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Clinical and Translational Science Institute

Keywords
Last Name

William Henry Gmeiner, Ph.D.

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentCancer Biology
Address
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentPhysiology and Pharmacology


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    R29CA060612     (GMEINER, WILLIAM H)Jul 16, 1993 - Jun 30, 1998
    NIH/NCI
    IMPACT OF 5-FU ON THE STRUCTURE OF THE U4-U6 COMPLEX
    Role: Principal Investigator

    R01CA060612     (GMEINER, WILLIAM H)Jul 16, 1993 - Jun 30, 2001
    NIH/NCI
    IMPACT OF 5FU ON THE STRUCTURE OF THE U4/U6 COMPLEX
    Role: Principal Investigator

    U01CA102532     (GMEINER, WILLIAM H)Aug 10, 2005 - Jul 31, 2011
    NIH/NCI
    DNA-DIRECTED EFFECTS OF FdUMP(N)
    Role: Principal Investigator

    R21CA218933     (GMEINER, WILLIAM H.)Feb 2, 2018 - Jan 31, 2020
    NIH/NCI
    Development of a CF10 Predictive Gene Signature in CRC Organoids.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bhatt NB, Pandya DN, Dezarn WA, Marini FC, Zhao D, Gmeiner WH, Triozzi PL, Wadas TJ. Practical Guidelines for Cerenkov Luminescence Imaging with Clinically Relevant Isotopes. Methods Mol Biol. 2018; 1790:197-208. PMID: 29858793.
      View in: PubMed
    2. Ghosh S, Mallick S, Das U, Verma A, Pal U, Chatterjee S, Nandy A, Saha KD, Maiti NC, Baishya B, Suresh Kumar G, Gmeiner WH. Curcumin stably interacts with DNA hairpin through minor groove binding and demonstrates enhanced cytotoxicity in combination with FdU nucleotides. Biochim Biophys Acta Gen Subj. 2018 Mar; 1862(3):485-494. PMID: 29107813.
      View in: PubMed
    3. Godwin RC, Gmeiner WH, Salsbury FR. All-atom molecular dynamics comparison of disease-associated zinc fingers. J Biomol Struct Dyn. 2018 Aug; 36(10):2581-2594. PMID: 28814200.
      View in: PubMed
    4. Melvin RL, Gmeiner WH, Salsbury FR. All-atom MD indicates ion-dependent behavior of therapeutic DNA polymer. Phys Chem Chem Phys. 2017 Aug 23; 19(33):22363-22374. PMID: 28805211.
      View in: PubMed
    5. Melvin RL, Gmeiner WH, Salsbury FR. All-Atom MD Predicts Magnesium-Induced Hairpin in Chemically Perturbed RNA Analog of F10 Therapeutic. J Phys Chem B. 2017 08 24; 121(33):7803-7812. PMID: 28745046.
      View in: PubMed
    6. Godwin RC, Melvin RL, Gmeiner WH, Salsbury FR. Binding Site Configurations Probe the Structure and Dynamics of the Zinc Finger of NEMO (NF-?B Essential Modulator). Biochemistry. 2017 01 31; 56(4):623-633. PMID: 28035815.
      View in: PubMed
    7. Stuart CH, Riley KR, Boyacioglu O, Herpai DM, Debinski W, Qasem S, Marini FC, Colyer CL, Gmeiner WH. Selection of a Novel Aptamer Against Vitronectin Using Capillary Electrophoresis and Next Generation Sequencing. Mol Ther Nucleic Acids. 2016 Nov 15; 5(11):e386. PMID: 27845768.
      View in: PubMed
    8. Melvin RL, Gmeiner WH, Salsbury FR. All-Atom Molecular Dynamics Reveals Mechanism of Zinc Complexation with Therapeutic F10. J Phys Chem B. 2016 10 06; 120(39):10269-10279. PMID: 27606431.
      View in: PubMed
    9. Gmeiner WH, Gearhart PJ, Pommier Y, Nakamura J. F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death. Future Oncol. 2016 Oct; 12(19):2183-8. PMID: 27333295.
      View in: PubMed
    10. Gmeiner WH, Debinski W, Milligan C, Caudell D, Pardee TS. The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current evidence. Future Oncol. 2016 Sep; 12(17):2009-20. PMID: 27279153.
