Loading...
Explore More at wakehealth.edu

Clinical and Translational Science Institute

Keywords
Last Name

Donald A. Mcclain, M.D., Ph.D.

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentInt Med-Endocrinology
Address
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    T35DK007400     (MCCLAIN, DONALD A.)May 1, 1980 - Jun 30, 2021
    NIH/NIDDK
    Wake Forest Short-term Research Training Program
    Role: Co-Principal Investigator

    R29DK043526     (MCCLAIN, DONALD A.)Jun 1, 1990 - May 31, 1996
    NIH/NIDDK
    ALTERNATE FORMS OF THE INSULIN RECEPTOR
    Role: Principal Investigator

    R01DK043526     (MCCLAIN, DONALD A)Jun 1, 1990 - Jun 30, 2014
    NIH/NIDDK
    Hexosamines, Glucose Toxicity and Insulin Resistance
    Role: Principal Investigator

    K30RR022962     (MCCLAIN, DONALD A)Sep 30, 2000 - Aug 31, 2010
    NIH/NCRR
    University of Utah Clinical Research Curriculum Award
    Role: Principal Investigator

    R56DK059512     (MCCLAIN, DONALD A)Apr 1, 2001 - Jun 30, 2008
    NIH/NIDDK
    Diabetes in Hemochromatosis: Prevalence and Mechanisms
    Role: Principal Investigator

    U01HL070525     (MCCLAIN, DONALD A)Sep 30, 2001 - Aug 31, 2007
    NIH/NHLBI
    ANIMAL MODELS OF DIABETIC CARDIOVASCULAR COMPLICATIONS
    Role: Principal Investigator

    R01DK059512     (MCCLAIN, DONALD A)Mar 1, 2002 - Nov 30, 2007
    NIH/NIDDK
    DIABETES IN HEMOCHROMATOSIS: PREVALENCE AND MECHANISMS
    Role: Principal Investigator

    KL2RR025763     (MCCLAIN, DONALD A)May 19, 2008 - Apr 30, 2013
    NIH/NCRR
    University of Utah Center for Clinical and Translational Science-KL2
    Role: Principal Investigator

    TL1RR025762     (MCCLAIN, DONALD A)May 19, 2008 - Apr 30, 2013
    NIH/NCRR
    University of Utah Center for Clinical and Translational Science-TL1
    Role: Principal Investigator

    UL1RR025764     (MCCLAIN, DONALD A)May 19, 2008 - Apr 30, 2013
    NIH/NCRR
    University of Utah Center for Clinical and Translational Science-UL1
    Role: Principal Investigator

    KL2TR000104     (MCCLAIN, DONALD A)May 19, 2008 - Oct 31, 2013
    NIH/NCATS
    University of Utah Center for Clinical and Translational Science-KL2
    Role: Principal Investigator

    TL1TR000103     (MCCLAIN, DONALD A)May 19, 2008 - Oct 31, 2013
    NIH/NCATS
    University of Utah Center for Clinical and Translational Science-TL1
    Role: Principal Investigator

    UL1TR000105     (MCCLAIN, DONALD A)May 19, 2008 - Oct 31, 2013
    NIH/NCATS
    University of Utah Center for Clinical and Translational Science-UL1
    Role: Principal Investigator

    R01DK081842     (MCCLAIN, DONALD A.)Jul 1, 2008 - Aug 31, 2018
    NIH/NIDDK
    Iron And Metabolism: Altered Fuel Oxidation And Mitochondrial Dysfunction
    Role: Principal Investigator

    I01BX001140     (MCCLAIN, DONALD A.)Apr 1, 2011 - Mar 31, 2019
    VA
    Iron, the circadian clock, and diabetes risk
    Role: Principal Investigator

    T32DK091317     (FISHER, SIMON J)Jul 1, 2011 - Jun 30, 2021
    NIH/NIDDK
    Interdisciplinary Training Program in Metabolism
    Role: Co-Principal Investigator

