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Clinical and Translational Science Institute

Last Name

Brian A. McCool, Ph.D.

InstitutionWake Forest School of Medicine
DepartmentPhysiology and Pharmacology
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    Collapse Research 
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    T32AA007565     (MCCOOL, BRIAN A)Jul 1, 1994 - Jun 30, 2019
    Multidisciplinary Training in the Biology of Alcohol Addiction
    Role: Principal Investigator

    F32NS009719     (MCCOOL, BRIAN A)Apr 1, 1995
    Role: Principal Investigator

    R21AA013120     (MCCOOL, BRIAN A)Jun 1, 2001 - Nov 30, 2004
    Ethanol &Anxiety:Fearful Adaptations in the Amygdala
    Role: Principal Investigator

    R56AA014445     (MCCOOL, BRIAN A)Jul 1, 2003 - Apr 30, 2009
    Ethanol &Anxiety: Cellular Mechanisms
    Role: Principal Investigator

    R01AA014445     (MCCOOL, BRIAN A)Jul 1, 2003 - Apr 30, 2018
    Ethanol & Anxiety: Cellular Mechanisms
    Role: Principal Investigator

    R21AA015179     (MCCOOL, BRIAN A)Apr 1, 2005 - Mar 31, 2008
    GABA-A Receptors, Ethanol, and Stress in Monkey Amygdala
    Role: Principal Investigator

    U01AA016671     (MCCOOL, BRIAN A)Feb 5, 2007 - Jul 31, 2010
    Genetic Regulation of the Ethanol/Anxiety Interaction: Neurobiological Mechanisms
    Role: Principal Investigator

    U01AA020942     (MCCOOL, BRIAN A)Feb 10, 2012 - Jan 31, 2017
    Withdrawal-Stress, Anxiety, and Amygdala Neurophysiology
    Role: Principal Investigator

