. Front Behav Neurosci. 2013; 7:173. PMID: 24324415; PMCID: PMC3840465.
    16. Bass CE, Grinevich VP, Kulikova AD, Bonin KD, Budygin EA. Terminal effects of optogenetic stimulation on dopamine dynamics in rat striatum. J Neurosci Methods. 2013 Apr 15; 214(2):149-55. PMID: 23391758; PMCID: PMC3602228.
    17. Pattison LP, McIntosh S, Budygin EA, Hemby SE. Differential regulation of accumbal dopamine transmission in rats following cocaine, heroin and speedball self-administration. J Neurochem. 2012 Jul; 122(1):138-46. PMID: 22443145; PMCID: PMC3843350.
    18. van Zessen R, Phillips JL, Budygin EA, Stuber GD. Activation of VTA GABA neurons disrupts reward consumption. Neuron. 2012 Mar 22; 73(6):1184-94. PMID: 22445345; PMCID: PMC3314244.
    19. Budygin EA, Park J, Bass CE, Grinevich VP, Bonin KD, Wightman RM. Aversive stimulus differentially triggers subsecond dopamine release in reward regions. Neuroscience. 2012 Jan 10; 201:331-7. PMID: 22108611; PMCID: PMC3258373.
    20. Adamantidis AR, Tsai HC, Boutrel B, Zhang F, Stuber GD, Budygin EA, Touriño C, Bonci A, Deisseroth K, de Lecea L. Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior. J Neurosci. 2011 Jul 27; 31(30):10829-35. PMID: 21795535; PMCID: PMC3171183.
    21. Pattison LP, Bonin KD, Hemby SE, Budygin EA. Speedball induced changes in electrically stimulated dopamine overflow in rat nucleus accumbens. Neuropharmacology. 2011 Feb-Mar; 60(2-3):312-7. PMID: 20869972; PMCID: PMC3014401.
    22. Bass CE, Grinevich VP, Vance ZB, Sullivan RP, Bonin KD, Budygin EA. Optogenetic control of striatal dopamine release in rats. J Neurochem. 2010 Sep 01; 114(5):1344-52. PMID: 20534006; PMCID: PMC2923233.
    23. Zimin IA, Abaimov DA, Budygin EA, Zolotarev IuA, Kovalev GI. [Role of the brain dopaminergic and serotoninergic systems in psychopharmacological effects of ladasten and sydnocarb]. Eksp Klin Farmakol. 2010 Feb; 73(2):2-5. PMID: 20369592.
      View in: PubMed
    24. Oleson EB, Salek J, Bonin KD, Jones SR, Budygin EA. Real-time voltammetric detection of cocaine-induced dopamine changes in the striatum of freely moving mice. Neurosci Lett. 2009 Dec 25; 467(2):144-6. PMID: 19822192; PMCID: PMC2787452.
    25. Mathews TA, Brookshire BR, Budygin EA, Hamre K, Goldowitz D, Jones SR. Ethanol-induced hyperactivity is associated with hypodopaminergia in the 22-TNJ ENU-mutated mouse. Alcohol. 2009 Sep; 43(6):421-31. PMID: 19801272; PMCID: PMC2782517.
    26. Anstrom KK, Miczek KA, Budygin EA. Increased phasic dopamine signaling in the mesolimbic pathway during social defeat in rats. Neuroscience. 2009 Jun 16; 161(1):3-12. PMID: 19298844; PMCID: PMC4445890.
    27. Oleson EB, Talluri S, Childers SR, Smith JE, Roberts DC, Bonin KD, Budygin EA. Dopamine uptake changes associated with cocaine self-administration. Neuropsychopharmacology. 2009 Apr; 34(5):1174-84. PMID: 18923398; PMCID: PMC2656581.
    28. Budygin EA. Dopamine uptake inhibition is positively correlated with cocaine-induced stereotyped behavior. Neurosci Lett. 2007 Dec 11; 429(1):55-8. PMID: 17980487; PMCID: PMC2220010.