      View in: PubMed
    11. Stuart CH, Singh R, Smith TL, D'Agostino R, Caudell D, Balaji KC, Gmeiner WH. Prostate-specific membrane antigen-targeted liposomes specifically deliver the Zn(2+) chelator TPEN inducing oxidative stress in prostate cancer cells. Nanomedicine (Lond). 2016 05; 11(10):1207-22. PMID: 27077564.
      View in: PubMed
    12. Godwin R, Gmeiner W, Salsbury FR. Importance of long-time simulations for rare event sampling in zinc finger proteins. J Biomol Struct Dyn. 2016; 34(1):125-34. PMID: 25734227.
      View in: PubMed
    13. Gmeiner WH, Ghosh S. Nanotechnology for cancer treatment. Nanotechnol Rev. 2015 Apr; 3(2):111-122. PMID: 26082884.
      View in: PubMed
    14. Gmeiner WH, Jennings-Gee J, Stuart CH, Pardee TS. Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway. Leuk Res. 2015 Feb; 39(2):229-35. PMID: 25510486.
      View in: PubMed
    15. Gmeiner WH, Boyacioglu O, Stuart CH, Jennings-Gee J, Balaji KC. The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn(2+) -chelation and inhibiting the serine protease Omi/HtrA2. Prostate. 2015 Mar 01; 75(4):360-9. PMID: 25408502.
      View in: PubMed
    16. Gmeiner WH, Willingham MC, Bourland JD, Hatcher HC, Smith TL, D'Agostino RB, Blackstock W. F10 Inhibits Growth of PC3 Xenografts and Enhances the Effects of Radiation Therapy. J Clin Oncol Res. 2014 Jul-Aug; 2(4). PMID: 26020060.
      View in: PubMed
    17. Pardee TS, Stadelman K, Jennings-Gee J, Caudell DL, Gmeiner WH. The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells. Oncotarget. 2014 Jun 30; 5(12):4170-9. PMID: 24961587.
      View in: PubMed
    18. Stuart CH, Horita DA, Thomas MJ, Salsbury FR, Lively MO, Gmeiner WH. Site-specific DNA-doxorubicin conjugates display enhanced cytotoxicity to breast cancer cells. Bioconjug Chem. 2014 Feb 19; 25(2):406-13. PMID: 24450459.
      View in: PubMed
    19. Gmeiner WH, Lema-Tome C, Gibo D, Jennings-Gee J, Milligan C, Debinski W. Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors. J Neurooncol. 2014 Feb; 116(3):447-54. PMID: 24346635.
      View in: PubMed
    20. Ghosh S, Ucer KB, D'Agostino R, Grant K, Sirintrapun J, Thomas MJ, Hantgan R, Bharadwaj M, Gmeiner WH. Non-covalent assembly of meso-tetra-4-pyridyl porphine with single-stranded DNA to form nano-sized complexes with hydrophobicity-dependent DNA release and anti-tumor activity. Nanomedicine. 2014 Feb; 10(2):451-61. PMID: 23988714.
      View in: PubMed
    21. Boyacioglu O, Stuart CH, Kulik G, Gmeiner WH. Dimeric DNA Aptamer Complexes for High-capacity-targeted Drug Delivery Using pH-sensitive Covalent Linkages. Mol Ther Nucleic Acids. 2013 Jul 16; 2:e107. PMID: 23860551.
      View in: PubMed
    22. Huang SY, Murai J, Dalla Rosa I, Dexheimer TS, Naumova A, Gmeiner WH, Pommier Y. TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs. Nucleic Acids Res. 2013 Sep; 41(16):7793-803. PMID: 23775789.
      View in: PubMed
    23. Wu SY, Chen TM, Gmeiner WH, Chu E, Schmitz JC. Development of modified siRNA molecules incorporating 5-fluoro-2'-deoxyuridine residues to enhance cytotoxicity. Nucleic Acids Res. 2013 Apr; 41(8):4650-9. PMID: 23449220.
      View in: PubMed
    24. Ghosh S, Salsbury FR, Horita DA, Gmeiner WH. Cooperative stabilization of Zn(2+):DNA complexes through netropsin binding in the minor groove of FdU-substituted DNA. J Biomol Struct Dyn. 2013; 31(11):1301-10. PMID: 23153072.
      View in: PubMed
    25. Jennings-Gee J, Pardee TS, Gmeiner WH. Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity. Exp Hematol. 2013 Feb; 41(2):180-188.e4. PMID: 23085462.
