Loading...
Explore More at wakehealth.edu

Clinical and Translational Science Institute

Keywords
Last Name

Debra I. Diz, Ph.D.

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentSurgery Hypertension
Address
vCardDownload vCard
    Other Positions
    TitleDirector
    InstitutionWake Forest School of Medicine
    DepartmentHypertension and Vascular Research Center


    Collapse Research 
    Collapse research activities and funding
    R29HL038535     (DIZ, DEBRA I.)Apr 1, 1988 - Nov 30, 1993
    NIH/NHLBI
    ANGIOTENSIN II BINDING SITES AND FUNCTION IN THE MEDULLA
    Role: Principal Investigator

    R01HL038535     (DIZ, DEBRA I.)Apr 1, 1988 - Nov 30, 1997
    NIH/NHLBI
    ANGIOTENSIN RECEPTOR FUNCTION IN THE DORSAL MEDULLA
    Role: Principal Investigator

    T35HL007790     (DIZ, DEBRA I.)May 1, 1993 - Apr 30, 2008
    NIH/NHLBI
    Excellence in Cardiovascular Sciences Summer Research
    Role: Principal Investigator

    R25GM064249     (DIZ, DEBRA I)Aug 5, 2001 - Feb 28, 2018
    NIH/NIGMS
    Postbaccalaureate Research Education Program (PREP)
    Role: Principal Investigator

    R21RR018370     (DIZ, DEBRA I.)Aug 4, 2003 - Jul 31, 2006
    NIH/NCRR
    Multianalyte Assays for Cardiovascular Disease
    Role: Principal Investigator

    R25HL092618     (TALLANT, ANN ANN)Apr 15, 2008 - Jan 31, 2023
    NIH/NHLBI
    Excellence in Cardiovascular Sciences Summer Research
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. South AM, Nixon PA, Chappell MC, Diz DI, Russell GB, Jensen ET, Shaltout HA, O'Shea TM, Washburn LK. Association between preterm birth and the renin-angiotensin system in adolescence: influence of sex and obesity. J Hypertens. 2018 Oct; 36(10):2092-2101. PMID: 29846325.
      View in: PubMed
    2. Hendricks AS, Shaltout HA, Westwood BM, Chappell MC, Diz DI. Sex-dependent expression of brain medullary MAP and PI3 kinases in adult sheep with antenatal betamethasone exposure. Clin Sci (Lond). 2018 Sep 14; 132(17):1953-1962. PMID: 30026259.
      View in: PubMed
    3. South AM, Nixon PA, Chappell MC, Diz DI, Russell GB, Jensen ET, Shaltout HA, O'Shea TM, Washburn LK. Renal function and blood pressure are altered in adolescents born preterm. Pediatr Nephrol. 2019 Jan; 34(1):137-144. PMID: 30112655.
      View in: PubMed
    4. Wagoner AL, Tarbell SE, Shaltout HA, Diz DI, Weese-Mayer DE, Fortunato JE. Chronic nausea and orthostatic intolerance: Diagnostic utility of orthostatic challenge duration, Nausea Profile Questionnaire, and neurohumoral measures. Neurogastroenterol Motil. 2018 Nov; 30(11):e13433. PMID: 30101470.
      View in: PubMed
    5. Zucker IH, Lindsey ML, Delmar M, De Windt LJ, Des Rosiers C, Diz DI, Hester RL, Jones SP, Kanagy NL, Kitakaze M, Liao R, Lopaschuk GD, Patel KP, Recchia FA, Sadoshima J, Shah AM, Ungvari Z, Benjamin IJ, Blaustein MP, Charkoudian N, Efimov IR, Gutterman D, Kass DA, Liao Y, O'Leary DS, Ripplinger CM, Wolin MS. Why publish in the American Journal of Physiology-Heart and Circulatory Physiology? Am J Physiol Heart Circ Physiol. 2017 Aug 01; 313(2):H221-H223. PMID: 28626081.
      View in: PubMed
    6. Shaltout HA, Eggebeen J, Marsh AP, Brubaker PH, Laurienti PJ, Burdette JH, Basu S, Morgan A, Dos Santos PC, Norris JL, Morgan TM, Miller GD, Rejeski WJ, Hawfield AT, Diz DI, Becton JT, Kim-Shapiro DB, Kitzman DW. Effects of supervised exercise and dietary nitrate in older adults with controlled hypertension and/or heart failure with preserved ejection fraction. Nitric Oxide. 2017 Sep 30; 69:78-90. PMID: 28549665.
