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Clinical and Translational Science Institute

Keywords
Last Name

Akiva Mintz, M.D., Ph.D.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentDiagnostic Radiology
AddressReynolds Tower
Medical Center Blvd
Phone336-716-4857
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentCTSI

    TitleSection Head
    InstitutionWake Forest School of Medicine
    DepartmentDivision of Radiologic Science


    Collapse Research 
    Collapse research activities and funding
    R21NS067471     (MINTZ, AKIVA)Sep 30, 2009 - Aug 31, 2012
    NIH/NINDS
    Targeted Molecular Nano-Irradiation Against a Malignant Glioma Biomarker
    Role: Principal Investigator

    R01CA179072     (MINTZ, AKIVA)Sep 1, 2015 - Aug 31, 2020
    NIH/NCI
    Therapeutically Exploiting a Newly Isolated Neural-like Stem Cell Against GBM
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Solingapuram Sai KK, Donald Gage H, Almaguel F, Neth B, Hughes TM, Tremblay S, Castellano CA, Cunnane SC, Jorgensen MJ, Craft S, Mintz A. Automated synthesis of 1-[11C]acetoacetate on a TRASIS AIO module. Appl Radiat Isot. 2017 Aug 02; 129:57-61. PMID: 28806598.
      View in: PubMed
    2. Sena IFG, Prazeres PHDM, Santos GSP, Borges IT, Azevedo PO, Andreotti JP, Almeida VM, Paiva AE, Guerra DAP, Lousado L, Souto L, Mintz A, Birbrair A. Identity of Gli1+ cells in the bone marrow. Exp Hematol. 2017 Oct; 54:12-16. PMID: 28690072.
      View in: PubMed
    3. Borges I, Sena I, Azevedo P, Andreotti J, Almeida V, Paiva A, Santos G, Guerra D, Prazeres P, Mesquita LL, Silva LSB, Leonel C, Mintz A, Birbrair A. Lung as a Niche for Hematopoietic Progenitors. Stem Cell Rev. 2017 Jul 01. PMID: 28669077.
      View in: PubMed
    4. Sattiraju A, Solingapuram Sai KK, Xuan A, Pandya DN, Almaguel FG, Wadas TJ, Herpai DM, Debinski W, Mintz A. IL13RA2 targeted alpha particle therapy against glioblastomas. Oncotarget. 2017 Jun 27; 8(26):42997-43007. PMID: 28562337.
      View in: PubMed
    5. Birbrair A, Borges IDT, Gilson Sena IF, Almeida GG, da Silva Meirelles L, Gonçalves R, Mintz A, Delbono O. How Plastic Are Pericytes? Stem Cells Dev. 2017 Jul 15; 26(14):1013-1019. PMID: 28490256.
      View in: PubMed
    6. Prabhakaran J, Zanderigo F, Sai KKS, Rubin-Falcone H, Jorgensen MJ, Kaplan JR, Mintz A, Mann JJ, Kumar JSD. Radiosynthesis and in Vivo Evaluation of [11C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain. ACS Chem Neurosci. 2017 Aug 16; 8(8):1697-1703. PMID: 28485573.
      View in: PubMed
    7. Dias Moura Prazeres PH, Sena IFG, Borges IDT, de Azevedo PO, Andreotti JP, de Paiva AE, de Almeida VM, de Paula Guerra DA, Pinheiro Dos Santos GS, Mintz A, Delbono O, Birbrair A. Pericytes are heterogeneous in their origin within the same tissue. Dev Biol. 2017 Jul 01; 427(1):6-11. PMID: 28479340.
      View in: PubMed
    8. Sai KKS, Zachar Z, Bingham PM, Mintz A. Metabolic PET Imaging in Oncology. AJR Am J Roentgenol. 2017 Aug; 209(2):270-276. PMID: 28463521.