      View in: PubMed
    26. Pardee TS, Gomes E, Jennings-Gee J, Caudell D, Gmeiner WH. Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity. Blood. 2012 Apr 12; 119(15):3561-70. PMID: 22362039.
      View in: PubMed
    27. Gmeiner WH, Salsbury F, Olsen CM, Marky LA. The stability of a model substrate for topoisomerase 1-mediated DNA religation depends on the presence of mismatched base pairs. J Nucleic Acids. 2011; 2011:631372. PMID: 21904666.
      View in: PubMed
    28. Ghosh S, Salsbury FR, Horita DA, Gmeiner WH. Zn2+ selectively stabilizes FdU-substituted DNA through a unique major groove binding motif. Nucleic Acids Res. 2011 May; 39(10):4490-8. PMID: 21296761.
      View in: PubMed
    29. Gmeiner WH, Reinhold WC, Pommier Y. Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons. Mol Cancer Ther. 2010 Dec; 9(12):3105-14. PMID: 21159603.
      View in: PubMed
    30. Ghosh S, Dutta S, Gomes E, Carroll D, D'Agostino R, Olson J, Guthold M, Gmeiner WH. Increased heating efficiency and selective thermal ablation of malignant tissue with DNA-encased multiwalled carbon nanotubes. ACS Nano. 2009 Sep 22; 3(9):2667-73. PMID: 19655728.
      View in: PubMed
    31. Gmeiner WH, Hellmann GM, Shen P. Tissue-dependent and -independent gene expression changes in metastatic colon cancer. Oncol Rep. 2008 Jan; 19(1):245-51. PMID: 18097602.
      View in: PubMed
    32. Bijnsdorp IV, Comijn EM, Padron JM, Gmeiner WH, Peters GJ. Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition. Oncol Rep. 2007 Jul; 18(1):287-91. PMID: 17549381.
      View in: PubMed
    33. Olsen CM, Gmeiner WH, Marky LA. Unfolding of G-quadruplexes: energetic, and ion and water contributions of G-quartet stacking. J Phys Chem B. 2006 Apr 06; 110(13):6962-9. PMID: 16571009.
      View in: PubMed
    34. Liao ZY, Sordet O, Zhang HL, Kohlhagen G, Antony S, Gmeiner WH, Pommier Y. A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes. Cancer Res. 2005 Jun 01; 65(11):4844-51. PMID: 15930305.
      View in: PubMed
    35. Mao XA, Gmeiner WH. NMR study of the folding-unfolding mechanism for the thrombin-binding DNA aptamer d(GGTTGGTGTGGTTGG). Biophys Chem. 2005 Feb 01; 113(2):155-60. PMID: 15617822.
      View in: PubMed
    36. Gmeiner WH. Novel chemical strategies for thymidylate synthase inhibition. Curr Med Chem. 2005; 12(2):191-202. PMID: 15638735.
      View in: PubMed
    37. Mao X, Marky LA, Gmeiner WH. NMR structure of the thrombin-binding DNA aptamer stabilized by Sr2+. J Biomol Struct Dyn. 2004 Aug; 22(1):25-33. PMID: 15214802.
      View in: PubMed
    38. Mao XA, Cui W, Gmeiner WH. Line shape analyses for water 17O NMR quintet observed in a bacteriophage Pf1 solution at different temperatures. Biophys Chem. 2004 Feb 15; 107(3):255-62. PMID: 14967240.
      View in: PubMed
    39. Gmeiner WH, Trump E, Wei C. Enhanced DNA-directed effects of FdUMP[10] compared to 5FU. Nucleosides Nucleotides Nucleic Acids. 2004; 23(1-2):401-10. PMID: 15043163.
      View in: PubMed
    40. Gmeiner WH, Yu S, Pon RT, Pourquier P, Pommier Y. Structural basis for topoisomerase I inhibition by nucleoside analogs. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug; 22(5-8):653-8. PMID: 14565246.
      View in: PubMed
    41. Gmeiner WH. Antimetabolite incorporation into DNA: structural and thermodynamic basis for anticancer activity. Biopolymers. 2002 Nov 05; 65(3):180-9. PMID: 12228923.