      View in: PubMed
    7. Sigmund CD, Diz DI, Chappell MC. No Brain Renin-Angiotensin System: Déjà vu All Over Again? Hypertension. 2017 06; 69(6):1007-1010. PMID: 28396531.
      View in: PubMed
    8. Yousif MHM, Benter IF, Diz DI, Chappell MC. Angiotensin-(1-7)-dependent vasorelaxation of the renal artery exhibits unique angiotensin and bradykinin receptor selectivity. Peptides. 2017 04; 90:10-16. PMID: 28192151.
      View in: PubMed
    9. Sun X, Tommasi E, Molina D, Sah R, Brosnihan KB, Diz D, Petrovic S. Deletion of proton-sensing receptor GPR4 associates with lower blood pressure and lower binding of angiotensin II receptor in SFO. Am J Physiol Renal Physiol. 2016 12 01; 311(6):F1260-F1266. PMID: 27681561.
      View in: PubMed
    10. South AM, Nixon PA, Chappell MC, Diz DI, Russell GB, Snively BM, Shaltout HA, Rose JC, O'Shea TM, Washburn LK. Antenatal corticosteroids and the renin-angiotensin-aldosterone system in adolescents born preterm. Pediatr Res. 2017 01; 81(1-1):88-93. PMID: 27636897.
      View in: PubMed
    11. Schaich CL, Grabenauer M, Thomas BF, Shaltout HA, Gallagher PE, Howlett AC, Diz DI. Medullary Endocannabinoids Contribute to the Differential Resting Baroreflex Sensitivity in Rats with Altered Brain Renin-Angiotensin System Expression. Front Physiol. 2016; 7:207. PMID: 27375489.
      View in: PubMed
    12. Gwathmey TM, Tallant EA, Howlett AC, Diz DI. Programs to Recruit and Retain a More Diverse Workforce in Biomedical Sciences Research. J Best Pract Health Prof Divers. 2016; 9(1):1188-1194. PMID: 28868526.
      View in: PubMed
    13. Wagoner AL, Shaltout HA, Fortunato JE, Diz DI. Distinct neurohumoral biomarker profiles in children with hemodynamically defined orthostatic intolerance may predict treatment options. Am J Physiol Heart Circ Physiol. 2016 Feb 01; 310(3):H416-25. PMID: 26608337; PMCID: PMC4888538 [Available on 02/01/17].
    14. Jefferson ME, Nicklas BJ, Chmelo EA, Crotts CI, Shaltout HA, Diz DI, Marsh AP, Brinkley TE. Effects of Resistance Training With and Without Caloric Restriction on Arterial Stiffness in Overweight and Obese Older Adults. Am J Hypertens. 2016 Apr; 29(4):494-500. PMID: 26297029; PMCID: PMC4850901 [Available on 04/01/17].
    15. Sesay JS, Gyapong RN, Najafi LT, Kabler SL, Diz DI, Howlett AC, Awumey EM. Gai/o-dependent Ca(2+) mobilization and Gaq-dependent PKCa regulation of Ca(2+)-sensing receptor-mediated responses in N18TG2 neuroblastoma cells. Neurochem Int. 2015 Nov; 90:142-51. PMID: 26190181; PMCID: PMC4641771 [Available on 11/01/16].
    16. Gardner AR, Diz DI, Tooze JA, Miller CD, Petty J. Injury patterns associated with hypotension in pediatric trauma patients: A national trauma database review. J Trauma Acute Care Surg. 2015 Jun; 78(6):1143-8. PMID: 26151515.
      View in: PubMed
    17. Schaich CL, Shaltout HA, Grabenauer M, Thomas BF, Gallagher PE, Howlett AC, Diz DI. Alterations in the Medullary Endocannabinoid System Contribute to Age-related Impairment of Baroreflex Sensitivity. J Cardiovasc Pharmacol. 2015 May; 65(5):473-9. PMID: 25636077.
      View in: PubMed
    18. Liu C, Wajih N, Liu X, Basu S, Janes J, Marvel M, Keggi C, Helms CC, Lee AN, Belanger AM, Diz DI, Laurienti PJ, Caudell DL, Wang J, Gladwin MT, Kim-Shapiro DB. Mechanisms of human erythrocytic bioactivation of nitrite. J Biol Chem. 2015 Jan 09; 290(2):1281-94. PMID: 25471374; PMCID: PMC4294492.
    19. Diz DI. Another chapter in the understanding of angiotensin-catecholamine interactions relevant to blood pressure control. Exp Physiol. 2014 Dec 01; 99(12):1595-6. PMID: 25447688.