      View in: PubMed
    9. Solingapuram Sai KK, Prabhakaran J, Sattiraju A, Mann JJ, Mintz A, Kumar JSD. Radiosynthesis and evaluation of IGF1R PET ligand [11C]GSK1838705A. Bioorg Med Chem Lett. 2017 Jul 01; 27(13):2895-2897. PMID: 28479199.
      View in: PubMed
    10. Sun Y, Xiong X, Pandya D, Jung Y, Mintz A, Hayasaka S, Wadas TJ, Li KCP. Enhancing tissue permeability with MRI guided preclinical focused ultrasound system in rabbit muscle: From normal tissue to VX2 tumor. J Control Release. 2017 Jun 28; 256:1-8. PMID: 28412225.
      View in: PubMed
    11. Gottesman RF, Schneider AL, Zhou Y, Coresh J, Green E, Gupta N, Knopman DS, Mintz A, Rahmim A, Sharrett AR, Wagenknecht LE, Wong DF, Mosley TH. Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition. JAMA. 2017 Apr 11; 317(14):1443-1450. PMID: 28399252.
      View in: PubMed
    12. Solingapuram Sai KK, Das BC, Sattiraju A, Almaguel FG, Craft S, Mintz A. Radiolabeling and initial biological evaluation of [18F]KBM-1 for imaging RAR-a receptors in neuroblastoma. Bioorg Med Chem Lett. 2017 Mar 15; 27(6):1425-1427. PMID: 28216044.
      View in: PubMed
    13. Wang L, Habib AA, Mintz A, Li KC, Zhao D. Phosphatidylserine-Targeted Nanotheranostics for Brain Tumor Imaging and Therapeutic Potential. Mol Imaging. 2017 Jan 01; 16:1536012117708722. PMID: 28654387.
      View in: PubMed
    14. Hu Y, Feng X, Mintz A, Jeffrey Petty W, Hsu W. Regulation of brachyury by fibroblast growth factor receptor 1 in lung cancer. Oncotarget. 2016 Dec 27; 7(52):87124-87135. PMID: 27893433.
      View in: PubMed
    15. Prabhakaran J, Solingapuram Sai KK, Zanderigo F, Rubin-Falcone H, Jorgensen MJ, Kaplan JR, Tooke KI, Mintz A, Mann JJ, Kumar JS. In vivo evaluation of [18F]FECIMBI-36, an agonist 5-HT2A/2C receptor PET radioligand in nonhuman primate. Bioorg Med Chem Lett. 2017 Jan 01; 27(1):21-23. PMID: 27889455.
      View in: PubMed
    16. Lodge MA, Holdhoff M, Leal JP, Bag AK, Nabors LB, Mintz A, Lesser GJ, Mankoff DA, Desai AS, Mountz JM, Lieberman FS, Fisher JD, Desideri S, Ye X, Grossman SA, Schiff D, Wahl RL. Repeatability of 18F-FLT PET in a Multicenter Study of Patients with High-Grade Glioma. J Nucl Med. 2017 Mar; 58(3):393-398. PMID: 27688473.
      View in: PubMed
    17. Birbrair A, Sattiraju A, Zhu D, Zulato G, Batista I, Nguyen VT, Messi ML, Solingapuram Sai KK, Marini FC, Delbono O, Mintz A. Novel Peripherally Derived Neural-Like Stem Cells as Therapeutic Carriers for Treating Glioblastomas. Stem Cells Transl Med. 2016 Sep 14. PMID: 27629764.
      View in: PubMed
    18. Birbrair A, Sattiraju A, Zhu D, Zulato G, Batista I, Nguyen VT, Messi ML, Solingapuram Sai KK, Marini FC, Delbono O, Mintz A. Novel Peripherally Derived Neural-Like Stem Cells as Therapeutic Carriers for Treating Glioblastomas. Stem Cells Transl Med. 2017 Feb; 6(2):471-481. PMID: 28191774.