    R01AA023999     (JONES, SARA RAULERSON)Aug 5, 2015 - Jun 30, 2020
    Ethanol Dependence Induced Changes in Dopamine Signaling in Basolateral Amygdala
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Alexander NJ, Rau AR, Jimenez VA, Daunais JB, Grant KA, McCool BA. SNARE Complex-Associated Proteins in the Lateral Amygdala of Macaca mulatta Following Long-Term Ethanol Drinking. Alcohol Clin Exp Res. 2018 Sep; 42(9):1661-1673. PMID: 29944190.
      View in: PubMed
    2. Morales M, McGinnis MM, Robinson SL, Chappell AM, McCool BA. Chronic Intermittent Ethanol Exposure Modulation of Glutamatergic Neurotransmission in Rat Lateral/Basolateral Amygdala is Duration-, Input-, and Sex-Dependent. Neuroscience. 2018 02 10; 371:277-287. PMID: 29237566.
      View in: PubMed
    3. Gioia DA, Alexander N, McCool BA. Ethanol Mediated Inhibition of Synaptic Vesicle Recycling at Amygdala Glutamate Synapses Is Dependent upon Munc13-2. Front Neurosci. 2017; 11:424. PMID: 28785200.
      View in: PubMed
    4. Gioia DA, McCool B. Strain-Dependent Effects of Acute Alcohol on Synaptic Vesicle Recycling and Post-Tetanic Potentiation in Medial Glutamate Inputs to the Mouse Basolateral Amygdala. Alcohol Clin Exp Res. 2017 04; 41(4):735-746. PMID: 28118494.
      View in: PubMed
    5. Gioia DA, Alexander NJ, McCool BA. Differential Expression of Munc13-2 Produces Unique Synaptic Phenotypes in the Basolateral Amygdala of C57BL/6J and DBA/2J Mice. J Neurosci. 2016 10 26; 36(43):10964-10977. PMID: 27798178.
      View in: PubMed
    6. Luessen DJ, Hinshaw TP, Sun H, Howlett AC, Marrs G, McCool BA, Chen R. RGS2 modulates the activity and internalization of dopamine D2 receptors in neuroblastoma N2A cells. Neuropharmacology. 2016 11; 110(Pt A):297-307. PMID: 27528587.
      View in: PubMed
    7. Rose JH, Karkhanis AN, Chen R, Gioia D, Lopez MF, Becker HC, McCool BA, Jones SR. Supersensitive Kappa Opioid Receptors Promotes Ethanol Withdrawal-Related Behaviors and Reduce Dopamine Signaling in the Nucleus Accumbens. Int J Neuropsychopharmacol. 2016 05; 19(5). PMID: 26625893; PMCID: PMC4886667.
    8. Robinson SL, Alexander NJ, Bluett RJ, Patel S, McCool BA. Acute and chronic ethanol exposure differentially regulate CB1 receptor function at glutamatergic synapses in the rat basolateral amygdala. Neuropharmacology. 2016 09; 108:474-84. PMID: 26707595.
      View in: PubMed
    9. Morales M, McGinnis MM, McCool BA. Chronic ethanol exposure increases voluntary home cage intake in adult male, but not female, Long-Evans rats. Pharmacol Biochem Behav. 2015 Dec; 139(Pt A):67-76. PMID: 26515190; PMCID: PMC4722864 [Available on 12/01/16].
    10. Robinson SL, McCool BA. Microstructural analysis of rat ethanol and water drinking patterns using a modified operant self-administration model. Physiol Behav. 2015 Oct 01; 149:119-30. PMID: 26037631; PMCID: PMC4506870 [Available on 10/01/16].
    11. Karkhanis AN, Alexander NJ, McCool BA, Weiner JL, Jones SR. Chronic social isolation during adolescence augments catecholamine response to acute ethanol in the basolateral amygdala. Synapse. 2015 Aug; 69(8):385-95. PMID: 25963724; PMCID: PMC4578716.
    12. McCool BA, Chappell AM. Chronic intermittent ethanol inhalation increases ethanol self-administration in both C57BL/6J and DBA/2J mice. Alcohol. 2015 Mar; 49(2):111-20. PMID: 25659650; PMCID: PMC4339516.
    13. Karkhanis AN, Locke JL, McCool BA, Weiner JL, Jones SR. Social isolation rearing increases nucleus accumbens dopamine and norepinephrine responses to acute ethanol in adulthood. Alcohol Clin Exp Res. 2014 Nov; 38(11):2770-9. PMID: 25421514; PMCID: PMC4519347.
    14. Peterson VL, McCool BA, Hamilton DA. Effects of ethanol exposure and withdrawal on dendritic morphology and spine density in the nucleus accumbens core and shell. Brain Res. 2015 Jan 12; 1594:125-35. PMID: 25452024; PMCID: PMC4267557.
    15. McCool BA, Christian DT, Fetzer JA, Chappell AM. Lateral/basolateral amygdala serotonin type-2 receptors modulate operant self-administration of a sweetened ethanol solution via inhibition of principal neuron activity. Front Integr Neurosci. 2014; 8:5. PMID: 24523680; PMCID: PMC3906593.
    16. McCool BA, Chappell AM. Persistent enhancement of ethanol drinking following a monosodium glutamate-substitution procedure in C57BL6/J and DBA/2J mice. Alcohol. 2014 Feb; 48(1):55-61. PMID: 24355071; PMCID: PMC3946935.
    17. Abrahao KP, Ariwodola OJ, Butler TR, Rau AR, Skelly MJ, Carter E, Alexander NP, McCool BA, Souza-Formigoni ML, Weiner JL. Locomotor sensitization to ethanol impairs NMDA receptor-dependent synaptic plasticity in the nucleus accumbens and increases ethanol self-administration. J Neurosci. 2013 Mar 13; 33(11):4834-42. PMID: 23486954; PMCID: PMC3658831.
    18. Christian DT, Alexander NJ, Diaz MR, McCool BA. Thalamic glutamatergic afferents into the rat basolateral amygdala exhibit increased presynaptic glutamate function following withdrawal from chronic intermittent ethanol. Neuropharmacology. 2013 Feb; 65:134-42. PMID: 22982568; PMCID: PMC3521082.
    19. Chappell AM, Carter E, McCool BA, Weiner JL. Adolescent rearing conditions influence the relationship between initial anxiety-like behavior and ethanol drinking in male Long Evans rats. Alcohol Clin Exp Res. 2013 Jan; 37 Suppl 1:E394-403. PMID: 22924742; PMCID: PMC3529208.
    20. Christian DT, Alexander NJ, Diaz MR, Robinson S, McCool BA. Chronic intermittent ethanol and withdrawal differentially modulate basolateral amygdala AMPA-type glutamate receptor function and trafficking. Neuropharmacology. 2012 Jun; 62(7):2430-9. PMID: 22387532; PMCID: PMC3314101.
    21. Diaz MR, Chappell AM, Christian DT, Anderson NJ, McCool BA. Dopamine D3-like receptors modulate anxiety-like behavior and regulate GABAergic transmission in the rat lateral/basolateral amygdala. Neuropsychopharmacology. 2011 Apr; 36(5):1090-103. PMID: 21270771; PMCID: PMC3074203.
    22. Diaz MR, Christian DT, Anderson NJ, McCool BA. Chronic ethanol and withdrawal differentially modulate lateral/basolateral amygdala paracapsular and local GABAergic synapses. J Pharmacol Exp Ther. 2011 Apr; 337(1):162-70. PMID: 21209156; PMCID: PMC3063746.
    23. McCool BA. Ethanol modulation of synaptic plasticity. Neuropharmacology. 2011 Dec; 61(7):1097-108. PMID: 21195719; PMCID: PMC3149748.
    24. McCool BA, Chappell AM. Using monosodium glutamate to initiate ethanol self-administration in inbred mouse strains. Addict Biol. 2012 Jan; 17(1):121-31. PMID: 21054690; PMCID: PMC3081409.
    25. McCool BA, Christian DT, Diaz MR, Läck AK. Glutamate plasticity in the drunken amygdala: the making of an anxious synapse. Int Rev Neurobiol. 2010; 91:205-33. PMID: 20813244; PMCID: PMC3032604.
    26. Silberman Y, Bajo M, Chappell AM, Christian DT, Cruz M, Diaz MR, Kash T, Lack AK, Messing RO, Siggins GR, Winder D, Roberto M, McCool BA, Weiner JL. Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions. Alcohol. 2009 Nov; 43(7):509-19. PMID: 19913194; PMCID: PMC2814297.
    27. McCool BA, Chappell AM. Early social isolation in male Long-Evans rats alters both appetitive and consummatory behaviors expressed during operant ethanol self-administration. Alcohol Clin Exp Res. 2009 Feb; 33(2):273-82. PMID: 19032581; PMCID: PMC2633417.
    28. Läck AK, Diaz MR, Chappell A, DuBois DW, McCool BA. Chronic ethanol and withdrawal differentially modulate pre- and postsynaptic function at glutamatergic synapses in rat basolateral amygdala. J Neurophysiol. 2007 Dec; 98(6):3185-96. PMID: 17898152; PMCID: PMC2269699.
    29. Budygin EA, Oleson EB, Mathews TA, Läck AK, Diaz MR, McCool BA, Jones SR. Effects of chronic alcohol exposure on dopamine uptake in rat nucleus accumbens and caudate putamen. Psychopharmacology (Berl). 2007 Sep; 193(4):495-501. PMID: 17492432.
      View in: PubMed
    30. Anderson NJ, Daunais JB, Friedman DP, Grant KA, McCool BA. Long-term ethanol self-administration by the nonhuman primate, Macaca fascicularis, decreases the benzodiazepine sensitivity of amygdala GABA(A) receptors. Alcohol Clin Exp Res. 2007 Jun; 31(6):1061-70. PMID: 17428292; PMCID: PMC2288551.
    31. McCool BA, Chappell A. Strychnine and taurine modulation of amygdala-associated anxiety-like behavior is 'state' dependent. Behav Brain Res. 2007 Mar 12; 178(1):70-81. PMID: 17207866; PMCID: PMC1839829.
    32. Hemby SE, O'connor JA, Acosta G, Floyd D, Anderson N, McCool BA, Friedman D, Grant KA. Ethanol-induced regulation of GABA-A subunit mRNAs in prefrontal fields of cynomolgus monkeys. Alcohol Clin Exp Res. 2006 Dec; 30(12):1978-85. PMID: 17117962.
      View in: PubMed
    33. DuBois DW, Perlegas A, Floyd DW, Weiner JL, McCool BA. Distinct functional characteristics of the lateral/basolateral amygdala GABAergic system in C57BL/6J and DBA/2J mice. J Pharmacol Exp Ther. 2006 Aug; 318(2):629-40. PMID: 16651400.
      View in: PubMed
    34. Läck AK, Floyd DW, McCool BA. Chronic ethanol ingestion modulates proanxiety factors expressed in rat central amygdala. Alcohol. 2005 Jun; 36(2):83-90. PMID: 16396741; PMCID: PMC1557647.
    35. Farroni JS, McCool BA. Extrinsic factors regulate partial agonist efficacy of strychnine-sensitive glycine receptors. BMC Pharmacol. 2004 Aug 09; 4:16. PMID: 15301692; PMCID: PMC514606.
    36. Floyd DW, Friedman DP, Daunais JB, Pierre PJ, Grant KA, McCool BA. Long-term ethanol self-administration by cynomolgus macaques alters the pharmacology and expression of GABAA receptors in basolateral amygdala. J Pharmacol Exp Ther. 2004 Dec; 311(3):1071-9. PMID: 15280440.
      View in: PubMed
    37. Floyd DW, Jung KY, McCool BA. Chronic ethanol ingestion facilitates N-methyl-D-aspartate receptor function and expression in rat lateral/basolateral amygdala neurons. J Pharmacol Exp Ther. 2003 Dec; 307(3):1020-9. PMID: 14534353.
      View in: PubMed
    38. Vrana KE, Hipp JD, Goss AM, McCool BA, Riddle DR, Walker SJ, Wettstein PJ, Studer LP, Tabar V, Cunniff K, Chapman K, Vilner L, West MD, Grant KA, Cibelli JB. Nonhuman primate parthenogenetic stem cells. Proc Natl Acad Sci U S A. 2003 Sep 30; 100 Suppl 1:11911-6. PMID: 14504386; PMCID: PMC304106.
    39. McCool BA, Frye GD, Pulido MD, Botting SK. Effects of chronic ethanol consumption on rat GABA(A) and strychnine-sensitive glycine receptors expressed by lateral/basolateral amygdala neurons. Brain Res. 2003 Feb 14; 963(1-2):165-77. PMID: 12560122; PMCID: PMC2925189.
    40. Hsiao SH, Parrish AR, Nahm SS, Abbott LC, McCool BA, Frye GD. Effects of early postnatal ethanol intubation on GABAergic synaptic proteins. Brain Res Dev Brain Res. 2002 Oct 20; 138(2):177-85. PMID: 12354645.
      View in: PubMed
    41. Jiang J, McCool BA, Parrish AR. Cadmium- and mercury-induced intercellular adhesion molecule-1 expression in immortalized proximal tubule cells: evidence for a role of decreased transforming growth factor-beta1. Toxicol Appl Pharmacol. 2002 Feb 15; 179(1):13-20. PMID: 11884233.
      View in: PubMed
    42. Han SH, McCool BA, Murchison D, Nahm SS, Parrish AR, Griffith WH. Single-cell RT-PCR detects shifts in mRNA expression profiles of basal forebrain neurons during aging. Brain Res Mol Brain Res. 2002 Jan 31; 98(1-2):67-80. PMID: 11834297.
      View in: PubMed
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