      View in: PubMed
    20. Miller GD, Isom S, Morgan TM, Vitolins MZ, Blackwell C, Brosnihan KB, Diz DI, Katula J, Goff D. Effects of a community-based weight loss intervention on adipose tissue circulating factors. Diabetes Metab Syndr. 2014 Oct-Dec; 8(4):205-11. PMID: 25293442; PMCID: PMC4254144.
    21. Arnold AC, Diz DI. Endogenous leptin contributes to baroreflex suppression within the solitary tract nucleus of aged rats. Am J Physiol Heart Circ Physiol. 2014 Dec 01; 307(11):H1539-46. PMID: 25260611; PMCID: PMC4255011.
    22. Schaich CL, Shaltout HA, Brosnihan KB, Howlett AC, Diz DI. Acute and chronic systemic CB1 cannabinoid receptor blockade improves blood pressure regulation and metabolic profile in hypertensive (mRen2)27 rats. Physiol Rep. 2014 Aug 01; 2(8). PMID: 25168868; PMCID: PMC4246581.
    23. Fortunato JE, Wagoner AL, Harbinson RL, D'Agostino RB, Shaltout HA, Diz DI. Effect of fludrocortisone acetate on chronic unexplained nausea and abdominal pain in children with orthostatic intolerance. J Pediatr Gastroenterol Nutr. 2014 Jul; 59(1):39-43. PMID: 25222805.
      View in: PubMed
    24. Tarbell SE, Shaltout HA, Wagoner AL, Diz DI, Fortunato JE. Relationship among nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained nausea. Exp Brain Res. 2014 Aug; 232(8):2645-50. PMID: 24829068.
      View in: PubMed
    25. Marshall AC, Pirro NT, Rose JC, Diz DI, Chappell MC. Evidence for an angiotensin-(1-7) neuropeptidase expressed in the brain medulla and CSF of sheep. J Neurochem. 2014 Jul; 130(2):313-23. PMID: 24661079; PMCID: PMC4137327.
    26. Washburn LK, Brosnihan KB, Chappell MC, Diz DI, Gwathmey TM, Nixon PA, Russell GB, Snively BM, O'Shea TM. The renin-angiotensin-aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia. J Renin Angiotensin Aldosterone Syst. 2015 Sep; 16(3):529-38. PMID: 24737639; PMCID: PMC4278943.
    27. Chappell MC, Marshall AC, Alzayadneh EM, Shaltout HA, Diz DI. Update on the Angiotensin converting enzyme 2-Angiotensin (1-7)-MAS receptor axis: fetal programing, sex differences, and intracellular pathways. Front Endocrinol (Lausanne). 2014 Jan 09; 4:201. PMID: 24409169; PMCID: PMC3886117.
    28. Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Enhanced activity of an angiotensin-(1-7) neuropeptidase in glucocorticoid-induced fetal programming. Peptides. 2014 Feb; 52:74-81. PMID: 24355101; PMCID: PMC4157337.
    29. Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Antenatal betamethasone exposure is associated with lower ANG-(1-7) and increased ACE in the CSF of adult sheep. Am J Physiol Regul Integr Comp Physiol. 2013 Oct 01; 305(7):R679-88. PMID: 23948771; PMCID: PMC3798802.
    30. Pulgar VM, Jeffers AB, Rashad HM, Diz DI, Aileru AA. Increased constrictor tone induced by ouabain treatment in rats. J Cardiovasc Pharmacol. 2013 Aug; 62(2):174-83. PMID: 23615157; PMCID: PMC3893306.
    31. Awumey EM, Bridges LE, Williams CL, Diz DI. Nitric-oxide synthase knockout modulates Ca²?-sensing receptor expression and signaling in mouse mesenteric arteries. J Pharmacol Exp Ther. 2013 Jul; 346(1):38-47. PMID: 23639802; PMCID: PMC3684838.
    32. Marshall AC, Shaltout HA, Nautiyal M, Rose JC, Chappell MC, Diz DI. Fetal betamethasone exposure attenuates angiotensin-(1-7)-Mas receptor expression in the dorsal medulla of adult sheep. Peptides. 2013 Jun; 44:25-31. PMID: 23538211; PMCID: PMC3690463.
    33. Nautiyal M, Shaltout HA, de Lima DC, do Nascimento K, Chappell MC, Diz DI. Response to Angiotensin-(1-7) and Bradykinin in Baroreceptor Reflex Sensitivity in Hypertension. Hypertension. 2013 Feb; 61(2):e20. PMID: 23444463.