      View in: PubMed
    19. Gerstner ER, Zhang Z, Fink JR, Muzi M, Hanna L, Greco E, Prah M, Schmainda KM, Mintz A, Kostakoglu L, Eikman EA, Ellingson BM, Ratai EM, Sorensen AG, Barboriak DP, Mankoff DA. ACRIN 6684: Assessment of Tumor Hypoxia in Newly Diagnosed Glioblastoma Using 18F-FMISO PET and MRI. Clin Cancer Res. 2016 Oct 15; 22(20):5079-5086. PMID: 27185374.
      View in: PubMed
    20. Pandya DN, Hantgan R, Budzevich MM, Kock ND, Morse DL, Batista I, Mintz A, Li KC, Wadas TJ. Preliminary Therapy Evaluation of (225)Ac-DOTA-c(RGDyK) Demonstrates that Cerenkov Radiation Derived from (225)Ac Daughter Decay Can Be Detected by Optical Imaging for In Vivo Tumor Visualization. Theranostics. 2016; 6(5):698-709. PMID: 27022417; PMCID: PMC4805664.
    21. Xiong X, Sun Y, Sattiraju A, Jung Y, Mintz A, Hayasaka S, Li KC. Remote spatiotemporally controlled and biologically selective permeabilization of blood-brain barrier. J Control Release. 2015 Nov 10; 217:113-20. PMID: 26334482; PMCID: PMC4623944.
    22. Solingapuram Sai KK, Gage D, Nader M, Mach RH, Mintz A. Improved Automated Radiosynthesis of [(11)C]PBR28. Sci Pharm. 2015 Jul-Sep; 83(3):413-27. PMID: 26839827; PMCID: PMC4727796.
    23. Sattiraju, A (Sattiraju, Anirudh); Xiong, XB (Xiong, Xiaobing); Pandya, D (Pandya, Darpan); Sun, Y (Sun, Yao); Jung, Y (Jung, Youngkyoo); Wadas, T (Wadas, Thaddeus); Li, K (Li, King); Mintz, A (Mintz, Akiva). Journal of Nuclear Medicine. Permeabilizing the blood-brain-barrier with alpha-particle therapy. 2015; 56(3):1230.
    24. Tamam M, Mintz A. Pseudoaneurysm of a pancreas allograft artery detected by 99mTc red blood cell SPECT/CT. Clin Nucl Med. 2015 Apr; 40(4):e241-4. PMID: 25674856.
      View in: PubMed
    25. Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O. Pericytes at the intersection between tissue regeneration and pathology. Clin Sci (Lond). 2015 Jan; 128(2):81-93. PMID: 25236972; PMCID: PMC4200531.
    26. Mintz A. PET/CT in prostate cancer: an unmet clinical need. Oncology (Williston Park). 2014 Dec; 28(12):1065-6. PMID: 25738198.
      View in: PubMed
    27. Birbrair A, Zhang T, Files DC, Mannava S, Smith T, Wang ZM, Messi ML, Mintz A, Delbono O. Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner. Stem Cell Res Ther. 2014 Nov 06; 5(6):122. PMID: 25376879; PMCID: PMC4445991.
    28. Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O. Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle. Front Aging Neurosci. 2014; 6:245. PMID: 25278877; PMCID: PMC4166895.
    29. Wadas TJ, Pandya DN, Solingapuram Sai KK, Mintz A. Molecular targeted a-particle therapy for oncologic applications. AJR Am J Roentgenol. 2014 Aug; 203(2):253-60. PMID: 25055256; PMCID: PMC4490786.
    30. Birbrair A, Zhang T, Wang ZM, Messi ML, Olson JD, Mintz A, Delbono O. Type-2 pericytes participate in normal and tumoral angiogenesis. Am J Physiol Cell Physiol. 2014 Jul 01; 307(1):C25-38. PMID: 24788248; PMCID: PMC4080181.