    R21DK096288     (MCCLAIN, DONALD A)Aug 7, 2012 - Jun 30, 2014
    NIH/NIDDK
    Iron reduction by phlebotomy for the prevention and treatment of type 2 diabetes
    Role: Principal Investigator

    KL2TR001065     (DERE, WILLARD H.)Sep 26, 2013 - Apr 30, 2018
    NIH/NCATS
    University of Utah Center for clinical and Translational Science
    Role: Co-Principal Investigator

    TL1TR001066     (DERE, WILLARD H.)Sep 26, 2013 - Apr 30, 2018
    NIH/NCATS
    University of Utah Center for clinical and Translational Science
    Role: Co-Principal Investigator

    UL1TR001067     (DERE, WILLARD H.)Sep 26, 2013 - Apr 30, 2018
    NIH/NCATS
    University of Utah Center for Clinical and Translational Science
    Role: Co-Principal Investigator

    UL1TR001420     (MCCLAIN, DONALD A.)Aug 13, 2015 - Mar 31, 2019
    NIH/NCATS
    Wake forest Clinical and Translational Science Award
    Role: Co-Principal Investigator

    R01DK119913     (MCCLAIN, DONALD A.)Jan 20, 2019 - Dec 31, 2023
    NIH/NIDDK
    Iron Reduction for the Treatment of Diabetes and Nonalcoholic Fatty Liver Disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. McClain DA, Sharma NK, Jain S, Harrison A, Salaye LN, Comeau ME, Langefeld CD, Lorenzo FR, Das SK. Adipose Tissue Transferrin and Insulin Resistance. J Clin Endocrinol Metab. 2018 Nov 01; 103(11):4197-4208. PMID: 30099506.
      View in: PubMed
    2. Lamar ZS, Dothard A, Kennedy L, Isom S, Robinson M, Vaidya R, Hurd D, McClain D, Lesser G. Hyperglycemia during first-line R-CHOP or dose adjusted R-EPOCH chemotherapy for non-Hodgkin lymphoma is prevalent and associated with chemotherapy alteration - a retrospective study. Leuk Lymphoma. 2018 08; 59(8):1871-1877. PMID: 29252084.
      View in: PubMed
    3. Nam H, Jones D, Cooksey RC, Gao Y, Sink S, Cox J, McClain DA. Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver. Diabetes. 2016 06; 65(6):1521-33. PMID: 26993063.
      View in: PubMed
    4. Fernández-Real JM, McClain D, Manco M. Mechanisms Linking Glucose Homeostasis and Iron Metabolism Toward the Onset and Progression of Type 2 Diabetes. Diabetes Care. 2015 Nov; 38(11):2169-76. PMID: 26494808.
      View in: PubMed
    5. Gao Y, Li Z, Gabrielsen JS, Simcox JA, Lee SH, Jones D, Cooksey B, Stoddard G, Cefalu WT, McClain DA. Adipocyte iron regulates leptin and food intake. J Clin Invest. 2015 Sep; 125(9):3681-91. PMID: 26301810.
      View in: PubMed
    6. Ge RL, Simonson TS, Gordeuk V, Prchal JT, McClain DA. Metabolic aspects of high-altitude adaptation in Tibetans. Exp Physiol. 2015 Nov; 100(11):1247-55. PMID: 26053282.
      View in: PubMed
    7. Zhang X, Zhang W, Saraf SL, Nouraie M, Han J, Gowhari M, Hassan J, Miasnikova G, Sergueeva A, Nekhai S, Kittles R, Machado RF, Garcia JG, Gladwin MT, Steinberg MH, Sebastiani P, McClain DA, Gordeuk VR. Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease. Hum Genet. 2015 Aug; 134(8):895-904. PMID: 26025476.
      View in: PubMed
    8. Kwon OS, Tanner RE, Barrows KM, Runtsch M, Symons JD, Jalili T, Bikman BT, McClain DA, O'Connell RM, Drummond MJ. MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance. Am J Physiol Endocrinol Metab. 2015 Jul 01; 309(1):E11-21. PMID: 25968578.