      View in: PubMed
    34. Nautiyal M, Arnold AC, Chappell MC, Diz DI. The brain Renin-Angiotensin system and mitochondrial function: influence on blood pressure and baroreflex in transgenic rat strains. Int J Hypertens. 2013; 2013:136028. PMID: 23401750; PMCID: PMC3564433.
    35. Arnold AC, Gallagher PE, Diz DI. Brain renin-angiotensin system in the nexus of hypertension and aging. Hypertens Res. 2013 Jan; 36(1):5-13. PMID: 23076408; PMCID: PMC3816955.
    36. Nautiyal M, Shaltout HA, de Lima DC, do Nascimento K, Chappell MC, Diz DI. Central angiotensin-(1-7) improves vagal function independent of blood pressure in hypertensive (mRen2)27 rats. Hypertension. 2012 Nov; 60(5):1257-65. PMID: 23045456; PMCID: PMC3491885.
    37. Arnold AC, Sakima A, Kasper SO, Vinsant S, Garcia-Espinosa MA, Diz DI. The brain renin-angiotensin system and cardiovascular responses to stress: insights from transgenic rats with low brain angiotensinogen. J Appl Physiol (1985). 2012 Dec 15; 113(12):1929-36. PMID: 22984245; PMCID: PMC3544491.
    38. Groban L, Wang H, Machado FS, Trask AJ, Kritchevsky SB, Ferrario CM, Diz DI. Low glial angiotensinogen improves body habitus, diastolic function, and exercise tolerance in aging male rats. Cardiovasc Endocrinol. 2012 Sep 01; 1(3):49-58. PMID: 23795309.
      View in: PubMed
    39. Nautiyal M, Katakam PV, Busija DW, Gallagher PE, Tallant EA, Chappell MC, Diz DI. Differences in oxidative stress status and expression of MKP-1 in dorsal medulla of transgenic rats with altered brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol. 2012 Oct 15; 303(8):R799-806. PMID: 22914751; PMCID: PMC3469665.
    40. Garcia-Espinosa MA, Shaltout HA, Gallagher PE, Chappell MC, Diz DI. In vivo expression of angiotensin-(1-7) lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats. J Cardiovasc Pharmacol. 2012 Aug; 60(2):150-7. PMID: 22526299; PMCID: PMC3419797.
    41. Lee TC, Greene-Schloesser D, Payne V, Diz DI, Hsu FC, Kooshki M, Mustafa R, Riddle DR, Zhao W, Chan MD, Robbins ME. Chronic administration of the angiotensin-converting enzyme inhibitor, ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment. Radiat Res. 2012 Jul; 178(1):46-56. PMID: 22687052; PMCID: PMC3422865.
    42. Marzetti E, Calvani R, DuPree J, Lees HA, Giovannini S, Seo DO, Buford TW, Sweet K, Morgan D, Strehler KY, Diz D, Borst SE, Moningka N, Krotova K, Carter CS. Late-life enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle. Age (Dordr). 2013 Aug; 35(4):1061-75. PMID: 22639176; PMCID: PMC3705103.
    43. Arnold AC, Nautiyal M, Diz DI. Protein phosphatase 1b in the solitary tract nucleus is necessary for normal baroreflex function. J Cardiovasc Pharmacol. 2012 May; 59(5):472-8. PMID: 22569287; PMCID: PMC3349073.
    44. Somasundaram C, Nath RK, Bukoski RD, Diz DI. Identification and characterization of novel perivascular adventitial cells in the whole mount mesenteric branch artery using immunofluorescent staining and scanning confocal microscopy imaging. Int J Cell Biol. 2012; 2012:172746. PMID: 22481943; PMCID: PMC3296306.
    45. Shaltout HA, Rose JC, Chappell MC, Diz DI. Angiotensin-(1-7) deficiency and baroreflex impairment precede the antenatal Betamethasone exposure-induced elevation in blood pressure. Hypertension. 2012 Feb; 59(2):453-8. PMID: 22215705; PMCID: PMC4157309.
    46. Logan EM, Aileru AA, Shaltout HA, Averill DB, Diz DI. The functional role of PI3K in maintenance of blood pressure and baroreflex suppression in (mRen2)27 and mRen2.Lewis rat. J Cardiovasc Pharmacol. 2011 Oct; 58(4):367-73. PMID: 21697727; PMCID: PMC3188661.