    31. Hu Y, Mintz A, Shah SR, Quinones-Hinojosa A, Hsu W. The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival. Carcinogenesis. 2014 Jul; 35(7):1491-9. PMID: 24445144; PMCID: PMC4593008.
    32. Kota G, Gupta P, Lesser GJ, Wilson JA, Mintz A. Somatostatin receptor molecular imaging for metastatic intracranial hemangiopericytoma. Clin Nucl Med. 2013 Dec; 38(12):984-7. PMID: 24212443.
      View in: PubMed
    33. Eriksson O, Mintz A, Liu C, Yu M, Naji A, Alavi A. On the use of [18F]DOPA as an imaging biomarker for transplanted islet mass. Ann Nucl Med. 2014 Jan; 28(1):47-52. PMID: 24166476.
      View in: PubMed
    34. Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O. Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle. Am J Physiol Cell Physiol. 2013 Dec 01; 305(11):C1098-113. PMID: 24067916; PMCID: PMC3882385.
    35. Kota G, Gupta P, Mintz A. PET/CT illustration of metastatic breast cancer to the left mandibular foramen. Clin Nucl Med. 2013 May; 38(5):385-6. PMID: 23486320.
      View in: PubMed
    36. Birbrair A, Zhang T, Wang ZM, Messi ML, Enikolopov GN, Mintz A, Delbono O. Role of pericytes in skeletal muscle regeneration and fat accumulation. Stem Cells Dev. 2013 Aug 15; 22(16):2298-314. PMID: 23517218; PMCID: PMC3730538.
    37. Deford-Watts LM, Mintz A, Kridel SJ. The potential of ¹¹C-acetate PET for monitoring the Fatty acid synthesis pathway in Tumors. Curr Pharm Biotechnol. 2013; 14(3):300-12. PMID: 23597406; PMCID: PMC3837380.
    38. Birbrair A, Zhang T, Wang ZM, Messi ML, Enikolopov GN, Mintz A, Delbono O. Skeletal muscle pericyte subtypes differ in their differentiation potential. Stem Cell Res. 2013 Jan; 10(1):67-84. PMID: 23128780; PMCID: PMC3781014.
    39. Birbrair A, Zhang T, Wang ZM, Messi ML, Enikolopov GN, Mintz A, Delbono O. Skeletal muscle neural progenitor cells exhibit properties of NG2-glia. Exp Cell Res. 2013 Jan 01; 319(1):45-63. PMID: 22999866; PMCID: PMC3597239.
    40. Nguyen V, Conyers JM, Zhu D, Gibo DM, Hantgan RR, Larson SM, Debinski W, Mintz A. A novel ligand delivery system to non-invasively visualize and therapeutically exploit the IL13Ra2 tumor-restricted biomarker. Neuro Oncol. 2012 Oct; 14(10):1239-53. PMID: 22952195; PMCID: PMC3452345.
    41. Beauchamp A, Lively MO, Mintz A, Gibo D, Wykosky J, Debinski W. EphrinA1 is released in three forms from cancer cells by matrix metalloproteases. Mol Cell Biol. 2012 Aug; 32(16):3253-64. PMID: 22688511; PMCID: PMC3434542.
    42. Gupta P, Kota G, Mintz A. Evolution of a ureteric stone from the renal pelvis to the ureter on skeletal scintigraphy with CT correlation. Clin Nucl Med. 2012 Feb; 37(2):188-9. PMID: 22228349.
      View in: PubMed
    43. Gupta P, Kota G, Alavi A, Mintz A. Unilateral diffusely increased muscle uptake of F-18 FDG in a patient with hemiparesis due to stroke. Clin Nucl Med. 2011 Dec; 36(12):1140-1. PMID: 22064095.
      View in: PubMed
    44. Nguyen V, Conyers JM, Zhu D, Gibo DM, Dorsey JF, Debinski W, Mintz A. IL-13Ra2-Targeted Therapy Escapees: Biologic and Therapeutic Implications. Transl Oncol. 2011 Dec; 4(6):390-400. PMID: 22191003; PMCID: PMC3243662.