      View in: PubMed
    42. Comolli LR, Ulyanov NB, Soto AM, Marky LA, James TL, Gmeiner WH. NMR structure of the 3' stem-loop from human U4 snRNA. Nucleic Acids Res. 2002 Oct 15; 30(20):4371-9. PMID: 12384583.
      View in: PubMed
    43. Liu C, Willingham M, Liu J, Gmeiner WH. Efficacy and safety of FdUMP[10] in treatment of HT-29 human colon cancer xenografts. Int J Oncol. 2002 Aug; 21(2):303-8. PMID: 12118325.
      View in: PubMed
    44. Pourquier P, Gioffre C, Kohlhagen G, Urasaki Y, Goldwasser F, Hertel LW, Yu S, Pon RT, Gmeiner WH, Pommier Y. Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I. Clin Cancer Res. 2002 Aug; 8(8):2499-504. PMID: 12171875.
      View in: PubMed
    45. Soto AM, Gmeiner WH, Marky LA. Energetic and conformational contributions to the stability of Okazaki fragments. Biochemistry. 2002 May 28; 41(21):6842-9. PMID: 12022889.
      View in: PubMed
    46. Gmeiner WH. The structure and dynamics of the U4/U6 snRNP: implications for pre-mRNA splicing and use as a model system to investigate the RNA-mediated effects of (5F)Ura. J Biomol Struct Dyn. 2002 Apr; 19(5):853-62. PMID: 11922840.
      View in: PubMed
    47. Gmeiner WH. The Lown Symposium: The Field of DNA Minor Groove Binders Celebrates the Career of Professor J. William Lown. J Biomol Struct Dyn. 2002 Apr; 19(5):731-733. PMID: 22594568.
      View in: PubMed
    48. Konerding D, James TL, Trump E, Soto AM, Marky LA, Gmeiner WH. NMR structure of a gemcitabine-substituted model Okazaki fragment. Biochemistry. 2002 Jan 22; 41(3):839-46. PMID: 11790105.
      View in: PubMed
    49. Cui W, Gmeiner WH. Effect of 5-FU substitution and mutation on Sm protein binding to human U4 snRNA. Nucleosides Nucleotides Nucleic Acids. 2002; 21(2):139-54. PMID: 11991141.
      View in: PubMed
    50. Liu J, Kolar C, Lawson TA, Gmeiner WH. Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells. J Org Chem. 2001 Aug 24; 66(17):5655-63. PMID: 11511236.
      View in: PubMed
    51. Guo JX, Gmeiner WH. Molecular dynamics simulation of the human U2B" protein complex with U2 snRNA hairpin IV in aqueous solution. Biophys J. 2001 Aug; 81(2):630-42. PMID: 11463612.
      View in: PubMed
    52. Gmeiner WH, Xu I, Horita DA, Smithgall TE, Engen JR, Smith DL, Byrd RA. Intramolecular binding of a proximal PPII helix to an SH3 domain in the fusion protein SH3Hck : PPIIhGAP. Cell Biochem Biophys. 2001; 35(2):115-26. PMID: 11892787.
      View in: PubMed
    53. Gmeiner WH, Horita DA. Implications of SH3 domain structure and dynamics for protein regulation and drug design. Cell Biochem Biophys. 2001; 35(2):127-40. PMID: 11892788.
      View in: PubMed
    54. Guo J, Daizadeh I, Gmeiner WH. Structure of the Sm binding site from human U4 snRNA derived from a 3 ns PME molecular dynamics simulation. J Biomol Struct Dyn. 2000 Dec; 18(3):335-44. PMID: 11149510.
      View in: PubMed
    55. Kotchetkov R, Gröschel B, Gmeiner WH, Krivtchik AA, Trump E, Bitoova M, Cinatl J, Kornhuber B, Cinatl J. Antineoplastic activity of a novel multimeric gemcitabine-monophosphate prodrug against thyroid cancer cells in vitro. Anticancer Res. 2000 Sep-Oct; 20(5A):2915-22. PMID: 11062701.
      View in: PubMed
    56. Gmeiner WH, Cui W, Sharma S, Soto AM, Marky LA, Lown JW. Shape-selective binding of geometrically-constrained bis-distamycins to a DNA duplex and a model Okazaki fragment of identical sequence. Nucleosides Nucleotides Nucleic Acids. 2000 Aug; 19(8):1365-79. PMID: 11097065.