    29. Budygin EA, Oleson EB, Mathews TA, Läck AK, Diaz MR, McCool BA, Jones SR. Effects of chronic alcohol exposure on dopamine uptake in rat nucleus accumbens and caudate putamen. Psychopharmacology (Berl). 2007 Sep; 193(4):495-501. PMID: 17492432.
      View in: PubMed
    30. Chen KC, Budygin EA. Extracting the basal extracellular dopamine concentrations from the evoked responses: re-analysis of the dopamine kinetics. J Neurosci Methods. 2007 Aug 15; 164(1):27-42. PMID: 17498808.
      View in: PubMed
    31. Mathews TA, John CE, Lapa GB, Budygin EA, Jones SR. No role of the dopamine transporter in acute ethanol effects on striatal dopamine dynamics. Synapse. 2006 Sep 15; 60(4):288-94. PMID: 16786536.
      View in: PubMed
    32. Jones SR, Mathews TA, Budygin EA. Effect of moderate ethanol dose on dopamine uptake in rat nucleus accumbens in vivo. Synapse. 2006 Sep 01; 60(3):251-5. PMID: 16752364.
      View in: PubMed
    33. John CE, Budygin EA, Mateo Y, Jones SR. Neurochemical characterization of the release and uptake of dopamine in ventral tegmental area and serotonin in substantia nigra of the mouse. J Neurochem. 2006 Jan; 96(1):267-82. PMID: 16300629.
      View in: PubMed
    34. Lapa GB, Byrd GD, Lapa AA, Budygin EA, Childers SR, Jones SR, Harp JJ. The synthesis and biological evaluation of dopamine transporter inhibiting activity of substituted diphenylmethoxypiperidines. Bioorg Med Chem Lett. 2005 Nov 15; 15(22):4915-8. PMID: 16165350.
      View in: PubMed
    35. Budygin EA, Mathews TA, Lapa GB, Jones SR. Local effects of acute ethanol on dopamine neurotransmission in the ventral striatum in C57BL/6 mice. Eur J Pharmacol. 2005 Oct 31; 523(1-3):40-5. PMID: 16226738.
      View in: PubMed
    36. Mateo Y, Budygin EA, John CE, Banks ML, Jones SR. Voltammetric assessment of dopamine clearance in the absence of the dopamine transporter: no contribution of other transporters in core or shell of nucleus accumbens. J Neurosci Methods. 2004 Dec 30; 140(1-2):183-7. PMID: 15589348.
      View in: PubMed
    37. Lapa GB, Mathews TA, Harp J, Budygin EA, Jones SR. Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties. Eur J Pharmacol. 2005 Jan 04; 506(3):237-40. PMID: 15627433.
      View in: PubMed
    38. Mateo Y, Budygin EA, Morgan D, Roberts DC, Jones SR. Fast onset of dopamine uptake inhibition by intravenous cocaine. Eur J Neurosci. 2004 Nov; 20(10):2838-42. PMID: 15548229.
      View in: PubMed
    39. Sotnikova TD, Budygin EA, Jones SR, Dykstra LA, Caron MG, Gainetdinov RR. Dopamine transporter-dependent and -independent actions of trace amine beta-phenylethylamine. J Neurochem. 2004 Oct; 91(2):362-73. PMID: 15447669.
      View in: PubMed
    40. Budygin EA, Brodie MS, Sotnikova TD, Mateo Y, John CE, Cyr M, Gainetdinov RR, Jones SR. Dissociation of rewarding and dopamine transporter-mediated properties of amphetamine. Proc Natl Acad Sci U S A. 2004 May 18; 101(20):7781-6. PMID: 15136721; PMCID: PMC419683.
    41. Montague PR, McClure SM, Baldwin PR, Phillips PE, Budygin EA, Stuber GD, Kilpatrick MR, Wightman RM. Dynamic gain control of dopamine delivery in freely moving animals. J Neurosci. 2004 Feb 18; 24(7):1754-9. PMID: 14973252.
