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Clinical and Translational Science Institute

Keywords
Last Name

Douglas S. Lyles, Ph.D.

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentBiochemistry
Address
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    Other Positions
    TitleChair
    InstitutionWake Forest School of Medicine
    DepartmentBiochemistry

    TitleProgram Director
    InstitutionWake Forest School of Medicine
    DepartmentComprehensive Cancer Center


    Collapse Research 
    Collapse research activities and funding
    R01AI015892     (LYLES, DOUGLAS S.)May 1, 1979 - Jun 30, 2014
    NIH/NIAID
    Assembly of enveloped viruses
    Role: Principal Investigator

    R01AI020778     (LYLES, DOUGLAS S.)Sep 1, 1984 - Aug 31, 1994
    NIH/NIAID
    ANALYSIS OF VIRAL AND H-2 ANTIGEN INTERACTIONS
    Role: Principal Investigator

    R55AI015892     (LYLES, DOUGLAS S.)Sep 30, 1991 - Jan 31, 1993
    NIH/NIAID
    ASSEMBLY OF ENVELOPED VIRUSES
    Role: Principal Investigator

    R01AI032983     (LYLES, DOUGLAS S.)May 1, 1994 - Mar 31, 2014
    NIH/NIAID
    Cellular interactions of viral matrix protein
    Role: Principal Investigator

    R21AI052304     (LYLES, DOUGLAS S.)Sep 29, 2003 - Sep 30, 2005
    NIH/NIAID
    Control of translation by VSV
    Role: Principal Investigator

    R01AI052304     (LYLES, DOUGLAS S.)Feb 1, 2004 - Jan 31, 2010
    NIH/NIAID
    Control of translation by VSV
    Role: Principal Investigator

    R56AI084886     (LYLES, DOUGLAS S.)Sep 21, 2010 - Aug 31, 2012
    NIH/NIAID
    Mechanism of host shut-off by VSV
    Role: Principal Investigator

    T32GM095440     (POOLE, LESLIE B)Jul 1, 2011 - Jun 30, 2021
    NIH/NIGMS
    Structural and Computational Biophysics Training Program
    Role: Co-Principal Investigator

    R01AI105012     (LYLES, DOUGLAS S.)Mar 1, 2014 - Feb 28, 2019
    NIH/NIAID
    RNA-Binding Proteins and Host Shut-Off by VSV
    Role: Principal Investigator

    R01AI120623     (LYLES, DOUGLAS S.)Jun 20, 2017 - May 31, 2022
    NIH/NIAID
    Cellular Interactions of VSV Nucleocapsids
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Freedman BI, Kistler AL, Skewes-Cox P, Ganem D, Spainhour M, Turner J, Divers J, Langefeld CD, Murea M, Hicks PJ, Hemal AK, Snipes JA, Zhao L, Abend JR, Lyles DS, Ma L, Skorecki KL. JC polyoma viruria associates with protection from chronic kidney disease independently from apolipoprotein L1 genotype in African Americans. Nephrol Dial Transplant. 2018 Nov 01; 33(11):1960-1967. PMID: 29420808.
      View in: PubMed
    2. Westcott MM, Smedberg J, Jorgensen MJ, Puckett S, Lyles DS. Immunogenicity in African Green Monkeys of M Protein Mutant Vesicular Stomatitis Virus Vectors and Contribution of Vector-Encoded Flagellin. Vaccines (Basel). 2018 Mar 19; 6(1). PMID: 29562688.
      View in: PubMed
    3. Yacovone SK, Smelser AM, Macosko JC, Holzwarth G, Ornelles DA, Lyles DS. Migration of Nucleocapsids in Vesicular Stomatitis Virus-Infected Cells Is Dependent on both Microtubules and Actin Filaments. J Virol. 2016 07 01; 90(13):6159-70. PMID: 27122580.
      View in: PubMed
    4. Yacovone SK, Ornelles DA, Lyles DS. The border-to-border distribution method for analysis of cytoplasmic particles and organelles. Cell Tissue Res. 2016 Feb; 363(2):351-60. PMID: 26310140.
      View in: PubMed
    5. Westcott MM, Liu J, Rajani K, D'Agostino R, Lyles DS, Porosnicu M. Interferon Beta and Interferon Alpha 2a Differentially Protect Head and Neck Cancer Cells from Vesicular Stomatitis Virus-Induced Oncolysis. J Virol. 2015 Aug; 89(15):7944-54. PMID: 25995245.
      View in: PubMed
    6. Yu N, Puckett S, Antinozzi PA, Cramer SD, Lyles DS. Changes in Susceptibility to Oncolytic Vesicular Stomatitis Virus during Progression of Prostate Cancer. J Virol. 2015 May; 89(10):5250-63. PMID: 25741004.
      View in: PubMed
    7. Smedberg JR, Westcott MM, Ahmed M, Lyles DS. Signaling pathways in murine dendritic cells that regulate the response to vesicular stomatitis virus vectors that express flagellin. J Virol. 2014 Jan; 88(2):777-85. PMID: 24198430.
      View in: PubMed
    8. Blackham AU, Northrup SA, Willingham M, Sirintrapun J, Russell GB, Lyles DS, Stewart JH. Molecular determinants of susceptibility to oncolytic vesicular stomatitis virus in pancreatic adenocarcinoma. J Surg Res. 2014 Apr; 187(2):412-26. PMID: 24252853.
      View in: PubMed
    9. Westcott MM, Ahmed M, Smedberg JR, Rajani KR, Hiltbold EM, Lyles DS. Preservation of dendritic cell function during vesicular stomatitis virus infection reflects both intrinsic and acquired mechanisms of resistance to suppression of host gene expression by viral M protein. J Virol. 2013 Nov; 87(21):11730-40. PMID: 23986580.
      View in: PubMed
    10. Randle RW, Northrup SA, Sirintrapun SJ, Lyles DS, Stewart JH. Oncolytic vesicular stomatitis virus as a treatment for neuroendocrine tumors. Surgery. 2013 Dec; 154(6):1323-29; discussion 1329-30. PMID: 23973113.
      View in: PubMed
    11. Lawrence TM, Wanjalla CN, Gomme EA, Wirblich C, Gatt A, Carnero E, García-Sastre A, Lyles DS, McGettigan JP, Schnell MJ. Comparison of Heterologous Prime-Boost Strategies against Human Immunodeficiency Virus Type 1 Gag Using Negative Stranded RNA Viruses. PLoS One. 2013; 8(6):e67123. PMID: 23840600.
      View in: PubMed
    12. Lyles DS. Assembly and budding of negative-strand RNA viruses. Adv Virus Res. 2013; 85:57-90. PMID: 23439024.
      View in: PubMed
    13. Blackham AU, Northrup SA, Willingham M, D'Agostino RB, Lyles DS, Stewart JH. Variation in susceptibility of human malignant melanomas to oncolytic vesicular stomatitis virus. Surgery. 2013 Mar; 153(3):333-43. PMID: 23102637.
      View in: PubMed
    14. Rajani KR, Pettit Kneller EL, McKenzie MO, Horita DA, Chou JW, Lyles DS. Complexes of vesicular stomatitis virus matrix protein with host Rae1 and Nup98 involved in inhibition of host transcription. PLoS Pathog. 2012 Sep; 8(9):e1002929. PMID: 23028327.
      View in: PubMed
    15. Johnson JB, Lyles DS, Alexander-Miller MA, Parks GD. Virion-associated complement regulator CD55 is more potent than CD46 in mediating resistance of mumps virus and vesicular stomatitis virus to neutralization. J Virol. 2012 Sep; 86(18):9929-40. PMID: 22761385.
      View in: PubMed
    16. Stewart JH, Ahmed M, Northrup SA, Willingham M, Lyles DS. Vesicular stomatitis virus as a treatment for colorectal cancer. Cancer Gene Ther. 2011 Dec; 18(12):837-49. PMID: 21886191.
      View in: PubMed
    17. Gerlier D, Lyles DS. Interplay between innate immunity and negative-strand RNA viruses: towards a rational model. Microbiol Mol Biol Rev. 2011 Sep; 75(3):468-90, second page of table of contents. PMID: 21885681.
      View in: PubMed
    18. Cary ZD, Willingham MC, Lyles DS. Oncolytic vesicular stomatitis virus induces apoptosis in U87 glioblastoma cells by a type II death receptor mechanism and induces cell death and tumor clearance in vivo. J Virol. 2011 Jun; 85(12):5708-17. PMID: 21450822.
      View in: PubMed
    19. Ahmed M, Puckett S, Arimilli S, Braxton CL, Mizel SB, Lyles DS. Stimulation of human dendritic cells by wild-type and M protein mutant vesicular stomatitis viruses engineered to express bacterial flagellin. J Virol. 2010 Nov; 84(22):12093-8. PMID: 20844045.
      View in: PubMed
    20. Braxton CL, Puckett SH, Mizel SB, Lyles DS. Protection against lethal vaccinia virus challenge by using an attenuated matrix protein mutant vesicular stomatitis virus vaccine vector expressing poxvirus antigens. J Virol. 2010 Apr; 84(7):3552-61. PMID: 20089648.
      View in: PubMed
    21. Faul EJ, Lyles DS, Schnell MJ. Interferon response and viral evasion by members of the family rhabdoviridae. Viruses. 2009 12; 1(3):832-51. PMID: 21994572.
      View in: PubMed
    22. Agnihothram SS, Dancho B, Grant KW, Grimes ML, Lyles DS, Nunberg JH. Assembly of arenavirus envelope glycoprotein GPC in detergent-soluble membrane microdomains. J Virol. 2009 Oct; 83(19):9890-900. PMID: 19625404.
      View in: PubMed
    23. Pearce AF, Lyles DS. Vesicular stomatitis virus induces apoptosis primarily through Bak rather than Bax by inactivating Mcl-1 and Bcl-XL. J Virol. 2009 Sep; 83(18):9102-12. PMID: 19587033.
      View in: PubMed
    24. Ahmed M, Mitchell LM, Puckett S, Brzoza-Lewis KL, Lyles DS, Hiltbold EM. Vesicular stomatitis virus M protein mutant stimulates maturation of Toll-like receptor 7 (TLR7)-positive dendritic cells through TLR-dependent and -independent mechanisms. J Virol. 2009 Apr; 83(7):2962-75. PMID: 19144711.
      View in: PubMed
    25. Dancho B, McKenzie MO, Connor JH, Lyles DS. Vesicular stomatitis virus matrix protein mutations that affect association with host membranes and viral nucleocapsids. J Biol Chem. 2009 Feb 13; 284(7):4500-9. PMID: 19088071.
      View in: PubMed
    26. Pettit Kneller EL, Connor JH, Lyles DS. hnRNPs Relocalize to the cytoplasm following infection with vesicular stomatitis virus. J Virol. 2009 Jan; 83(2):770-80. PMID: 19004954.
      View in: PubMed
    27. Carey BL, Ahmed M, Puckett S, Lyles DS. Early steps of the virus replication cycle are inhibited in prostate cancer cells resistant to oncolytic vesicular stomatitis virus. J Virol. 2008 Dec; 82(24):12104-15. PMID: 18829743.
      View in: PubMed
    28. Ahmed M, Marino TR, Puckett S, Kock ND, Lyles DS. Immune response in the absence of neurovirulence in mice infected with m protein mutant vesicular stomatitis virus. J Virol. 2008 Sep; 82(18):9273-7. PMID: 18614644.
      View in: PubMed
    29. Swinteck BD, Lyles DS. Plasma membrane microdomains containing vesicular stomatitis virus M protein are separate from microdomains containing G protein and nucleocapsids. J Virol. 2008 Jun; 82(11):5536-47. PMID: 18367537.
      View in: PubMed
    30. Whitlow ZW, Connor JH, Lyles DS. New mRNAs are preferentially translated during vesicular stomatitis virus infection. J Virol. 2008 Mar; 82(5):2286-94. PMID: 18094194.
      View in: PubMed
    31. Trottier MD, Lyles DS, Reiss CS. Peripheral, but not central nervous system, type I interferon expression in mice in response to intranasal vesicular stomatitis virus infection. J Neurovirol. 2007 Oct; 13(5):433-45. PMID: 17994428.
      View in: PubMed
    32. Connor JH, McKenzie MO, Parks GD, Lyles DS. Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses. Virology. 2007 May 25; 362(1):109-19. PMID: 17258257.
      View in: PubMed
    33. Gaddy DF, Lyles DS. Oncolytic vesicular stomatitis virus induces apoptosis via signaling through PKR, Fas, and Daxx. J Virol. 2007 Mar; 81(6):2792-804. PMID: 17192316.
      View in: PubMed
    34. Whitlow ZW, Connor JH, Lyles DS. Preferential translation of vesicular stomatitis virus mRNAs is conferred by transcription from the viral genome. J Virol. 2006 Dec; 80(23):11733-42. PMID: 17005665.
      View in: PubMed
    35. Connor JH, McKenzie MO, Lyles DS. Role of residues 121 to 124 of vesicular stomatitis virus matrix protein in virus assembly and virus-host interaction. J Virol. 2006 Apr; 80(8):3701-11. PMID: 16571787.
      View in: PubMed
    36. Brown EL, Lyles DS. Pseudotypes of vesicular stomatitis virus with CD4 formed by clustering of membrane microdomains during budding. J Virol. 2005 Jun; 79(11):7077-86. PMID: 15890947.
      View in: PubMed
    37. Gaddy DF, Lyles DS. Vesicular stomatitis viruses expressing wild-type or mutant M proteins activate apoptosis through distinct pathways. J Virol. 2005 Apr; 79(7):4170-9. PMID: 15767418.
      View in: PubMed
    38. Connor JH, Lyles DS. Inhibition of host and viral translation during vesicular stomatitis virus infection. eIF2 is responsible for the inhibition of viral but not host translation. J Biol Chem. 2005 Apr 08; 280(14):13512-9. PMID: 15705563.
      View in: PubMed
    39. Ahmed M, Cramer SD, Lyles DS. Sensitivity of prostate tumors to wild type and M protein mutant vesicular stomatitis viruses. Virology. 2004 Dec 05; 330(1):34-49. PMID: 15527832.
      View in: PubMed
    40. Hantgan RR, Stahle MC, Connor JH, Lyles DS, Horita DA, Rocco M, Nagaswami C, Weisel JW, McLane MA. The disintegrin echistatin stabilizes integrin alphaIIbbeta3's open conformation and promotes its oligomerization. J Mol Biol. 2004 Oct 01; 342(5):1625-36. PMID: 15364586.
      View in: PubMed
    41. Connor JH, Naczki C, Koumenis C, Lyles DS. Replication and cytopathic effect of oncolytic vesicular stomatitis virus in hypoxic tumor cells in vitro and in vivo. J Virol. 2004 Sep; 78(17):8960-70. PMID: 15308693.
      View in: PubMed
    42. Brown EL, Lyles DS. A novel method for analysis of membrane microdomains: vesicular stomatitis virus glycoprotein microdomains change in size during infection, and those outside of budding sites resemble sites of virus budding. Virology. 2003 Jun 05; 310(2):343-58. PMID: 12781721.
      View in: PubMed
    43. Kopecky SA, Lyles DS. The cell-rounding activity of the vesicular stomatitis virus matrix protein is due to the induction of cell death. J Virol. 2003 May; 77(9):5524-8. PMID: 12692256.
      View in: PubMed
    44. Brown EL, Lyles DS. Organization of the vesicular stomatitis virus glycoprotein into membrane microdomains occurs independently of intracellular viral components. J Virol. 2003 Apr; 77(7):3985-92. PMID: 12634358.
      View in: PubMed
    45. Ahmed M, McKenzie MO, Puckett S, Hojnacki M, Poliquin L, Lyles DS. Ability of the matrix protein of vesicular stomatitis virus to suppress beta interferon gene expression is genetically correlated with the inhibition of host RNA and protein synthesis. J Virol. 2003 Apr; 77(8):4646-57. PMID: 12663771.
      View in: PubMed
    46. Kopecky SA, Lyles DS. Contrasting effects of matrix protein on apoptosis in HeLa and BHK cells infected with vesicular stomatitis virus are due to inhibition of host gene expression. J Virol. 2003 Apr; 77(8):4658-69. PMID: 12663772.
      View in: PubMed
    47. Hantgan RR, Lyles DS, Mallett TC, Rocco M, Nagaswami C, Weisel JW. Ligand binding promotes the entropy-driven oligomerization of integrin alpha IIb beta 3. J Biol Chem. 2003 Jan 31; 278(5):3417-26. PMID: 12426312.
      View in: PubMed
    48. Connor JH, Lyles DS. Vesicular stomatitis virus infection alters the eIF4F translation initiation complex and causes dephosphorylation of the eIF4E binding protein 4E-BP1. J Virol. 2002 Oct; 76(20):10177-87. PMID: 12239292.
      View in: PubMed
    49. Li HH, Lyles DS, Pan W, Alexander E, Thomas MJ, Sorci-Thomas MG. ApoA-I structure on discs and spheres. Variable helix registry and conformational states. J Biol Chem. 2002 Oct 18; 277(42):39093-101. PMID: 12167653.
      View in: PubMed
    50. Desforges M, Despars G, Bérard S, Gosselin M, McKenzie MO, Lyles DS, Talbot PJ, Poliquin L. Matrix protein mutations contribute to inefficient induction of apoptosis leading to persistent infection of human neural cells by vesicular stomatitis virus. Virology. 2002 Mar 30; 295(1):63-73. PMID: 12033766.
      View in: PubMed
    51. Ahmed M, Lyles DS. Effect of vesicular stomatitis virus matrix protein on transcription directed by host RNA polymerases I, II, and III. J Virol. 1998 Oct; 72(10):8413-9. PMID: 9733895.
      View in: PubMed
    52. Ahmed M, Lyles DS. Identification of a consensus mutation in M protein of vesicular stomatitis virus from persistently infected cells that affects inhibition of host-directed gene expression. Virology. 1997 Oct 27; 237(2):378-88. PMID: 9356348.
      View in: PubMed
    53. Lyles DS, McKenzie MO. Activity of vesicular stomatitis virus M protein mutants in cell rounding is correlated with the ability to inhibit host gene expression and is not correlated with virus assembly function. Virology. 1997 Mar 03; 229(1):77-89. PMID: 9123880.
      View in: PubMed
    54. Lyles DS, McKenzie MO, Ahmed M, Woolwine SC. Potency of wild-type and temperature-sensitive vesicular stomatitis virus matrix protein in the inhibition of host-directed gene expression. Virology. 1996 Nov 01; 225(1):172-80. PMID: 8918544.
      View in: PubMed
    55. Lyles DS, McKenzie MO, Hantgan RR. Stopped-flow, classical, and dynamic light scattering analysis of matrix protein binding to nucleocapsids of vesicular stomatitis virus. Biochemistry. 1996 May 21; 35(20):6508-18. PMID: 8639598.
      View in: PubMed
    56. Lyles DS, McKenzie MO, Kaptur PE, Grant KW, Jerome WG. Complementation of M gene mutants of vesicular stomatitis virus by plasmid-derived M protein converts spherical extracellular particles into native bullet shapes. Virology. 1996 Mar 01; 217(1):76-87. PMID: 8599238.
      View in: PubMed
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