    47. Isa K, Arnold AC, Westwood BM, Chappell MC, Diz DI. Angiotensin-converting enzyme inhibition, but not AT(1) receptor blockade, in the solitary tract nucleus improves baroreflex sensitivity in anesthetized transgenic hypertensive (mRen2)27 rats. Hypertens Res. 2011 Dec; 34(12):1257-62. PMID: 21937997; PMCID: PMC4160904.
    48. Fortunato JE, Shaltout HA, Larkin MM, Rowe PC, Diz DI, Koch KL. Fludrocortisone improves nausea in children with orthostatic intolerance (OI). Clin Auton Res. 2011 Dec; 21(6):419-23. PMID: 21796356.
      View in: PubMed
    49. Gilliam-Davis S, Gallagher PE, Payne VS, Kasper SO, Tommasi EN, Westwood BM, Robbins ME, Chappell MC, Diz DI. Long-term systemic angiotensin II type 1 receptor blockade regulates mRNA expression of dorsomedial medulla renin-angiotensin system components. Physiol Genomics. 2011 Jul 14; 43(13):829-35. PMID: 21540301; PMCID: PMC3132839.
    50. Benter IF, Yousif MH, Al-Saleh FM, Raghupathy R, Chappell MC, Diz DI. Angiotensin-(1-7) blockade attenuates captopril- or hydralazine-induced cardiovascular protection in spontaneously hypertensive rats treated with NG-nitro-L-arginine methyl ester. J Cardiovasc Pharmacol. 2011 May; 57(5):559-67. PMID: 21326110; PMCID: PMC3095755.
    51. Arnold AC, Shaltout HA, Gilliam-Davis S, Kock ND, Diz DI. Autonomic control of the heart is altered in Sprague-Dawley rats with spontaneous hydronephrosis. Am J Physiol Heart Circ Physiol. 2011 Jun; 300(6):H2206-13. PMID: 21460193; PMCID: PMC3119102.
    52. Shaltout HA, Chappell MC, Rose JC, Diz DI. Exaggerated sympathetic mediated responses to behavioral or pharmacological challenges following antenatal betamethasone exposure. Am J Physiol Endocrinol Metab. 2011 Jun; 300(6):E979-85. PMID: 21386063; PMCID: PMC3118588.
    53. Diz DI, Arnold AC, Nautiyal M, Isa K, Shaltout HA, Tallant EA. Angiotensin peptides and central autonomic regulation. Curr Opin Pharmacol. 2011 Apr; 11(2):131-7. PMID: 21367658; PMCID: PMC3120135.
    54. Gwathmey TM, Shaltout HA, Rose JC, Diz DI, Chappell MC. Glucocorticoid-induced fetal programming alters the functional complement of angiotensin receptor subtypes within the kidney. Hypertension. 2011 Mar; 57(3):620-6. PMID: 21220702; PMCID: PMC3041840.
    55. Gwathmey TM, Westwood BM, Pirro NT, Tang L, Rose JC, Diz DI, Chappell MC. Nuclear angiotensin-(1-7) receptor is functionally coupled to the formation of nitric oxide. Am J Physiol Renal Physiol. 2010 Nov; 299(5):F983-90. PMID: 20810609; PMCID: PMC2980408.
    56. Arnold AC, Isa K, Shaltout HA, Nautiyal M, Ferrario CM, Chappell MC, Diz DI. Angiotensin-(1-12) requires angiotensin converting enzyme and AT1 receptors for cardiovascular actions within the solitary tract nucleus. Am J Physiol Heart Circ Physiol. 2010 Sep; 299(3):H763-71. PMID: 20562338; PMCID: PMC2944473.
    57. Shaltout HA, Rose JC, Figueroa JP, Chappell MC, Diz DI, Averill DB. Acute AT(1)-receptor blockade reverses the hemodynamic and baroreflex impairment in adult sheep exposed to antenatal betamethasone. Am J Physiol Heart Circ Physiol. 2010 Aug; 299(2):H541-7. PMID: 20543085; PMCID: PMC2930394.
    58. Dhaunsi GS, Yousif MH, Akhtar S, Chappell MC, Diz DI, Benter IF. Angiotensin-(1-7) prevents diabetes-induced attenuation in PPAR-gamma and catalase activities. Eur J Pharmacol. 2010 Jul 25; 638(1-3):108-14. PMID: 20447391; PMCID: PMC2907528.
    59. Garcia-Espinosa MA, Shaltout HA, Olson J, Westwood BM, Robbins ME, Link K, Diz DI. Proton magnetic resonance spectroscopy detection of neurotransmitters in dorsomedial medulla correlate with spontaneous baroreceptor reflex function. Hypertension. 2010 Feb; 55(2):487-93. PMID: 20065146; PMCID: PMC2826127.
    60. Gwathmey TM, Pendergrass KD, Reid SD, Rose JC, Diz DI, Chappell MC. Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus. Hypertension. 2010 Jan; 55(1):166-71. PMID: 19948986; PMCID: PMC2821807.
    61. Arnold AC, Shaltout HA, Gallagher PE, Diz DI. Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus. Hypertension. 2009 Nov; 54(5):1001-8. PMID: 19770402; PMCID: PMC2789663.
    62. Anton L, Merrill DC, Neves LA, Diz DI, Corthorn J, Valdes G, Stovall K, Gallagher PE, Moorefield C, Gruver C, Brosnihan KB. The uterine placental bed Renin-Angiotensin system in normal and preeclamptic pregnancy. Endocrinology. 2009 Sep; 150(9):4316-25. PMID: 19520788; PMCID: PMC2736074.
    63. Pulgar VM, Hong JK, Jessup JA, Massmann AG, Diz DI, Figueroa JP. Mild chronic hypoxemia modifies expression of brain stem angiotensin peptide receptors and reflex responses in fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2009 Aug; 297(2):R446-52. PMID: 19515988; PMCID: PMC2724228.
    64. Isa K, García-Espinosa MA, Arnold AC, Pirro NT, Tommasi EN, Ganten D, Chappell MC, Ferrario CM, Diz DI. Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2009 Jul; 297(1):R111-5. PMID: 19403863; PMCID: PMC2711698.
    65. Gwathmey TM, Shaltout HA, Pendergrass KD, Pirro NT, Figueroa JP, Rose JC, Diz DI, Chappell MC. Nuclear angiotensin II type 2 (AT2) receptors are functionally linked to nitric oxide production. Am J Physiol Renal Physiol. 2009 Jun; 296(6):F1484-93. PMID: 19244399; PMCID: PMC2692453.
    66. Al-Maghrebi M, Benter IF, Diz DI. Endogenous angiotensin-(1-7) reduces cardiac ischemia-induced dysfunction in diabetic hypertensive rats. Pharmacol Res. 2009 Apr; 59(4):263-8. PMID: 19166939; PMCID: PMC2682227.
    67. Robbins ME, Payne V, Tommasi E, Diz DI, Hsu FC, Brown WR, Wheeler KT, Olson J, Zhao W. The AT1 receptor antagonist, L-158,809, prevents or ameliorates fractionated whole-brain irradiation-induced cognitive impairment. Int J Radiat Oncol Biol Phys. 2009 Feb 01; 73(2):499-505. PMID: 19084353; PMCID: PMC2631653.
    68. Shaltout HA, Figueroa JP, Rose JC, Diz DI, Chappell MC. Alterations in circulatory and renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 in fetal programmed hypertension. Hypertension. 2009 Feb; 53(2):404-8. PMID: 19047579; PMCID: PMC2674380.
    69. Diz DI. Future directions in cardiovascular pharmacology: examples from the Renin-Angiotensin system. Mol Interv. 2008 Oct; 8(5):222-5. PMID: 19015385.
      View in: PubMed
    70. Diz DI, Garcia-Espinosa MA, Gallagher PE, Ganten D, Ferrario CM, Averill DB. Angiotensin-(1-7) and baroreflex function in nucleus tractus solitarii of (mRen2)27 transgenic rats. J Cardiovasc Pharmacol. 2008 Jun; 51(6):542-8. PMID: 18475201; PMCID: PMC2676577.
    71. Diz DI. Lewis K. Dahl memorial lecture: the renin-angiotensin system and aging. Hypertension. 2008 Jul; 52(1):37-43. PMID: 18474827; PMCID: PMC2701673.
    72. Diz DI, Varagic J, Groban L. Aging and the brain renin-angiotensin system: relevance to age-related decline in cardiac function. Future Cardiol. 2008 May; 4(3):237-45. PMID: 19804328; PMCID: PMC2929677.
    73. Awumey EM, Hill SK, Diz DI, Bukoski RD. Cytochrome P-450 metabolites of 2-arachidonoylglycerol play a role in Ca2+-induced relaxation of rat mesenteric arteries. Am J Physiol Heart Circ Physiol. 2008 May; 294(5):H2363-70. PMID: 18375719.
      View in: PubMed
    74. Diz DI, Garcia-Espinosa MA, Gegick S, Tommasi EN, Ferrario CM, Ann Tallant E, Chappell MC, Gallagher PE. Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats. Exp Physiol. 2008 May; 93(5):694-700. PMID: 18356558; PMCID: PMC2704611.
    75. Arnold AC, Sakima A, Ganten D, Ferrario CM, Diz DI. Modulation of reflex function by endogenous angiotensins in older transgenic rats with low glial angiotensinogen. Hypertension. 2008 May; 51(5):1326-31. PMID: 18347230; PMCID: PMC2483961.
    76. Anton L, Merrill DC, Neves LA, Stovall K, Gallagher PE, Diz DI, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Activation of local chorionic villi angiotensin II levels but not angiotensin (1-7) in preeclampsia. Hypertension. 2008 Apr; 51(4):1066-72. PMID: 18259034; PMCID: PMC2705753.
    77. Benter IF, Yousif MH, Dhaunsi GS, Kaur J, Chappell MC, Diz DI. Angiotensin-(1-7) prevents activation of NADPH oxidase and renal vascular dysfunction in diabetic hypertensive rats. Am J Nephrol. 2008; 28(1):25-33. PMID: 17890855.
      View in: PubMed
    78. Gilliam-Davis S, Payne VS, Kasper SO, Tommasi EN, Robbins ME, Diz DI. Long-term AT1 receptor blockade improves metabolic function and provides renoprotection in Fischer-344 rats. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1327-33. PMID: 17616746.
      View in: PubMed
    79. Diz DI, Kasper SO, Sakima A, Ferrario CM. Aging and the brain renin-angiotensin system: insights from studies in transgenic rats. Cleve Clin J Med. 2007 Feb; 74 Suppl 1:S95-8. PMID: 17455554.
      View in: PubMed
    80. Awumey EM, Howlett AC, Putney JW, Diz DI, Bukoski RD. Ca(2+) mobilization through dorsal root ganglion Ca(2+)-sensing receptor stably expressed in HEK293 cells. Am J Physiol Cell Physiol. 2007 May; 292(5):C1895-905. PMID: 17267550.
      View in: PubMed
    81. Benter IF, Yousif MH, Cojocel C, Al-Maghrebi M, Diz DI. Angiotensin-(1-7) prevents diabetes-induced cardiovascular dysfunction. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H666-72. PMID: 17213482.
      View in: PubMed
    82. Zhao W, Payne V, Tommasi E, Diz DI, Hsu FC, Robbins ME. Administration of the peroxisomal proliferator-activated receptor gamma agonist pioglitazone during fractionated brain irradiation prevents radiation-induced cognitive impairment. Int J Radiat Oncol Biol Phys. 2007 Jan 01; 67(1):6-9. PMID: 17189061.
      View in: PubMed
    83. Sakima A, Averill DB, Kasper SO, Jackson L, Ganten D, Ferrario CM, Gallagher PE, Diz DI. Baroreceptor reflex regulation in anesthetized transgenic rats with low glia-derived angiotensinogen. Am J Physiol Heart Circ Physiol. 2007 Mar; 292(3):H1412-9. PMID: 17085537.
      View in: PubMed
    84. Kasper SO, Ferrario CM, Ganten D, Diz DI. Rats with low brain angiotensinogen do not exhibit insulin resistance during early aging. Endocrine. 2006 Oct; 30(2):167-74. PMID: 17322575.
      View in: PubMed
    85. Shaltout HA, Westwood BM, Averill DB, Ferrario CM, Figueroa JP, Diz DI, Rose JC, Chappell MC. Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2-dependent processing of angiotensin II. Am J Physiol Renal Physiol. 2007 Jan; 292(1):F82-91. PMID: 16896185.
      View in: PubMed
    86. Somasundaram C, Diz DI, Coleman T, Bukoski RD. Adventitial neuronal somata. J Vasc Res. 2006; 43(3):278-88. PMID: 16636576.
      View in: PubMed
    87. Diz DI. Approaches to establishing angiotensin II as a neurotransmitter revisited. Hypertension. 2006 Mar; 47(3):334-6. PMID: 16446395.
      View in: PubMed
    88. Pendergrass KD, Averill DB, Ferrario CM, Diz DI, Chappell MC. Differential expression of nuclear AT1 receptors and angiotensin II within the kidney of the male congenic mRen2. Lewis rat. Am J Physiol Renal Physiol. 2006 Jun; 290(6):F1497-506. PMID: 16403834.
      View in: PubMed
    89. Robbins ME, Diz DI. Pathogenic role of the renin-angiotensin system in modulating radiation-induced late effects. Int J Radiat Oncol Biol Phys. 2006 Jan 01; 64(1):6-12. PMID: 16377409.