      View in: PubMed
    42. Mateo Y, Budygin EA, John CE, Jones SR. Role of serotonin in cocaine effects in mice with reduced dopamine transporter function. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):372-7. PMID: 14691264; PMCID: PMC314192.
    43. Budygin EA, John CE, Mateo Y, Daunais JB, Friedman DP, Grant KA, Jones SR. Chronic ethanol exposure alters presynaptic dopamine function in the striatum of monkeys: a preliminary study. Synapse. 2003 Dec 01; 50(3):266-8. PMID: 14515345.
      View in: PubMed
    44. Phillips PE, Johns JM, Lubin DA, Budygin EA, Gainetdinov RR, Lieberman JA, Wightman RM. Presynaptic dopaminergic function is largely unaltered in mesolimbic and mesostriatal terminals of adult rats that were prenatally exposed to cocaine. Brain Res. 2003 Jan 24; 961(1):63-72. PMID: 12535777; PMCID: PMC3101370.
    45. Garris PA, Budygin EA, Phillips PE, Venton BJ, Robinson DL, Bergstrom BP, Rebec GV, Wightman RM. A role for presynaptic mechanisms in the actions of nomifensine and haloperidol. Neuroscience. 2003; 118(3):819-29. PMID: 12710989.
      View in: PubMed
    46. Budygin EA, John CE, Mateo Y, Jones SR. Lack of cocaine effect on dopamine clearance in the core and shell of the nucleus accumbens of dopamine transporter knock-out mice. J Neurosci. 2002 May 15; 22(10):RC222. PMID: 12006604.
      View in: PubMed
    47. Raevskii KS, Gainetdinov RR, Budygin EA, Mannisto P, Wightman M. Dopaminergic transmission in the rat striatum in vivo in conditions of pharmacological modulation. Neurosci Behav Physiol. 2002 Mar-Apr; 32(2):183-8. PMID: 11942697.
      View in: PubMed
    48. Joseph JD, Wang YM, Miles PR, Budygin EA, Picetti R, Gainetdinov RR, Caron MG, Wightman RM. Dopamine autoreceptor regulation of release and uptake in mouse brain slices in the absence of D(3) receptors. Neuroscience. 2002; 112(1):39-49. PMID: 12044470.
      View in: PubMed
    49. Budygin EA, Phillips PE, Wightman RM, Jones SR. Terminal effects of ethanol on dopamine dynamics in rat nucleus accumbens: an in vitro voltammetric study. Synapse. 2001 Nov; 42(2):77-9. PMID: 11574942.
      View in: PubMed
    50. Robinson DL, Phillips PE, Budygin EA, Trafton BJ, Garris PA, Wightman RM. Sub-second changes in accumbal dopamine during sexual behavior in male rats. Neuroreport. 2001 Aug 08; 12(11):2549-52. PMID: 11496146.
      View in: PubMed
    51. Budygin EA, Phillips PE, Robinson DL, Kennedy AP, Gainetdinov RR, Wightman RM. Effect of acute ethanol on striatal dopamine neurotransmission in ambulatory rats. J Pharmacol Exp Ther. 2001 Apr; 297(1):27-34. PMID: 11259524.
      View in: PubMed
    52. Raevskii KS, Gainetdinov RR, Budygin EA, Mannisto P, Wightman M. [Pharmacological modulation of dopaminergic transmission in the rat striatum in vivo]. Ross Fiziol Zh Im I M Sechenova. 2000 Sep; 86(9):1152-9. PMID: 11081220.
      View in: PubMed
    53. Budygin EA, Kilpatrick MR, Gainetdinov RR, Wightman RM. Correlation between behavior and extracellular dopamine levels in rat striatum: comparison of microdialysis and fast-scan cyclic voltammetry. Neurosci Lett. 2000 Mar 03; 281(1):9-12. PMID: 10686403.
      View in: PubMed
    54. Logman MJ, Budygin EA, Gainetdinov RR, Wightman RM. Quantitation of in vivo measurements with carbon fiber microelectrodes. J Neurosci Methods. 2000 Feb 15; 95(2):95-102. PMID: 10752479.
      View in: PubMed
    55. Budygin EA, Kilpatrick M, Gainetdinov RR, Raevskii KS, Wightman RM. [The effect of the dopamine neuronal reuptake inhibitor GBR 12909 on the dopaminergic neurotransmission parameters in the rat striatum in vivo]. Eksp Klin Farmakol. 1999 Sep-Oct; 62(5):3-6. PMID: 10572741.
      View in: PubMed
    56. Budygin EA, Gainetdinov RR, Kilpatrick MR, Rayevsky KS, Männistö PT, Wightman RM. Effect of tolcapone, a catechol-O-methyltransferase inhibitor, on striatal dopaminergic transmission during blockade of dopamine uptake. Eur J Pharmacol. 1999 Apr 09; 370(2):125-31. PMID: 10323260.
      View in: PubMed
    57. Budygin EA, Gainetdinov RR, Raevskii KS, Mannisto PT. [Effect of subchronic administration of tolcapone on release of striatum dopamine and its metabolites induced by L-DOPA and carbidopa]. Biull Eksp Biol Med. 1998 Feb; 125(2):168-71. PMID: 9559129.
      View in: PubMed
    58. Budygin EA, Gainetdinov RR, Raevskii KS, Li IH, Mannisto PT. [Microdialysis study of tolcapone effect during blockage of neuronal dopamine reuptake caused by GBR-12909]. Eksp Klin Farmakol. 1997 Sep-Oct; 60(5):8-10. PMID: 9483396.
      View in: PubMed
    59. Budygin EA, Gainetdinov RR, Titov DA, Kovalev GI. [Effect of aspartic acid derivatives, N-acetyl-aspartate and its phosphonic analog PIR-87-6-0, on dopamine release from the rat striatum during perfusion in vitro]. Biull Eksp Biol Med. 1997 Jan; 123(1):57-60. PMID: 9213460.
      View in: PubMed
    60. Budygin EA, Gainetdinov RR, Titov DA, Kovalev GI. [The effect of a low dose of piracetam on the activity of the dopaminergic system in the rat striatum]. Eksp Klin Farmakol. 1996 Mar-Apr; 59(2):6-8. PMID: 8974570.
      View in: PubMed
    61. Kovalev GI, Budygin EA, Gainetdinov RR, Kudrin VS, Trofimov SS, Ostrovskaia RU. [The sodium oxybutyrate and nooglutil correction of dopamine release in the striatum of prenatally alcoholized rat pups]. Biull Eksp Biol Med. 1993 Jul; 116(7):56-8. PMID: 8400184.
      View in: PubMed
    62. Budygin EA, Kovalev GI, Gaintdinov RR, Kudrin VS, Voronina TA. [Age-related changes in the dopaminergic system in rat striatum]. Biull Eksp Biol Med. 1993 Mar; 115(3):301-3. PMID: 8054633.
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    63. Gainetdinov RR, Miroshnichenko II, Kudrin VS, Bogdanov MB, Pogorelov VM, Budygin EA, Kovalev GI, Raevskii KS. [A comparative study of the neurochemical profiles of carbidine stereoisomers]. Eksp Klin Farmakol. 1993 Jan-Feb; 56(1):24-7. PMID: 8100728.
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    64. Gainetdinov RR, Budygin EA, Kovalev GI, Kudrin VS, Raevskii KS. [Different effects of typical and atypical neuroleptics on K+-stimulated dopamine release from isolated rat striatum]. Biull Eksp Biol Med. 1992 Jul; 114(7):47-9. PMID: 1358258.
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    65. Gainetdinov RR, Bogdanov MB, Kudrin VS, Budygin EA, Kovalev GI, Raevskii KS. [A comparative study of the neurochemical profiles of remoxipride, raclopride and metoclopramide activity]. Biull Eksp Biol Med. 1992 Jul; 114(8):165-8. PMID: 1467481.
      View in: PubMed
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