    45. Kota GK, Gupta P, Conyers JM, Mintz A. Targeting angiogenesis in an age of personalized medicine. Cancer Biol Ther. 2010 Nov 01; 10(9):874-7. PMID: 21057212.
      View in: PubMed
    46. Nguyen V, Conyers JM, Mintz A. Pretargeting the masses: a means of improving and mainstreaming targeted molecular delivery? Cancer Biol Ther. 2010 Oct 15; 10(8):775-9. PMID: 20935465.
      View in: PubMed
    47. Nguyen V, Mintz A. New frontiers in biomarker-targeted molecular imaging. Cancer Biol Ther. 2009 Dec; 8(23):2248-51. PMID: 20009566.
      View in: PubMed
    48. Dorsey JF, Mintz A, Tian X, Dowling ML, Plastaras JP, Dicker DT, Kao GD, El-Deiry WS. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and paclitaxel have cooperative in vivo effects against glioblastoma multiforme cells. Mol Cancer Ther. 2009 Dec; 8(12):3285-95. PMID: 19996278.
      View in: PubMed
    49. Mintz A, Gibo DM, Madhankumar AB, Cladel NM, Christensen ND, Debinski W. Protein- and DNA-based active immunotherapy targeting interleukin-13 receptor alpha2. Cancer Biother Radiopharm. 2008 Oct; 23(5):581-9. PMID: 18976118; PMCID: PMC2936944.
    50. Mintz A, Wang L, Ponde DE. Comparison of radiolabeled choline and ethanolamine as probe for cancer detection. Cancer Biol Ther. 2008 May; 7(5):742-7. PMID: 18296919.
      View in: PubMed
    51. Wang S, Mintz A, Mochizuki K, Dorsey JF, Ackermann JM, Alavi A, El-Deiry WS. Multimodality optical imaging and 18F-FDG uptake in wild-type p53-containing and p53-null human colon tumor xenografts. Cancer Biol Ther. 2007 Oct; 6(10):1649-53. PMID: 17932466.
      View in: PubMed
    52. Madhankumar AB, Slagle-Webb B, Mintz A, Sheehan JM, Connor JR. Interleukin-13 receptor-targeted nanovesicles are a potential therapy for glioblastoma multiforme. Mol Cancer Ther. 2006 Dec; 5(12):3162-9. PMID: 17172420.
      View in: PubMed
    53. Madhankumar AB, Mintz A, Debinski W. Interleukin 13 mutants of enhanced avidity toward the glioma-associated receptor, IL13Ralpha2. Neoplasia. 2004 Jan-Feb; 6(1):15-22. PMID: 15068667; PMCID: PMC1508627.
    54. Mintz A, Gibo DM, Madhankumar AB, Debinski W. Molecular targeting with recombinant cytotoxins of interleukin-13 receptor alpha2-expressing glioma. J Neurooncol. 2003 Aug-Sep; 64(1-2):117-23. PMID: 12952292.
      View in: PubMed
    55. Debinski W, Gibo D, Mintz A. Epigenetics in high-grade astrocytomas: opportunities for prevention and detection of brain tumors. Ann N Y Acad Sci. 2003 Mar; 983:232-42. PMID: 12724228.
      View in: PubMed
    56. Mintz A, Gibo DM, Slagle-Webb B, Christensen ND, Debinski W. IL-13Ralpha2 is a glioma-restricted receptor for interleukin-13. Neoplasia. 2002 Sep-Oct; 4(5):388-99. PMID: 12192597; PMCID: PMC1564118.
    57. Madhankumar AB, Mintz A, Debinski W. Alanine-scanning mutagenesis of alpha-helix D segment of interleukin-13 reveals new functionally important residues of the cytokine. J Biol Chem. 2002 Nov 08; 277(45):43194-205. PMID: 12189139.
      View in: PubMed
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