      View in: PubMed
    9. Bai Z, Wuren T, Liu S, Han S, Chen L, McClain D, Ge RL. Intermittent cold exposure results in visceral adipose tissue "browning" in the plateau pika (Ochotona curzoniae). Comp Biochem Physiol A Mol Integr Physiol. 2015 Jun; 184:171-8. PMID: 25662677.
      View in: PubMed
    10. Simcox JA, Mitchell TC, Gao Y, Just SF, Cooksey R, Cox J, Ajioka R, Jones D, Lee SH, King D, Huang J, McClain DA. Dietary iron controls circadian hepatic glucose metabolism through heme synthesis. Diabetes. 2015 Apr; 64(4):1108-19. PMID: 25315005.
      View in: PubMed
    11. Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson TS, Jorde LB, Kaelin WG, Koivunen P, Prchal JT. A genetic mechanism for Tibetan high-altitude adaptation. Nat Genet. 2014 Sep; 46(9):951-6. PMID: 25129147.
      View in: PubMed
    12. Carlin MB, Tanner RE, Agergaard J, Jalili T, McClain DA, Drummond MJ. Skeletal muscle Ras-related GTP binding B mRNA and protein expression is increased after essential amino acid ingestion in healthy humans. J Nutr. 2014 Sep; 144(9):1409-14. PMID: 25056691.
      View in: PubMed
    13. Abbas MA, Abraham D, Kushner JP, McClain DA. Anti-obesity and pro-diabetic effects of hemochromatosis. Obesity (Silver Spring). 2014 Oct; 22(10):2120-2. PMID: 25044717.
      View in: PubMed
    14. Drummond MJ, Addison O, Brunker L, Hopkins PN, McClain DA, LaStayo PC, Marcus RL. Downregulation of E3 ubiquitin ligases and mitophagy-related genes in skeletal muscle of physically inactive, frail older women: a cross-sectional comparison. J Gerontol A Biol Sci Med Sci. 2014 Aug; 69(8):1040-8. PMID: 24526667.
      View in: PubMed
    15. Creighton Mitchell T, McClain DA. Diabetes and hemochromatosis. Curr Diab Rep. 2014; 14(5):488. PMID: 24682660.
      View in: PubMed
    16. Zhu Y, Soto J, Anderson B, Riehle C, Zhang YC, Wende AR, Jones D, McClain DA, Abel ED. Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1a. Am J Physiol Heart Circ Physiol. 2013 Jul 01; 305(1):H41-51. PMID: 23624629.
      View in: PubMed
    17. Stapleton D, Nelson C, Parsawar K, Flores-Opazo M, McClain D, Parker G. The 3T3-L1 adipocyte glycogen proteome. Proteome Sci. 2013 Mar 22; 11(1):11. PMID: 23521774.
      View in: PubMed
    18. Huang J, Simcox J, Mitchell TC, Jones D, Cox J, Luo B, Cooksey RC, Boros LG, McClain DA. Iron regulates glucose homeostasis in liver and muscle via AMP-activated protein kinase in mice. FASEB J. 2013 Jul; 27(7):2845-54. PMID: 23515442.
      View in: PubMed
    19. Simcox JA, McClain DA. Iron and diabetes risk. Cell Metab. 2013 Mar 05; 17(3):329-41. PMID: 23473030.
      View in: PubMed
    20. Lee SH, Jouihan HA, Cooksey RC, Jones D, Kim HJ, Winge DR, McClain DA. Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion. Endocrinology. 2013 Mar; 154(3):1029-38. PMID: 23372018.
      View in: PubMed
    21. Byington CL, Savitz L, Varner M, McClain D. The Utah Center for Clinical and Translational Science: transformation through collaboration. Clin Transl Sci. 2012 Oct; 5(5):377-8. PMID: 23814914.