      View in: PubMed
    57. Gmeiner WH, Hudalla CJ, Soto AM, Marky L. Binding of ethidium to DNA measured using a 2D diffusion-modulated gradient COSY NMR experiment. FEBS Lett. 2000 Jan 14; 465(2-3):148-52. PMID: 10631323.
      View in: PubMed
    58. Horita DA, Zhang W, Smithgall TE, Gmeiner WH, Byrd RA. Dynamics of the Hck-SH3 domain: comparison of experiment with multiple molecular dynamics simulations. Protein Sci. 2000 Jan; 9(1):95-103. PMID: 10739251.
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    59. Gmeiner WH, Cui W, Konerding DE, Keifer PA, Sharma SK, Soto AM, Marky LA, Lown JW. Shape-selective recognition of a model Okazaki fragment by geometrically-constrained bis-distamycins. J Biomol Struct Dyn. 1999 Dec; 17(3):507-18. PMID: 10636085.
      View in: PubMed
    60. Liu J, Kolath J, Anderson J, Kolar C, Lawson TA, Talmadge J, Gmeiner WH. Positive interaction between 5-FU and FdUMP[10] in the inhibition of human colorectal tumor cell proliferation. Antisense Nucleic Acid Drug Dev. 1999 Oct; 9(5):481-6. PMID: 10555156.
      View in: PubMed
    61. Liu J, Skradis A, Kolar C, Kolath J, Anderson J, Lawson T, Talmadge J, Gmeiner WH. Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU. Nucleosides Nucleotides. 1999 Aug; 18(8):1789-802. PMID: 10478484.
      View in: PubMed
    62. Engen JR, Gmeiner WH, Smithgall TE, Smith DL. Hydrogen exchange shows peptide binding stabilizes motions in Hck SH2. Biochemistry. 1999 Jul 13; 38(28):8926-35. PMID: 10413466.
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    63. Gmeiner WH, Skradis A, Pon RT, Liu J. Cytotoxicity and in-vivo tolerance of FdUMP[10]: a novel pro-drug of the TS inhibitory nucleotide FdUMP. Nucleosides Nucleotides. 1999 Jun-Jul; 18(6-7):1729-30. PMID: 10474257.
      View in: PubMed
    64. Gmeiner WH, Skradis A, Pon RT, Liu J. Cytarabine-induced destabilization and bending of a model Okazaki fragment. Nucleosides Nucleotides. 1999 Jun-Jul; 18(6-7):1577-8. PMID: 10474234.
      View in: PubMed
    65. Engen JR, Smithgall TE, Gmeiner WH, Smith DL. Comparison of SH3 and SH2 domain dynamics when expressed alone or in an SH(3+2) construct: the role of protein dynamics in functional regulation. J Mol Biol. 1999 Apr 02; 287(3):645-56. PMID: 10092465.
      View in: PubMed
    66. Gmeiner WH, Konerding D, James TL. Effect of cytarabine on the NMR structure of a model okazaki fragment from the SV40 genome. Biochemistry. 1999 Jan 26; 38(4):1166-75. PMID: 9930976.
      View in: PubMed
    67. Zhang W, Smithgall TE, Gmeiner WH. Self-association and backbone dynamics of the hck SH2 domain in the free and phosphopeptide-complexed forms. Biochemistry. 1998 May 19; 37(20):7119-26. PMID: 9585523.
      View in: PubMed
    68. Gmeiner WH, Skradis A, Pon RT, Liu J. Cytarabine-induced destabilization of a model Okazaki fragment. Nucleic Acids Res. 1998 May 15; 26(10):2359-65. PMID: 9580686.
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    69. Horita DA, Baldisseri DM, Zhang W, Altieri AS, Smithgall TE, Gmeiner WH, Byrd RA. Solution structure of the human Hck SH3 domain and identification of its ligand binding site. J Mol Biol. 1998 Apr 24; 278(1):253-65. PMID: 9571048.
      View in: PubMed
    70. Gmeiner WH. NMR spectroscopy as a tool to investigate the structural basis of anticancer drugs. Curr Med Chem. 1998 Apr; 5(2):115-35. PMID: 9481037.
      View in: PubMed
    71. Engen JR, Smithgall TE, Gmeiner WH, Smith DL. Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry. Biochemistry. 1997 Nov 25; 36(47):14384-91. PMID: 9398156.
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    72. Zhang W, Smithgall TE, Gmeiner WH. Three-dimensional structure of the Hck SH2 domain in solution. J Biomol NMR. 1997 Oct; 10(3):263-72. PMID: 9390404.
      View in: PubMed
    73. Sahasrabudhe PV, Gmeiner WH. Solution structures of 5-fluorouracil-substituted RNA duplexes containing G-U wobble base pairs. Biochemistry. 1997 May 20; 36(20):5981-91. PMID: 9166768.
      View in: PubMed
    74. Zhang W, Smithgall TE, Gmeiner WH. Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase. FEBS Lett. 1997 Apr 07; 406(1-2):131-5. PMID: 9109402.
      View in: PubMed
    75. Sahasrabudhe PV, Sun J, Gmeiner WH. The 5' stem-loop from human U4 snRNA adopts a novel conformation stabilized by G-C and G-U base pairs. J Biomol Struct Dyn. 1997 Apr; 14(5):567-77. PMID: 9130079.
      View in: PubMed
    76. Sahasrabudhe PV, Pon RT, Gmeiner WH. Solution structures of 5-fluorouracil-substituted DNA and RNA decamer duplexes. Biochemistry. 1996 Oct 22; 35(42):13597-608. PMID: 8885839.
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    77. Zhang W, Gmeiner WH. A 3D NOESY-(HCACO)NH experiment for the measurement of NOEs involving 1H alpha in 13C/15N-labeled proteins dissolved in H2O. J Biomol NMR. 1996 Oct; 8(3):357-9. PMID: 8953222.
      View in: PubMed
    78. Zhang W, Smithgall TE, Gmeiner WH. Separation of NOEs from degenerate amide protons in 13C/15N-labeled proteins using a 3D 13C'-edited NOESY-H(N)CO experiment. J Magn Reson B. 1996 Jun; 111(3):305-9. PMID: 8661298.
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    79. Zhang W, Gmeiner WH. Improved 3D gd-HCACO and gd-(H)CACO-TOCSY experiments for isotopically enriched proteins dissolved in H2O. J Biomol NMR. 1996 May; 7(3):247-50. PMID: 8785500.
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    80. Gmeiner WH, Facelli JC. Quantum mechanical calculations and experimental measurement of N-terminal charge effects on 1HN and 1HC alpha chemical shifts in peptides. Biopolymers. 1996 May; 38(5):573-81. PMID: 8722227.
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    81. Sahasrabudhe PV, Gmeiner WH. The affinity of an oligodeoxynucleotide-peptide conjugate for an RNA hairpin loop depends on stereochemistry at the DNA-peptide junction. J Biomol Struct Dyn. 1996 Feb; 13(4):585-91. PMID: 8906879.
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    82. Sherman SA, Gmeiner WH, Kirnarskiy L, Perini F, Ruddon RW. A linear 23-residue peptide reveals a propensity to form an unusual native-like conformation. J Biomol Struct Dyn. 1995 Dec; 13(3):441-6. PMID: 8825723.
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    83. Sahasrabudhe PV, Pon RT, Gmeiner WH. Effects of site-specific substitution of 5-fluorouridine on the stabilities of duplex DNA and RNA. Nucleic Acids Res. 1995 Oct 11; 23(19):3916-21. PMID: 7479036.
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    84. McConnell JR, Swindells S, Ong CS, Gmeiner WH, Chu WK, Brown DK, Gendelman HE. Prospective utility of cerebral proton magnetic resonance spectroscopy in monitoring HIV infection and its associated neurological impairment. AIDS Res Hum Retroviruses. 1994 Aug; 10(8):977-82. PMID: 7811549.
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    85. Gmeiner WH, Rayner B, Morvan F, Imbach JL, Lown JW. Structure and conformation in solution of the parallel-stranded hybrid alpha-d(CGCAATTCGC).beta-d(GCGTTAAGCG) by high-resolution 2D NMR. J Biomol NMR. 1992 May; 2(3):275-88. PMID: 1392570.
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    86. Gmeiner WH, Rao KE, Rayner B, Vasseur JJ, Morvan F, Imbach JL, Lown JW. Polarity of annealing and structural analysis of the RNase H resistant alpha-5'-d[TACACA].beta-5'-r[AUGUGU] hybrid determined by high-field 1H, 13C, and 31P NMR analysis. Biochemistry. 1990 Nov 13; 29(45):10329-41. PMID: 1702022.
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