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Clinical and Translational Science Institute

Keywords
Last Name

Daniel Clark Files, M.D.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine - Pulmonary
Address
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentInternal Medicine-Gerontology and Geriatric Medicine


    Collapse Research 
    Collapse research activities and funding
    F32AR057637     (FILES, DANIEL CLARK)Sep 16, 2009 - Sep 15, 2011
    NIH/NIAMS
    Acute Lung Injury Induces Skeletal Muscle Atrophy
    Role: Principal Investigator

    U01HL123027     (MILLER, CHADWICK DAVID)Jun 17, 2014 - Apr 30, 2021
    NIH/NHLBI
    Wake Forest Clinical Center for the NHLBI PETAL Network
    Role: Co-Principal Investigator

    K08GM123322     (FILES, DANIEL CLARK)Jun 10, 2018 - May 31, 2023
    NIH/NIGMS
    Accelerating Muscle Recovery in Critical Illness
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Files DC, Neiberg R, Rushing J, Morris PE, Young MP, Ayonayon H, Harris T, Newman A, Rubin S, Shiroma E, Houston D, Miller ME, Kritchevsky SB. Influence of Prehospital Function and Strength on Outcomes of Critically Ill Older Adults. J Am Geriatr Soc. 2018 Mar; 66(3):525-531. PMID: 29322491.
      View in: PubMed
    2. Limaye AP, Stapleton RD, Peng L, Gunn SR, Kimball LE, Hyzy R, Exline MC, Files DC, Morris PE, Frankel SK, Mikkelsen ME, Hite D, Enfield KB, Steingrub J, O'Brien J, Parsons PE, Cuschieri J, Wunderink RG, Hotchkin DL, Chen YQ, Rubenfeld GD, Boeckh M. Effect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With Critical Illness: A Randomized Clinical Trial. JAMA. 2017 08 22; 318(8):731-740. PMID: 28829877.
      View in: PubMed
    3. Pereyra AS, Wang ZM, Messi ML, Zhang T, Wu H, Register TC, Forbes E, Devarie-Baez NO, Files DC, Abba MC, Furdui C, Delbono O. BDA-410 Treatment Reduces Body Weight and Fat Content by Enhancing Lipolysis in Sedentary Senescent Mice. J Gerontol A Biol Sci Med Sci. 2017 Aug 01; 72(8):1045-1053. PMID: 27789616.
      View in: PubMed
    4. Xu Z, Feng X, Dong J, Wang ZM, Lee J, Furdui C, Files DC, Beavers KM, Kritchevsky S, Milligan C, Jin JP, Delbono O, Zhang T. Cardiac troponin T and fast skeletal muscle denervation in ageing. J Cachexia Sarcopenia Muscle. 2017 Oct; 8(5):808-823. PMID: 28419739.
      View in: PubMed
    5. LoVerde D, Files DC, Krishnaswamy G. Angioedema. Crit Care Med. 2017 Apr; 45(4):725-735. PMID: 28291095.
      View in: PubMed
    6. Hartman L, Barnes E, Bachmann L, Schafer K, Lovato J, Files DC. Opiate Injection-associated Infective Endocarditis in the Southeastern United States. Am J Med Sci. 2016 Dec; 352(6):603-608. PMID: 27916215.
      View in: PubMed
    7. Files DC, Ilaiwy A, Parry TL, Gibbs KW, Liu C, Bain JR, Delbono O, Muehlbauer MJ, Willis MS. Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism. Metabolomics. 2016 Aug; 12(8). PMID: 28217037.
      View in: PubMed
    8. Morris PE, Berry MJ, Files DC, Thompson JC, Hauser J, Flores L, Dhar S, Chmelo E, Lovato J, Case LD, Bakhru RN, Sarwal A, Parry SM, Campbell P, Mote A, Winkelman C, Hite RD, Nicklas B, Chatterjee A, Young MP. Standardized Rehabilitation and Hospital Length of Stay Among Patients With Acute Respiratory Failure: A Randomized Clinical Trial. JAMA. 2016 Jun 28; 315(24):2694-702. PMID: 27367766.
      View in: PubMed
    9. D'Alessio FR, Craig JM, Singer BD, Files DC, Mock JR, Garibaldi BT, Fallica J, Tripathi A, Mandke P, Gans JH, Limjunyawong N, Sidhaye VK, Heller NM, Mitzner W, King LS, Aggarwal NR. Enhanced resolution of experimental ARDS through IL-4-mediated lung macrophage reprogramming. Am J Physiol Lung Cell Mol Physiol. 2016 04 15; 310(8):L733-46. PMID: 26895644.
      View in: PubMed
    10. Zhang T, Pereyra AS, Wang ZM, Birbrair A, Reisz JA, Files DC, Purcell L, Feng X, Messi ML, Feng H, Chalovich J, Jin JP, Furdui C, Delbono O. Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice. Aging Cell. 2016 06; 15(3):488-98. PMID: 26892246.
      View in: PubMed
    11. Miller JJ, Morris P, Files DC, Gower E, Young M. Decision conflict and regret among surrogate decision makers in the medical intensive care unit. J Crit Care. 2016 Apr; 32:79-84. PMID: 26810482.
      View in: PubMed
    12. Choi SJ, Files DC, Zhang T, Wang ZM, Messi ML, Gregory H, Stone J, Lyles MF, Dhar S, Marsh AP, Nicklas BJ, Delbono O. Intramyocellular Lipid and Impaired Myofiber Contraction in Normal Weight and Obese Older Adults. J Gerontol A Biol Sci Med Sci. 2016 Apr; 71(4):557-64. PMID: 26405061; PMCID: PMC5014190 [Available on 04/01/17].
    13. Files DC, Sanchez MA, Morris PE. A conceptual framework: the early and late phases of skeletal muscle dysfunction in the acute respiratory distress syndrome. Crit Care. 2015 Jul 02; 19:266. PMID: 26134116; PMCID: PMC4488983.
    14. Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O. Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting. Sci Transl Med. 2015 Mar 11; 7(278):278ra32. PMID: 25761888; PMCID: PMC4820823.
    15. Birbrair A, Zhang T, Files DC, Mannava S, Smith T, Wang ZM, Messi ML, Mintz A, Delbono O. Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner. Stem Cell Res Ther. 2014 Nov 06; 5(6):122. PMID: 25376879; PMCID: PMC4445991.
    16. Silverstein MG, Ordanes D, Wylie AT, Files DC, Milligan C, Presley TD, Kavanagh K. Inducing Muscle Heat Shock Protein 70 Improves Insulin Sensitivity and Muscular Performance in Aged Mice. J Gerontol A Biol Sci Med Sci. 2015 Jul; 70(7):800-8. PMID: 25123646; PMCID: PMC4481685.
    17. Mock JR, Garibaldi BT, Aggarwal NR, Jenkins J, Limjunyawong N, Singer BD, Chau E, Rabold R, Files DC, Sidhaye V, Mitzner W, Wagner EM, King LS, D'Alessio FR. Foxp3+ regulatory T cells promote lung epithelial proliferation. Mucosal Immunol. 2014 Nov; 7(6):1440-51. PMID: 24850425; PMCID: PMC4205163.
    18. Files DC, Xiao K, Zhang T, Liu C, Qian J, Zhao W, Morris PE, Delbono O, Feng X. The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injury. PLoS One. 2014; 9(1):e87587. PMID: 24498144; PMCID: PMC3909200.
    19. Aggarwal NR, D'Alessio FR, Eto Y, Chau E, Avalos C, Waickman AT, Garibaldi BT, Mock JR, Files DC, Sidhaye V, Polotsky VY, Powell J, Horton M, King LS. Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury. Am J Respir Cell Mol Biol. 2013 May; 48(5):635-46. PMID: 23349051; PMCID: PMC3707379.
    20. Files DC, Hite RD. Predicting acute lung injury resolution: a role for chest CT? Crit Care Med. 2013 Feb; 41(2):668. PMID: 23353949; PMCID: PMC4673397.
    21. Andres-Mateos E, Brinkmeier H, Burks TN, Mejias R, Files DC, Steinberger M, Soleimani A, Marx R, Simmers JL, Lin B, Finanger Hedderick E, Marr TG, Lin BM, Hourdé C, Leinwand LA, Kuhl D, Föller M, Vogelsang S, Hernandez-Diaz I, Vaughan DK, Alvarez de la Rosa D, Lang F, Cohn RD. Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy. EMBO Mol Med. 2013 01; 5(1):80-91. PMID: 23161797; PMCID: PMC3569655.
    22. Garibaldi BT, D'Alessio FR, Mock JR, Files DC, Chau E, Eto Y, Drummond MB, Aggarwal NR, Sidhaye V, King LS. Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte recruitment. Am J Respir Cell Mol Biol. 2013 Jan; 48(1):35-43. PMID: 23002097.
      View in: PubMed
    23. D'Alessio FR, Tsushima K, Aggarwal NR, Mock JR, Eto Y, Garibaldi BT, Files DC, Avalos CR, Rodriguez JV, Waickman AT, Reddy SP, Pearse DB, Sidhaye VK, Hassoun PM, Crow MT, King LS. Resolution of experimental lung injury by monocyte-derived inducible nitric oxide synthase. J Immunol. 2012 Sep 01; 189(5):2234-45. PMID: 22844117; PMCID: PMC3424351.
    24. Files DC, D'Alessio FR, Johnston LF, Kesari P, Aggarwal NR, Garibaldi BT, Mock JR, Simmers JL, DeGorordo A, Murdoch J, Willis MS, Patterson C, Tankersley CG, Messi ML, Liu C, Delbono O, Furlow JD, Bodine SC, Cohn RD, King LS, Crow MT. A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting. Am J Respir Crit Care Med. 2012 Apr 15; 185(8):825-34. PMID: 22312013; PMCID: PMC3360571.
    25. Zaiman AL, Damico R, Thoms-Chesley A, Files DC, Kesari P, Johnston L, Swaim M, Mozammel S, Myers AC, Halushka M, El-Haddad H, Shimoda LA, Peng CF, Hassoun PM, Champion HC, Kitsis RN, Crow MT. A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension. Circulation. 2011 Dec 06; 124(23):2533-42. PMID: 22082675; PMCID: PMC4583146.
    26. Finanger Hedderick EL, Simmers JL, Soleimani A, Andres-Mateos E, Marx R, Files DC, King L, Crawford TO, Corse AM, Cohn RD. Loss of sarcolemmal nNOS is common in acquired and inherited neuromuscular disorders. Neurology. 2011 Mar 15; 76(11):960-7. PMID: 21403107; PMCID: PMC3059139.
    27. Aggarwal NR, D'Alessio FR, Tsushima K, Files DC, Damarla M, Sidhaye VK, Fraig MM, Polotsky VY, King LS. Moderate oxygen augments lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2010 Mar; 298(3):L371-81. PMID: 20034961; PMCID: PMC2838673.
    28. Files DC, Patel N, Gebretsadik T, Moore PE, Sheller J. A retrospective characterization of African- and European American asthmatic children in a pediatric critical care unit. J Natl Med Assoc. 2009 Nov; 101(11):1119-24. PMID: 19998640.
      View in: PubMed
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