      View in: PubMed
    22. McClain DA, Abuelgasim KA, Nouraie M, Salomon-Andonie J, Niu X, Miasnikova G, Polyakova LA, Sergueeva A, Okhotin DJ, Cherqaoui R, Okhotin D, Cox JE, Swierczek S, Song J, Simon MC, Huang J, Simcox JA, Yoon D, Prchal JT, Gordeuk VR. Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolism. J Mol Med (Berl). 2013 Jan; 91(1):59-67. PMID: 23015148.
      View in: PubMed
    23. Gabrielsen JS, Gao Y, Simcox JA, Huang J, Thorup D, Jones D, Cooksey RC, Gabrielsen D, Adams TD, Hunt SC, Hopkins PN, Cefalu WT, McClain DA. Adipocyte iron regulates adiponectin and insulin sensitivity. J Clin Invest. 2012 Oct; 122(10):3529-40. PMID: 22996660.
      View in: PubMed
    24. Kusminski CM, Holland WL, Sun K, Park J, Spurgin SB, Lin Y, Askew GR, Simcox JA, McClain DA, Li C, Scherer PE. MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity. Nat Med. 2012 Oct; 18(10):1539-49. PMID: 22961109.
      View in: PubMed
    25. Yang G, Jia Z, Aoyagi T, McClain D, Mortensen RM, Yang T. Systemic PPAR? deletion impairs circadian rhythms of behavior and metabolism. PLoS One. 2012; 7(8):e38117. PMID: 22899986.
      View in: PubMed
    26. Underwood PC, Chamarthi B, Williams JS, Vaidya A, Garg R, Adler GK, Grotzke MP, Staskus G, Wadwekar D, Hopkins PN, Ferri C, McCall A, McClain D, Williams GH. Nonmodulation as the mechanism for salt sensitivity of blood pressure in individuals with hypertension and type 2 diabetes mellitus. J Clin Endocrinol Metab. 2012 Oct; 97(10):3775-82. PMID: 22865897.
      View in: PubMed
    27. Boudina S, Sena S, Sloan C, Tebbi A, Han YH, O'Neill BT, Cooksey RC, Jones D, Holland WL, McClain DA, Abel ED. Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity. Endocrinology. 2012 Jun; 153(6):2677-88. PMID: 22510273.
      View in: PubMed
    28. Shamoon H, Center D, Davis P, Tuchman M, Ginsberg H, Califf R, Stephens D, Mellman T, Verbalis J, Nadler L, Shekhar A, Ford D, Rizza R, Shaker R, Brady K, Murphy B, Cronstein B, Hochman J, Greenland P, Orwoll E, Sinoway L, Greenberg H, Jackson R, Coller B, Topol E, Guay-Woodford L, Runge M, Clark R, McClain D, Selker H, Lowery C, Dubinett S, Berglund L, Cooper D, Firestein G, Johnston SC, Solway J, Heubi J, Sokol R, Nelson D, Tobacman L, Rosenthal G, Aaronson L, Barohn R, Kern P, Sullivan J, Shanley T, Blazar B, Larson R, FitzGerald G, Reis S, Pearson T, Buchanan T, McPherson D, Brasier A, Toto R, Disis M, Drezner M, Bernard G, Clore J, Evanoff B, Imperato-McGinley J, Sherwin R, Pulley J. Preparedness of the CTSA's structural and scientific assets to support the mission of the National Center for Advancing Translational Sciences (NCATS). Clin Transl Sci. 2012 Apr; 5(2):121-9. PMID: 22507116.
      View in: PubMed
    29. Ge RL, Simonson TS, Cooksey RC, Tanna U, Qin G, Huff CD, Witherspoon DJ, Xing J, Zhengzhong B, Prchal JT, Jorde LB, McClain DA. Metabolic insight into mechanisms of high-altitude adaptation in Tibetans. Mol Genet Metab. 2012 Jun; 106(2):244-7. PMID: 22503288.
      View in: PubMed
    30. Simonson TS, McClain DA, Jorde LB, Prchal JT. Genetic determinants of Tibetan high-altitude adaptation. Hum Genet. 2012 Apr; 131(4):527-33. PMID: 22068265.