      View in: PubMed
    90. Chen Y, Chen H, Hoffmann A, Cool DR, Diz DI, Chappell MC, Chen AF, Chen A, Morris M. Adenovirus-mediated small-interference RNA for in vivo silencing of angiotensin AT1a receptors in mouse brain. Hypertension. 2006 Feb; 47(2):230-7. PMID: 16380517.
      View in: PubMed
    91. Kasper SO, Carter CS, Ferrario CM, Ganten D, Ferder LF, Sonntag WE, Gallagher PE, Diz DI. Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems. Physiol Genomics. 2005 Nov 17; 23(3):311-7. PMID: 16131528.
      View in: PubMed
    92. Awumey EM, Howlett AC, Diz DI. Is there a role for anandamide in cardiovascular regulation? Insights from studies of endocannabinoid metabolism. Am J Physiol Heart Circ Physiol. 2005 Aug; 289(2):H520-1. PMID: 16014613.
      View in: PubMed
    93. Sakima A, Averill DB, Gallagher PE, Kasper SO, Tommasi EN, Ferrario CM, Diz DI. Impaired heart rate baroreflex in older rats: role of endogenous angiotensin-(1-7) at the nucleus tractus solitarii. Hypertension. 2005 Aug; 46(2):333-40. PMID: 16009784.
      View in: PubMed
    94. Kasper SO, Basso N, Kurnjek ML, Paglia N, Ferrario CM, Ferder LF, Diz DI. Divergent regulation of circulating and intrarenal renin-angiotensin systems in response to long-term blockade. Am J Nephrol. 2005 Jul-Aug; 25(4):335-41. PMID: 15976496.
      View in: PubMed
    95. Ferrario CM, Jessup J, Chappell MC, Averill DB, Brosnihan KB, Tallant EA, Diz DI, Gallagher PE. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation. 2005 May 24; 111(20):2605-10. PMID: 15897343.
      View in: PubMed
    96. Carter CS, Cesari M, Ambrosius WT, Hu N, Diz D, Oden S, Sonntag WE, Pahor M. Angiotensin-converting enzyme inhibition, body composition, and physical performance in aged rats. J Gerontol A Biol Sci Med Sci. 2004 May; 59(5):416-23. PMID: 15123750.
      View in: PubMed
    97. Aileru AA, Logan E, Callahan M, Ferrario CM, Ganten D, Diz DI. Alterations in sympathetic ganglionic transmission in response to angiotensin II in (mRen2)27 transgenic rats. Hypertension. 2004 Feb; 43(2):270-5. PMID: 14732737.
      View in: PubMed
    98. Kasper SO, Ferrario CM, Ganten D, Diz DI. Central depletion of angiotensinogen is associated with elevated AT1 receptors in the SFO and PVN. Neurotox Res. 2004; 6(4):259-65. PMID: 15545009.
      View in: PubMed
    99. Chappell MC, Modrall JG, Diz DI, Ferrario CM. Novel aspects of the renal renin-angiotensin system: angiotensin-(1-7), ACE2 and blood pressure regulation. Contrib Nephrol. 2004; 143:77-89. PMID: 15248357.
      View in: PubMed
    100. Clark MA, Tallant EA, Tommasi E, Bosch S, Diz DI. Angiotensin-(1-7) reduces renal angiotensin II receptors through a cyclooxygenase-dependent mechanism. J Cardiovasc Pharmacol. 2003 Feb; 41(2):276-83. PMID: 12548089.
      View in: PubMed
    101. Nakamura S, Averill DB, Chappell MC, Diz DI, Brosnihan KB, Ferrario CM. Angiotensin receptors contribute to blood pressure homeostasis in salt-depleted SHR. Am J Physiol Regul Integr Comp Physiol. 2003 Jan; 284(1):R164-73. PMID: 12482748.
      View in: PubMed
    102. Ferrario CM, Averill DB, Brosnihan KB, Chappell MC, Iskandar SS, Dean RH, Diz DI. Vasopeptidase inhibition and Ang-(1-7) in the spontaneously hypertensive rat. Kidney Int. 2002 Oct; 62(4):1349-57. PMID: 12234305.
      View in: PubMed
    103. Diz DI, Jessup JA, Westwood BM, Bosch SM, Vinsant S, Gallagher PE, Averill DB. Angiotensin peptides as neurotransmitters/neuromodulators in the dorsomedial medulla. Clin Exp Pharmacol Physiol. 2002 May-Jun; 29(5-6):473-82. PMID: 12010195.
      View in: PubMed
    Diz's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _