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Clinical and Translational Science Institute

Keywords
Last Name

Adrian W. Laxton, M.D.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentSurgery Neurosurgery
Address
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Soike MH, McTyre ER, Shah N, Puchalski RB, Holmes JA, Paulsson AK, Miller LD, Cramer CK, Lesser GJ, Strowd RE, Hinson WH, Mott RT, Johnson AJ, Lo HW, Laxton AW, Tatter SB, Debinski W, Chan MD. Glioblastoma radiomics: can genomic and molecular characteristics correlate with imaging response patterns? Neuroradiology. 2018 Oct; 60(10):1043-1051. PMID: 30094640.
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    2. McTyre E, Lucas JT, Helis C, Farris M, Soike M, Mott R, Laxton AW, Tatter SB, Lesser GJ, Strowd RE, Lo HW, Debinski W, Chan MD. Outcomes for Anaplastic Glioma Treated With Radiation Therapy With or Without Concurrent Temozolomide. Am J Clin Oncol. 2018 Aug; 41(8):813-819. PMID: 28301347.
      View in: PubMed
    3. Hughes RT, McTyre ER, LeCompte M, Cramer CK, Munley MT, Laxton AW, Tatter SB, Ruiz J, Pasche B, Watabe K, Chan MD. Clinical Outcomes of Upfront Stereotactic Radiosurgery Alone for Patients With 5 to 15 Brain Metastases. Neurosurgery. 2018 Jul 06. PMID: 29982831.
      View in: PubMed
    4. Dohm A, McTyre ER, Okoukoni C, Henson A, Cramer CK, LeCompte MC, Ruiz J, Munley MT, Qasem S, Lo HW, Xing F, Watabe K, Laxton AW, Tatter SB, Chan MD. Staged Stereotactic Radiosurgery for Large Brain Metastases: Local Control and Clinical Outcomes of a One-Two Punch Technique. Neurosurgery. 2018 Jul 01; 83(1):114-121. PMID: 28973432.
      View in: PubMed
    5. Soike MH, McTyre ER, Hughes RT, Farris M, Cramer CK, LeCompte MC, Lanier CM, Ruiz J, Su J, Watabe K, Bourland JD, Munley MT, O'Neill S, Laxton AW, Tatter SB, Chan MD. Initial brain metastasis velocity: does the rate at which cancers first seed the brain affect outcomes? J Neurooncol. 2018 Sep; 139(2):461-467. PMID: 29740743.
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    6. Ahluwalia M, Barnett GH, Deng D, Tatter SB, Laxton AW, Mohammadi AM, Leuthardt E, Chamoun R, Judy K, Asher A, Essig M, Dietrich J, Chiang VL. Laser ablation after stereotactic radiosurgery: a multicenter prospective study in patients with metastatic brain tumors and radiation necrosis. J Neurosurg. 2018 May 04; 130(3):804-811. PMID: 29726782.
      View in: PubMed
    7. Taylor JM, McTyre ER, Tatter SB, Laxton AW, Munley MT, Chan MD, Cramer CK. Gamma Knife Stereotactic Radiosurgery for the Treatment of Brain Metastases from Primary Tumors of the Urinary Bladder. Stereotact Funct Neurosurg. 2018; 96(2):108-112. PMID: 29698968.
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    8. Hampson RE, Song D, Robinson BS, Fetterhoff D, Dakos AS, Roeder BM, She X, Wicks RT, Witcher MR, Couture DE, Laxton AW, Munger-Clary H, Popli G, Sollman MJ, Whitlow CT, Marmarelis VZ, Berger TW, Deadwyler SA. Developing a hippocampal neural prosthetic to facilitate human memory encoding and recall. J Neural Eng. 2018 Jun; 15(3):036014. PMID: 29589592.
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    9. Moran RJ, Kishida KT, Lohrenz T, Saez I, Laxton AW, Witcher MR, Tatter SB, Ellis TL, Phillips PE, Dayan P, Montague PR. The Protective Action Encoding of Serotonin Transients in the Human Brain. Neuropsychopharmacology. 2018 05; 43(6):1425-1435. PMID: 29297512.
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    10. Lanier CM, McTyre E, LeCompte M, Cramer CK, Hughes R, Watabe K, Lo HW, O'Neill S, Munley MT, Laxton AW, Tatter SB, Ruiz J, Chan MD. The number of prior lines of systemic therapy as a prognostic factor for patients with brain metastases treated with stereotactic radiosurgery: Results of a large single institution retrospective analysis. Clin Neurol Neurosurg. 2018 02; 165:24-28. PMID: 29289917.
      View in: PubMed
    11. LeCompte MC, McTyre E, Henson A, Farris M, Okoukoni C, Cramer CK, Triozzi P, Ruiz J, Watabe K, Lo HW, Munley MT, Laxton AW, Tatter SB, Zhou X, Chan M. Survival and Failure Outcomes Predicted by Brain Metastasis Volumetric Kinetics in Melanoma Patients Following Upfront Treatment with Stereotactic Radiosurgery Alone. Cureus. 2017 Dec 11; 9(12):e1934. PMID: 29464141.
      View in: PubMed
    12. Alphonse-Sullivan N, Taksler GB, Lycan T, Weaver KE, McTyre ER, Shenker RF, Page BR, Isom S, Johnson A, Munley MT, Laxton AW, Tatter SB, Watabe K, Chan MD, Ruiz J. Sociodemographic predictors of patients with brain metastases treated with stereotactic radiosurgery. Oncotarget. 2017 Nov 24; 8(60):101005-101011. PMID: 29254141.
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    13. Dohm A, McTyre ER, Chan MD, Fan C, Isom S, Bourland JD, Mott RT, Cramer CK, Tatter SB, Laxton AW. Early or late radiotherapy following gross or subtotal resection for atypical meningiomas: Clinical outcomes and local control. J Clin Neurosci. 2017 Dec; 46:90-98. PMID: 28917587.
      View in: PubMed
    14. Renfrow JJ, Strowd RE, Laxton AW, Tatter SB, Geer CP, Lesser GJ. Surgical Considerations in the Optimal Management of Patients with Malignant Brain Tumors. Curr Treat Options Oncol. 2017 08; 18(8):46. PMID: 28681208.
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    15. Wang EC, Huang AJ, Huang KE, McTyre ER, Lo HW, Watabe K, Metheny-Barlow L, Laxton AW, Tatter SB, Strowd RE, Chan MD, Page BR. Leptomeningeal failure in patients with breast cancer receiving stereotactic radiosurgery for brain metastases. J Clin Neurosci. 2017 Sep; 43:6-10. PMID: 28511975.
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    16. Shenker RF, McTyre ER, Ruiz J, Weaver KE, Cramer C, Alphonse-Sullivan NK, Farris M, Petty WJ, Bonomi MR, Watabe K, Laxton AW, Tatter SB, Warren GW, Chan MD. The Effects of smoking status and smoking history on patients with brain metastases from lung cancer. Cancer Med. 2017 May; 6(5):944-952. PMID: 28401684.
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    17. McTyre ER, Johnson AG, Ruiz J, Isom S, Lucas JT, Hinson WH, Watabe K, Laxton AW, Tatter SB, Chan MD. Predictors of neurologic and nonneurologic death in patients with brain metastasis initially treated with upfront stereotactic radiosurgery without whole-brain radiation therapy. Neuro Oncol. 2017 04 01; 19(4):558-566. PMID: 27571883.
      View in: PubMed
    18. McTyre E, Helis CA, Farris M, Wilkins L, Sloan D, Hinson WH, Bourland JD, Dezarn WA, Munley MT, Watabe K, Xing F, Laxton AW, Tatter SB, Chan MD. Emerging Indications for Fractionated Gamma Knife Radiosurgery. Neurosurgery. 2017 02 01; 80(2):210-216. PMID: 28536486.
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    19. Page BR, Wang EC, White L, McTyre E, Peiffer A, Alistar A, Mu F, Loganathan A, Bourland JD, Laxton AW, Tatter SB, Chan MD. Gamma Knife radiosurgery for brain metastases from gastrointestinal primary. J Med Imaging Radiat Oncol. 2017 Aug; 61(4):522-527. PMID: 28139076.
      View in: PubMed
    20. Farris M, McTyre ER, Cramer CK, Hughes R, Randolph DM, Ayala-Peacock DN, Bourland JD, Ruiz J, Watabe K, Laxton AW, Tatter SB, Zhou X, Chan MD. Brain Metastasis Velocity: A Novel Prognostic Metric Predictive of Overall Survival and Freedom From Whole-Brain Radiation Therapy After Distant Brain Failure Following Upfront Radiosurgery Alone. Int J Radiat Oncol Biol Phys. 2017 05 01; 98(1):131-141. PMID: 28586952.
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    21. Randolph DM, McTyre E, Klepin H, Peiffer AM, Ayala-Peacock D, Lester S, Laxton AW, Dohm A, Tatter SB, Shaw EG, Chan MD. Impact of radiosurgical management of geriatric patients with brain metastases: Clinical and quality of life outcomes. J Radiosurg SBRT. 2017; 5(1):35-42. PMID: 29296461.
      View in: PubMed
    22. Johnston H, McTyre ER, Cramer CK, Lesser GJ, Ruiz J, Bourland JD, Watabe K, Lo HW, Qasem S, Laxton AW, Tatter SB, Chan MD. Stereotactic radiosurgery in the treatment of brain metastases from gynecologic primary cancer. J Radiosurg SBRT. 2017; 5(1):55-61. PMID: 29296463.
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    23. Wicks RT, Jermakowicz WJ, Jagid JR, Couture DE, Willie JT, Laxton AW, Gross RE. Laser Interstitial Thermal Therapy for Mesial Temporal Lobe Epilepsy. Neurosurgery. 2016 Dec; 79 Suppl 1:S83-S91. PMID: 27861328.
      View in: PubMed
    24. Randolph DM, McTyre ER, Paulsson AK, Holmes JA, Hinson WH, Lesser GJ, Strowd R, Lo HW, Laxton AW, Tatter SB, Debinski W, Chan MD. Impact of timing of radiotherapy in patients with newly diagnosed glioblastoma. Clin Neurol Neurosurg. 2016 Dec; 151:73-78. PMID: 27816029.
      View in: PubMed
    25. Henson A, McTyre E, Ayala-Peacock DN, Triozzi P, Savage P, Laxton AW, Chan MD. Outcomes for Metastatic Melanoma Treated With Stereotactic Radiosurgery In the Era of Targeted Systemic Therapies. Int J Radiat Oncol Biol Phys. 2016 Oct 01; 96(2S):E135-E136. PMID: 27673868.
      View in: PubMed
    26. McKay WH, McTyre ER, Okoukoni C, Alphonse-Sullivan NK, Ruiz J, Munley MT, Qasem S, Lo HW, Xing F, Laxton AW, Tatter SB, Watabe K, Chan MD. Repeat stereotactic radiosurgery as salvage therapy for locally recurrent brain metastases previously treated with radiosurgery. J Neurosurg. 2017 Jul; 127(1):148-156. PMID: 27494815.
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    27. Hughes RT, Black PJ, Page BR, Lucas JT, Qasem SA, Watabe K, Ruiz J, Laxton AW, Tatter SB, Debinski W, Chan MD. Local control of brain metastases after stereotactic radiosurgery: the impact of whole brain radiotherapy and treatment paradigm. J Radiosurg SBRT. 2016; 4(2):89-96. PMID: 29296433.
      View in: PubMed
    28. Lucas JT, Huang AJ, Bourland JD, Laxton AW, Tatter SB, Chan MD. Predictors of trigeminal nerve dysfunction following stereotactic radiosurgery for trigeminal neuralgia. J Radiosurg SBRT. 2016; 4(2):117-123. PMID: 29296436.
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    29. Kishida KT, Saez I, Lohrenz T, Witcher MR, Laxton AW, Tatter SB, White JP, Ellis TL, Phillips PE, Montague PR. Subsecond dopamine fluctuations in human striatum encode superposed error signals about actual and counterfactual reward. Proc Natl Acad Sci U S A. 2016 Jan 05; 113(1):200-5. PMID: 26598677.
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    30. Helis CA, Lucas JT, Bourland JD, Chan MD, Tatter SB, Laxton AW. Repeat Radiosurgery for Trigeminal Neuralgia. Neurosurgery. 2015 Nov; 77(5):755-61; discussion 761. PMID: 26214319.
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    31. Johnson AG, Ruiz J, Hughes R, Page BR, Isom S, Lucas JT, McTyre ER, Houseknecht KW, Ayala-Peacock DN, Bourland DJ, Hinson WH, Laxton AW, Tatter SB, Debinski W, Watabe K, Chan MD. Impact of systemic targeted agents on the clinical outcomes of patients with brain metastases. Oncotarget. 2015 Aug 07; 6(22):18945-55. PMID: 26087184.
      View in: PubMed
    32. Holmes JA, Paulsson AK, Page BR, Miller LD, Liu W, Xu J, Hinson WH, Lesser GJ, Laxton AW, Tatter SB, Debinski W, Chan MD. Genomic predictors of patterns of progression in glioblastoma and possible influences on radiation field design. J Neurooncol. 2015 Sep; 124(3):447-53. PMID: 26186902.
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    33. Lucas JT, Colmer HG, White L, Fitzgerald N, Isom S, Bourland JD, Laxton AW, Tatter SB, Chan MD. Competing Risk Analysis of Neurologic versus Nonneurologic Death in Patients Undergoing Radiosurgical Salvage After Whole-Brain Radiation Therapy Failure: Who Actually Dies of Their Brain Metastases? Int J Radiat Oncol Biol Phys. 2015 Aug 01; 92(5):1008-1015. PMID: 26050609.
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    34. Mu F, Lucas JT, Watts JM, Johnson AJ, Daniel Bourland J, Laxton AW, Chan MD, Tatter SB. Tumor resection with carmustine wafer placement as salvage therapy after local failure of radiosurgery for brain metastasis. J Clin Neurosci. 2015 Mar; 22(3):561-5. PMID: 25560387.
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    35. Liu A, Kuhn EN, Lucas JT, Laxton AW, Tatter SB, Chan MD. Gamma Knife radiosurgery for meningiomas in patients with neurofibromatosis Type 2. J Neurosurg. 2015 Mar; 122(3):536-42. PMID: 25555193.
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    36. Black PJ, Page BR, Lucas JT, Hughes RT, Laxton AW, Tatter SB, Munley MT, Chan MD. Factors that determine local control with gamma knife radiosurgery: The role of primary histology. J Radiosurg SBRT. 2015; 3(4):281-286. PMID: 26478823.
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    37. Sankar T, Chakravarty MM, Bescos A, Lara M, Obuchi T, Laxton AW, McAndrews MP, Tang-Wai DF, Workman CI, Smith GS, Lozano AM. Deep Brain Stimulation Influences Brain Structure in Alzheimer's Disease. Brain Stimul. 2015 May-Jun; 8(3):645-54. PMID: 25814404.
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    38. Kuhn EN, Taksler GB, Dayton O, Loganathan A, Bourland D, Tatter SB, Laxton AW, Chan MD. Is there a tumor volume threshold for postradiosurgical symptoms? A single-institution analysis. Neurosurgery. 2014 Nov; 75(5):536-45; discussion 544-5; quiz 545. PMID: 25171304.
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    39. Laxton AW, Stone S, Lozano AM. The neurosurgical treatment of Alzheimer's disease: a review. Stereotact Funct Neurosurg. 2014; 92(5):269-81. PMID: 25247891.
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    40. Huang AJ, Huang KE, Page BR, Ayala-Peacock DN, Lucas JT, Lesser GJ, Laxton AW, Tatter SB, Chan MD. Risk factors for leptomeningeal carcinomatosis in patients with brain metastases who have previously undergone stereotactic radiosurgery. J Neurooncol. 2014 Oct; 120(1):163-9. PMID: 25048529.
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    41. Paulsson AK, Holmes JA, Peiffer AM, Miller LD, Liu W, Xu J, Hinson WH, Lesser GJ, Laxton AW, Tatter SB, Debinski W, Chan MD. Comparison of clinical outcomes and genomic characteristics of single focus and multifocal glioblastoma. J Neurooncol. 2014 Sep; 119(2):429-35. PMID: 24990827.
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    42. Witcher M, Moran R, Tatter SB, Laxton AW. Neuronal oscillations in Parkinson's disease. Front Biosci (Landmark Ed). 2014 Jun 01; 19:1291-9. PMID: 24896351.
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    43. Mohammadi AM, Hawasli AH, Rodriguez A, Schroeder JL, Laxton AW, Elson P, Tatter SB, Barnett GH, Leuthardt EC. The role of laser interstitial thermal therapy in enhancing progression-free survival of difficult-to-access high-grade gliomas: a multicenter study. Cancer Med. 2014 Aug; 3(4):971-9. PMID: 24810945.
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    44. Lucas JT, Nida AM, Isom S, Marshall K, Bourland JD, Laxton AW, Tatter SB, Chan MD. Predictive nomogram for the durability of pain relief from gamma knife radiation surgery in the treatment of trigeminal neuralgia. Int J Radiat Oncol Biol Phys. 2014 May 01; 89(1):120-6. PMID: 24613811.
      View in: PubMed
    45. Ayala-Peacock DN, Peiffer AM, Lucas JT, Isom S, Kuremsky JG, Urbanic JJ, Bourland JD, Laxton AW, Tatter SB, Shaw EG, Chan MD. A nomogram for predicting distant brain failure in patients treated with gamma knife stereotactic radiosurgery without whole brain radiotherapy. Neuro Oncol. 2014 Sep; 16(9):1283-8. PMID: 24558022.
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    46. Kuhn EN, Taksler GB, Dayton O, Loganathan AG, Vern-Gross TZ, Bourland JD, Laxton AW, Chan MD, Tatter SB. Patterns of recurrence after stereotactic radiosurgery for treatment of meningiomas. Neurosurg Focus. 2013 Dec; 35(6):E14. PMID: 24289122.
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    47. Lester SC, Taksler GB, Kuremsky JG, Lucas JT, Ayala-Peacock DN, Randolph DM, Bourland JD, Laxton AW, Tatter SB, Chan MD. Clinical and economic outcomes of patients with brain metastases based on symptoms: an argument for routine brain screening of those treated with upfront radiosurgery. Cancer. 2014 Feb 01; 120(3):433-41. PMID: 24452675.
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    48. Somasundaram A, Laxton AW, Perrin RG. The clinical features of periorbital ecchymosis in a series of trauma patients. Injury. 2014 Jan; 45(1):203-5. PMID: 24095269.
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    49. Laxton AW, Neimat JS, Davis KD, Womelsdorf T, Hutchison WD, Dostrovsky JO, Hamani C, Mayberg HS, Lozano AM. Neuronal coding of implicit emotion categories in the subcallosal cortex in patients with depression. Biol Psychiatry. 2013 Nov 15; 74(10):714-9. PMID: 23773792.
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    50. Laxton AW, Lipsman N, Lozano AM. Deep brain stimulation for cognitive disorders. Handb Clin Neurol. 2013; 116:307-11. PMID: 24112904.
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    51. Laxton AW, Sankar T, Lozano AM, Hamani C. Deep brain stimulation effects on memory. J Neurosurg Sci. 2012 Dec; 56(4):341-4. PMID: 23111294.
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    52. Smith GS, Laxton AW, Tang-Wai DF, McAndrews MP, Diaconescu AO, Workman CI, Lozano AM. Increased cerebral metabolism after 1 year of deep brain stimulation in Alzheimer disease. Arch Neurol. 2012 Sep; 69(9):1141-8. PMID: 22566505.
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    53. Laxton AW, Lozano AM. Deep brain stimulation for the treatment of Alzheimer disease and dementias. World Neurosurg. 2013 Sep-Oct; 80(3-4):S28.e1-8. PMID: 22722036.
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    54. Hamani C, Mayberg H, Stone S, Laxton A, Haber S, Lozano AM. The subcallosal cingulate gyrus in the context of major depression. Biol Psychiatry. 2011 Feb 15; 69(4):301-8. PMID: 21145043.
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    55. Laxton AW, Tang-Wai DF, McAndrews MP, Zumsteg D, Wennberg R, Keren R, Wherrett J, Naglie G, Hamani C, Smith GS, Lozano AM. A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease. Ann Neurol. 2010 Oct; 68(4):521-34. PMID: 20687206.
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    56. Torres CV, Moro E, Lopez-Rios AL, Hodaie M, Chen R, Laxton AW, Hutchison WD, Dostrovsky JO, Lozano AM. Deep brain stimulation of the ventral intermediate nucleus of the thalamus for tremor in patients with multiple sclerosis. Neurosurgery. 2010 Sep; 67(3):646-51; discussion 651. PMID: 20647964.
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    57. Hamani C, Dubiela FP, Soares JC, Shin D, Bittencourt S, Covolan L, Carlen PL, Laxton AW, Hodaie M, Stone SS, Ha Y, Hutchison WD, Lozano AM, Mello LE, Oliveira MG. Anterior thalamus deep brain stimulation at high current impairs memory in rats. Exp Neurol. 2010 Sep; 225(1):154-62. PMID: 20558163.
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    58. Hamani C, Stone S, Laxton A, Lozano AM. The pedunculopontine nucleus and movement disorders: anatomy and the role for deep brain stimulation. Parkinsonism Relat Disord. 2007; 13 Suppl 3:S276-80. PMID: 18267250.
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    59. Laxton AW, Perrin RG. Cordectomy for the treatment of posttraumatic syringomyelia. Report of four cases and review of the literature. J Neurosurg Spine. 2006 Feb; 4(2):174-8. PMID: 16506486.
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    60. Laxton AW, Shannon P, Nag S, Farb RI, Bernstein M. Rapid expansion of a previously asymptomatic subependymoma. Case report. J Neurosurg. 2005 Dec; 103(6):1084-7. PMID: 16381197.
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    61. Perrin RG, Laxton AW. Metastatic spine disease: epidemiology, pathophysiology, and evaluation of patients. Neurosurg Clin N Am. 2004 Oct; 15(4):365-73. PMID: 15450871.
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    62. Laxton AW, Perrin RG. The relations between social support, life stress, and quality of life following spinal decompression surgery. Spinal Cord. 2003 Oct; 41(10):553-8. PMID: 14504612.
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