      View in: PubMed
    31. Soesanto Y, Luo B, Parker G, Jones D, Cooksey RC, McClain DA. Pleiotropic and age-dependent effects of decreased protein modification by O-linked N-acetylglucosamine on pancreatic ß-cell function and vascularization. J Biol Chem. 2011 Jul 22; 286(29):26118-26. PMID: 21622566.
      View in: PubMed
    32. Flann KL, LaStayo PC, McClain DA, Hazel M, Lindstedt SL. Muscle damage and muscle remodeling: no pain, no gain? J Exp Biol. 2011 Feb 15; 214(Pt 4):674-9. PMID: 21270317.
      View in: PubMed
    33. Huang J, Jones D, Luo B, Sanderson M, Soto J, Abel ED, Cooksey RC, McClain DA. Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. Diabetes. 2011 Jan; 60(1):80-7. PMID: 20876715.
      View in: PubMed
    34. Cooksey RC, McClain DA. Increased hexosamine pathway flux and high fat feeding are not additive in inducing insulin resistance: evidence for a shared pathway. Amino Acids. 2011 Mar; 40(3):841-6. PMID: 20658157.
      View in: PubMed
    35. Stapleton D, Nelson C, Parsawar K, McClain D, Gilbert-Wilson R, Barker E, Rudd B, Brown K, Hendrix W, O'Donnell P, Parker G. Analysis of hepatic glycogen-associated proteins. Proteomics. 2010 Jun; 10(12):2320-9. PMID: 20391537.
      View in: PubMed
    36. Cooksey RC, Jones D, Gabrielsen S, Huang J, Simcox JA, Luo B, Soesanto Y, Rienhoff H, Abel ED, McClain DA. Dietary iron restriction or iron chelation protects from diabetes and loss of beta-cell function in the obese (ob/ob lep-/-) mouse. Am J Physiol Endocrinol Metab. 2010 Jun; 298(6):E1236-43. PMID: 20354157.
      View in: PubMed
    37. McClain DA. Bridging the gap between basic and clinical investigation. Trends Biochem Sci. 2010 Apr; 35(4):187-8. PMID: 20172732.
      View in: PubMed
    38. Tabbi-Anneni I, Cooksey R, Gunda V, Liu S, Mueller A, Song G, McClain DA, Wang L. Overexpression of nuclear receptor SHP in adipose tissues affects diet-induced obesity and adaptive thermogenesis. Am J Physiol Endocrinol Metab. 2010 05; 298(5):E961-70. PMID: 20124506.
      View in: PubMed
    39. Symons JD, McMillin SL, Riehle C, Tanner J, Palionyte M, Hillas E, Jones D, Cooksey RC, Birnbaum MJ, McClain DA, Zhang QJ, Gale D, Wilson LJ, Abel ED. Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure. Circ Res. 2009 May 08; 104(9):1085-94. PMID: 19342603.
      View in: PubMed
    40. Shakya A, Cooksey R, Cox JE, Wang V, McClain DA, Tantin D. Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity. Nat Cell Biol. 2009 Mar; 11(3):320-7. PMID: 19219035.
      View in: PubMed
    41. Marcus RL, Lastayo PC, Dibble LE, Hill L, McClain DA. Increased strength and physical performance with eccentric training in women with impaired glucose tolerance: a pilot study. J Womens Health (Larchmt). 2009 Feb; 18(2):253-60. PMID: 19183097.
      View in: PubMed
    42. Yang S, Liu A, Weidenhammer A, Cooksey RC, McClain D, Kim MK, Aguilera G, Abel ED, Chung JH. The role of mPer2 clock gene in glucocorticoid and feeding rhythms. Endocrinology. 2009 May; 150(5):2153-60. PMID: 19179447.
      View in: PubMed
    43. Taylor RP, Geisler TS, Chambers JH, McClain DA. Up-regulation of O-GlcNAc transferase with glucose deprivation in HepG2 cells is mediated by decreased hexosamine pathway flux. J Biol Chem. 2009 Feb 06; 284(6):3425-32. PMID: 19073609.
      View in: PubMed
    44. McClain DA. Introduction to a mini-forum on "glyconutrients". Glycobiology. 2008 Sep; 18(9):651. PMID: 18710891.
      View in: PubMed
    45. Soesanto YA, Luo B, Jones D, Taylor R, Gabrielsen JS, Parker G, McClain DA. Regulation of Akt signaling by O-GlcNAc in euglycemia. Am J Physiol Endocrinol Metab. 2008 Oct; 295(4):E974-80. PMID: 18728220.
      View in: PubMed
    46. Ruddock MW, Stein A, Landaker E, Park J, Cooksey RC, McClain D, Patti ME. Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling. J Biochem. 2008 Nov; 144(5):599-607. PMID: 18713797.
      View in: PubMed
    47. Jouihan HA, Cobine PA, Cooksey RC, Hoagland EA, Boudina S, Abel ED, Winge DR, McClain DA. Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis. Mol Med. 2008 Mar-Apr; 14(3-4):98-108. PMID: 18317567.
      View in: PubMed
    48. Taylor RP, Parker GJ, Hazel MW, Soesanto Y, Fuller W, Yazzie MJ, McClain DA. Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked N-acetylglucosaminyltransferase. J Biol Chem. 2008 Mar 07; 283(10):6050-7. PMID: 18174169.
      View in: PubMed
    49. Luo B, Soesanto Y, McClain DA. Protein modification by O-linked GlcNAc reduces angiogenesis by inhibiting Akt activity in endothelial cells. Arterioscler Thromb Vasc Biol. 2008 Apr; 28(4):651-7. PMID: 18174452.
      View in: PubMed
    50. Young ME, Yan J, Razeghi P, Cooksey RC, Guthrie PH, Stepkowski SM, McClain DA, Tian R, Taegtmeyer H. Proposed regulation of gene expression by glucose in rodent heart. Gene Regul Syst Bio. 2007 Nov 05; 1:251-62. PMID: 19936093.
      View in: PubMed
    51. Huang J, Gabrielsen JS, Cooksey RC, Luo B, Boros LG, Jones DL, Jouihan HA, Soesanto Y, Knecht L, Hazel MW, Kushner JP, McClain DA. Increased glucose disposal and AMP-dependent kinase signaling in a mouse model of hemochromatosis. J Biol Chem. 2007 Dec 28; 282(52):37501-7. PMID: 17971451.
      View in: PubMed
    52. Wende AR, Schaeffer PJ, Parker GJ, Zechner C, Han DH, Chen MM, Hancock CR, Lehman JJ, Huss JM, McClain DA, Holloszy JO, Kelly DP. A role for the transcriptional coactivator PGC-1alpha in muscle refueling. J Biol Chem. 2007 Dec 14; 282(50):36642-51. PMID: 17932032.
      View in: PubMed
    53. Hao HX, Cardon CM, Swiatek W, Cooksey RC, Smith TL, Wilde J, Boudina S, Abel ED, McClain DA, Rutter J. PAS kinase is required for normal cellular energy balance. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15466-71. PMID: 17878307.
      View in: PubMed
    54. Abraham D, Sharma PK, Bentz J, Gault PM, Neumayer L, McClain DA. Utility of ultrasound-guided fine-needle aspiration of parathyroid adenomas for localization before minimally invasive parathyroidectomy. Endocr Pract. 2007 Jul-Aug; 13(4):333-7. PMID: 17669707.
      View in: PubMed
    55. Hsueh W, Abel ED, Breslow JL, Maeda N, Davis RC, Fisher EA, Dansky H, McClain DA, McIndoe R, Wassef MK, Rabadán-Diehl C, Goldberg IJ. Recipes for creating animal models of diabetic cardiovascular disease. Circ Res. 2007 May 25; 100(10):1415-27. PMID: 17525381.
      View in: PubMed
    56. Luo B, Parker GJ, Cooksey RC, Soesanto Y, Evans M, Jones D, McClain DA. Chronic hexosamine flux stimulates fatty acid oxidation by activating AMP-activated protein kinase in adipocytes. J Biol Chem. 2007 Mar 09; 282(10):7172-80. PMID: 17227772.
      View in: PubMed
    57. Cooksey RC, Pusuluri S, Hazel M, McClain DA. Hexosamines regulate sensitivity of glucose-stimulated insulin secretion in beta-cells. Am J Physiol Endocrinol Metab. 2006 Feb; 290(2):E334-40. PMID: 16188910.
      View in: PubMed
    58. McClain DA, Hazel M, Parker G, Cooksey RC. Adipocytes with increased hexosamine flux exhibit insulin resistance, increased glucose uptake, and increased synthesis and storage of lipid. Am J Physiol Endocrinol Metab. 2005 May; 288(5):E973-9. PMID: 15613679.
      View in: PubMed
    59. Donthi RV, Ye G, Wu C, McClain DA, Lange AJ, Epstein PN. Cardiac expression of kinase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and reduces insulin sensitivity. J Biol Chem. 2004 Nov 12; 279(46):48085-90. PMID: 15331593.
      View in: PubMed
    60. Cooksey RC, Jouihan HA, Ajioka RS, Hazel MW, Jones DL, Kushner JP, McClain DA. Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis. Endocrinology. 2004 Nov; 145(11):5305-12. PMID: 15308612.
      View in: PubMed
    61. Parker G, Taylor R, Jones D, McClain D. Hyperglycemia and inhibition of glycogen synthase in streptozotocin-treated mice: role of O-linked N-acetylglucosamine. J Biol Chem. 2004 May 14; 279(20):20636-42. PMID: 15014073.
      View in: PubMed
    62. Hazel M, Cooksey RC, Jones D, Parker G, Neidigh JL, Witherbee B, Gulve EA, McClain DA. Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance. Endocrinology. 2004 May; 145(5):2118-28. PMID: 14684615.
      View in: PubMed
    63. Parker GJ, Lund KC, Taylor RP, McClain DA. Insulin resistance of glycogen synthase mediated by o-linked N-acetylglucosamine. J Biol Chem. 2003 Mar 21; 278(12):10022-7. PMID: 12510058.
      View in: PubMed
    64. McClain DA, Lubas WA, Cooksey RC, Hazel M, Parker GJ, Love DC, Hanover JA. Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10695-9. PMID: 12136128.
      View in: PubMed
    65. Cooksey RC, McClain DA. Transgenic mice overexpressing the rate-limiting enzyme for hexosamine synthesis in skeletal muscle or adipose tissue exhibit total body insulin resistance. Ann N Y Acad Sci. 2002 Jun; 967:102-11. PMID: 12079840.
      View in: PubMed
    66. Belke DD, Betuing S, Tuttle MJ, Graveleau C, Young ME, Pham M, Zhang D, Cooksey RC, McClain DA, Litwin SE, Taegtmeyer H, Severson D, Kahn CR, Abel ED. Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Invest. 2002 Mar; 109(5):629-39. PMID: 11877471.
      View in: PubMed
    67. McClain DA. Hexosamines as mediators of nutrient sensing and regulation in diabetes. J Diabetes Complications. 2002 Jan-Feb; 16(1):72-80. PMID: 11872372.
      View in: PubMed
    Mcclain's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _