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Clinical and Translational Science Institute

Keywords
Last Name

Carol A. Shively, Ph.D.

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentComparative Medicine
Address
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    Collapse Research 
    Collapse research activities and funding
    R01HL039789     (SHIVELY, CAROL A.)Apr 1, 1988 - Mar 31, 1993
    NIH/NHLBI
    SOCIAL STATUS AND ATHEROSCLEROSIS IN FEMALES
    Role: Principal Investigator

    R01RR014100     (SHIVELY, CAROL A.)Jun 1, 1993 - Jun 14, 2001
    NIH/NCRR
    CLINICAL EVALUATION OF COGNITIVE FUNCTION IN MONKEYS
    Role: Principal Investigator

    R01AA011204     (SHIVELY, CAROL A.)Sep 30, 1996 - Aug 31, 2003
    NIH/NIAAA
    RISKS AND BENEFITS OF MODERATE ALCOHOL
    Role: Principal Investigator

    R01MH056881     (SHIVELY, CAROL A.)Dec 15, 1998 - Nov 30, 2005
    NIH/NIMH
    IMAGING DOPAMINE FUNCTION IN STRESS AND DEPRESSION
    Role: Principal Investigator

    R01HL087103     (SHIVELY, CAROL A.)Dec 1, 2006 - Mar 31, 2018
    NIH/NHLBI
    Dietary Mitigation of Psychosocial Stress Effects on CVD Risk
    Role: Principal Investigator

    R21MH086731     (SHIVELY, CAROL A.)Jul 1, 2009 - Mar 31, 2012
    NIH/NIMH
    Cellular and Molecular Basis of Hippocampal Atrophy in Depressed Female Monkeys
    Role: Principal Investigator

    R01HL122393     (REGISTER, THOMAS COSTIN)Aug 1, 2015 - Jul 31, 2019
    NIH/NHLBI
    Social Stress, Diet. and Primate Monocyte Programming in Cardiovascular Risk
    Role: Co-Principal Investigator

    R01AG058829     (SHIVELY, CAROL A.)Aug 15, 2018 - Mar 31, 2022
    NIH/NIA
    Effects of Western and Mediterranean Diets on Metabolic and Neuropathologic Risk Factors for Alzheimer's Disease in Nonhuman Primates
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Nagpal R, Shively CA, Appt SA, Register TC, Michalson KT, Vitolins MZ, Yadav H. Gut Microbiome Composition in Non-human Primates Consuming a Western or Mediterranean Diet. Front Nutr. 2018; 5:28. PMID: 29922651.
      View in: PubMed
    2. Jarczok MN, Koenig J, Shively CA, Thayer JF. Behavioral depression is associated with increased vagally mediated heart rate variability in adult female cynomolgus monkeys (Macaca fascicularis). Int J Psychophysiol. 2018 09; 131:139-143. PMID: 29128294.
      View in: PubMed
    3. Justice JN, Silverstein-Metzler MG, Uberseder B, Appt SE, Clarkson TB, Register TC, Kritchevsky SB, Shively CA. Relationships of depressive behavior and sertraline treatment with walking speed and activity in older female nonhuman primates. Geroscience. 2017 12; 39(5-6):585-600. PMID: 29080976.
      View in: PubMed
    4. Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Shively C, Andrews RN, Neth B, Keene CD, Mintz A, Craft S, Molina AJA. Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism. Oxid Med Cell Longev. 2017; 2017:7317251. PMID: 29098063.
      View in: PubMed
    5. Silverstein-Metzler MG, Justice JN, Appt SE, Groban L, Kitzman DW, Carr JJ, Register TC, Shively CA. Long-term sertraline treatment and depression effects on carotid artery atherosclerosis in premenopausal female primates. Menopause. 2017 Oct; 24(10):1175-1184. PMID: 28609387.
      View in: PubMed
    6. Postupna N, Latimer CS, Larson EB, Sherfield E, Paladin J, Shively CA, Jorgensen MJ, Andrews RN, Kaplan JR, Crane PK, Montine KS, Craft S, Keene CD, Montine TJ. Human Striatal Dopaminergic and Regional Serotonergic Synaptic Degeneration with Lewy Body Disease and Inheritance of APOE e4. Am J Pathol. 2017 Apr; 187(4):884-895. PMID: 28212814.
      View in: PubMed
    7. Maldjian JA, Shively CA, Nader MA, Friedman DP, Whitlow CT. Erratum to: Multi-Atlas Library for Eliminating Normalization Failures in Non-Human Primates. Neuroinformatics. 2017 01; 15(1):111. PMID: 27585913.
      View in: PubMed
    8. Shively CA, Silverstein-Metzler M, Justice J, Willard SL. The impact of treatment with selective serotonin reuptake inhibitors on primate cardiovascular disease, behavior, and neuroanatomy. Neurosci Biobehav Rev. 2017 Mar; 74(Pt B):433-443. PMID: 27590831.
      View in: PubMed
    9. Kalidindi A, Kelly SD, Singleton KS, Guzman D, Merrill L, Willard SL, Shively CA, Neigh GN. Reduced marker of vascularization in the anterior hippocampus in a female monkey model of depression. Physiol Behav. 2017 04 01; 172:12-15. PMID: 27423324.
      View in: PubMed
    10. Kavanagh K, Brown RN, Davis AT, Uberseder B, Floyd E, Pfisterer B, Shively CA. Microbial translocation and skeletal muscle in young and old vervet monkeys. Age (Dordr). 2016 Jun; 38(3):58. PMID: 27194407.
      View in: PubMed
    11. Maldjian JA, Shively CA, Nader MA, Friedman DP, Whitlow CT. Multi-Atlas Library for Eliminating Normalization Failures in Non-Human Primates. Neuroinformatics. 2016 04; 14(2):183-90. PMID: 26643442.
      View in: PubMed
    12. Silverstein-Metzler MG, Shively CA, Clarkson TB, Appt SE, Carr JJ, Kritchevsky SB, Jones SR, Register TC. Sertraline inhibits increases in body fat and carbohydrate dysregulation in adult female cynomolgus monkeys. Psychoneuroendocrinology. 2016 06; 68:29-38. PMID: 26939086.
      View in: PubMed
    13. Willard SL, Uberseder B, Clark A, Daunais JB, Johnston WD, Neely D, Massey A, Williamson JD, Kraft RA, Bourland JD, Jones SR, Shively CA. Long term sertraline effects on neural structures in depressed and nondepressed adult female nonhuman primates. Neuropharmacology. 2015 Dec; 99:369-78. PMID: 26116816.
      View in: PubMed
    14. Santago AC, Plate JF, Shively CA, Register TC, Smith TL, Saul KR. Age-related structural changes in upper extremity muscle tissue in a nonhuman primate model. J Shoulder Elbow Surg. 2015 Oct; 24(10):1660-8. PMID: 25963066.
      View in: PubMed
    15. Justice JN, Cesari M, Seals DR, Shively CA, Carter CS. Comparative Approaches to Understanding the Relation Between Aging and Physical Function. J Gerontol A Biol Sci Med Sci. 2016 10; 71(10):1243-53. PMID: 25910845.
      View in: PubMed
    16. Shively CA, Register TC, Appt SE, Clarkson TB. Effects of long-term sertraline treatment and depression on coronary artery atherosclerosis in premenopausal female primates. Psychosom Med. 2015 Apr; 77(3):267-78. PMID: 25829239.
      View in: PubMed
    17. Xu F, Wu Q, Xie L, Gong W, Zhang J, Zheng P, Zhou Q, Ji Y, Wang T, Li X, Fang L, Li Q, Yang D, Li J, Melgiri ND, Shively C, Xie P. Macaques exhibit a naturally-occurring depression similar to humans. Sci Rep. 2015 Mar 18; 5:9220. PMID: 25783476.
      View in: PubMed
    18. Needham BL, Smith JA, Zhao W, Wang X, Mukherjee B, Kardia SL, Shively CA, Seeman TE, Liu Y, Diez Roux AV. Life course socioeconomic status and DNA methylation in genes related to stress reactivity and inflammation: The multi-ethnic study of atherosclerosis. Epigenetics. 2015; 10(10):958-69. PMID: 26295359.
      View in: PubMed
    19. Shively CA, Day SM. Social inequalities in health in nonhuman primates. Neurobiol Stress. 2015 Jan; 1:156-63. PMID: 27589665.
      View in: PubMed
    20. Silverstein MG, Kaplan JR, Appt SE, Register TC, Shively CA. Effect of soy isoflavones on thyroid hormones in intact and ovariectomized cynomolgus monkeys (Macaca fascicularis). Menopause. 2014 Oct; 21(10):1136-42. PMID: 24618766.
      View in: PubMed
    21. Xie L, Zhou Q, Liu S, Xu F, Shively CA, Wu Q, Gong W, Ji Y, Fang L, Li L, Melgiri ND, Xie P. Effect of living conditions on biochemical and hematological parameters of the cynomolgus monkey. Am J Primatol. 2014 Nov; 76(11):1011-24. PMID: 24990222.
      View in: PubMed
    22. Silverstein MG, El-Amin CK, Shively CA. Selective serotonin reuptake inhibitor and bleeding in a cynomolgus macaque (Macaca fascicularis). Comp Med. 2014 Jun; 64(3):221-3. PMID: 24956214.
      View in: PubMed
    23. Phillips KA, Bales KL, Capitanio JP, Conley A, Czoty PW, 't Hart BA, Hopkins WD, Hu SL, Miller LA, Nader MA, Nathanielsz PW, Rogers J, Shively CA, Voytko ML. Why primate models matter. Am J Primatol. 2014 Sep; 76(9):801-27. PMID: 24723482.
      View in: PubMed
    24. Groban L, Kitzman DW, Register TC, Shively CA. Effect of depression and sertraline treatment on cardiac function in female nonhuman primates. Psychosom Med. 2014 Feb; 76(2):137-46. PMID: 24470133.
      View in: PubMed
    25. Willard SL, Hemby SE, Register TC, McIntosh S, Shively CA. Altered expression of glial and synaptic markers in the anterior hippocampus of behaviorally depressed female monkeys. Neurosci Lett. 2014 Mar 20; 563:1-5. PMID: 24440617.
      View in: PubMed
    26. Shively CA, Register TC, Higley JD, Willard SL. Sertraline effects on cerebrospinal fluid monoamines and species-typical socioemotional behavior of female cynomolgus monkeys. Psychopharmacology (Berl). 2014 Apr; 231(7):1409-16. PMID: 24193371.
      View in: PubMed
    27. Li X, Xu F, Xie L, Ji Y, Cheng K, Zhou Q, Wang T, Shively C, Wu Q, Gong W, Fang L, Zhan Q, Melgiri ND, Xie P. Depression-like behavioral phenotypes by social and social plus visual isolation in the adult female Macaca fascicularis. PLoS One. 2013; 8(9):e73293. PMID: 24023857.
      View in: PubMed
    28. Murphy RA, Register TC, Shively CA, Carr JJ, Ge Y, Heilbrun ME, Cummings SR, Koster A, Nevitt MC, Satterfield S, Tylvasky FA, Strotmeyer ES, Newman AB, Simonsick EM, Scherzinger A, Goodpaster BH, Launer LJ, Eiriksdottir G, Sigurdsson S, Sigurdsson G, Gudnason V, Lang TF, Kritchevsky SB, Harris TB. Adipose tissue density, a novel biomarker predicting mortality risk in older adults. J Gerontol A Biol Sci Med Sci. 2014 Jan; 69(1):109-17. PMID: 23707956.
      View in: PubMed
    29. Sophonsritsuk A, Appt SE, Clarkson TB, Shively CA, Espeland MA, Register TC. Differential effects of estradiol on carotid artery inflammation when administered early versus late after surgical menopause. Menopause. 2013 May; 20(5):540-7. PMID: 23615645.
      View in: PubMed
    30. Willard SL, Riddle DR, Forbes ME, Shively CA. Cell number and neuropil alterations in subregions of the anterior hippocampus in a female monkey model of depression. Biol Psychiatry. 2013 Dec 15; 74(12):890-7. PMID: 23607969.
      View in: PubMed
    31. Kalinin S, Willard SL, Shively CA, Kaplan JR, Register TC, Jorgensen MJ, Polak PE, Rubinstein I, Feinstein DL. Development of amyloid burden in African Green monkeys. Neurobiol Aging. 2013 Oct; 34(10):2361-9. PMID: 23601810.
      View in: PubMed
    32. Nattkemper LA, Zhao ZQ, Nichols AJ, Papoiu ADP, Shively CA, Chen ZF, Yosipovitch G. Overexpression of the gastrin-releasing peptide in cutaneous nerve fibers and its receptor in the spinal cord in primates with chronic itch. J Invest Dermatol. 2013 Oct; 133(10):2489-2492. PMID: 23558404.
      View in: PubMed
    33. Plate JF, Bates CM, Mannava S, Smith TL, Jorgensen MJ, Register TC, Stehle JR, High KP, Shively CA, Kaplan JR, Saul KR, Tuohy CJ. Age-related degenerative functional, radiographic, and histological changes of the shoulder in nonhuman primates. J Shoulder Elbow Surg. 2013 Aug; 22(8):1019-29. PMID: 23352182.
      View in: PubMed
    34. Feneran AN, O'Donnell R, Press A, Yosipovitch G, Cline M, Dugan G, Papoiu AD, Nattkemper LA, Chan YH, Shively CA. Monkey see, monkey do: contagious itch in nonhuman primates. Acta Derm Venereol. 2013 Jan; 93(1):27-9. PMID: 22735614.
      View in: PubMed
    35. Choi SJ, Shively CA, Register TC, Feng X, Stehle J, High K, Ip E, Kritchevsky SB, Nicklas B, Delbono O. Force-generation capacity of single vastus lateralis muscle fibers and physical function decline with age in African green vervet monkeys. J Gerontol A Biol Sci Med Sci. 2013 Mar; 68(3):258-67. PMID: 22923428.
      View in: PubMed
    36. Shively CA, Willard SL, Register TC, Bennett AJ, Pierre PJ, Laudenslager ML, Kitzman DW, Childers MK, Grange RW, Kritchevsky SB. Aging and physical mobility in group-housed Old World monkeys. Age (Dordr). 2012 Oct; 34(5):1123-31. PMID: 22203457.
      View in: PubMed
    37. Willard SL, Shively CA. Modeling depression in adult female cynomolgus monkeys (Macaca fascicularis). Am J Primatol. 2012 Jun; 74(6):528-42. PMID: 22076882.
      View in: PubMed
    38. Schnatz PF, Nudy M, Shively CA, Powell A, O'Sullivan DM. A prospective analysis of the association between cardiovascular disease and depression in middle-aged women. Menopause. 2011 Oct; 18(10):1096-100. PMID: 21646923.
      View in: PubMed
    39. Shively CA, Willard SL. Behavioral and neurobiological characteristics of social stress versus depression in nonhuman primates. Exp Neurol. 2012 Jan; 233(1):87-94. PMID: 21983263.
      View in: PubMed
    40. Willard SL, Daunais JB, Cline JM, Shively CA. Hippocampal volume in postmenopausal cynomolgus macaques with behavioral depression. Menopause. 2011 May; 18(5):582-6. PMID: 21242818.
      View in: PubMed
    41. Chilton FH, Lee TC, Willard SL, Ivester P, Sergeant S, Register TC, Shively CA. Depression and altered serum lipids in cynomolgus monkeys consuming a Western diet. Physiol Behav. 2011 Aug 03; 104(2):222-7. PMID: 21256145.
      View in: PubMed
    42. Maki PM, Freeman EW, Greendale GA, Henderson VW, Newhouse PA, Schmidt PJ, Scott NF, Shively CA, Soares CN. Summary of the National Institute on Aging-sponsored conference on depressive symptoms and cognitive complaints in the menopausal transition. Menopause. 2010 Jul; 17(4):815-22. PMID: 20616668.
      View in: PubMed
    43. Shively CA, Register TC, Clarkson TB. Social stress, visceral obesity, and coronary artery atherosclerosis: product of a primate adaptation. Am J Primatol. 2009 Sep; 71(9):742-51. PMID: 19452515.
      View in: PubMed
    44. Shively CA, Clarkson TB. The unique value of primate models in translational research. Nonhuman primate models of women's health: introduction and overview. Am J Primatol. 2009 Sep; 71(9):715-21. PMID: 19507247.
      View in: PubMed
    45. Willard SL, Friedman DP, Henkel CK, Shively CA. Anterior hippocampal volume is reduced in behaviorally depressed female cynomolgus macaques. Psychoneuroendocrinology. 2009 Nov; 34(10):1469-75. PMID: 19493628.
      View in: PubMed
    46. Shively CA, Register TC, Clarkson TB. Social stress, visceral obesity, and coronary artery atherosclerosis in female primates. Obesity (Silver Spring). 2009 Aug; 17(8):1513-20. PMID: 19325545.
      View in: PubMed
    47. Sgoifo A, Montano N, Shively C, Thayer J, Steptoe A. The inevitable link between heart and behavior: new insights from biomedical research and implications for clinical practice. Neurosci Biobehav Rev. 2009 Feb; 33(2):61-2. PMID: 19014966.
      View in: PubMed
    48. Shively CA, Register TC, Adams MR, Golden DL, Willard SL, Clarkson TB. Depressive behavior and coronary artery atherogenesis in adult female cynomolgus monkeys. Psychosom Med. 2008 Jul; 70(6):637-45. PMID: 18596246.
      View in: PubMed
    49. Shively CA, Musselman DL, Willard SL. Stress, depression, and coronary artery disease: modeling comorbidity in female primates. Neurosci Biobehav Rev. 2009 Feb; 33(2):133-44. PMID: 18619999.
      View in: PubMed
    50. Shively CA, Wood CE, Register TC, Willard SL, Lees CJ, Chen H, Sitruk-Ware RL, Tsong YY, Cline JM. Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys. Psychoneuroendocrinology. 2007 Sep-Nov; 32(8-10):981-90. PMID: 17768011.
      View in: PubMed
    51. Shively CA, Mietus JE, Grant KA, Goldberger AL, Bennett AJ, Willard SL. Effects of chronic moderate alcohol consumption and novel environment on heart rate variability in primates (Macaca fascicularis). Psychopharmacology (Berl). 2007 Jun; 192(2):183-91. PMID: 17297637.
      View in: PubMed
    52. Shively CA, Friedman DP, Gage HD, Bounds MC, Brown-Proctor C, Blair JB, Henderson JA, Smith MA, Buchheimer N. Behavioral depression and positron emission tomography-determined serotonin 1A receptor binding potential in cynomolgus monkeys. Arch Gen Psychiatry. 2006 Apr; 63(4):396-403. PMID: 16585468.
      View in: PubMed
    53. Shively CA, Register TC, Friedman DP, Morgan TM, Thompson J, Lanier T. Social stress-associated depression in adult female cynomolgus monkeys (Macaca fascicularis). Biol Psychol. 2005 Apr; 69(1):67-84. PMID: 15740826.
      View in: PubMed
    54. Shively CA, Register TC, Grant KA, Johnson JL, Cline JM. Effects of social status and moderate alcohol consumption on mammary gland and endometrium of surgically postmenopausal monkeys. Menopause. 2004 Jul-Aug; 11(4):389-99. PMID: 15243276.
      View in: PubMed
    55. Shively CA, Bethea CL. Cognition, mood disorders, and sex hormones. ILAR J. 2004; 45(2):189-99. PMID: 15111738.
      View in: PubMed
    56. Ivester P, Shively CA, Register TC, Grant KA, Reboussin DM, Cunningham CC. The effects of moderate ethanol consumption on the liver of the monkey, Macaca fascicularis. Alcohol Clin Exp Res. 2003 Nov; 27(11):1831-7. PMID: 14634501.
      View in: PubMed
    57. Shively CA, Grant KA, Register TC. Effects of long-term moderate alcohol consumption on agonistic and affiliative behavior of socially housed female cynomolgus monkeys (Macaca fascicularis). Psychopharmacology (Berl). 2002 Dec; 165(1):1-8. PMID: 12474112.
      View in: PubMed
    58. Shively CA, Williams JK, Laber-Laird K, Anton RF. Depression and coronary artery atherosclerosis and reactivity in female cynomolgus monkeys. Psychosom Med. 2002 Sep-Oct; 64(5):699-706. PMID: 12271100.
      View in: PubMed
    59. Register TC, Cline JM, Shively CA. Health issues in postmenopausal women who drink. Alcohol Res Health. 2002; 26(4):299-307. PMID: 12875041.
      View in: PubMed
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